Preliminary examination of early neuroconnectivity features in the R6/1 mouse model of Huntington's disease by ultra-high field diffusion MRI

作     者：Rodolfo G.Gatto Carina Weissmann Rodolfo G.Gatto;Carina Weissmann

作者机构：Department of Bioengineeringthe University of Illinois at ChicagoChicagoILUSA Instituto de Fisiología Biología Molecular y Neurociencias-IFIBYNECONICETUniversidad de Buenos AiresBuenos AiresArgentina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第5期

页      面：983-986页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported in part by the High Magnetic Field Laboratory(NHMFL)and Advanced Magnetic Resonance Imaging and Spectroscopy(AMRIS)under Magnetic Laboratory Visiting Scientist Program Award No.VSP#327(to RG) 

主　　题：brain repair diffusion tensor imaging Huntington's disease neurite orientation dispersion and density imaging neuroconnectivity neuroinflammation neuroplasticity neuroregeneration R6/1 mice ultra-high field diffusion MRI 

摘      要：During the last decades,advances in the understanding of genetic,cellular,and microstructural alterations associated to Huntington s disease(HD)have improved the understanding of this progressive and fatal ***,events related to early neuropathological events,neuroinflammation,deterioration of neuronal connectivity and compensatory mechanisms still remain vastly ***-high field diffusion MRI(UHFD-MRI)techniques can contribute to a more comprehensive analysis of the early microstructural changes observed in *** addition,it is possible to evaluate if early imaging microstructural parameters might be linked to histological ***,qualitative studies analyzing histological complexity in brain areas susceptible to neurodegeneration could provide information on inflammatory events,compensatory increase of neuroconnectivity and mechanisms of brain repair and *** application of ultra-high field diffusion-MRI technology in animal models,particularly the R6/1 mice(a common preclinical mammalian model of HD),provide the opportunity to analyze alterations in a physiologically intact model of the *** some disparities in volumetric changes across different brain structures between preclinical and clinical models has been documented,further application of different diffusion MRI techniques used in combination like diffusion tensor imaging,and neurite orientation dispersion and density imaging have proved effective in characterizing early parameters associated to alteration in water diffusion exchange within intracellular and extracellular compartments in brain white and grey ***,the combination of diffusion MRI imaging techniques and more complex neuropathological analysis could accelerate the discovery of new imaging biomarkers and the early diagnosis and neuromonitoring of patients affected with HD.