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Expression of Multidrug Resistance ATP-Binding Cassette(ABC)Transporters in Canine Mammary Tumors

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Advances in Breast Cancer Research 2015年第3期4卷 77-85页

作者： Breno S.Salgado Suely Nonogaki Luisa M.Soares Angela Akamatsu Cristiano R.N.da Silva Thiago P.Anacleto rodolfo malagó Rafael M.Rocha Fátima Gartner Noeme S.Rocha Departamento de Patologia Faculdade de Medicina de BotucatuUniversidade Estadual PaulistaCampus de BotucatuBotucatuBrazil Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto(Intitute of Biomedical Sciences Abel Salazar of University of Porto)OportoPortugal Fundacao Antonio Prudente Hospital A.C.CamargoSao PauloBrazil Departamento de Clínica Veterinária Faculdade de Medicina Veterinária e ZootecniaUniversidade Estadual PaulistaUNESP.BotucatuBrazil Hospital Escola de Medicina Veterinária Fundacao de Ensino e Pesquisa de Itajubá—FEPIItajubáBrazil

Mammary neoplasms are the most common tumors in female dogs. They are usually treated using solely surgical mastectomy—which is recognized as unsatisfactory in many cases. Given this, the benefits of chemotherapy in dogs with mammary cancer need to be further explored. Some drugs that can be used for treating canines with mammary tumors may be substrates of uptake and/or efflux transporters such as the ATP-binding cassette (ABC) transporters. Unfortunately, very little is known regarding the pathobiology of such proteins in canine tumors, including mammary cancer. Accordingly, this study was designed to characterize the expression of ABC transporters P-glycoprotein, MRP1, and MRP2 and their relation with clinicopathologic factors in order to allow a better understanding of their influence in canine mammary cancer. P-glycoprotein was expressed in tumors from 55.8% of patients, while MRP1 and MRP2 were expressed in 37.2% and 39.5% of tumors, respectively. P-glycoprotein expression showed to be related with regional lymph node spread (P = 0.0038), as well as with tumor grade (P = 0.0353) and with a shorter survival (P = 0.0245). MRP1 revealed a strong association with a higher histological grade (P < 0.0001) and overall survival (P = 0.0002). Additionally, MRP1 was determined as prognostic indicator independent of lymph node status using Cox proportional-hazards regression multivariate analysis (P = 0.0216). No relations between MRP2 and clinicopathologic features were observed. We have found that P-glycoprotein and MRP1 are expressed in highly aggressive canine mammary tumors and are related with poor prognosis. Our results suggest that they may play a significant role in the course of canine mammary cancer progression and be promising candidate markers for a validation study on therapy outcome.

关键词： MDR1 P-Gp MRP1 MRP2 ABCC2 Mammary Neoplasms Prognosis Dog

Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala Sara Pischedda Miriam Cebey-Lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez rodolfo Gomez Federico Martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

Nonlinear criterion for strength mobilization in brittle failure of rock and its extension to the tunnel scale

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International Journal of Mining Science and Technology 2022年第4期32卷 685-705页

作者： rodolfo Cabezas Javier Vallejos Faculty of Engineering and Technology Universidad San SebastianSantiagoChile Advanced Mining Technology Center Universidad de ChileSantiagoChile Department of Mining Engineering Universidad de ChileSantiagoChile

As underground excavations are getting deeper and field stresses increase, the behavior of intact rock blocks plays an increasingly important role in understanding and estimating the overall rock mass strength. To model the brittle behavior of intact rock blocks, the stress–strain curve is usually idealized considering a linear strength mobilization approach(cohesion-weakening-friction-strengthening, CWFS),however, it is well recognized that rock presents a nonlinear behavior in terms of the confining *** study extends the strength mobilization in brittle failure of rock using nonlinear criteria. To determine the model parameters, a standard statistical method that uses the complete laboratory stress–strain curves of the intact rock is employed. Several hypotheses of linear and nonlinear models are statistically compared for different types of rock and confining stress levels. Results demonstrate that the best approach to model the brittle failure of rock is to consider a nonlinear strength envelope, such as the Hoek-Brown criterion assuming a residual uniaxial compressive strength different from zero and a mi parameter that increases, both with simultaneous mobilization. This model helps to recreate highconfining conditions and a more realistic transition between peak and post-peak strength. The obtained parameters are discussed and compared with literature values to verify the validity and to develop guidelines for the estimation of parameters, providing an objective mobilization criterion. Finally, the nonlinear model was applied to a finite element code and extended to a tunnel scale in the brittle rock under high-stress conditions. A reasonable fit between the simulations and the in-situ overbreak measurements was found.

关键词： Nonlinear strength Strength mobilization Brittle failure Intact rock Scaling

Antecedent Precipitation Index to Estimate Soil Moisture and Correlate as a Triggering Process in the Occurrence of Landslides

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International Journal of Geosciences 2024年第1期15卷 70-86页

作者： Marcio Augusto Ernesto De Moraes Walter Manoel Mendes Filho rodolfo Moreda Mendes Cassiano Antonio Bortolozo Daniel Metodiev Marcio Roberto Magalhães De Andrade Harideva Marturano Egas Tatiana Sussel Gonçalves Mendes Luana Albertani Pampuch CEMADEN - National Centre for Monitoring and Early Warnings of Natural Disasters General Coordination of Research and Development S&#227o José dos Campos Brazil Faculty of Science and Technology Goias Federal University Aparecida de Goi&#226nia Brazil Institute of Science and Technology S&#227o Paulo State University (Unesp) S&#227o José dos Campos Brazil

Landslides are highly dangerous phenomena that occur in different parts of the world and pose significant threats to human populations. Intense rainfall events are the main triggering process for landslides in urbanized slope regions, especially those considered high-risk areas. Various other factors contribute to the process;thus, it is essential to analyze the causes of such incidents in all possible ways. Soil moisture plays a critical role in the Earth’s surface-atmosphere interaction systems;hence, measurements and their estimations are crucial for understanding all processes involved in the water balance, especially those related to landslides. Soil moisture can be estimated from in-situ measurements using different sensors and techniques, satellite remote sensing, hydrological modeling, and indicators to index moisture conditions. Antecedent soil moisture can significantly impact runoff for the same rainfall event in a watershed. The Antecedent Precipitation Index (API) or “retained rainfall,” along with the antecedent moisture condition from the Natural Resources Conservation Service, is generally applied to estimate runoff in watersheds where data is limited or unavailable. This work aims to explore API in estimating soil moisture and establish thresholds based on landslide occurrences. The estimated soil moisture will be compared and calibrated using measurements obtained through multisensor capacitance probes installed in a high-risk area located in the mountainous region of Campos do Jordão municipality, São Paulo, Brazil. The API used in the calculation has been modified, where the recession coefficient depends on air temperature variability as well as the climatological mean temperature, which can be considered as losses in the water balance due to evapotranspiration. Once the API is calibrated, it will be used to extrapolate to the entire watershed and consequently estimate soil moisture. By utilizing recorded mass movements and comparing them with AP

关键词： Landslides Antecedent Precipitation Index Soil Moisture Threshold Water Balance

ARHCS (Automatic Rainfall Half-Life Cluster System): A Landslides Early Warning System (LEWS) Using Cluster Analysis and Automatic Threshold Definition

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International Journal of Geosciences 2024年第1期15卷 54-69页

作者： Cassiano Antonio Bortolozo Luana Albertani Pampuch Marcio Roberto Magalhães De Andrade Daniel Metodiev Adenilson Roberto Carvalho Tatiana Sussel Gonçalves Mendes Tristan Pryer Harideva Marturano Egas rodolfo Moreda Mendes Isadora Araújo Sousa Jenny Power Cemaden - National Center for Monitoring and Early Warning of Natural Disasters General Coordination of Research and Development S&#227o José dos Campos Brazil Environmental Engineering Department Institute of Science and Technology S&#227o Paulo State University S&#227o José dos Campos Brazil Department of Mathematical Sciences University of Bath Bath UK Institute for Mathematical Innovation University of Bath Bath UK

A significant portion of Landslide Early Warning Systems (LEWS) relies on the definition of operational thresholds and the monitoring of cumulative rainfall for alert issuance. These thresholds can be obtained in various ways, but most often they are based on previous landslide data. This approach introduces several limitations. For instance, there is a requirement for the location to have been previously monitored in some way to have this type of information recorded. Another significant limitation is the need for information regarding the location and timing of incidents. Despite the current ease of obtaining location information (GPS, drone images, etc.), the timing of the event remains challenging to ascertain for a considerable portion of landslide data. Concerning rainfall monitoring, there are multiple ways to consider it, for instance, examining accumulations over various intervals (1 h, 6 h, 24 h, 72 h), as well as in the calculation of effective rainfall, which represents the precipitation that actually infiltrates the soil. However, in the vast majority of cases, both the thresholds and the rain monitoring approach are defined manually and subjectively, relying on the operators’ experience. This makes the process labor-intensive and time-consuming, hindering the establishment of a truly standardized and rapidly scalable methodology on a large scale. In this work, we propose a Landslides Early Warning System (LEWS) based on the concept of rainfall half-life and the determination of thresholds using Cluster Analysis and data inversion. The system is designed to be applied in extensive monitoring networks, such as the one utilized by Cemaden, Brazil’s National Center for Monitoring and Early Warning of Natural Disasters.

关键词： Landslides Early Warning System (LEWS) Cluster Analysis Landslides Brazil

Preliminary examination of early neuroconnectivity features in the R6/1 mouse model of Huntington's disease by ultra-high field diffusion MRI

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Neural Regeneration Research 2022年第5期17卷 983-986页

作者： rodolfo G.Gatto Carina Weissmann Department of Bioengineering the University of Illinois at ChicagoChicagoILUSA Instituto de Fisiología Biología Molecular y Neurociencias-IFIBYNECONICET Universidad de Buenos AiresBuenos AiresArgentina

During the last decades,advances in the understanding of genetic,cellular,and microstructural alterations associated to Huntington's disease(HD)have improved the understanding of this progressive and fatal ***,events related to early neuropathological events,neuroinflammation,deterioration of neuronal connectivity and compensatory mechanisms still remain vastly ***-high field diffusion MRI(UHFD-MRI)techniques can contribute to a more comprehensive analysis of the early microstructural changes observed in *** addition,it is possible to evaluate if early imaging microstructural parameters might be linked to histological ***,qualitative studies analyzing histological complexity in brain areas susceptible to neurodegeneration could provide information on inflammatory events,compensatory increase of neuroconnectivity and mechanisms of brain repair and *** application of ultra-high field diffusion-MRI technology in animal models,particularly the R6/1 mice(a common preclinical mammalian model of HD),provide the opportunity to analyze alterations in a physiologically intact model of the *** some disparities in volumetric changes across different brain structures between preclinical and clinical models has been documented,further application of different diffusion MRI techniques used in combination like diffusion tensor imaging,and neurite orientation dispersion and density imaging have proved effective in characterizing early parameters associated to alteration in water diffusion exchange within intracellular and extracellular compartments in brain white and grey ***,the combination of diffusion MRI imaging techniques and more complex neuropathological analysis could accelerate the discovery of new imaging biomarkers and the early diagnosis and neuromonitoring of patients affected with HD.

关键词： brain repair diffusion tensor imaging Huntington's disease neurite orientation dispersion and density imaging neuroconnectivity neuroinflammation neuroplasticity neuroregeneration R6/1 mice ultra-high field diffusion MRI

A Review on the Mechanical Behaviour of Bamboo Reinforced Concrete Beams

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Journal of Renewable Materials 2022年第12期10卷 3629-3657页

作者： Usama Sayed Assima Dauletbek Xue Xin rodolfo Lorenzo Haitao Li College of Civil Engineering Nanjing Forestry UniversityNanjing 210037China Joint International Research Laboratory for Bio-composite Building Materials and Structures Nanjing Forestry UniversityNanjing210037China University College London LondonWC1E 6BTUK

In light of the increasing demand for sustainable building materials,the effectiveness of bamboo utilization in various fields has become the object of scientists'close *** increased interest in bamboo is explained by its sustainable characteristics,which make it the most preferred material for environmentally friendly and cost-effective construction compared to conventional *** of bamboo is vast and diverse:from decora-tion and furniture to structural members and re *** to the low price,rich resources,and high ela sticity,bamboo culms have also been used as an alternative to steel reinforcement in concrete ***-sive research has been done to assess feasibilty of bamboo reinforcement in structural elements made of *** article discusses the mechanical properties of three types of structural bamboo reinforced concrete(BRC)*** original papers on the mechanical behaviour of structural BRC members were studied,and the fundamental properties induding typical failure modes,reasons of failure,load displacement relationships,and influencing factors were discussed and *** and conclusions of the review will contribute to deep understanding of structural feasibility of BRC beams and serve as a base for future research.

关键词： Concrete bamboo bamboo reinforced concrete mechanical behaviour

Obtaining 2D Soil Geotechnical Profiles from Cokriging Interpolation of Sample Data and Electrical Resistivity Tomography (ERT)—Applications in Mass Movements Studies

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International Journal of Geosciences 2024年第7期15卷 525-548页

作者： Cassiano Antonio Bortolozo Noel Howley Andy Legg Tristan Pryer Danielle Silva de Paula Tatiana Sussel Gonçalves Mendes Daniel Metodiev Marcio Roberto Magalhães de Andrade Silvio Jorge Coelho Simões Maiconn Vinicius de Moraes Marcio Augusto Ernesto de Moraes Luana Albertani Pampuch rodolfo Moreda Mendes Harideva Marturano Egas Institute of Science and Technology So Paulo State University (UNESP) So Jos dos Campos Brazil Cemaden-National Center for Monitoring and Early Warning of Natural Disasters General Coordination of Research and Development So Jos dos Campos Brazil Institute for Mathematical Innovation University of Bath Bath UK Department of Mathematical Sciences University of Bath Bath UK

Brazil annually faces significant challenges with mass movements, particularly in areas with poorly constructed housing, inadequate engineering, and lacking sanitation infrastructure. Campos do Jordão, in São Paulo state, is a city currently grappling with these issues. This paper details a study conducted within a pilot area in Campos do Jordão, where geophysical surveys and geotechnical borehole data were integrated. The geophysical surveys provided 2D profiles, and samples were collected to analyse soil moisture and plasticity. These datasets were combined using a Cokriging-based model to produce an accurate representation of the subsurface conditions. The enhanced modelling of subsurface variability facilitates a deeper understanding of soil behavior, which can be used to improve landslide risk assessments. This approach is innovative, particularly within the international context where similar studies often do not address the complexities associated with urban planning deficits such as those observed in some areas of Brazil. These conditions, including the lack of proper sanitation and irregular housing, significantly influence the geological stability of the region, adding layers of complexity to subsurface assessments. Adapting geotechnical evaluation methods to local challenges offers the potential to increase the efficacy and relevance of geological risk management in regions with similar socio-economic and urban characteristics.

关键词： Mass Movements Geophysics ERT Geotechnical Surveys Campos do Jordão Cokriging

A Review of Experimental Research on the Mode I Fracture Behavior of Bamboo

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Journal of Renewable Materials 2023年第6期11卷 2787-2808页

作者： Yue Chen Haitao Li Lei Gao Wei Xu rodolfo Lorenzo Milan Gaff College of Civil Engineering Nanjing Forestry UniversityNanjing210037China Joint International Research Laboratory for Bio-Composite Building Materials and Structures Nanjing Forestry UniversityNanjing210037China Department of Civil and Airport Engineering Nanjing University of Aeronautics and AstronauticsNanjing211106China University College London LondonWC1E 6BTUK Department of Furniture Design and Habitat BrnoMendel University in BrnoBrno61300Czech Republic Faculty of Civil Engineering Experimental CentreCzech Technical University in PragueThakurova 7Prague16629Czech Republic

Bamboo is an eco-friendly material with light weight,high strength,short growth cycle and high sustainability,which is widely used in building *** bamboo has further promoted the development of modern bamboo structures due to its unrestricted size and ***,as a fiber-reinforced material,fracture damage,especially Mode I fracture damage,becomes the most likely damage mode of its structure,so Mode I fracture characteristics are an important subject in the research of mechanical properties of *** paper summarizes the current status of experimental research on the Mode I fracture properties of bamboo based on the three-point bending(TPB)method,the single-edge notched beam(SENB)method,the compact tension(CT)method and the double cantilever beam(DCB)method,compares the fracture toughness of different species of bamboo,analyzes the toughening mechanisms and fracture damage modes,discusses the applicability of different theoretical calculation methods,and makes suggestions for future research priorities,aiming to provide a reference for future research and engineering applications in related fields.

关键词： Mode I fracture properties test method toughening mechanism fracture damage modes