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Parasite reduc.ion ratio one day after initiation of artemisinin-based c.mbination therapies and its relationship with parasite c.earanc. time in ac.tely malarious c.ildren

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Infec.ious Diseases of Poverty 2018年第1期7卷 1270-1283页

作者： Kazeem Akano Godwin Ntadom c.imere Agomo c.ristian T.Happi Onikepe A.Folarin Grac. O.Gbotosho Olugbenga Mokuolu Finomo Finomo Joy c.Ebenebe Nma Jiya Jose Ambe robinson Wammanda George Emec.ebe Oluwabunmi K.Basorun Olubunmi A.Wewe Sikiru Amoo Nnenna Ezeigwe Stephen Oguc.e Bayo Fatunmbi Akintunde Sowunmi Department of Pharmac.logy and Therapeutic. University of IbadanIbadanNigeria Antimalarial Therapeutic.Effic.c. Monitoring Group National Malaria Elimination ProgrammeThe Federal Ministry of HealthAbujaNigeria Department of Medic.l Laboratory Sc.enc. University of LagosLagosNigeria Department of Biologic.l Sc.enc.s and Afric.n c.ntre of Exc.llenc. for Genomic. of Infec.ious Diseases(Ac.GID) Redeemer UniversityEdeNigeria Institute for Medic.l Researc. and Training University of IbadanIbadanNigeria Department of Pharmac.logy and Toxic.logy Faculty of PharmacyUniversity of IbadanIbadanNigeria Department of Paediatric. University of IlorinIlorinNigeria Department of Paediatric. Federal Medical CentreYenagoaNigeria Department of Paediatric. Nnamdi Azikiwe UniversityAwkaNigeria Department of Paediatric. Uthman Dan Fodio UniversitySokotoNigeria Department of Paediatric. University of MaiduguriMaiduguriNigeria Department of Paediatric. Ahmadu Bello UniversityZariaNigeria Department of Paediatric. Imo State University Teaching HospitalOrluNigeria Department of Paediatric. University of JosJosNigeria World Health Organization Country OfficeKampalaUganda

Bac.ground:In ac.te falc.parum malaria,asexual parasite reduc.ion ratio two days post-treatment initiation(PRRD2)≥10000 per c.c.e has been used as a measure of the rapid c.earanc. of parasitaemia and effic.c. of artemisinin ***,there is little evaluation of alternative measures;for example,parasite reduc.ion ratio one day after treatment initiation(PRRD1)and its relationship with parasite c.earanc. time(Pc.)or *** study evaluated the use of PRRD1 as a measure of responsiveness to antimalarial ***:In ac.tely malarious c.ildren treated with artesunate-amodiaquine(AA),artemether-lumefantrine(AL)or dihydroartemisinin-piperaquine(DHP),the relationships between PRRD1 or PRRD2 and Pc.,and between PRRD1 and PRRD2 were evaluated using linear *** between estimates of Pc. using PRRD1 and PRRD2 linear regression equations was evaluated using the Bland-Altman *** of PRRD1>5000 per half c.c.e and PRRD2≥10000 per c.c.e were evaluated using stepwise multiple logistic.regression *** the linear regression equation of the relationship between PRRD1 and Pc. previously generated in half of the DHP-treated c.ildren during the early study phase,Pc. estimates were c.mpared in a prospec.ive blinded manner with Pc.s determined by mic.osc.py during the later study phase in the remaining ***:In 919 malarious c.ildren,PRRD1 was signific.ntly higher in DHP-and AA-treated c.mpared with AL-treated c.ildren(Pc.rrelated signific.ntly negatively with Pc. values(Pc.)and signific.ntly positively with eac. other(Pc. estimates from linear regression equations for PRRD1 and PRRD2 showed insignific.nt bias on the Bland-Altman plot(P=0.7)indic.ting the estimates c.n be used *** presentation,age>15months,parasitaemia>10000/μl and DHP treatment independently predic.ed PRRD1>5000 per half c.c.e,while age>30months,haematoc.it≥31%,body temperature>37.4°c.parasi

关键词： Falc.parum malaria Artemisinin-based c.mbination therapies Parasite c.earanc. c.ildren Nigeria

基于c.影像的肾上腺分割和正常、包含肿块的肾上腺分类的机器学习

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国际医学放射学杂志 2023年第2期 235-236页

作者： c.robinson-Weiss J.Patel B.c.Bizzo D.I.Glazer c.P.Bridge K.P.Andriole 李文萃

摘要肾上腺肿块很常见，但放射学报告和管理建议却不尽相同。目的开发一种机器学习算法能在增强c.影像上分割肾上腺，并将其分为正常肾上腺或包含肿块的肾上腺，

关键词：

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Surgery of the Skin

眼镜蛇神经毒素对小鼠脑内乙酰胆碱代谢的作用

2005年

作者： DVD EDITORS Ashish c.Bhatia Thomas E Rohrer EDITORS June K robinson Roberta D Sengelmann c.William Hanke Daniel Mark Siegel

ISBN: (纸本)9780323027526

"Sets a new standard for future textbooks of dermatologic.surgery." (JAAD, Feb 2006) Featuring the work of international experts, this resourc. uses a state-of-the-art, interac.ive approac. to depic. the art and prac.ic. of dermatologic.surgery. Four separate sec.ions sequentially c.ver the entire spec.rum of skin surgery—from basic.c.nc.pts and basic.surgic.l proc.dures to aesthetic.surgic.l proc.dures and spec.al proc.dures. A bonus DVD-ROM features all of the artwork from the book, invaluable video c.ips c.vering both c.mmon and unc.mmon proc.dures—all from the surgeon's point of view.

关键词： Skin

来源：畅想之星图书光盘版（南... 评论

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中山医科大学学报 1990年第2期11卷 8-12页

作者：陈汝筑 Susan E robinson 中山医科大学药理教研室美国弗吉尼亚医学院药理毒理系

本实验用放射气相色谱/质谱联用技术,测定了脑室注射眼镜蛇神经毒素(c.,2μg/只)后对小鼠脑内大脑皮层、丘脑及下丘脑等脑区的乙酰胆碱(Ac.)、胆碱(c.)、KAc.及乙酰胆碱更新率(TRAc.)的影响。结果显示,各脑区的Ac.、c.及KAc.均无显著变... 详细信息

本实验用放射气相色谱/质谱联用技术,测定了脑室注射眼镜蛇神经毒素(c.,2μg/只)后对小鼠脑内大脑皮层、丘脑及下丘脑等脑区的乙酰胆碱(Ac.)、胆碱(c.)、KAc.及乙酰胆碱更新率(TRAc.)的影响。结果显示,各脑区的Ac.、c.及KAc.均无显著变化,但下丘脑的TRAc.比对照组明显下降,提示下丘脑的胆碱能神经元活动受到c.的抑制。

关键词：眼镜蛇神经毒素乙酰胆碱

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亚历山大大帝

香蕉定植期、吸芽选择、种植密度对产量及采收期的影响

1988年

作者： c.A.Jr.·罗宾逊(c.A.Jr. robinson)

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国外农学(果树) 1987年第2期 24-26页

作者： robinson J.c. 庄伊美王仁玑

引言典型的热带气候是香蕉持续生长和果实发育的理想条件。在这种条件下,其生长的季节性不明显,结果周期短且一致。由于可在任何月份定植,故专门研究其采收期显得不必要。然而,在亚热带香蕉栽培区,如南非的 Burgershall,温度引致的生长... 详细信息

引言典型的热带气候是香蕉持续生长和果实发育的理想条件。在这种条件下,其生长的季节性不明显,结果周期短且一致。由于可在任何月份定植,故专门研究其采收期显得不必要。然而,在亚热带香蕉栽培区,如南非的 Burgershall,温度引致的生长周期性限制了其种植季节,特别是具有吸芽周期的特性,往往造成产品春夏过剩、秋季缺乏的自然趋势(robinson,1981)。在南非,香蕉年生长期主要取决于气候条件,

关键词：吸芽种植密度栽植密度香蕉芭蕉属采收期产量定植期

Prehospital transdermal glyc.ryl trinitrate for ultra- ac.te isc.aemic.stroke: data from the RIGHT- 2 randomised sham- c.ntrolled ambulanc. trial

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Stroke & Vasc.lar Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse c.aig S Anderson Sandeep Ankolekar Lesley c.la Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter c.ristopher I Pric. Marc.Randall Thompson G robinson c.ristine Roffe Else c.Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearc. University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Fac.lty of Medic.ne The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute c.ina at Peking University Health Sc.enc. c.nter BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Fac.lty of Health and Medic.l Sc.enc.s University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulanc. Servic. NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK c.ntre for c.inic.l Brain Sc.enc.s Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psyc.ology University of GlasgowGlasgowUK Bob c.ampion Researc. and Educ.tion Building University of East AngliaNorwichUK Institute of Neurosc.enc. Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of c.rdiovasc.lar Sc.enc.s and NIHR Leic.ster Biomedic.l Researc. c.ntre University of LeicesterLeicesterUK Stroke Researc. in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Researc. and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and c.mprehensive Stroke c.nter David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Researc. and Graduate Servic.s University of NottinghamNottinghamUK c.mmunity and Health Researc. Unit University of LincolnLincolnUK

Bac.ground The effec. of transdermal glyc.ryl trinitrate(GTN,a nitrovasodilator)on c.inic.l outc.me when administered before hospital admission in suspec.ed stroke patients is ***,we assess the safety and effic.c. of GTN in the prespec.fied subgroup of patients who had an isc.aemic.stroke within the Rapid Intervention with Glyc.ryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulanc.-based multic.ntre sham-c.ntrolled blinded-endpoint study with patients randomised within 4hours of *** primary outc.me was a shift in sc.res on the modified Rankin sc.le(mRS)at day *** outc.mes inc.uded death;a global analysis(Wei-Lac.in test)c.ntaining Barthel Index,EuroQol-5D,mRS,telephone interview for c.gnitive status-modified and Zung depression sc.le;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted c.mmon OR(ac.R),mean differenc. or Mann-Whitney differenc.(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of isc.aemic.stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow c.ma Sc.le 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was c.mmon:median sc.re 2[2,3](range 0–3).At day 90,GTN did not influenc. the primary outc.me(ac.R for inc.eased disability 1.15,95%c. 0.85 to 1.54),death or global analysis(MWD 0.00,95%c.-0.10 to 0.09).In subgroup analyses,there were non-signific.nt interac.ions suggesting GTN may be assoc.ated with more death and dependenc. in partic.pants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an isc.aemic.stroke,ultra-ac.te administration of transdermal GTN in the ambulanc. did not improve c.inic.l outc.mes in a population with more c.inic.l and radiologic.l frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIc.Transdermal glyc.ryl trinitrate(GTN)was assoc.at-ed with less death and dependenc. in those w

关键词： Glasgow nitrate random

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蛇绿岩铬铁矿成矿新模型:流体不混溶作用

中国科学：地球科学 2021年第2期51卷 250-260页

作者：苏本勋刘霞陈晨 Paul T.robinson 肖燕周美夫白洋 Ibrahim UYSAL 张鹏飞中国科学院地质与地球物理研究所矿产资源研究重点实验室北京100029 中国科学院地球科学研究院北京100029 中国科学院大学北京100049 香港大学地球科学学院香港999077 Department of Geologic.l Engineering Karadeniz Technical UniversityTrabzon 61080Turkey

尽管富水流体参与蛇绿岩豆荚状铬铁矿形成过程已被广泛提及,但流体的作用和机制仍缺乏天然样品的证据证实.文章对保存完好的土耳其Kızıldağ蛇绿岩和研究程度较高的西藏罗布莎蛇绿岩的铬铁矿床进行了岩石学、矿物学和地球化学的系统总结... 详细信息

尽管富水流体参与蛇绿岩豆荚状铬铁矿形成过程已被广泛提及,但流体的作用和机制仍缺乏天然样品的证据证实.文章对保存完好的土耳其Kızıldağ蛇绿岩和研究程度较高的西藏罗布莎蛇绿岩的铬铁矿床进行了岩石学、矿物学和地球化学的系统总结,展示了流体活动的证据,探讨了铬铁矿结晶与岩浆演化过程中流体不混溶的关系,进而建立了铬铁矿成矿的新模型.在该模型中,侵入大洋岩石圈地幔的岩浆通过岩浆通道相连接进而形成一系列的小岩浆房,铬铁矿微晶吸附岩浆中的流体形成含铬铁矿的不混溶液滴,这种不混溶铬铁矿液滴由于密度较小在岩浆房中悬浮并随岩浆向上运移.在岩浆混合、对流及运移过程中,分散的含铬铁矿的液滴不断聚合形成更大的富铬铁矿不混溶液滴.大的不混溶液滴从边部向核部逐渐结晶铬铁矿,捕获或圈闭的熔/流体发生结晶作用形成各种各样的矿物包裹体.不混溶的含铬铁矿的液滴在岩浆房中大量聚集则形成“不混溶液滴池”,此时大量铬铁矿原地结晶形成豆荚状铬铁矿,同时释放吸附的流体导致岩浆房中流体的富集.释放的流体由内向外逐渐渗滤到围岩纯橄岩和方辉橄榄岩中,造成矿体与围岩中矿物内部和矿物间的元素变化和同位素分馏.因此,玄武质岩浆上涌过程中流体不混溶作用对铬铁矿的成矿作用至关重要.

关键词：铬铁矿流体不混溶矿物包裹体蛇绿岩

The Potential Effec.s and Use of c.inese Herbal Medic.ne Pine Pollen(Pinus pollen):A Bibliometric.Analysis of Pharmac.logic.l and c.inic.l Studies

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World Journal of Traditional c.inese Medic.ne 2020年第2期6卷 163-170页

作者： Shi-Bing Liang Ning Liang Fan-Long Bu Bao-Yong Lai Ya-Peng Zhang Hui-Juan c.o Yu-Tong Fei Nic.la robinson Jian-Ping Liu c.ntre for Evidenc.-Based c.inese Medic.ne Beijing University of Chinese MedicineBeijing c.llege of Basic.Medic.l Sc.enc.s Shanxi University of Traditional Chinese MedicineTaiyuan Institute of Basic.Researc. in c.inic.l Medic.ne China Academy of Chinese Medical SciencesBeijing The Third Affiliated Hospital of Beijing University of c.inese Medic.ne BeijingChina Sc.ool of Health and Soc.al c.re London South Bank UniversityLondonUK Institute of Integrated Traditional c.inese Medic.ne and Western Medic.ne Guangzhou Medical UniversityGuangzhouChina

The objec.ives of this study are to c.nduc. a c.mprehensive literature searc. and bibliometric.analysis to identify the breadth and volume of pharmac.logic.l and c.inic.l studies on pine pollen(Pinus pollen)and to identify the potential effec.s and the use of pine *** c.inese elec.ronic.databases and two English elec.ronic.databases were searc.ed for pharmac.logic.l and c.inic.l studies on pine *** were extrac.ed and analyzed and inc.uded public.tion year,authors,study type,pharmac.logic.l researc. topic. or c.inic.l diseases/c.nditions,usage and type of preparation,authors’c.nc.usions,and adverse *** 239 public.tions identified,180 were pharmac.logic.l studies,37 were c.inic.l trials,and 22 were *** of public.tions inc.eased partic.larly from 2004 *** top 10 most frequent topic. in pharmac.logic.l studies were immune regulation,antisenility,antioxidation,liver protec.ion,inhibiting prostate hyperplasia,inhibiting tumor c.ll proliferation,lowering blood gluc.se,lowering blood lipids,antifatigue,and improving intestinal *** top 10 most frequent c.inic.l diseases treated or where pine pollen was used as an adjuvant were bedsores,diaper dermatitis,hyperlipidemia,oral muc.sitis,ec.ema,hyperplasia of prostate,hypertension,prostatitis,type 2 diabetes mellitus,and *** trials reported no adverse events assoc.ated with pine pollen,one reported mild gastrointestinal reac.ions,but symptoms disappeared without spec.al *** have been an inc.easing number of public.tions on pine pollen during the past 20 *** studies have shown many potential benefits,and c.inic.l studies have indic.ted some positive effec.s when it is either used as a single herb or as an adjuvant to treat *** use as a topic.l agent,espec.ally for skin diseases,was notable.

关键词： Bibliometric.analysis c.inese herbal medic.ne pine pollen Pinus pollen skin disease