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Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review

World Journal of Gastroenterology 2020年第37期26卷 5617-5628页

作者： Miguel Jimenez Perez rocio gonzalez grande UGC de Aparato Digestivo Unidad de Hepatologia-Trasplante HepaticoHospital Regional Universitario de MalagaMalaga 29010Spain

Although artificial intelligence(AI)was initially developed many years ago,it has experienced spectacular advances over the last 10 years for application in the field of medicine,and is now used for diagnostic,therapeutic and prognostic purposes in almost all *** application in the area of hepatology is especially relevant for the study of hepatocellular carcinoma(HCC),as this is a very common tumor,with particular radiological characteristics that allow its diagnosis without the need for a histological ***,the interpretation and analysis of the resulting images is not always easy,in addition to which the images vary during the course of the disease,and prognosis and treatment response can be conditioned by multiple *** vast amount of data available lend themselves to study and analysis by AI in its various branches,such as deeplearning(DL)and machine learning(ML),which play a fundamental role in decision-making as well as overcoming the constraints involved in human *** is a form of AI based on automated learning from a set of previously provided data and training in algorithms to organize and recognize *** is a more extensive form of learning that attempts to simulate the working of the human brain,using a lot more data and more complex *** review specifies the type of AI used by the various ***,welldesigned prospective studies are needed in order to avoid as far as possible any bias that may later affect the interpretability of the images and thereby limit the acceptance and application of these models in clinical *** addition,professionals now need to understand the true usefulness of these techniques,as well as their associated strengths and limitations.

关键词： Artificial intelligence Machine learning Hepatocellular carcinoma Diagnosis Treatment Prognosis

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Critical care specialists,the missing link in organ procurement for transplantation

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World Journal of Critical Care Medicine 2024年第2期13卷 1-6页

作者： Francisca Del rocio gonzalez Cohens Fernando M gonzalez Web Intelligence Centre Faculty of Physics and Mathematical SciencesUniversidad de ChileSantiago 8370397Chile Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile

The procurement process for organ donation begins with the identification of potential organ donors in emergency or critical care units(CCU),followed by their clinical evaluation,diagnostic procedures,and therapeutic interventions,mostly conducted in *** concludes with the request for organ donation and,if accepted,the retrieval of *** most interventions occurring in detection units,there has been a neglect of the strategic role played by critical care specialists(CCS)in managing and caring for brain-dead or near-brain-death *** arise:Are they willing to undertake this responsibility?Do they fully comprehend the nature of organ procurement?Are they aware of the specific interventions required to maintain possible organ donors in optimal physiological condition?Our objective is to examine the role of CCS in organ procurement and propose ways to enhance it,ultimately aiming to increase and enhance organ donation rates.

关键词： Organ procurement Transplantation Brain death Cardiac death Organ donation

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Pain assessment and management in the newborn:A systematized review

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World Journal of Clinical Cases 2021年第21期9卷 5921-5931页

作者： Maria Teresa Garcia-Rodriguez Sergio Bujan-Bravo rocio Seijo-Bestilleiro Cristina gonzalez-Martin Research in Nursing and Health Care Institute of Biomedical Research of A Coruña(INIBIC)Complexo Hospitalario Universitario de A Coruña(CHUAC)SERGASAs Xubias 8415006 A Coruña Universidade da Coruña(UDC)A Coruña 15006Spain Health Sciences Complexo Hospitalario Universitario de A CoruñaA Coruña 15006Spain

BACKGROUND Neonatal pain has been underdiagnosed due to several false *** To determine the status of neonatal pain in newborns who are admitted to intensive care *** Different databases were *** reviews and research reports conducted in newborns that were written in English,Spanish,or Portuguese,published between 2010 and 2020,and having free access to the full text were selected.A total of 135 articles were found,and 18 articles were finally *** Newborns are exposed to numerous painful *** order to assess their pain levels,several scales have been used,although they are sometimes not correctly *** terms of pain management,the nursing team plays a very important role based mainly on both pharmacological and non-pharmacological *** Nursing staff members must be well trained in order to identify pain and to interpret the scales ***,they have an important role in performing non-pharmacological procedures for pain management.

关键词： Neonatal pain Intensive care unit Nursing Management Treatment Systematized review

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What is the most effective exercise protocol to improve cardiovascular fitness in overweight and obese subjects？

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Journal of Sport and Health Science 2017年第4期6卷 454-461页

作者： Eliane Aparecida Castro Ana Belen Peinado Pedro Jose Benito MercedeS Galindo Marcela gonzalez-Gross rocio Cupeiro Department of Health and Human Performance Faculty of Physical Activity and Sport Sciences Universidad Polit~cnica de Madrid Madrid 28040 Spain LFE Research Group Universidad PolitOcnica de Madrid Madrid 28040 Spain Faculty of Physical Activity and Sport Sciences Universidad Politecnica de Madrid Madrid 28040 Spain ImFINE Research Group Universidad PolitOcnica de Madrid Madrid 28040 Spain

Background: Increased peak oxygen consumption(VO2 peak) can reduce cardiovascular risks associated with obesity. Our aim was to analyze the effect of a weight loss program on cardiovascular fitness in overweight(W) and obese(O) ***: One hundred and sixty-seven subjects(77 males and 90 females), aged 18–50 years, performed a modified Bruce protocol before(pre)and after(post) a weight loss program of 24 weeks. This program combined physical training(strength, S; endurance, E; combined strength + endurance, SE; or physical activity recommendation, PA) 3 times per week, with a 25%–30% caloric restriction ***: VO2 peak improved in overweight and obese males(pre and post values in L/min, respectively; W = 3.2 ± 0.6 vs. 3.7 ± 0.5, p < 0.001;O = 3.6 ± 0.6 vs. 3.8 ± 0.6, p = 0.013) as well as in overweight females(2.0 ± 0.3 vs. 2.3 ± 0.4, p < 0.001). VO2 peak in the first ventilatory threshold(VT1) increased for all 4 interventions in males(p < 0.05), except for S in the obese group(1.6 ± 0.2 vs. 1.7 ± 0.3, p = 0.141). In females, it increased in E(0.9 ± 0.2 vs. 1.4 ± 0.3, p < 0.001), SE(0.9 ± 0.2 vs. 1.2 ± 0.4, p = 0.003), and PA(0.9 ± 0.1 vs. 1.2 ± 0.2, p = 0.006) in overweight groups. Time-to-exhaustion improved in all subjects except for females in PA group(15.7 ± 0.3 min vs. 15.9 ± 0.3 min, p = 0.495).Conclusion: Our results suggest that all methods, including the recommendation of physical activity, can improve cardiovascular fitness in overweight subjects and obese males.

关键词： Combined training Endurance training Obesity Oxygen consumption Physical activity Strength training Ventilatory threshold

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Re-emerging threat of Trypanosoma cruzi vector transmission in El Salvador, update from 2018 to 2020

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Infectious Diseases of Poverty 2022年第4期11卷 101-102页

作者： Marvin Stanley Rodriguez Yuko Nitahara Michelle Cornejo Kevin Siliezar Rafael grande Ana gonzalez Kotaro Tasaki Yu Nakagama Yu Michimuko Yoko Onizuka Junko Nakajima-Shimada Jose Eduardo Romero Jose Ricardo Palacios Carmen Elena Arias Wilam Mejia Yasutoshi Kido Ricardo Cardona Alvarenga Department of Virology and Parasitology Graduate School of MedicineOsaka Metropolitan University1-4-3 Asahi-machiAbeno-kuOsaka 545-8585 Japan 不详

Background:Since the late twentieth century,Chagas disease gained global attention to suppress the vector burden as a main control strategy in endemic *** Central America,multi-national initiative successfully achieved significant reduction in the estimated disease prevalence as well as elimination of the region's principal vector species at the time in *** the last decade has witnessed significant changes in ecosystem-such as urbanization and replacement of the main vector species-that can possibly affect the vector's habitation and residual transmission,the up-to-date vector burden in the region has not been evaluated thoroughly due to the cessation of active vector *** aim of this study was to update the risk of vector-borne Trypanosoma cruzi infection in El Salvador,the top Chagas disease-endemic country in Central ***:A nationwide vector survey was conducted in the domestic environment of El Salvador from September 2018 to November *** selection of the houses for inspection was based on expert purposeful *** for *** was examined by microscopic observation of the insects'feces,followed by a species confrmation using *** data were analyzed using R software version *** estimates with 95%confidence intervals were inferred using the Jeffrey's method provided under the epiR ***:A total of 1529 Triatoma dimidiata was captured from 107 houses(infestation rate,34.4%;107/311)in all the fourteen departments of the country visited within the period;prevalence of *** infection was as high as 10%(153/1529).In the country,domestic *** infestation was distributed ubiquitously,while *** infection rates varied across the *** out of fourteen departments showed higher infection rates than the average,suggesting sporadic high-risk areas in the ***:Our comprehensive study revealed substantial *** infection of *** across the country,in

关键词： Chagas disease Vector transmission Triatomine Trypanosoma cruzi Triatoma dimidiata

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Testicular expression of the TGF-<i>β</i>1 system and the control of Leydig cell proliferation

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Advances in Bioscience and Biotechnology 2013年第10期4卷 1-7页

作者： gonzalez Candela rocio Calandra Ricardo Saul gonzalez-Calvar Silvia Ines Institute of Biology and Experimental Medicine National Council for Scientific and Technical Research Buenos Aires Argentina Research Center of Biomedical Biotechnology Environmental and Diagnostic Studies Maimónides University Buenos Aires Ar- gentina

Transforming growth factor beta 1 (TGF-β1) is a key regulator that modulates male reproductive function. Testicular TGF-β1 modulates the steroidogenesis of Leydig cells, the organization of peritubular myoid cells, testis development and spermatogenesis. Several studies have indicated that TGF-β1 is involved in the tight balance between proliferative and apoptotic responses in the Leydig cells. In the present review, we summarize the direct effects of this cytokine in Leydig cells under normal and pathological conditions. We analyze the effect of TGF-β1 inLeydig cells depending on the type of receptors involved in the signaling pathway of TGF-β1. Our group has been analyzing the canonical and non canonical intracellular signaling pathways of TGF-β1 that are involved in the expression of proliferative and apoptotic markers in Leydig cells. On the basis of our studies and from those of other authors we conclude that the balance between the expression of TGF-β1 receptors and co receptors is of relevance in Leydig cell physiology and pathophisiology.

关键词： TGF-β1 Leydig ALK Endoglin

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Energy Signaling in the Regulation of Gene Expression during Stress

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Molecular Plant 2010年第2期3卷 300-313页

作者： Elena Baena-gonzalez Instituto Gulbenkian de Ciencia Rua da Quinta Grande 6 2780-156 Oeiras Portugal

Maintenance of homeostasis is pivotal to all forms of life. In the case of plants, homeostasis is constantly threatened by the inability to escape environmental fluctuations, and therefore sensitive mechanisms must have evolved to allow rapid perception of environmental cues and concomitant modification of growth and developmental patterns for adaptation and survival. Re-establishment of homeostasis in response to environmental perturbations requires reprog- ramming of metabolism and gene expression to shunt energy sources from growth-related biosynthetic processes to defense, acclimation, and, ultimately, adaptation. Failure to mount an initial ＇emergency＇ response may result in nutrient deprivation and irreversible senescence and cell death. Early signaling events largely determine the capacity of plants to orchestrate a successful adaptive response. Early events, on the other hand, are likely to be shared by different conditions through the generation of similar signals and before more specific responses are elaborated. Recent studies lend credence to this hypothesis, underpinning the importance of a shared energy signal in the transcriptional response to various types of stress. Energy deficiency is associated with most environmental perturbations due to their direct or indirect deleterious impact on photosynthesis and/or respiration. Several systems are known to have evolved for monitoring the available resources and triggering metabolic, growth, and developmental decisions accordingly. In doing so, energy-sensing systems regulate gene expression at multiple levels to allow flexibility in the diversity and the kinetics of the stress response.

关键词： Abiotic/environmental stress metabolic regulation cell signaling gene expression post-transcriptionalcontrol transcriptional control and transcription factors.

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Fluorometric Viability Assessment of Capacitated and Acrosome-Reacted Boar Spermatozoa by Flow Cytometry

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Optics and Photonics Journal 2013年第1期3卷 40-44页

作者： Reyna Fierro Humberto gonzalez-Marquez rocio Ortiz Jerome Chevrier Bernard Foliguet Departamento de Ciencias de la Salud Universidad Autonoma Metropolitana-IztapalapaMexico CityMexico Laboratoire d’Histologie Embryologie et Microscopie ElectroniqueUniversite LorraineNancyFrance

Sperm capacitation involves functional changes, such as the removal or appearance of specific molecules and changes in the plasma membrane;the acrosome reaction (AR) is an exocytotic event induced by calcium influx, enabling the spermatozoa to penetrate the zona pellucida. These processes can be achieved only if the spermatozoa have good viability;indeed, determination of sperm viability is used for the assessment of semen quality. Membrane integrity and mitochondrial activity are important viability parameters of spermatozoa and fluorescent techniques based on membrane permeability to dyes have been developed to determine these parameters. The aim of this work was to determine the viability of boar sperm (fresh, one hour of capacitation induction and 20 min of AR induction) by flow cytometry using propidium iodide (PI) (1.25 μg/mL) and rhodamine 123 (R123) (0.20 μg/mL). Aliquots of 5 × 105 sperm were incubated with each fluorochrome separately and simultaneously for 10 or 20 min, respectively, at 38℃. The proportion of labeled spermatozoa and their fluorescence intensities were measured using a flow cytometer. The fluorescence index (FI) with PI gradually increased during the incubation and we found significant differences between all the groups. With R123, the FI increased in the capacitated sperm but decreased in the acrosome-reacted sperm, with significant differences between the fresh and capacitated spermatozoa. Our results suggest that the increase in the R123 fluorescence intensity in capacitated spermatozoa is due to changes in the mitochondrial membrane activity because the spermatozoa experienced changes in membrane fluidity and flagellar activation during capacitation. The use of fluorochromes and flow cytometry is a good tool for monitoring many markers of sperm function. Although capacitation and AR processes have been well studied, there is still much information to be elucidated with regard to these complex processes.

关键词： Boar Sperm Flow Cytometry Propidium Iodide Rhodamine 123 Viability

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Novel device for monitoring respiratory rate during endoscopy-A thermodynamic sensor

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2019年第3期10卷 57-66页

作者： Vaibhav Wadhwa Adalberto J gonzalez Kristen Selema Ronen Feldman rocio Lopez John J Vargo Department of Gastroenterology and Hepatology Cleveland Clinic FloridaWestonFL 33324United States Department of Internal Medicine Cleveland Clinic FloridaWestonFL 33331United States Department of Technology Artep IncorporatedElliot CityMD 21042United States Department of Quantitative Health Sciences Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology and Hepatology Digestive Disease and Surgery InstituteCleveland ClinicClevelandOH 44195United States

BACKGROUND Monitoring ventilation accurately is an indispensable aspect of patient care in procedural *** current gold standard method of monitoring ventilation is by measuring exhaled carbon dioxide concentration,known as capnography.A new device utilizing thermodynamic measurement,the Linshom Respiratory Monitoring Device(LRMD),has been designed to measure respiratory rate(RR)by using the temperature of exhaled *** hypothesized that the temperature sensor is at least equivalent in accuracy to capnography in monitoring *** To determine if the temperature sensor is equivalent to capnography in monitoring procedural *** In this prospective study,participants were individually fitted with a face mask monitored by both LRMD and *** following data were collected:gender,age,body mass index,type of procedure,and doses of *** each patient,we report the mean RR for each device as well as the mean *** analyses were performed using SAS,and a P<0.05 was considered statistically *** Twelve consecutive patients undergoing endoscopic procedures at our institution were *** patients were excluded due to incomplete data,inadequate data,patient cooperation,and capnography ***,we found that LRMD RR highly correlated to capnography RR(P<0.001);the average capnography RR increases by 0.66 breaths for every one additional breath measured by the *** addition,apnea rates were 7.4%for the capnography and 6.4%for the LRMD(95%confidence interval:0.92-1.10).CONCLUSION The LRMD correlated with the gold standard capnography with respect to respiratory rate detection and apnea *** LRMD could be used as an alternative to capnography for measuring respiration in endoscopy.

关键词： Sedation Capnography Linshom Thermodynamic sensor Endoscopy

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Genome-wide QTL analysis of tomato fruit cuticle deposition and composition

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Horticulture Research 2021年第1期8卷 1443-1457页

作者： Rida Barraj Barraj Patricia Segado rocio Moreno-gonzalez Antonio Heredia Rafael Fernandez-Munoz Eva Dominguez Instituto de Hortofruticultura Subtropical y Mediterranea La Mayora Universidad de Malaga-Consejo Superior de Investigaciones CientificasDepartamento de Mejora Genetica y BiotecnologiaEstacion Experimental La MayoraAlgarrobo-CostaE-29750 MalagaSpain Instituto de Hortofruticultura Subtropical y Mediterranea La Mayora Universidad de Malaga0Consejo Superior de Investigaciones CientificasDepartamento de Biologia Molecular y BioquimicaUniversidad de MalagaE-29071 MalagaSpain Departament de Bioquimica i Fisiologia and Institut de Recerca en Nutricioi Seguretat Alimentaria(INSA-UB) Universitat de Barcelona(UB)E-08028 BarcelonaSpain

Genetics of traits related to fruit cuticle deposition and composition was studied in two red-fruited tomato *** mapping populations derived from the cross between the cultivated tomato(Solanum lycopersicum L.)and its closest relative wild species Solanum pimpinellifolium *** employed to conduct a QTL analysis.A combination of fruit cuticle deposition,components and anatomical traits were investigated and the individual effect of each QTL evaluated.A total of 70 QTLs were identified,indicating that all the cuticle traits analyzed have a complex polygenic nature.A combination of additive and epistatic interactions was observed for all the traits,with positive contribution of both parental lines to most of *** of QTLs for various traits uncovered novel genomic regions producing extensive changes in the *** density emerges as an important trait since it can modulate cuticle thickness and invagination thus providing a strategy for sustaining mechanical strength without compromising *** genomic regions,located in chromosomes 1 and 12,are responsible for the negative interaction between cuticle waxes and phenolics identified in tomato *** candidate genes,including transcription factors and structural genes,are postulated and their expression analyzed throughout development.

关键词： cultivated traits additive

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