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Confounding response of macrofauna from a confluence of impacts: brine and sewage pollution

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Acta Oceanologica Sinica 2013年第10期32卷 74-81页

作者： rodrigo Riera fernando Tuya Myriam Rodríguez óscar Monterroso Eva Ramos Centro de Investigaciones Medioambientales del Atlántico (CIMA SL) Arzobispo Elías Yanes 4438206 La LagunaTenerifeCanary IslandsSpain BIOGES University of Las Palmas de G.C.35017 Las Palmas de Gran CanariaCanary IslandsSpain

Throughout the shores of the world, a confluence of different sources of pollution is common, e.g., through outlets releasing brine, industrial, and domestic sewage. In this study, we assessed whether a combined disposal of domestic sewage and brine altered the patterns of abundance and assemblage structure of sub- tidal macrofauna inhabiting sandy seabeds on the south coast of Gran Canaria （Canary Islands, NE Atlantic Ocean）. Samples were collected in two surveys （May 2008 and January 2009） at three distances （0, 15, and 30 m） away from the discharge point. Macrofaunal abundances showed different patterns with varying proximity from the disposal point in the two surveys. In May 2008, lower abundances were observed at 0 m （53.89±46.82 ind.） than at 15 m （120±91.7 ind.） and 30 m （283.89±189.33 ind.） away from the dis- posal point. In January 2009, however, higher abundances were observed at 0 m （131.33±58.69 ind.） than at 30 m （100±24.44 ind.） and 15 m （84.78±58.39 ind.） away from the disposal point. Significant differ- ences in macrofaunal assemblage structure were found with varying proximity from the discharge point in both surveys. The effect of proximity from the disposal point was confounded by changes in sedimen- tary composition between surveys, which contributed to explain differences in macrofaunal abundances and assemblage structure with varying proximity from the discharge point. As a result, confounding driver- s of macrofaunal assemblage structure, here, changes in sediment composition, accounted for changes in macrofaunal abundances and assemblage structure with varying proximity from a combined disposal point of brine and sewage.

关键词： macrofauna amphipoda polychaeta brine sewage Canary Islands

Hepatolithiasis:Epidemiology,presentation,classification and management of a complex disease

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World Journal of Gastroenterology 2024年第13期30卷 1836-1850页

作者： rodrigo V.Motta Francesca Saffioti Vasileios K Mavroeidis Translational Gastroenterology and Liver Unit Nuffield Department of MedicineUniversity of OxfordOxford OX39DUUnited Kingdom Department of Gastroenterology and Hepatology Oxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxford OX39DUUnited Kingdom UCL Institute for Liver and Digestive Health and Sheila Sherlock Liver Unit Royal Free Hospital and University College LondonLondon NW32QGUnited Kingdom Department of HPB Surgery Bristol Royal InfirmaryUniversity Hospitals Bristol and Weston NHS Foundation TrustBristol BS28HWUnited Kingdom Department of Transplant Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom Department of Gastrointestinal Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom

The term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts,above the hilar confluence of the hepatic *** disease is more prevalent in Asia,mainly owing to socioeconomic and dietary factors,as well as the prevalence of biliary *** the last century,owing to migration,its global incidence has *** main pathophysiological mechanisms involve cholangitis,bile infection and biliary strictures,creating a self-sustaining cycle that perpetuates the disease,frequently characterised by recurrent episodes of bacterial infection referred to as syndrome of“recurrent pyogenic cholangitis”.Furthermore,long-standing hepatolithiasis is a known risk factor for development of intrahepatic *** classifications have aimed at providing useful insight of clinically relevant aspects and guidance for *** management of symptomatic patients and those with complications can be complex,and relies upon a multidisciplinary team of hepatologists,endoscopists,interventional radiologists and hepatobiliary surgeons,with the main goal being to offer relief from the clinical presentations and prevent the development of more serious *** comprehensive review provides insight on various aspects of hepatolithiasis,with a focus on epidemiology,new evidence on pathophysiology,most important clinical aspects,different classification systems and contemporary management.

关键词： Cholelithiasis Intrahepatic stones Cholangiocarcinoma Biliary parasites Recurrent pyogenic cholangitis Oriental cholangiohepatitis Hepatectomy Cholangioscopy Liver transplant Paediatric

The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders

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Translational Neurodegeneration 2022年第1期11卷 401-425页

作者： Margrethe A.Olesen Francisca Villavicencio-Tejo rodrigo A.Quintanilla Laboratory of Neurodegenerative Diseases Facultad de Ciencias de La SaludInstituto de Ciencias BiomédicasUniversidad Autónoma de ChileSantiagoChile

Neurological disorders(NDs)are characterized by progressive neuronal dysfunction leading to synaptic failure,cognitive impairment,and motor *** these diseases,Alzheimer’s disease(AD),Parkinson’s disease(PD),Huntington’s disease(HD),and amyotrophic lateral sclerosis(ALS)have raised a significant research *** disorders present common neuropathological signs,including neuronal dysfunction,protein accumulation,oxidative damage,and mitochondrial *** this context,mitochondrial impairment is characterized by a deficiency in ATP production,excessive production of reactive oxygen species,calcium dysregulation,mitochondrial transport failure,and mitochondrial dynamics *** defects in mitochondrial health could compromise the synaptic process,leading to early cognitive dysfunction observed in these ***,skin fibroblasts from AD,PD,HD,and ALS patients have been suggested as a useful strategy to investigate and detect early mitochondrial abnormalities in these *** this context,fibroblasts are considered a viable model for studying neurodegenerative changes due to their metabolic and biochemical relationships with ***,studies of our group and others have shown impairment of mitochondrial bioenergetics in fibroblasts from patients diagnosed with sporadic and genetic forms of AD,PD,HD,and ***,these mitochondrial abnormalities have been observed in the brain tissues of patients suffering from the same ***,fibroblasts represent a novel strategy to study the genesis and progression of mitochondrial dysfunction in AD,PD,HD,and *** review discusses recent evidence that proposes fibroblasts as a potential target to study mitochondrial bioenergetics impairment in neurological disorders and consequently to search for new biomarkers of neurodegeneration.

关键词： Mitochondria Fibroblasts Cell reprogramming Alzheimer’s disease Parkinson’s disease Huntington’s disease Amyotrophic lateral sclerosis Mitochondrial dysfunction

Prognostic angiogenic markers(endoglin, VEGF, CD31) and tumor cell proliferation(Ki67) for gastrointestinal stromal tumors

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World Journal of Gastroenterology 2015年第22期21卷 6924-6930页

作者： rodrigo Panno Basilio-de-Oliveira Vera Lucia Nunes Pannain Pathology Post-Graduate Program Federal University of Rio de Janeiro Department of Pathology and Clinical Support Federal University of Rio de Janeiro State Department of Pathology Pathology Post-Graduate Program Federal University of Rio de Janeiro

AIM: To evaluate the correlation between the immunoexpression of angiogenic markers [CD31, CD105 and vascular endothelial growth factor(VEGF)], proliferative index(Ki67), and prognosis of patients with gastrointestinal stromal tumors(GIST).METHODS: This is a retrospective study of 54 GIST cases. Medical records were searched to obtain the GIST patients' demographic and clinical data, and paraffin-embedded blocks of tumor samples were retrieved from the hospital archives to conduct a new immunohistochemical evaluation. The tumor samples of GIST patients were subject to immunohistochemical evaluation for endoglin(CD105), CD31, VEGF, and Ki67 expression. The CD105 and CD31 intratumoral microvascular density(IMVD) was measured using automated analysis. We determined the correlation between the immunoexpression of CD105, CD31, VEGF,Ki67 and prognosis. In addition, we conducted a cutoff analysis using the receiver-operating characteristic curve. VEGF positivity was classified as either null/weak or strong. Ki67 was evaluated using a cutoff of 5%positive cells. The prognosis was classified as good(patient alive without recurrence) or poor(patient with recurrence/death).RESULTS: The distribution of tumor sites among the54 analyzed samples was as follows: 27(50%) in the stomach, 20(37.1%) in the small intestine, 6(11.1%)in the colon, and 1(1.8%) in the esophagus. The size of the tumors ranged from 2 to 33 cm(median: 8cm); in 12 cases(22.2%), the tumor was below 5 cm at the largest diameter, but in 42 cases(77.7%), the tumor was larger than 5 cm. The means of CD105 and CD31 were significantly higher in the group with poor prognosis(P 1.2%) and CD31(> 2.5%) in the receiver-operating characteristic curve were related to a poorer *** with a better prognosis showed significantly null/weak staining for VEGF(P < 0.001). Ki-67 expression of≥ 5% was strongly correlated with a worse prognosis(P< 0.001). In the multivariate analysis, C

关键词： Angiogenesis Immunohistochemistry,CD105 CD31 Gastrointestinal stromal tumors Vascularendothelial growth factor Ki-67

Distributed Discrimination of Strain and Temperature Based on Brillouin Dynamic Grating in an Optical Fiber

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Photonic Sensors 2013年第4期3卷 332-344页

作者： Kazuo HOTATE Weiwen ZOU rodrigo Kendy YAMASHITA Zuyuan HE Department of Electrical Engineering and Information Systems The University of Tokyo Japan State Key Laboratory Advanced Optical Communication Systems and Networks Department of Electronic EngineeringShanghai Jiao Tong University China

This paper reviews distributed discrimination of strain and temperature by use of an optical fiber based on fiber optic nerve systems. The preliminary method based on multiple resonance peaks of the Brillouin gain spectrum in a specially-designed fiber is firstly introduced. The complete discrimination of strain and temperature based on the Brillouin dynamic grating in a polarization maintaining fiber is extensively presented. The basic principle and two experimental schemes of distributed discrimination based on fiber optic nerve systems are demonstrated. The performance of the high discriminative accuracy （0.1 ~C-0.3 ~C and 5 kte-12~te） and high spatial resolution （-10 cm） with the effective measurement points of about 50 for a standard system configuration or about 1000 for a modified one will be highly expected in real industry applications.

关键词： Fiber optic nerve systems Brillouin optical correlation-domain analysis Brillouin dynamic grating distributed discrimination strain temperature

Extremal Coalitions for Influence Games Through Swarm Intelligence-Based Methods

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Computers, Materials & Continua 2022年第3期70卷 6305-6321页

作者： Fabián Riquelme rodrigo Olivares Francisco Munoz Xavier Molinero Maria Serna Escuela de Ingeniería Informática Universidad de ValparaísoValparaísoChile Computer Science Department Universitat Politècnica de CatalunyaBarcelonaSpain Mathematics Department Universitat Politècnica de CatalunyaTerrassaSpain

An influence game is a simple game represented over an influence graph(i.e.,a labeled,weighted graph)on which the influence spread phenomenon is *** games allow applying different properties and parameters coming from cooperative game theory to the contexts of social network analysis,decision-systems,voting systems,and collective *** exact calculation of several of these properties and parameters is computationally hard,even for a small number of *** examples of these parameters are the length and the width of a *** length of a game is the size of its smaller winning coalition,while the width of a game is the size of its larger losing *** parameters are relevant to know the levels of difficulty in reaching agreements in collective decision-making *** the above,new bio-inspired metaheuristic algorithms have recently been developed to solve the NP-hard influence maximization problem in an efficient and approximate way,being able to find small winning coalitions that maximize the influence spread within an influence *** this article,we apply some variations of this solution to find extreme winning and losing coalitions,and thus efficient approximate solutions for the length and the width of influence *** a case study,we consider two real social networks,one formed by the 58 members of the European Union Council under nice voting rules,and the other formed by the 705 members of the European Parliament,connected by political *** are promising and show that it is feasible to generate approximate solutions for the length and width parameters of influence games,in reduced solving time.

关键词： Influence game influence spread collective behavior swarm intelligence bio-inspired computing

OPTIMAL DESIGN OF HOUSING ATTICS WITH INTEGRATED SOLAR COLLECTORS

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Journal of Green Building 2017年第4期12卷 3-20页

作者： rodrigo García Alvarado Pedro G.Campos Paulina Wegertseder Departmento Diseño y Teoría de la Arquitectura Universidad del Bío-BíoAv.Collao 1202Concepción 4051381Chile Departmento de Sistemas de Información Universidad del Bío-BíoAv.Collao 1202Concepción 4051381Chile Diseño y Teoría de la Arquitectura Universidad del Bío-BíoAv.Collao 1202Concepción 4051381Chile

In order to reduce the increasing energy consumption for the domestic demands of existing single-family housing and take advantage of frequent building enlargements,this paper presents a methodology and supporting software tool for determining the optimal design configuration of an attic with integrated solar *** analysis procedure is based on parametric modeling,energy simulation and the use of evolutionary algorithms for finding optimal *** has been implemented as a Web-platform for public use that provides users with a proposal of an attic shape with maximum solar energy collection,maximum living space and minimum construc-tion envelope for each house according its size and *** attic integrates PV,thermal and hybrid solar panels on one side of the *** paper describes the methodology and software design,asssment of the Web-platform usage and case-studies to verify its *** a matter of minutes,the Web-platform enables users to select a specific attic design for each house that has integrated solar collectors that can produce energy to cover almost 100%of domestic energy *** attics designed provide a nearly 30%increase in living space through the extension of one to four rooms,and the construction cost of the envelope is similar to that of a standard housing extension.

关键词： web platform for attic design integrated solar collectors attic spaces energy consumption of single family housing parametric modeling energy simulation optimal designs

Real-world evidence on adjuvant chemotherapy in older adults with stage II/III colon cancer

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World Journal of Gastrointestinal Oncology 2020年第6期12卷 604-618页

作者： Atul Batra rodrigo Rigo Dropen Sheka Winson Y Cheung Department of Medicine Tom Baker Cancer CentreCalgaryAlberta T2N 1N4Canada Department of Oncology University of CalgaryCalgaryAlberta T 2N 4N2Canada

Colon cancer represents one of the most common cancers diagnosed in older adults *** standard of care in resected stage II and stage III colon cancer continues to *** there is unequivocal evidence to suggest both disease free and overall survival benefits with the use of combination chemotherapy in patients with stage III colon cancer,data regarding its use in patients with stage II colon cancer are less ***,although colon cancer is a disease that affects older adults,there is considerable debate on the value of adjuvant chemotherapy in the aging *** particular,many older patients are undertreated when compared to their younger *** this review,we will describe the clinical trials that contributed to the current adjuvant chemotherapy approach in colon cancer,discuss representation of older adults in trials and the specific challenges associated with the management of this subpopulation,and highlight the role of comprehensive geriatric *** will also review how real-world evidence complements the data gaps from clinical trials of early stage colon cancer.

关键词： Colon cancer Older adults Adjuvant chemotherapy Real-world evidence

Peripheral nerve regeneration with conduits:use of vein tubes

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Neural Regeneration Research 2015年第4期10卷 529-533页

作者： rodrigo Guerra Sabongi Marcela fernandes Joao Baptista Gomes dos Santos Department of Orthopedics and Traumatology Escola Paulista de MedicinaFederal University of Sao Paulo Division of Hand Surgery Department of Orthopedics and TraumatologyEscola Paulista de MedicinaFederal University of Sao Paulo

Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the com-plexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the au-tologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.

关键词： peripheral nerve injury nerve graft nerve conduit Wallerian degeneration neurotrophic factors veins autografts nerve regeneration