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Comment on“Hypothermic machine perfusion in liver transplantation-a randomized trial”

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 364-366页

作者： Fabien robin Heithem Jeddou Department of Hepatobiliary and Digestive Surgery University HospitalRennes 1 UniversityRennesFrance INSERM U1242 Chemistry Oncogenesis Stress SignalingRennes 1 UniversityRennesFrance

We read with great interest the article by van Rijn et *** in March 2021,in The New England Journal of Medicine(1).In this multicenter,randomized controlled trial,the authors investigated the efficacy of dual hypothermic oxygenated perfusion(D-HOPE)versus static cold storage(SCS)in grafts from donors after cardiac death(DCD)to decrease the rate of non-anastomotic biliary stenosis(NAS)within the first 6 post-transplant months.

关键词： randomized therm perfusion

Recent advances in the systemic treatment of gastrointestinal stromal tumors

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Cancer Biology & Medicine 2023年第10期20卷 701-705页

作者： robin L.Jones Marin Golcic Sarcoma Unit The Royal Marsden NHS Foundation Trust and Institute of Cancer ResearchFulham RoadLondon SW36JJUnited Kingdom Clinic for Tumors Clinical Hospital CenterRijeka 51000Croatia

Historical overview of the treatment for advanced gastrointestinal stromal tumors(GISTs)GISTs represent a relatively rare entity;however,GISTs are still the most common mesenchymal neoplasm in the gastrointestinal *** majority of GISTs express the transmembrane receptor,KIT,a product of the KIT proto-oncogene that can lead to uncontrolled cell proliferation and resistance to apoptosis1-3.

关键词： gastrointestinal tumors treatment

Exercise and hippocampal neurogenesis: a dogma re-examined and lessons learned

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Neural Regeneration Research 2018年第8期13卷 1354-1355页

作者： Patrick Z.Liu robin Nusslock Department of Psychology Northwestern University

Exercise is a potent force of nature with significant potential for extending longevity and boosting physical fitness. It is also be- ing increasingly used as a prophylactic and curative measure for various physical a... 详细信息

关键词： a dogma re-examined and lessons learned Exercise and hippocampal neurogenesis

Carbene-catalyzed activation of cyclopropylcarbaldehydes for mannich reaction andδ-lactam formation:remote enantioselecitvity control and dynamic kinetic asymmetric transformation

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Science China Chemistry 2021年第6期64卷 985-990页

作者： Jie Lv Jun Xu Xuling Pan Zhichao Jin Yonggui robin Chi State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Division of Chemistry&Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

An N-heterocyclic carbene(NHC)-catalyzed enantioselective Mannich reaction of the remoteγ-carbon of cyclopropylcarbaldehydes is disclosed for the first ***-and enantiomerically enriched multicyclicδ-lactam compound is afforded as the main product from 8 possible stereo-specific isomers through dynamic kinetic asymmetric transformation(DYKAT)*** chiral functional molecules can be afforded from the lactam products through simple protocols with retentions of the optical purities.

关键词： N-heterocyclic carbene organocatalysis dynamic kinetic asymmetric transformation 1-cyclopropylcarbaldehydes asymmetric reactions

Analyzing voting power in decentralized governance:Who controls DAOs?

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Blockchain(Research and Applications) 2024年第3期5卷 123-129页

作者： robin Fritsch Marino Müller Roger Wattenhofer ETH Zurich 8092ZurichSwitzerland

We empirically study the state of three prominent DAO governance systems on the Ethereum blockchain:Compound,Uniswap and Ethereum name service(ENS).In particular,we examine how the voting power is distributed in these *** a comprehensive dataset of all governance token holders,delegates,propos-als,and votes,we analyze who holds the voting power and how this power is being used to influence governance *** we reveal that the majority of voting power is concentrated in the hands of a small number of addresses,we rarely observe these powerful entities overturning a vote by choosing a different outcome than that of the overall community and less influential voters.

关键词： Decentralized autonomous organization DAO governance Liquid democracy Blockchain

The emerging roles of transplanted radial glial cells in regenerating the central nervous system

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Neural Regeneration Research 2015年第10期10卷 1548-1551页

作者： robin E.White Denis S.Barry Biology Department Westfield State University Department of Anatomy Trinity Biomedical Sciences Institute Trinity College Dublin University of Dublin

Scientists conclude that a combination of treatments involving rehabilitation,drug delivery,surgery and cell transplantation are necessary to achieve significant progress in regenerating the injured central nervous sy... 详细信息

关键词： cell The emerging roles of transplanted radial glial cells in regenerating the central nervous system

Changing face of hepatic encephalopathy:Role of inflammation and oxidative stress

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World Journal of Gastroenterology 2010年第27期16卷 3347-3357页

作者： Amit S Seyan robin D Hughes Debbie L Shawcross Institute of Liver Studies King's College London School of Medicine at King's College HospitalKing's College Hospital

The face of hepatic encephalopathy(HE) is *** review explores how this neurocognitive disorder,which is associated with both acute and chronic liver injury,has grown to become a dynamic syndrome that spans a spectrum of neuropsychological impairment,from normal performance to *** central role of ammonia in the pathogenesis of HE remains ***,over the past 10 years,the HE community has begun to characterise the key roles of inflammation,infection,and oxidative/nitrosative stress in modulating the pathophysiological effects of ammonia on the *** review explores the current thoughts and evidence base in this area and discusses the potential role of existing and novel therapies that might abrogate the oxidative and nitrosative stresses inflicted on the brain in patients with,or at risk of developing,HE.

关键词： Hepatic encephalopathy Ammonia Inflammation Oxidative stress Astrocyte

On the inviscid limit of the compressible Navier-Stokes equations near Onsager's regularity in bounded domains

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Science China Mathematics 2024年第1期67卷 1-22页

作者： robin Ming Chen Zhilei Liang Dehua Wang Runzhang Xu Department of Mathematics University of PittsburghPittsburghPA 15260USA School of Mathematics Southwestern University of Finance and EconomicsChengdu 611130China College of Mathematical Sciences Harbin Engineering UniversityHarbin 150001China

The viscous dissipation limit of weak solutions is considered for the Navier-Stokes equations of compressible isentropic flows confined in a bounded *** establish a Kato-type criterion for the validity of the inviscid limit for the weak solutions of the Navier-Stokes equations in a function space with the regularity index close to Onsager’s critical *** particular,we prove that under such a regularity assumption,if the viscous energy dissipation rate vanishes in a boundary layer of thickness in the order of the viscosity,then the weak solutions of the Navier-Stokes equations converge to a weak admissible solution of the Euler *** approach is based on the commutator estimates and a subtle foliation technique near the boundary of the domain.

关键词： inviscid limit Navier-Stokes equations Euler equations weak solutions bounded domain Katotype criterion Onsager’s regularity

Unexpectedly large energy variations from dopant interactions in ferroelectric HfO_(2) from high-throughput ab initio calculations

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npj Computational Materials 2018年第1期4卷 45-53页

作者： Max Falkowski Christopher Künneth robin Materlik Alfred Kersch Munich University of Applied Sciences Lothstr.3480335 MunichGermany

Insight into the origin of process-related properties like small-scale inhomogeneities is key for material ***,we analyze DFT calculations of randomly doped HfO_(2) structures with Si,La,and VO and relate them to the kind of production *** energies of the relevant ferroelectric Pbc2_(1) phase are compared with the competing crystallographic phases under the influence of the arising local inhomogeneities in a coarse-grained *** interaction among dopants adds to the statistical effect from the random positioning of the *** anneals after atomic layer or chemical solution deposition processes,which are short compared to ceramic process tempering,the large energy variations remain because the dopants do not *** the energy difference is the criterion for the phase stability,the large variation suggests the possibility of nanoregions and diffuse phase transitions because these local doping effects may move the system over the paraelectric-ferroelectric phase boundary.

关键词： ferroelectric dopant grain