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Genome-wide Studies Reveal Genetic Risk factors for Hepatic fat Content

Genomics, proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li Eline H.van den Berg Alexander Kurilshikov Dasha V.Zhernakova Ranko Gacesa Shixian Hu Esteban A.Lopera-Maya Alexandra Zhernakova Lifelines Cohort Study Vincent E.de Meijer Serena Sanna robin p.f.dullaart Hans Blokzijl Eleonora A.M.festen Jingyuan fu Rinse K.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of precision Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(MAfLD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(MRI-pDff)in 16,050 participants and fatty liver index(fLI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University Medical Center Groningen(UMCG)Genetics Lifelines Initiative(UGLI).Meta-analysis of GWASs of MRI-pDff in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3L1(rs72910057-T,p=5.40E−09)and GCM1(rs1491489378-T,p=3.16E−09),respectively,as well as three previously reported loci:pNpLA3,TM6Sf2,and *** of fLI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZpR1(p=3.35E−13)and fTO(p=2.11E−09).Statistically significant genetic correlation(rg)between MRI-pDff(UKBB)and fLI(UGLI)GWAS results was found(rg=0.5276,p=1.45E−03).Novel MRI-pDff genetic signals(CREB3L1 and GCM1)were replicated in the fLI *** identified two novel genes for MRI-pDff and 49 replicable loci for *** a difference in hepatic fat content assessment between MRI-pDff and fLI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content MAfLD Genome-wide association study fatty liver index Magnetic resonance imaging proton density fat fraction

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pleiotropic effects of lipid genes on plasma glucose,HbA1c,and HOMA-IR levels

Pleiotropic effects of lipid genes on plasma glucose,HbA1c,a...

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第十四次全国医学遗传学学术会议

作者： Naishi Li Marijke R.van der Sijde LifeLines Cohort Study Stephan J.L.Bakker robin p.f.dullaart pim van der Harst Ron T.Gansevoort Clara C.Elbers Cisca Wijmenga Harold Snieder Marten H.Hofker Jingyuan fu 荷兰格罗宁根大学医学中心中国医学科学院北京协和医院

Objectives:Dyslipidemia is strongly associated with raised plasma glucose levels and insulin resistance(IR),and genome-wide association studies have identified 95loci that explain a substantial proportion of the variance in blood ***,the loci’s effects on glucose-related traits are largely *** current research aims to investigate relationship between the lipid loci and glucose-related *** and methods:We have studied these lipid loci and tested their association collectively and individually with fasting plasma glucose(fpG),glycated hemoglobin(HbA1c),and IR in two independent cohorts:10,995 subjects from LifeLines Cohort Study and 2,438subjects from prevention of Renal and Vascular Endstage Disease(pREVEND)***:In contrast to the positive relationship between dyslipidemia and glucose traits,the genetic predisposition to dyslipidemia showed a pleiotropic lowering effect on glucose ***,the genetic risk score related to higher triglyceride level was correlated with lower levels of fpG(p=9.6×10(-10)and p=0.03 in LifeLines and pREVEND,respectively),HbA1c(p=4.2×10(-7)in LifeLines),and HOMA of estimated IR(p=6.2×10(-4)in pREVEND),after adjusting for blood lipid *** the single nucleotide polymorphism level,15 lipid loci showed a pleiotropic association with glucose traits(pf which eight(CETp,MLXIpL,pLTp,GCKR,ApOB,ApOE-C1-C2,CYp7A1,and TIMD4)had opposite allelic directions of effect on dyslipidemia and glucose ***:for the first time,we have systematically assessed the pleiotropic effect of lipid-associated SNps on glucose-related ***,at a clinical level,dyslipidemia is associated with elevated plasma glucose levels and insulin resistance,we observed that the genetic predisposition to dyslipidemia is related to lower levels of fasting plasma glucose,HbA1c,and *** findings suggest a complex genetic regulation and metabolic interplay between lipids and glucose.

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Learning about good nutrition with the 5-color front-of-package label"Nutri-Score":an experimental study

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food Science and Human Wellness 2024年第3期13卷 1195-1200页

作者： robin C.Hau Klaus W.Lange University of Applied Sciences Landshut Landshut 84036Germany faculty of Human Sciences University of RegensburgRegensburg 93040Germany

The Nutri-Score is a 5-color front-of-pack nutrition label designed to provide consumers with an easily understandable guideline to the healthiness of food *** impact that the Nutri-Score may have on consumers'choices is unclear since different experimental paradigms have found vastly different effect *** the present study,we have investigated how student participants change a hypothetical personal 1-daydietary plan after a learning phase during which they learn about the Nutri-Scores of the available food *** were instructed to compose a healthy diet plan in order that the question of whether the NutriScore would improve their ability to compose a healthy dietary plan could be investigated,independent of the question of whether they would apply this knowledge in their ordinary *** found a substantial(Cohen's d=0.86)positive impact on nutritional quality(as measured by the Nutrient profiling System score of the food Standards Agency)and a medium-sized(Cohen's d=0.43)reduction of energy *** content reduction was larger for participants who had initially composed plans with higher energy *** results suggest that the Nutri-Score has the potential to guide consumers to healthier food *** remains unclear,however,whether this potential will be reflected in real-life dietary choices.

关键词： Nutri-Score front-of-package label Nudge Nutrition Health

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Analyzing voting power in decentralized governance: Who controls DAOs?

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BLOCKCHAIN-RESEARCH AND AppLICATIONS 2024年第3期5卷 123-129页

作者： fritsch, robin Muller, Marino Wattenhofer, Roger Swiss fed Inst Technol CH-8092 Zurich Switzerland

We empirically study the state of three prominent DAO governance systems on the Ethereum blockchain: Compound, Uniswap and Ethereum name service (ENS). In particular, we examine how the voting power is distributed in these systems. Using a comprehensive dataset of all governance token holders, delegates, proposals, and votes, we analyze who holds the voting power and how this power is being used to influence governance decisions. While we reveal that the majority of voting power is concentrated in the hands of a small number of addresses, we rarely observe these powerful entities overturning a vote by choosing a different outcome than that of the overall community and less influential voters.

关键词： Decentralized autonomous organization DAO governance Liquid democracy Blockchain

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On the inviscid limit of the compressible Navier-Stokes equations near Onsager's regularity in bounded domains

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Science China Mathematics 2024年第1期67卷 1-22页

作者： robin Ming Chen Zhilei Liang Dehua Wang Runzhang Xu Department of Mathematics University of PittsburghPittsburghPA 15260USA School of Mathematics Southwestern University of Finance and EconomicsChengdu 611130China College of Mathematical Sciences Harbin Engineering UniversityHarbin 150001China

The viscous dissipation limit of weak solutions is considered for the Navier-Stokes equations of compressible isentropic flows confined in a bounded *** establish a Kato-type criterion for the validity of the inviscid limit for the weak solutions of the Navier-Stokes equations in a function space with the regularity index close to Onsager’s critical *** particular,we prove that under such a regularity assumption,if the viscous energy dissipation rate vanishes in a boundary layer of thickness in the order of the viscosity,then the weak solutions of the Navier-Stokes equations converge to a weak admissible solution of the Euler *** approach is based on the commutator estimates and a subtle foliation technique near the boundary of the domain.

关键词： inviscid limit Navier-Stokes equations Euler equations weak solutions bounded domain Katotype criterion Onsager’s regularity

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Chiral boryl radical catalyzed asymmetric radical cycloisomerization

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Science China Chemistry 2024年第7期67卷 2121-2123页

作者： Jiamiao Jin Shi-Chao Ren Yonggui robin Chi National Key Laboratory of Green pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore

Asymmetric catalytic organic synthesis is of profound importance in modern research and industries,providing optically enriched molecules with diverse structures and functions[1].Enzymes,transition metal complexes,and simple organic molecules have all been found as powerful catalysts that enable the bond breaking and forming events with excellent control over stereo-selectivity *** the realm of designed small molecule organic catalysts.

关键词： radical catalyzed asymmetric

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New approach for particle size and shape analysis of iron-based oxygen carriers at multiple oxidation states

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particuology 2024年第7期90卷 493-503页

作者： Victor purnomo Marcelo Dal Belo Takehara robin faust Lidiya Abdisa Ejjeta Henrik Leion Division of Energy and Materials Department of Chemistry and Chemical EngineeringChalmers University of TechnologyGöteborg 41258Sweden Division of Energy Science Department of Engineering Sciences and MathematicsLuleåUniversity of TechnologyLuleå97187Sweden

One of the crucial issues in the chemical looping technology lies in its bed material:the oxygen *** size analysis of an oxygen carrier is important since in a fluidized bed the material can only work well within a specific size *** the favorable size ranges for oxygen carrier materials have already been reported,none of the published studies has analyzed the particle size and shape of oxygen carriers in ***,the effect of oxygen carriers'oxidation degree on such properties has not been considered *** study aimed to report the particle size and shape analysis of five iron-based oxygen carriers,one natural ore,one synthetic material,and three residue products,at different oxidation degrees using dynamic image analysis(DIA).The oxygen carriers were prepared at different mass conversion degrees in a fluidized bed batch *** size distribution,sphericity,and aspect ratio of the oxygen carrier particles were examined experimentally using a Camsizer *** results show that the DIA method was successfully able to analyze the particle size and shape of our oxygen carriers with satisfying accuracy for *** oxidation state of the investigated materials seems to only affect the particle size and shape of oxygen carriers to a minor ***,exposures to redox cycles in a fluidized bed reactor may alter the particle size and shape of most oxygen carriers.

关键词： Oxygen carrier Size and shape analysis Dynamic image analysis Oxidation state fluidized bed Chemical looping

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Automation and Orchestration of Zero Trust Architecture:potential Solutions and Challenges

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Machine Intelligence Research 2024年第2期21卷 294-317页

作者： Yang Cao Shiva Raj pokhrel Ye Zhu robin Doss Gang Li Centre for Cyber Resilience and Trust Deakin UniversityBurwood 3125Australia School of Information Technology Deakin UniversityGeelong 3216Australia

Zero trust architecture(ZTA)is a paradigm shift in how we protect data,stay connected and access *** is non-perimeter-based defence,which has been emerging as a promising revolution in the cyber security *** can be used to continuously maintain security by safeguarding against attacks both from inside and outside of the network ***,ZTA automation and orchestration,towards seamless deployment on real-world networks,has been limited to be reviewed in the existing *** this paper,we first identify the bottlenecks,discuss the background of ZTA and compare it with traditional perimeter-based security *** importantly,we provide an in-depth analysis of state-of-the-art AI techniques that have the potential in the automation and orchestration of ***,in this review paper,we develop a foundational view on the challenges and potential enablers for the automation and orchestration of ZTA.

关键词： Zero trust architecture cyber security artificial intelligence access control authentication

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Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile formation and Desymmetrization Reaction

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Research 2024年第3期2024卷 715-721页

作者： Yuanlin Cai Ya Lv Liangzhen Shu Zhichao Jin Yonggui robin Chi Tingting Li National Key Laboratory of Green pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore.

An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules, showing great potential as catalysts in organic chemistry.

关键词： chemistry. aldehydes chiral

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Chalcogenide Ovonic Threshold Switching Selector

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Nano-Micro Letters 2024年第5期16卷 1-40页

作者： Zihao Zhao Sergiu Clima Daniele Garbin robin Degraeve Geoffrey pourtois Zhitang Song Min Zhu National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050People’s Republic of China University of Chinese Academy of Sciences Beijing 100029People’s Republic of China IMEC Kapedreef 75LeuvenBelgium

Today’s explosion of data urgently requires memory technologies capable of storing large volumes of data in shorter time frames,a feat unattain-able with flash or *** Optane,commonly referred to as three-dimensional phase change memory,stands out as one of the most promising *** Optane with cross-point architecture is constructed through layering a storage element and a selector known as the ovonic threshold switch(OTS).The OTS device,which employs chalcogenide film,has thereby gathered increased attention in recent *** this paper,we begin by providing a brief introduction to the discovery process of the OTS ***,we summarize the key elec-trical parameters of OTS devices and delve into recent explorations of OTS materials,which are categorized as Se-based,Te-based,and S-based material ***,we discuss various models for the OTS switching mechanism,including field-induced nucleation model,as well as several carrier injection ***,we review the progress and innovations in OTS mechanism ***,we highlight the successful application of OTS devices in three-dimensional high-density memory and offer insights into their promising performance and extensive prospects in emerging applications,such as self-selecting memory and neuromorphic computing.

关键词： Non-volatile memory Ovonic threshold switch(OTS) Chalcogenide Selector

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