Cirrhosis and autoimmune liver disease:Current understanding

作     者：Rodrigo Liberal Charlotte R Grant 

作者机构：Institute of Liver StudiesKing’s College London School of Medicine at King’s College Hospital 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2016年第8卷第28期

页      面：1157-1168页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Hepatic fibrosis Cirrhosis Myofibroblasts Primary biliary cirrhosis Primary sclerosing cholangitis Autoimmune hepatitis Liver transplantation 

摘      要：Primary biliary cirrhosis(PBC),primary sclerosing cholangitis(PSC) and autoimmune hepatitis(AIH) constitute the classic autoimmune liver diseases(AILDs).While AIH target the hepatocytes,in PBC and PSC the targets of the autoimmune attack are the biliary epithelial *** liver injury,associated with chronic AILD,leads to un-resolving inflammation,cell proliferation and the deposition of extracellular matrix proteins by hepatic stellate cells and portal *** cirrhosis,and the resultant loss of normal liver function,inevitably *** with cirrhosis have higher risks or morbidity and mortality,and that in the decompensated phase,complications of portal hypertension and/or liver dysfunction lead to rapid *** diagnosis and monitoring of cirrhosis is,therefore of upmost *** biopsy is currently the gold standard technique,but highly promising non-invasive methodology is under *** transplantation(LT) is an effective therapeutic option for the management of endstage liver disease secondary to AIH,PBC and *** is indicated for AILD patients who have progressed to end-stage chronic liver disease or developed intractable symptoms or hepatic malignancy;in addition,LT may also be indicated for patients presenting with acute liver disease due to AIH who do not respond to steroids.