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Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation

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Neural Regeneration Research 2020年第3期15卷 407-415页

作者： Heather R.Lucas Ricardo D.fernández Department of Chemistry Virginia Commonwealth University

N-acetylatedα-synuclein(αSyn)has long been established as an intrinsically disordered protein associated with a dysfunctional role in Parkinson’s *** recent years,a physiologically relevant,higher order conformation has been identified as a helical tetramer that is tailored by buried hydrophobic interactions and is distinctively aggregation *** canonical mechanism by which the tetramer assembles remains *** novel biochemical approaches,computational methods,pioneering purification platforms,and powerful imaging techniques continue to develop,puzzling information that once sparked debate as to the veracity of the tetramer has now shed light upon this new counterpart inαSyn *** magnetic resonance and computational studies on multimericαSyn structure have revealed that the protein folding propensity is controlled by small energy barriers that enable large scale ***,familial mutations ablate tetramerization and reconfigure polymorphic *** this review,we will discuss the dynamic landscape ofαSyn quaternary structure with a focus on the tetrameric conformation.

关键词： alpha-synuclein amyloid fibrils intrinsically disordered protein multimer N-acetylation oligomer Parkinson’s disease protein folding protein structure tetramer

Characterization of housing stock for energy retrofitting purposes in Spain

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Building Simulation 2023年第6期16卷 947-962页

作者： Juan M.González-Caballín Sánchez A.Meana-fernández J.C.Ríos-fernández A.J.Gutiérrez Trashorras Thermal Engines and Motors Area Department of EnergyUniversity of OviedoC/Wifredo Ricart s/nGijónAsturias33204Spain

Energy saving in existing buildings is of vital *** this work,the characterization of housing stock in Spain for energy retrofitting purposes has been *** regulations in force when the existing stock was constructed(1980–2007)were considered to model the envelope and thermal systems of single-family and block *** energy consumption and CO_(2) emissions were estimated for each type of dwelling and location,ranging from 44.2 to 130.6 kWh/(m^(2)·year)(13.6–32 kg CO_(2)/(m^(2)·year))for multi-family homes,and 85.5 to 213.5 kWh/(m^(2)·year)(17.1–45.2 kg CO_(2)/(m^(2)·year))for single-family homes.A global picture of the energy performance and emissions for 13 different climate zones was obtained with a total of 504 *** of the envelope allowed the reduction of consumption and emissions from 37.7%to 58%,depending on the climate *** consumption per square meter in block housing was lower than in single-family housing;nevertheless,single-family houses responded more effectively to energy improvement ***,non-renewable primary energy savings seem a better indicator of the improvement by retrofitting than the energy *** building models designed in this work may serve as a reference for subsequent research concerning energy retrofitting and energy savings of housing stock.

关键词： housing stock characterization building retrofitting representative building climate zone simulation model

Anther and pollen development:A conserved developmental pathway

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Journal of Integrative Plant Biology 2015年第11期57卷 876-891页

作者： José fernndez Gmez Behzad Talle Zoe A Wilson School of Biosciences University of NottinghamSutton Bonington Campus

Pollen development is a critical step in plant development that is needed for successful breeding and seed formation. Manipulation of male fertility has proved a useful trait for hybrid breeding and increased crop yield. However, although there is a good understanding developing of the molecular mechanisms of anther and pollen anther development in model species, such as Arabidopsis and rice, little is known about the equivalent processes in important crops. Nevertheless the onset of increased genomic information and genetic tools is facilitating translation of information from the models to crops, such as barley and wheat; this will enable increased understanding and manipulation of these pathways for agricultural improvement.

关键词： Anther Arabdiopsis cereals comparative biology pollen

Parameter Control of Genetic Algorithms by Learning and Simulation of Bayesian Networks——A Case Study for the Optimal Ordering of Tables

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Journal of Computer Science & Technology 2013年第4期28卷 720-731页

作者： Concha Bielza Juan A. fernndez del Pozo Pedro Larranaga Computational Intelligence Group Department of Artificial IntelligenceTechnical University of Madrid

Parameter setting for evolutionary algorithms is still an important issue in evolutionary computation. There are two main approaches to parameter setting： parameter tuning and parameter control. In this paper, we introduce self-adaptive parameter control of a genetic algorithm based on Bayesian network learning and simulation. The nodes of this Bayesian network are genetic algorithm parameters to be controlled. Its structure captures probabilistie conditional （in）dependence relationships between the parameters. They are learned from the best individuals, i.e., the best configurations of the genetic algorithm. Individuals are evaluated by running the genetic algorithm for the respective parameter configuration. Since all these runs are time-consuming tasks, each genetic algorithm uses a small-sized population and is stopped before convergence. In this way promising individuals should not be lost. Experiments with an optimal search problem for simultaneous row and column orderings yield the same optima as state-of-the-art methods but with a sharp reduction in computational time. Moreover, our approach can cope with as yet unsolved high-dimensional problems.

关键词： genetic algorithm estimation of distribution algorithm parameter control parameter setting Bayesian network

Usefulness of duodenal biopsy during routine upper gastrointestinal endoscopy for diagnosis of celiac disease

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World Journal of Gastroenterology 2006年第31期12卷 5028-5032页

作者： S Riestra F Domínguez E fernández-Ruiz E García-Riesco R Nieto E fernández L Rodrigo Gastroenterology Section and Gastroenterology ServiceHospital Central de Asturias Spain Gastroenterology Section and Pathology ServiceHospital Valle del Nalón Spain Gastroenterology Section and Biochemistry ServiceHospital de Cabuenes Spain

AIM： To describe the trend in duodenal biopsy performance during routine upper gastrointestinal endoscopy in an adult Spanish population, and to analyze its value for the diagnosis of celiac disease in clinical practice. METHODS： A 15 year-trend （1990 to 2004） in duodenal biopsy performed when undertaking upper gastrointestinal endoscopy was studied. We analysed the prevalence of celiac disease in the overall group, and in the subgroups with anaemia and/or chronic diarrhoea. RESULTS： Duodenal biopsy was performed in 1033 of 13 678 upper gastrointestinal endoscopies （7.6%）; an increase in the use of such was observed over the study period （1.9% in 1990-1994, 5% in 1995-1999 and 12.8% in 2000-2004）. Celiac disease was diagnosed in 22 patients （2.2%）, this being more frequent in women than in men （3% and 1% respectively）. Fourteen out of 514 （2.7%） patients with anaemia, 12 out of 141 （8.5%） with chronic diarrhoea and 8 out of 42 （19%） with anaemia plus chronic diarrhoea had celiac disease. A classical clinical presentation was observed in 55% of the cases, 23% of the patients had associated dermatitis herpetiformis and 64% presented anaemia; 9% were diagnosed by familial screening and 5% by cryptogenetic hypertransaminasaemia. CONCLUSION： Duodenal biopsy undertaken during routine upper gastrointestinal endoscopy in adults, has been gradually incorporated into clinical practice, and is a useful tool for the diagnosis of celiac disease in high risk groups such as those with anaemia and/or chronic diarrhoea.

关键词： Duodenal biopsy Upper gastrointestinal endoscopy Celiac disease Anemia Chronic diarrhea

Influence of parameters on the microstructure of a duplex stainless steel joint welded by a GMAW welding process

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Progress in Natural Science:Materials International 2022年第4期32卷 415-423页

作者： Sandra Chacón-fernández Antonio Portolés García Gerardo Romaní Labanda Universidad Politécnica de Madrid Escuela Técnica Superior de Ingenieros Industriales UPM

Duplex stainless steels（DSSs） are widely used in industry for their desirable properties. Any fusion welding technique modifies the microstructure and, consequently, the properties of the material. This paper presents a parametric study of the variables that determine the energy contribution（current, voltage and welding speed） and the structural modifications produced during gas metal arc welding. The analysis comprises metallographic study,phase balance, dimensioning of the weld beads and tensile and hardness tests. The influence of the variables studied on the thermal cycles obtained（temperatures reached and cooling rate） was determined by using a finite element model. The results showed that, in addition to the indicated parameters, the parameter power transfer per volume（W/m3） and the geometry in the bead must be controlled due to their influence on the heat flow distribution and phase balance.

关键词： Welding Heat input GMAW Duplex stainless steels (DSS) Finite element model (FEM)

Elastic Smart Contracts in Blockchains

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IEEE/CAA Journal of Automatica Sinica 2021年第12期8卷 1901-1912页

作者： Schahram Dustdar Pablo fernández JoséMaría García Antonio Ruiz-Cortés Distributed Systems Group Vienna University of TechnologyWien 1040Austria Smart Computer Systems Research and Engineering Lab Research Institute of Computer EngineeringUniversity of SevillaSevilla 41012Spain

In this paper,we deal with questions related to blockchains in complex Internet of Things(IoT)-based *** ecosystems are typically composed of IoT devices,edge devices,cloud computing software services,as well as people,who are decision makers in scenarios such as smart *** decisions related to analytics can be based on data coming from IoT sensors,software services,and ***,they are typically based on different levels of abstraction and *** poses a number of challenges when multiple blockchains are used together with smart *** work proposes to apply our concept of elasticity to smart contracts and thereby enabling analytics in and between multiple blockchains in the context of *** propose a reference architecture for Elastic Smart Contracts and evaluate the approach in a smart city scenario,discussing the benefits in terms of performance and self-adaptability of our solution.

关键词： Blockchain elasticity Internet of Things(IoT) smart cities smart contracts virtual chains

Adenosine A2A-dopamine D2 receptor heteromers operate striatal function:impact on Parkinson's disease pharmacotherapeutics

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Neural Regeneration Research 2018年第2期13卷 241-243页

作者： víctor fernández-duenas sergi ferré francisco ciruela unitat de farmacologia departament patologia i terapèutica experimentalfacultat de medicinaidibelluniversitat de barcelonal’hospitalet de llobregatBarcelonaSpain institut de neurociències universitat de barcelonaBarcelonaSpain integrative neurobiology section national institute on drug abuseintramural research programnational institutes of healthBaltimoreMDUSA

The basal ganglia （BG） assemble a series of deep gray matter structures forming recurrent loops that include the cortex and thalamus, and that participate in the regulation of a plethora of brain functions, including elicitation and learning of reward-and aversive stimuli-associated behaviors, motor activity control and sensorimotor gating （Brom- berg-Martin et al., 2010）.

关键词： AR Adenosine A impact on Parkinson’s disease pharmacotherapeutics Figure

Transport coefficients of a massive pion gas

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Chinese Physics C 2010年第9期34卷 1453-1455页

作者： D.fernández-Fraile A.Gómez Nicola Institut für Theoretische Physik Johann Wolfgang Goethe-Universitt Departamento de Física Teórica II Universidad Complutense

We review our main results concerning the transport coefficients of a light meson gas,in particular we focus on the case of a massive pion *** order results according to the chiral power-counting are presented for the DC electrical conductivity,thermal conductivity,shear viscosity,and bulk *** also comment on the possible correlation between the bulk viscosity and the trace anomaly in QCD,as well as the relation between unitarity and a minimum of the quotient η/s near the phase transition.

关键词： transport coefficients heavy-ion collisions Chiral Perturbation Theory