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New perspectives on robotic pancreaticoduodenectomy:An analysis of the National Cancer Database

World Journal of Gastrointestinal Surgery 2023年第1期15卷 60-71页

作者： Aleksandr Kalabin Vishnu R Mani robin l kruse Chase Schlesselman Kai Yu li Kevin F Staveley-O'Carroll Eric T Kimchi Department of Surgery University of MissouriColumbiaMO 65212United States Department of Surgery The Johns Hopkins HospitalBaltimoreMD 21287United States

BACKGROUND Pancreatic ductal adenocarcinoma is a common *** all advancements,the prognosis remains,poor with an overall 5-year survival of only 10.8%.Recently,a robotic platform has become an attractive tool for treating pancreatic cancer(PC).While recent studies indicated improved lymph node(lN)harvest during robotic pancreaticoduodenectomy(PD),data on long-term outcomes are *** To evaluate absolute lN harvest during *** outcomes included evaluating the association between lN harvest and short-and long-term oncological outcomes for three different surgical *** We conducted an analysis of the National Cancer Database,including patients diagnosed with PC who underwent open,laparoscopic,or robotic PD in ***-way analysis of variance was used to compare continuous variables,chi-square test-for *** survival was defined as the time between surgery and *** survival time was estimated with the Kaplan-Meier method,and groups were compared with the Wilcoxon test.A Cox proportional hazards model was used to assess the association of covariates with survival after controlling for patient characteristics and procedure *** 17169 patients were included,8859(52%)males;mean age 65;14509(85%)white.13816(80.5%)patients had an open PD,2677(15.6%)and 676(3.9%)-laparoscopic and robotic PD *** comorbidity index(Charlson-Deyo Score)*** average,18.84 lNs were *** lN harvest during open,laparoscopic and robotic PD was 18.59,19.65 and 20.70 respectively(PlNs were positive for cancer and did not differ by the procedure type(P=0.26).Vascular invasion was noted in 42.6%of lNs and did differ by the approach:42.1%for open,44.0%for laparoscopic and 47.2%for robotic PD(P=0.015).Median survival for open PD was 26.1 mo,laparoscopic-27.2 mo,robotic-29.1 mo(P=0.064).Survival was associated with higher lN harvest,while higher number of positive lNs was assoc

关键词： Pancreatic cancer Pancreaticoduodenectomy Robotic surgery National Cancer Database

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A study on wildfire impacts on greenhouse gas emissions and regional air quality in South of Orléans,France

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Journal of Environmental Sciences 2024年第1期135卷 521-533页

作者： Chaoyang Xue Gisèle Krysztofiak Yangang Ren Min Cai Patrick Mercier Frédéric le Fur Corinne robin Benoit Grosselin Véronique Daele Max RMcGillen Yujing Mu Valéry Catoire Abdelwahid Mellouki laboratoire de Physique et Chimie de l’Environnement et de l’Espace(lPC2E) CNRS–UniversitéOrléans–CNES(UMR 7328)Orléans Cedex 245071France Institut de Combustion AérothermiqueRéactivitéEnvironnement(ICARE)CNRSOrléans Cedex 245071France Research Centre for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China lig’Air-Association de surveillance de la qualitéde l’air en région Centre-Val de loire Saint-Cyr-en-Val 45590France Mohammed V University RabatMorocco

Wildfire events are increasing globally which may be partly associated with climate change,resulting in significant adverse impacts on local,regional air quality and global *** September 2020,a small wildfire(burned area:36.3 ha)event occurred in Souesmes(loiret-Cher,Sologne,France),and its plume spread out over 200 km on the following day as observed by the MODIS *** on measurements at a suburban site(~50 km northwest of the fire location)in Orléans and backward trajectory analysis,young wildfire plumes were *** increases in gaseous pollutants(CO,CH_(4),N_(2)O,VOCs,etc.)and particles(including black carbon)were found within the wildfire plumes,leading to a reduced air *** factors,defined as EF(X)=ΔX/ΔCO(where,X represents the target species),of various trace gases and black carbon within the young wildfire plumes were determined accordingly and compared with previous *** in the ambient ions(such as ammonium,sulfate,nitrate,chloride,and nitrite in the particle-and gasphase)and aerosol properties(e.g.,aerosol water content,aerosol p H)were also quantified and ***,we estimated the total carbon and climate-related species(e.g.,CO_(2),CH_(4),N_(2)O,and BC)emissions and compared them with fire emission *** biomass burning emission inventories have uncertainties in estimating small fire burned areas and *** instance,we found that the Global Fire Assimilation System(GFAS)may underestimate emissions(e.g.,CO)of this small wildfire while other inventories(GFED and FINN)showed significant *** that it is the first time to record wildfire plumes in this region,related atmospheric implications are presented and discussed.

关键词： Wildfire Air quality Emission factor Emission inventory VOlTAIRE supersite

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Recent advances in the systemic treatment of gastrointestinal stromal tumors

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Cancer Biology & Medicine 2023年第10期20卷 701-705页

作者： robin l.Jones Marin Golcic Sarcoma Unit The Royal Marsden NHS Foundation Trust and Institute of Cancer ResearchFulham RoadLondon SW36JJUnited Kingdom Clinic for Tumors Clinical Hospital CenterRijeka 51000Croatia

Historical overview of the treatment for advanced gastrointestinal stromal tumors(GISTs)GISTs represent a relatively rare entity;however,GISTs are still the most common mesenchymal neoplasm in the gastrointestinal *** majority of GISTs express the transmembrane receptor,KIT,a product of the KIT proto-oncogene that can lead to uncontrolled cell proliferation and resistance to apoptosis1-3.

关键词： gastrointestinal tumors treatment

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Pasture-finishing of bison improves animal metabolic health and potential health-promoting compounds in meat

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1759-1776页

作者： Stephan van Vliet Amanda D.Blair lydia M.Hite Jennifer Cloward Robert E.Ward Carter kruse Herman A.van Wietmarchsen Nick van Eekeren Scott l.Kronberg Frederick D.Provenza Center for Human Nutrition Studies Department of NutritionDieteticsand Food SciencesCollege of Agriculture and Applied SciencesUtah State UniversityLoganUT 84322USA Department of Wildland Resources Utah State UniversityLoganUT 84332USA Department of Animal Science South Dakota State UniversityBrookingsSD 57707USA Turner Institute of Ecoagriculture BozemanMT 59718USA louis Bolk Institute Bunnik 3981AJthe Netherlands Northern Great Plains Research laboratory USDA-Agricultural Research ServiceMandanND 58554USA

Background With rising concerns regarding the effects of red meat on human and environmental health,a growing number of livestock producers are exploring ways to improve production systems.A promising avenue includes agro-ecological practices such as rotational grazing of locally adapted ***,growing consumer interest in pasture-finished meat(i.e.,grass-fed)has raised questions about its nutritional ***,the goal of this study was to determine the impact of two common finishing systems in North American bison—pasture-finished or pen-finished on concentrates for 146 d—on metabolomic,lipidomic,and fatty acid profiles of striploins(*** lumborum).Results Six hundred and seventy-one(671)out of 1570 profiled compounds(43%)differed between pasture-and penfinished conditions(n=20 animals per group)(all,Plative to pasture-finished animals,the muscle of pen-finished animals displayed elevated glucose metabolites(~1.6-fold),triglycerides(~2-fold),markers of oxidative stress(~1.5-fold),and proteolysis(~1.2-fold).In contrast,pasture-finished animals displayed improved mitochondrial(~1.3-fold higher levels of various Krebs cycle metabolites)and carnitine metabolism(~3-fold higher levels of long-chain acyl carnitines)(all Plso concentrated higher levels of phenolics(~2.3-fold),alpha-tocopherol(~5.8-fold),carotene(~2.0-fold),and very long-chain fatty acids(~1.3-fold)in their meat,while having lower levels of a common advanced lipoxidation(4-hydroxy-nonenal-glutathione;~2-fold)and glycation end-product(N6-carboxymethyllysine;~1.7-fold)(all Pl,and three phenolics commonly found in alfalfa were~2.5-fold higher in pen-finished animals(all Plants rich in those compounds,may be *** Pasture-finishing(i.e.,grass-fed)broadly improves bison metabolic health and accumulates additional po

关键词： Bison Grass-fed Meat Nutrition Omega-3 fats Pasture-raised Phytochemicals

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Changing face of hepatic encephalopathy:Role of inflammation and oxidative stress

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World Journal of Gastroenterology 2010年第27期16卷 3347-3357页

作者： Amit S Seyan robin D Hughes Debbie l Shawcross Institute of liver Studies King's College London School of Medicine at King's College HospitalKing's College Hospital

The face of hepatic encephalopathy(HE) is *** review explores how this neurocognitive disorder,which is associated with both acute and chronic liver injury,has grown to become a dynamic syndrome that spans a spectrum of neuropsychological impairment,from normal performance to *** central role of ammonia in the pathogenesis of HE remains ***,over the past 10 years,the HE community has begun to characterise the key roles of inflammation,infection,and oxidative/nitrosative stress in modulating the pathophysiological effects of ammonia on the *** review explores the current thoughts and evidence base in this area and discusses the potential role of existing and novel therapies that might abrogate the oxidative and nitrosative stresses inflicted on the brain in patients with,or at risk of developing,HE.

关键词： Hepatic encephalopathy Ammonia Inflammation Oxidative stress Astrocyte

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Dermatofibrosarcoma protuberans: from translocation to targeted therapy

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Cancer Biology & Medicine 2015年第4期12卷 375-384页

作者： Jonathan Noujaim Khin Thway Cyril Fisher robin l.Jones Sarcoma Unit Royal Marsden NHS Foundation Trust

Dermatofibrosarcoma protuberans(DFSP), the most common dermal sarcoma, is a low-grade, slow growing fibroblastic malignant neoplasm that most frequently affects middle aged adults and is characterized by a high local recurrence rate and a low propensity for metastasis. Wide surgical resection or Mohs micrographic surgery(MMS) are the preferred approaches for localized disease, while radiation therapy is warranted for inoperable disease or for cases with positive margins where re-excision is not possible. DFSP is generally regarded as refractory to conventional chemotherapy. Treatment options for systemic disease were limited until the discovery of a unique translocation, t(17;22)(q22;q13)(COl1A1;PDGFB) found in a majority of cases. In recent years, imatinib, a PDGFβR, ABl and KIT inhibitor, has revolutionized systemic therapy in DFSP. In this review, we summarize the epidemiological, clinical, histological and genetic characteristics of DFSP and update the readers on its current management.

关键词：靶向治疗皮肤肿瘤纤维肉瘤全身性疾病转运显微外科手术成纤维细胞恶性肿瘤

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Pazopanib in advanced soft tissue sarcomas

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Signal Transduction and Targeted Therapy 2019年第1期4卷 538-547页

作者： Alex T.J.lee robin l.Jones Paul H.Huang Division of Molecular Pathology The Institute of Cancer ResearchLondonUK Sarcoma Unit The Royal Marsden NHS Foundation TrustLondonUK Division of Clinical Studies Institute of Cancer ResearchLondonUK

Pazopanib is the first and only tyrosine kinase inhibitor currently approved for the treatment of multiple histological subtypes of soft tissue sarcoma(STS).Initially developed as a small molecule inhibitor of vascular endothelial growth factor receptors,preclinical work indicates that pazopanib exerts an anticancer effect through the inhibition of both angiogenic and oncogenic signaling *** the establishment of optimal dosing and safety profiles in early phase studies and approval for the treatment of advanced renal cell carcinoma,pazopanib was investigated in STS.A landmark phase III randomized study demonstrated improved progression-free survival with pazopanib compared to that with placebo in pretreated patients with STS of various *** efficacy of pazopanib in specific STS subtypes has been further described in real-world-based case series in both mixed and subtype-specific STS *** present,there are no clinically validated predictive biomarkers for use in selecting patients with advanced STS for pazopanib therapy,limiting the clinical effectiveness and cost-effectiveness of the *** this review,we summarize the preclinical and clinical data for pazopanib,outline the evidence base for its effect in STS and explore reported studies that have investigated putative biomarkers.

关键词： sarcoma clinical approval

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Some Effects of Rotation Rate on Planetary-Scale Wave Flows

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Advances in Atmospheric Sciences 1993年第3期10卷 296-306页

作者：李国庆 robin Kung Richard l.Pfeffer Institute of Atmospheric Physics Chinese Academy of Sciences.Beijing 100080 Geophysical Fluid Dynamics Institute. Florida State University. Tallahassee Florida U. S. A. Geophysical Fluid Dynamics Institute and Departmenl of Meteorology Florida Stare UniversityTallahassee Florida. U. S. A.

A series of experiments were performed in a rotating annulus of fluid to study effects of rotation rate on pianeta ry-scale baroclinic wave flows. The experiments reveal that change in rotation rate of fluid container causes variation in Rossby number and Taylor number in flows and leads to change in flow patterns and in phase and amplitude of quasi-stationary waves. For instance, with increasing rotation rate, amplitude of quasi-stationary waves increases and phase shifts upstream. On the contrary, with decreasing rotation rate, amplitude of quasi-stationary waves de creases and phase shifts downstream. In the case of the earth's atmosphere, although magnitude of variation in earth's rotation rate is very small, yet it causes a very big change in zonal velocity component of wind in the atmosphere and of currents in the ocean, and therefore causes a remarkable change in Rossby number and Taylor number determining regimes in planetary-scale geophysical flows. 1 he observation reveals that intensity and geographic location of subtropic anticyclones in both of the Northern and Southern Hemispheres change consistently with the variation in earth's rotation rate. The results of fluid experiments are consistent, qualitatively, with observed phenomena in the atmospheric circulation.

关键词： Effects of rotation. Planetary-scale wave flows. Annulus experiments

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A Fluid Experiment of large-Scale Topography Effect on Baroclinic Wave Flows

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Advances in Atmospheric Sciences 1992年第1期9卷 17-28页

作者：李国庆 robin Kung Richard l.Pfeffer Institute of Atmospheric Physics Academia Sinica Beijing China Geophysical Fluid Dynamics Institute Florida State UniversityTallahassee Florida U. S. A. Geophysical Fluid Dynamics Institute and Department of Meteorology Florida State University TallahasseeFlorida U. S. A.he effects of topography on baroclinic wave flows are studied experimentally in a thermally driven rotating annulus of fluid.Fourier analysis and complex principal component (CPC) analysis of the experimental data show that due to topographic forcing the flow is bimodal rather than a single mode. Under suitable imposed experimental parameters near thermal Rossby number ROT = 0.1 and Taylor number Ta = 2.2 × 107 the large-scale topography produces low-frequency oscillation in the flow and rather long-lived flow pattern resembling blocking in the atmospheric circulation. The 'blocking' phenomenon is caused by the resonance of travelling waves and the quasi-stationary waves forced by topography.The large-scale topography transforms wavenumber-homogeneous flows into wavenumber-dispersed flows and the dispersed flows possess lower wavenumbers.

The effects of topography on baroclinic wave flows are studied experimentally in a thermally driven rotating annulus of *** analysis and complex principal component (CPC) analysis of the experimental data show that, due to topographic forcing, the flow is bimodal rather than a single mode. Under suitable imposed experimental parameters, near thermal Rossby number ROT = 0.1 and Taylor number Ta = 2.2 × 107, the large-scale topography produces low-frequency oscillation in the flow and rather long-lived flow pattern resembling blocking in the atmospheric circulation. The 'blocking' phenomenon is caused by the resonance of travelling waves and the quasi-stationary waves forced by *** large-scale topography transforms wavenumber-homogeneous flows into wavenumber-dispersed flows, and the dispersed flows possess lower wavenumbers.

关键词： A Fluid Experiment of large-Scale Topography Effect on Baroclinic Wave Flows

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Heat and drought impact on carbon exchange in an age-sequence of temperate pine forests

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Ecological Processes 2022年第1期11卷 108-125页

作者： M.Altaf Arain Bing Xu Jason J.Brodeur Myroslava Khomik Matthias Peichl Eric Beamesderfer Natalia Restrepo‑Couple robin Thorne School of Earth Environment and Society and McMaster Centre for Climate ChangeMcMaster University1280 Main Street WestHamiltonON L8S 4K1Canada Department of Biological Sciences University of CalgaryAlbertaCanada Department of Geography and Environmental Management University of WaterlooWaterlooONCanada Department of Forest Ecology and Management Swedish University of Agricultural SciencesUmeåSweden School of Informatics Computingand Cyber SystemsNorthern Arizona UniversityFlagstaffAZUSA Department of Ecology and Evolutionary Biology University of ArizonaTucsonAZUSA Department of Geography Wilfrid Laurier UniversityWaterlooONCanada

Background:Most North American temperate forests are plantation or regrowth forests,which are actively *** forests are in different stages of their growth cycles and their ability to sequester atmospheric carbon is affected by extreme weather *** this study,the impact of heat and drought events on carbon sequestration in an age‑sequence(80,45,and 17 years as of 2019)of eastern white pine(Pinus strobus l.)forests in southern Ontario,Canada was examined using eddy covariance flux measurements from 2003 to ***:Over the 17‑year study period,the mean annual values of net ecosystem productivity(NEP)were 180±96,538±177 and 64±165 g C m^(–2)yr^(–1)in the 80‑,45‑and 17‑year‑old stands,respectively,with the highest annual carbon sequestration rate observed in the 45‑year‑old *** found that air temperature(Ta)was the dominant control on NEP in all three different‑aged stands and drought,which was a limiting factor for both gross ecosystem productivity(GEP)and ecosystems respiration(RE),had a smaller impact on ***,the simultaneous occurrence of heat and drought events during the early growing seasons or over the consecutive years had a significant negative impact on annual NEP in all three *** observed a similar trend of NEP decline in all three stands over three consecutive years that experienced extreme weather events,with 2016 being a hot and dry,2017 being a dry,and 2018 being a hot *** youngest stand became a net source of carbon for all three of these years and the oldest stand became a small source of carbon for the first time in 2018 since observations started in ***,in 2019,all three stands reverted to annual net carbon ***:Our study results indicate that the timing,frequency and concurrent or consecutive occurrence of extreme weather events may have significant implications for carbon sequestration in temperate conifer forests in Eastern North *** study is one of few globally available t

关键词： Carbon fluxes Net ecosystem productivity Ecosystem respiration Extreme weather events Drought Temperate forest White pine Eddy covariance

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