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Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression:a randomized controlled study

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Neural Regeneration Research 2024年第9期19卷 2036-2040页

作者： Xiaoyue Li Tao Liu Xuan Mo Runhua Wang Xueyan Kong robin shao Roger S.Mclntyre Kwok-Fai So Kangguang Lin Department of Affective Disorders The Affiliated Brain Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital)GuangzhouGuangdong ProvinceChina Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Psychiatry The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Mood Disorders Psychopharmacology Unit Poul Hansen Family Centre for DepressionUniversity Health NetworkTorontoONCanada Department of Psychiatry University of TorontoTorontoONCanada Brain and Cognition Discovery Foundation TorontoCanada Ministry of Education Joint International Research Laboratory of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Strong evidence has accumulated to show a correlation between depression symptoms and inflammatory responses.Moreover,anti-inflammatory treatment has shown partial effectiveness in alleviating depression symptoms.Lycium barbarum polysaccharide(LBP),derived from Goji berries,exhibits notable antioxidative and anti-inflammatory properties.In our recent double-blinded randomized placebo-controlled trial,we found that LBP significantly reduced depressive symptoms in adolescents with subthreshold depression.It is presumed that the antidepressant effect of LBP may be associated with its influence on inflammatory cytokines.In the double-blinded randomized controlled trial,we enrolled 29 adolescents with subthreshold depression and randomly divided them into an LBP group and a placebo group.In the LBP group,adolescents were given 300 mg/d LBP.A 6-week follow up was completed by 24 adolescents,comprising 14 adolescents from the LBP group(15.36±2.06 years,3 men and 11 women)and 10 adolescents from the placebo group(14.9±1.6 years,2 men and 8 women).Our results showed that after 6 weeks of treatment,the interleukin-17A level in the LBP group was lower than that in the placebo group.Network analysis showed that LBP reduced the correlations and connectivity between inflammatory factors,which were associated with the improvement in depressive symptoms.These findings suggest that 6-week administration of LBP suppresses the immune response by reducing interleukin-17A level,thereby exerting an antidepressant effect.

关键词： adolescents cytokines efficacy Goji berry inflammatory responses interleukin-17A Lycium barbarum polysaccharide randomized controlled study subthreshold depression

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The positive and negative emotion functions related to loneliness:a systematic review of behavioural and neuroimaging studies

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Psychoradiology 2023年第1期3卷 118-134页

作者： Qianyi Luo robin shao Department of Clinical Psychology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370P.R.China Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou Medical UniversityGuangzhou 511436P.R.China Department of Affective Disorder The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 511370P.R.China

Loneliness is associated with high prevalences of major psychiatric illnesses such as major depression.However,the underlying emotional mechanisms of loneliness remained unclear.We hypothesized that loneliness originates from both decreases in positive emotional processing and increases in negative emotion processing.To test this,we conducted a systematic review of 29 previous studies(total participants n=19560,mean age=37.16 years,female proportion=59.7%),including 18 studies that included ques-tionnaire measures of emotions only,and 11 studies that examined the brain correlates of emotions.The main findings were that loneliness was negatively correlated with general positive emotions and positively correlated with general negative emotions.Fur-thermore,limited evidence indicates loneliness exhibited negative and positive correlations with the brain positive(e.***.the striatum)and negative(e.***.insula)emotion systems,respectively,but the sign of correlation was not entirely consistent.Additionally,loneli-ness was associated with the structure and function of the brain emotion regulation systems,particularly the prefrontal cortex,but the direction of this relationship remained ambiguous.We concluded that the existing evidence supported a bivalence model of lone-liness,but several critical gaps existed that could be addressed by future studies that include adolescent and middle-aged samples,use both questionnaire and task measures of emotions,distinguish between general emotion and social emotion as well as between positive and negative emotion regulation,and adopt a longitudinal design that allows us to ascertain the causal relationships between loneliness and emotion dysfunction.Our findings provide new insights into the underlying emotion mechanisms of loneliness that can inform interventions for lonely individuals.

关键词： loneliness positive emotion negative emotion emotion regulation social emotion striatum prefrontal cortex

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Efficacy of Lycium barbarum polysaccharide in adolescents with subthreshold depression: interim analysis of a randomized controlled study

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Neural Regeneration Research 2022年第7期17卷 1582-1587页

作者： Xiaoyue Li Xuan Mo Tao Liu robin shao Kayla Teopiz Roger S.McIntyre Kwok-Fai So Kangguang Lin Department of Affective Disorders The Affiliated Brain Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital)GuangzhouGuangdong ProvinceChina Laboratory of Emotion and Cognition The Affiliated Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital)GuangzhouGuangdong ProvinceChina Department of Psychiatry The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Canadian Rapid Treatment Center of Excellence MississaugaONCanada Mood Disorders Psychopharmacology Unit Poul Hansen Family Centre for DepressionUniversityHealth NetworkTorontoONCanada Department of Psychiatry University of TorontoTorontoONCanada Brain and Cognition Discovery Foundation TorontoONCanada Ministry of Education Joint International Research Laboratory of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Subthreshold depression is a highly prevalent condition in adolescents who are at high risk for developing major depressive disorder.In preclinical models of neurological and psychiatric diseases,Lycium barbarum polysaccharide(LBP)extracted from Goji berries had antidepressant effects including but not limited to anti-oxidative and anti-inflammatory properties.However,the effect of LBP on subthreshold depression is unclear.To investigate the clinical efficacy and safety of LBP for treating subthreshold depression in adolescents,we conducted a randomized,double-blind,placebo-controlled trial(RCT)with 29 adolescents with subthreshold depression recruited at The Fifth Affiliated Hospital of Guangzhou Medical University.The participants were randomly assigned to groups where they received either 300 mg LBP(LBP group,n=15,3 boys and 12 girls aged 15.13±2.17 years)or a placebo(placebo group,n=14,2 boys and 12 girls aged 15±1.71 years)for 6 successive weeks.Interim analyses revealed that the LBP group exhibited a greater change in Hamilton Depression Scale(HAMD-24)scores relative to the baseline and a higher remission rate(HAMD-24 total score≤7)at 6 weeks compared with the placebo group.Scores on the Beck Depression Inventory-II(BDI-II),Pittsburgh Sleep Quality Index(PSQI),Kessler Psychological Distress Scale(Kessler),and Screen for Child Anxiety-Related Emotional Disorders(SCARED)were similar between the LBP and placebo groups.No side effects related to the intervention were reported in either group.These results indicate that LBP administration reduced depressive symptoms in adolescents with subthreshold depression.Furthermore,LBP was well tolerated with no treatment-limiting adverse events.Clinical trials involving a larger sample size are needed to further confirm the anti-depressive effects of LBP in adolescents with subthreshold depression.This study was approved by the Medical Ethics Committee of the Fifth Affiliated Hospital of Guangzhou Medical University(Guangzhou,China;approval No.L2019-08)on April 4,2019 and

关键词： adolescents efficacy Goji berry Lycium barbarum polysaccharide randomized clinical trial safety subthreshold depression tolerance

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带分数阶robin边界条件的时间-空间分数阶扩散方程的有限差分方法

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Chinese Quarterly Journal of Mathematics 2024年第1期39卷 18-30页

作者：唐忠华房少梅 College of Mathematics and Informatics South China Agricultural UniversityGuangzhou 510642China

In this paper, an efficient numerical method is proposed to solve the Caputo-Riesz fractional diffusion equation with fractional robin boundary conditions. We approximate the Riesz space fractional derivatives using the fractional central difference scheme with second-order accurate. A priori estimation of the solution of the numerical scheme is given, and the stability and convergence of the numerical scheme are analyzed.Finally, a numerical example is used to verify the accuracy and efficiency of the numerical method.

关键词： Fractional boundary conditions Stability and convergence Caputo-Riesz fractional diffusion equation

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Finite Di erence Method for Riesz Space Fractional Advection-dispersion Equation with Fractional robin Boundary Condition

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Chinese Quarterly Journal of Mathematics 2020年第3期35卷 278-289页

作者： LIN Hai-xin FANG shao-mei College of Mathematics and Information South China Agricultural UniversityGuangzhou 510642China School of Mathematics and Statistics Yangtzc Normal UniversityChongqing 408100China

In this paper,a Riesz space fractional advection-dispersion equation with fractional robin boundary condition is considered.By applying the fractional central di erence formula and the weighted and shifted Grunwald-Letnikov formula,we derive a weighted implicit nite difference scheme with accuracy O(△t^2+h^2).The solvability,stability,and convergence of the proposed numerical scheme are proved.A numerical example is presented to confirm the accuracy and efficiency of the scheme.

关键词： fractional advection-dispersion equation Riesz fractional derivative fractional central difference stability convergence

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可自管理的分布式工作流引擎的设计与实现

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计算机集成制造系统 2005年第11期11卷 1544-1550,1615页

作者：辛鹏王少锋清华大学软件学院北京100084

针对当前企业和政府对分布式工作流应用的需求,给出了一个基于Java管理扩展框架和观察者模式的可自管理的分布式工作流引擎的设计与实现。在该实现中,以观察者模式为主控引擎与各个执行引擎进行分布式协作。利用Java管理扩展框架通知模... 详细信息

针对当前企业和政府对分布式工作流应用的需求,给出了一个基于Java管理扩展框架和观察者模式的可自管理的分布式工作流引擎的设计与实现。在该实现中,以观察者模式为主控引擎与各个执行引擎进行分布式协作。利用Java管理扩展框架通知模型和Java管理扩展框架时间服务实现观察者模式的异步特性。主控引擎充当目标对象,所有的执行引擎充当观察者并关注主控引擎的状态改变。主控引擎的调度机采用轮转法为所有的实例活动动态分配执行引擎。执行引擎通过在启动时自动注册到主控引擎,关闭时自动从主控引擎注销,实现了整个系统的可自管理性,而以工作流命名空间的形式对工作流相关数据的封装和企业级Java bean容器提供的良好的事务特性,保证了整个系统的可靠性。

关键词： Java管理扩展框架观察者模式分布式工作流引擎

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直升机机身、平尾、垂尾的气动干扰

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航空动力学报 2014年第5期29卷 1122-1127页

作者：吕少杰曹义华肖阳北京航空航天大学航空科学与工程学院北京100191 总参陆航研究所机体发动机室北京101114

运用面元法模拟直升机机身流场,计算前飞状态的robin(rotor body interaction)模型孤立机身顶部中线的压力系数分布,并与参考数据、CFD计算结果对比,验证了本方法的准确性.采用离散涡系模拟平尾、垂尾和短翼等升力面,以带短翼的UH-60直... 详细信息

运用面元法模拟直升机机身流场,计算前飞状态的robin(rotor body interaction)模型孤立机身顶部中线的压力系数分布,并与参考数据、CFD计算结果对比,验证了本方法的准确性.采用离散涡系模拟平尾、垂尾和短翼等升力面,以带短翼的UH-60直升机为例,研究了升力面参数变化对机身、平尾、垂尾气动干扰的影响.结果表明:改变升力面的安装角显著改变了气流对其周围的绕流情况,在参数中影响最大;平尾参数尤其是安装角会对垂尾和短翼的压力系数产生较大影响;减小垂尾展长和增大短翼安装角会提升各自的压力系数.

关键词：气动干扰直升机平尾垂尾涡格法面元法

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扩张的血管周围腔隙在阿尔茨海默病海马萎缩中的作用

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医学理论与实践 2023年第17期36卷 2890-2893页

作者：邵元伟朱彦周群江苏大学附属医院影像科江苏省镇江市212001

目的:探讨扩张的血管周围腔隙(dVRS)存在状态在阿尔茨海默病患者海马萎缩中所起的作用。方法:收集77例阿尔茨海默病患者和30例正常受试者,采用3.0T高场磁共振对所有受试者的海马以及其内dVRS进行扫描成像并进行三维重建分析。比较海马内... 详细信息

目的:探讨扩张的血管周围腔隙(dVRS)存在状态在阿尔茨海默病患者海马萎缩中所起的作用。方法:收集77例阿尔茨海默病患者和30例正常受试者,采用3.0T高场磁共振对所有受试者的海马以及其内dVRS进行扫描成像并进行三维重建分析。比较海马内dVRS分布、数目以及体积大小与海马萎缩程度的相关性,将dVRS形态学指标对海马体积萎缩的预测价值进行ROC曲线分析。结果:阿尔茨海默病患者的双侧海马较正常受试者明显萎缩,海马内dVRS表现更为明显,差异具有统计学意义(P<0.05),其中海马头部dVRS占比高、分布多;dVRS数目及总体积与海马体积均呈负相关性(左侧海马dVRS数目与左侧海马体积相关系数:r=-0.486,P<0.05;左侧海马dVRS总体积与左侧海马体积相关系数:r=-0.572,P<0.05;右侧海马dVRS数目与左侧海马体积相关系数:r=-0.421,P<0.05;右侧海马dVRS总体积与左侧海马体积相关系数:r=-0.465,P<0.05);ROC曲线分析表明dVRS存在状态对阿尔茨海马病患者海马体积萎缩的预测价值明显(左侧海马dVRS数目AUC=0.845,灵敏度66.76%,特异度94.81%;左侧海马dVRS总体积AUC=0.920,灵敏度76.67%,特异度98.70%;右侧海马dVRS数目AUC=0.722,灵敏度60.00%,特异度83.12%;右侧海马dVRS总体积AUC=0.872,灵敏度80.00%,特异度81.82%)。结论:海马中dVRS存在状态对阿尔茨海默病患者的海马萎缩具有一定的预测价值。

关键词：血管周围间隙海马萎缩阿尔茨海默病

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基于博弈论的云资源调度算法

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计算机科学 2019年第B6期46卷 295-299页

作者：徐飞王少昌杨卫霞西安工业大学计算机科学与工程学院西安710021 西北工业大学航海学院西安710072

在云环境下的大数据中心中,虚拟机数目和虚拟机的负载会随着用户和应用的需求而时常发生变化。虚拟机需要进行动态资源调整,及时移除系统中的热点资源,从而达到整个系统的负载均衡。通过对云资源分配的理论研究,获取到First-Fit贪心算法... 详细信息

在云环境下的大数据中心中,虚拟机数目和虚拟机的负载会随着用户和应用的需求而时常发生变化。虚拟机需要进行动态资源调整,及时移除系统中的热点资源,从而达到整个系统的负载均衡。通过对云资源分配的理论研究,获取到First-Fit贪心算法和Round robin轮询算法等。将它们应用到一些云系统中虽然能够在短时间内解决问题,但存在资源利用率和负载均衡等方面的问题。文中提出一种基于博弈论的FUTG(Fairness-Utilization Tradeoff Gme)云资源调度算法。该算法打破了固定数量的资源分配瓶颈,将QoS因素纳入考量范围,解决了资源利用率以及资源分配的公平性这两个优化目标的资源调度问题。仿真实验结果表明,FUTG算法能够显著提高动态资源调度的有效性和动态负载下资源使用的执行效率。

关键词：云资源调度服务质量博弈论 FUTG 动态负载

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基于FPGA的SRIO多通道控制系统设计与实现

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电子技术应用 2023年第1期49卷 107-113页

作者：薛培官剑邵春伟张鑫刚郑思旭无锡华普微电子有限公司江苏无锡214000 中国电子科技集团公司第五十八研究所江苏无锡214000

在板间互联及芯片互联方式上,SRIO具有更高的带宽及实时性。使用MSG(消息)接口的HELLO格式,发送端采用多接口设计方法,内部采用Round-robin处理机制,实现了多通道接口在同时发送数据时共用一个SRIO接口的竞争处理;同时封装为多通道的输... 详细信息

在板间互联及芯片互联方式上,SRIO具有更高的带宽及实时性。使用MSG(消息)接口的HELLO格式,发送端采用多接口设计方法,内部采用Round-robin处理机制,实现了多通道接口在同时发送数据时共用一个SRIO接口的竞争处理;同时封装为多通道的输入输出的方式,支持接口数量、时钟域的任意扩展。经过测试验证,该系统最大可实现64个不同时钟下通道的数据收发,单通道下包和包之间延时最低可到4μs,在SRIO传输应用方向上,具有较好的应用价值。

关键词： XILINX SRIO 多通道 Round-robin

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