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Blockchain(Research and Applications) 2021年第2期2卷 82-96页

作者： Nikita Karandikar rockey abhishek Nishant Saurabh Zhiming Zhao Alexander Lercher Ninoslav Marina Radu Prodan Chunming Rong Antorweep Chakravorty Department of Electrical Engineering and Computer Science University of StavangerStavanger86004036Norway Department of Energy and Petroleum Engineering University of StavangerStavanger86004036Norway Institute of Information Technology University of KlagenfurtKlagenfurt am Worthersee9020Austria Multiscale Networked Systems University of AmsterdamAmsterdam 1012 WXNetherlands University of Information Science and Technology OhridNorth Macedonia

Peak mitigation is of interest to power companies as peak periods may require the operator to over provision supply in order to meet the peak *** the usage curve can result in cost savings,both for the power companies and the end *** of renewable energy into the energy infrastructure presents an opportunity to use excess renewable generation to supplement supply and alleviate *** addition,demand side management can shift the usage from peak to off-peak times and reduce the magnitude of *** this work,we present a data driven approach for incentive-based peak *** user energy profiles is an essential step in this *** begin by analysing a popular energy research dataset published by the Ausgrid *** aggregated user energy behavior in temporal contexts and semantic linking and contextual clustering give us insight into consumption and rooftop solar generation *** implement,and performance test a blockchain-based prosumer incentivization *** smart contract logic is based on our analysis of the Ausgrid *** implementation is capable of supporting 792,540 customers with a reasonably low infrastructure footprint.

关键词： Peak shaving Aggregation analysis Contextual clustering Blockchain Incentivization

Endoscopic ultrasound-guided portal pressure gradient identifies patients with previously undiagnosed clinically significant portal hypertension

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Portal Hypertension & Cirrhosis 2024年第2期3卷 67-74页

作者： Jerome C.Edelson Scott F.D.Edelson John G.Quiles Cyrus V.Edelson Eric M.Montminy Christian L.Horn John P.Magulick Don C.rockey Department of Gastroenterology and Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA Department of Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA Department of Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger Jr.Hospital of Cook County ChicagoIllinoisUSA Digestive Disease Research Center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a complication of cirrhosis that leads to hepatic *** the portal pressure gradient(PPG)provides valuable information for disease assessment,staging,and *** this study,we aimed to report the utilization of endoscopic ultrasound(EUS)-guided PPG(EUS-PPG)measurements in a real-world ***:This retrospective analysis included patients at a tertiary care center who underwent EUS-PPG between February 2021 and May *** most common indication was to establish or exclude the diagnosis of cirrhosis,followed by an assessment of surgical risk in the setting of suspected *** demographic and clinical data were collected,and statistical analysis was performed using the Student's t ***:Eighteen patients underwent *** success was achieved in 17 of the 18 *** complications were *** mean scores of Child-Pugh,Model for End-Stage Liver Disease-Sodium,and Fibrosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 patients,two presented with esophageal varices and six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and five patients exhibited clinically significant PH(CSPH).Of the 18 patients,15 underwent concurrent EUS-liver biopsy,which was 100%successful and provided diagnostic histology for all *** PPG data led to changes in the clinical management of 17 ***:EUS-PPG is safe and technically *** Child-Pugh score did not correlate well with the presence of CSPH;however,PPG measurements resulted in changes in the management of almost all *** studies correlating EUS-PPG with other assessments of liver diseases are required.

关键词： EUS portal hypertension portal pressure gradient

The cellular microenvironment and cytoskeletal actin dynamics in liver fibrogenesis

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BIOCELL 2022年第9期46卷 2003-2007页

作者： NOUR HIJAZI DON C.rockey ZENGDUN SHI Medical University of South Carolina Charleston29425USA

Hepatic stellate cells(HSCs)are the primary effector cells in liver *** the normal liver,HSCs serve as the primary vitamin A storage cells in the body and retain a“quiescent”***,after liver injury,they transdifferentiate to an“activated”myofibroblast-like phenotype,which is associated with dramatic upregulation of smooth muscle specific actin and extracellular matrix *** result is a fibrotic,stiff,and dysfunctional ***,understanding the molecular mechanisms that govern HSC function is essential for the development of anti-fibrotic *** actin cytoskeleton has emerged as a key component of the fibrogenic response in wound *** data indicate that the cytoskeleton receives signals from the cellular microenvironment and translates them to cellular function—in particular,increased type I collagen *** in nature,the actin cytoskeleton continuously polymerizes and depolymerizes in response to changes in the cellular *** this viewpoint,we discuss the recent developments underlying cytoskeletal actin dynamics in liver fibrosis,including how the cellular microenvironment affects HSC function and the molecular mechanisms that regulate the actininduced increase in collagen expression typical of activated HSCs.

关键词： Extracellular matrix Actin dynamics Transcriptional regulation Signaling

The natural history of patients with compensated cirrhosis and elevated hepatic venous pressure gradient

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Portal Hypertension & Cirrhosis 2022年第2期1卷 101-106页

作者： Andrew Wortham Ali Khalifa Don C.rockey Digestive Disease Research Center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension is a major complication of liver *** venous pressure gradient(HVPG)appears to be one of the best surrogates of clinical ***,the utility of elevated HVPG in predicting subsequent clinical decompensation is ***:We analyzed 410 patients who underwent HVPG assessment between 2014 and *** these,we identified and analyzed 20 patients with HVPG>12 mmHg without evidence of clinical decompensation(defined as ascites,nonbleeding esophageal varices or bleeding esophageal varices,hepatic encephalopathy,hepatopulmonary syndrome,or hepatic hydrothorax).Additionally,we compared this group to 40 randomly selected cirrhotic patients with HVPG>12 mmHg with signs of clinical *** events were subsequently assessed(mean=33 months)after HVPG ***:Patients with high HVPG without evidence of clinical decompensation had a significantly lower model for end‐stage liver disease(MELD)scores(8±4)compared to decompensated patients(13±8,p=0.05).HVPG measurements were similar in compensated(17±6 mmHg)and decompensated(18±4 mmHg)*** follow‐up for 33 months,8/20 compensated patients had a decompensating event and neither MELD(8 and 8,respectively)nor HVPG(17 and 18 mmHg,respectively)differentiated patients who remained compensated versus those that *** albumin at the time of HVPG measurement was significantly higher in patients who remained compensated than those with a decompensating event(3.5 vs.2.6 g/dl,respectively,p=0.05).Conclusions:A small,unique,population of cirrhotic patients with substantially elevated HVPG appear to remain free of complications over long‐term follow‐up.

关键词： Child‐Pugh score fibrosis liver disease mortality portal hypertension

沉默Ebp1蛋白对胃癌HGC-27细胞增殖、侵袭和迁移的影响

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沉默Ebp1蛋白对胃癌HGC-27细胞增殖、侵袭和迁移的影响

作者：路琪（PRAJAPATI rockey）延边大学

学位级别：硕士

目的:Ebp1是Erb B3受体的主要结合蛋白之一,具有多种细胞功能包括凋亡、增殖和分化。研究表明Ebp1不同类型的癌症中表达,并在癌症的发展中起重要作用,Ebp1在胃癌细胞中也高表达,但其在胃癌中的确切作用仍不清楚。本研究探讨沉默Ebp1蛋... 详细信息

目的:Ebp1是Erb B3受体的主要结合蛋白之一,具有多种细胞功能包括凋亡、增殖和分化。研究表明Ebp1不同类型的癌症中表达,并在癌症的发展中起重要作用,Ebp1在胃癌细胞中也高表达,但其在胃癌中的确切作用仍不清楚。本研究探讨沉默Ebp1蛋白对胃癌HGC-27细胞增殖、侵袭和迁移的影响、为胃癌的诊断和预后提供实验依据。方法:本实验利用胃癌HGC-27细胞株,用重组慢病毒载体感染72小时观察细胞中Ebp1蛋白的沉默。实验分为两组:Ebp1沉默组（KD组）和无病毒感染对照组（NC组）。采用蛋白免疫印迹法检测两组细胞Ebp1蛋白表达,Ebp1蛋白表达显著降低表明转染成功。转染成功后用MTT法检测细胞活性,平板克隆实验检测细胞增殖能力和集落形成能力,流式细胞术检测细胞的细胞周期和凋亡,划痕实验检测细胞的迁移能力,Transwell小室法检测细胞的侵袭能力,蛋白免疫印迹法检测细胞的上皮-间质转化相关蛋白的表达水平。结果1.蛋白质印迹检测结果显示:KD组Ebp1的表达明显低于NC组,表明成功构建了胃癌HGC-27细胞Ebp1的沉默。***检测结果显示:KD组比NC组细胞增殖能力明显减弱（*P＜0.05）。3.平板克隆法检测结果显示:KD组比NC组的克隆能力明显降低（***P＜0.001）。4.划痕实验结果显示:KD组的愈合能力明显低于NC组,表明Ebp1基因沉默后HGC-27细胞的迁移能力减弱。***小室法检测结果表明:KD组比NC组侵袭能力明显降低,表明Ebp1基因沉默减弱了HGC-27细胞的侵袭能力。6.流式细胞术检测结果显示:KD组G0/G1期细胞比例明显高于NC组,而S期和G2/M期细胞比例明显低于NC组,该结果表明沉默Ebp1之后,胃癌细胞发生细胞周期阻滞,细胞主要阻滞在G0/G1期。7.蛋白质印迹法检测结果显示:与NC组相比,KD组N-cadherin、Vimentin、Snail和Slug蛋白的表达降低,而E-cadherin的表达增加。E-cadherin蛋白的增加和Ncadherin、Vimentin、Snail和Slug蛋白的减少意味着上皮-间充质转变的减少。上皮-间质转化状态的降低,即KD组侵袭和转移活动的减少。结论:***1基因沉默减弱了HGC-27细胞的增殖、抑制了胃癌HGC-27细胞的侵袭和转移。***1诱导胃癌细胞的上皮-间质转化。

关键词：胃癌 Ebp1基因 HGC-27细胞系细胞增殖凋亡侵袭上皮-间质转化

The launch of Portal Hypertension&Cirrhosis in discovery and patient care

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Portal Hypertension & Cirrhosis 2022年第2期1卷 87-89页

作者： Don C.rockey Digestive Disease Research Center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Cirrhosis represents the body's wound healing response to liver injury,is analogous to wound healing in other parenchymal organs,1 and is associated with portal ***,portal hypertension represents the major complication of cirrhosis and is tightly linked to clinical outcomes in patients with *** fact,of all the clinical variables used to predict outcomes in patients with cirrhosis,the hepatic venous pressure gradient(HVPG)is arguably the ***,the measurement of HVPG is considered to be an invasive procedure and requires specific expertise.

关键词： healing wound clinical

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门静脉高压治疗最新进展

传染病网络动态 2004年第2期 30-31页

作者：赵春燕 DonC．rockey

第54届美国肝脏疾病研究学会年会于2003年10月28日在波士顿召开，会上就肝硬化和门静脉高压患者的治疗提出了最新观点。这个报道对会议的若干记录加以集中并提供了地方临床医师与其病相关的更为关键的信息。

关键词：门静脉高压治疗肝硬化预防

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肝硬化的最新进展一纤维化标记的作用

传染病网络动态 2004年第11期 23-24页

作者： DonC．rockey 赵春燕

在本年度的消化性疾病周(DDW)会议上提出了新的重要的资料一强调和评论了目前非堡篓性的（血清)标记可替代肝活检来检测纤维化的现状。本报告集中了一些与临床医师有关的和实用的会议记录及重要信息。

关键词：肝硬化纤维化标记透明质酸酶 a-2巨球蛋白

气钡灌肠、CT结肠成像和结肠镜检:前瞻性对比研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 8-9页

作者： rockey D.C. Paulson E. Niedzwiecki D. 姜志茹 Duke University Medical Center Durham NC United States Dr.

Background The usefulness of currently available colon imaging tests, including air contrast barium enema (ACBE), computed tomographic colonography (CTC), and colonoscopy, to detect colon polyps and cancers is uncertain. We aimed to assess the sensitivity of these three imaging tests. Methods Patients with faecal occult blood, haematochezia, iron-deficiency anaemia, or a family history of colon cancer underwent three separate colon-imaging studies -ACBE, followed 7-14 days later by CTC and colonoscopy on the same day. The primary outcome was detection of colonic polyps and cancers. Outcomes were assessed by building an aggregate view of the colon, taking into account results of all three tests. Findings 614 patients completed all three imaging tests. When analysed on a per-patient basis, for lesions 10 mm or larger in size (n=63), the sensitivity of ACBE was 48%(95%CI 35-61), CTC 59%(46-71, p=0.1083 for CTC vs ACBE), and colonoscopy 98%(91-100, p< 0.0001 for colonoscopy vs CTC). For lesions 6-9 mm in size (n=116), sensitivity was 35%for ACBE (27-45), 51%for CTC (41-60, p=0.0080 for CTC vs ACBE), and 99%for colonoscopy (95-100, p<0.0001 for colonoscopy vs CTC). For lesions of 10 mm or larger in size, the specificity was greater for colonoscopy (0.996) than for either ACBE (0.90) or CTC (0.96) and declined for ACBE and CTC when smaller lesions were considered. Interpretation Colonoscopy was more sensitive than other tests, as currently undertaken, for detection of colonic polyps and cancers. These data have important implications for diagnostic use of colon imaging tests.

关键词：结肠镜检 CT结肠成像钡灌肠结肠息肉大便隐血特异性

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2003—2004年美国毕业后医学教育

美国医学会杂志（中文版） 2005年第5期24卷 299-304页

作者： Sarah E. Brotherton Paul H. rockey Sylvia I. Etzel 唐福林（译） Division of Graduate Medical Education Amedcan Medical Association Chicago Ili 不详

背景：近几年医学院校研究生情况和毕业后医学教育（graduate medical education，GME）中医师培训特点预示着今后美国医务工作者的规模和构成。目的：调查即将毕业的住院医师接受培训课程的趋势和职业选择特点，监测整个住院医师群体... 详细信息

背景：近几年医学院校研究生情况和毕业后医学教育（graduate medical education，GME）中医师培训特点预示着今后美国医务工作者的规模和构成。目的：调查即将毕业的住院医师接受培训课程的趋势和职业选择特点，监测整个住院医师群体规模的变化趋势。设计、地点和参试者：美国医学会（American Medical Association）和美国医学院联合会（Association of American Medical Colleges）共同调查了2003～2004学年在职、转调及毕业住院医师参加的培训课程及其特点。有8192项课程反映了94．6％的住院医师接受培训的情况。近86％的课程负责人（n=7040）完成了相关的课程调查。主要观察指标：过去6年中住院医师及其培训课程的数量、特点的总体趋势，即将毕业的住院医师的专业。结果：2003～2004学年在职住院医师有99964人，为全国GME普查记录之最。首次参加美国毕业后医学教育课程的住院医师人数（n=22444）也为记录之最。1999年，28773名医师完成了培训课程，其中10546人（36．7％）为女性。2003年研究生为29745名，其中11681人（39．3％）为女性，增长了10．8％。从事妇产科的男性研究生的数量减少了31．3％，而从事妇产科的女性研究生的人数增长了18．2％。皮肤病学、家庭医学、内科学、眼科学、病理学、精神病学和普通外科学等专业亦见男性比例减少而女性比例增加的现象。继续参加其他专业培训的研究生比例有所增长：1999年的百分比为27．2％，2001年为29．6％，2003年为32．1％。2000年，35．7％的课程有助于提高受训者的文化水平；2003年，这一比例为50．7％。提供备选或自选医学课程的培训项目比例稳定在24％。结论：参加GME的医师人数正处于历史最高峰，近三分之一的医师在完成某一培训项目后继续参加其他培训课程。虽然女性住院医师的选择在许多方面与男性住院医师相似，但他们之间仍存在重大差异。

关键词：毕业后医学教育美国医学会 Medical 住院医师培训课程 medical 医师培训医学教育课程医学院校培训项目