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The bone marrow niche landscape:a journey through aging,extrinsic and intrinsic stressors in the haemopoietic milieu

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 526-537页

作者： Antonio Giovanni Solimando Assunta Melaccio Angelo Vacca roberto ria Department of Biomedical Sciences and Human Oncology Section of Internal Medicine and Clinical OncologyUniversity of Bari Medical SchoolBari 70124 Italy

Inflammation and its effects in the bone marrow microenvironment represent a paradigmatic condition in which the hematopoietic niche and the immune systems,thought to properly sustain blood cell production and distinguish between friend and foe,can actively sustain a corrupted neighborhood within a chronic aberrant inflamed *** bone marrow niche hijacks the physiologic *** interactions between the hematopoietic stem cells and the niche in the bone marrow are critical determinants of *** examined several approaches to confront the available evidence;three key points emerged,pointing to the chronic inflammation process,especially the chronic infection and systemic inflammatory states,as leading causes of hematopoietic stem cell *** hematopoiesis,defined as a relative expansion of individual clones,is caused by somatic alterations in essential hematopoietic genes,which increase stem cell ***,terminal differentiation plays a significant role in progenitor loss and inflammatory signaling,promoting clonal selection and clonal hematopoiesis *** myeloid malignancies as paradigmatic examples are discussed as a condition associated with inflammation,including the 5q-syndrome,Philadelphia negative myeloproliferative neoplasms,and chronic myeloid *** with increased fitness and hematopoietic stem cell attrition,extrinsic stress,enhanced stressor-specific fitness,and intrinsic defect across the hematopoietic process represent the route for novel insights in defective *** discussion in this review also points out that the hematopoietic niches’inflammatory stimulation may affect differentiation patterns and the function of downstream cells.

关键词： Hematopoietic niche immune system inflammation tumor microenvironment

Novel agents and new therapeutic approaches for treatment of multiple myeloma

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World Journal of Methodology 2014年第2期4卷 73-90页

作者： roberto ria Antonia Reale Angelo Vacca Section of Internal Medicine Department of Biomedical Sciences and Human On-cologyUniversity of Bari Medical SchoolI-70124 BariItaly

This review summarizes the therapeutic strategies and the drugs actually in development for the management of myeloma patients. Multiple myeloma is caused by the expansion of monoclonal plasma cells and secretion of M-protein(immunoglobulins, Bence Jones protein and free light chains). Multiple myeloma still remains an incurable disease with a high incidence rate in the elderly, despite the introduction of several new therapeutic agents(bortezomib, lenalidomide and thalidomide) which have changed its natural history. The high heterogeneity of this disease leads to large differences in clinical responses to treatments. Thus, the choice of the best treatment is a difficult issue. However, the introduction of new drugs has made it possible to achieve high response rates and good quality respons-es with long-term disease control. Interactions between tumor cells and their bone marrow microenvironment play a pivotal role in the development, maintenance, and progression of myeloma, inducing also drug resistance. These knowledges have improved treatment options, leading to the approval of new drugs which not only target the malignant cell itself, but also its microenvironment. These agents are in preclinical/early clinical evaluation and they appear to further improve disease control, but their use is still not approved outside of clinical trials.

关键词： Immunomodulators Multiple myeloma New drugs Proteasome inhibitors Target therapy

Neuroprotective agents effective against radiation damage of central nervous system

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Neural Regeneration Research 2022年第9期17卷 1885-1892页

作者： Mária Lalkovičová Laboratory of Radiation Biology Joint Institute for Nuclear ResearchDubnaRussia Slovak Academy of Sciences Institute of Experimental PhysicsKošiceSlovakia

Ionizing radiation caused by medical treatments,nuclear events or even space flights can irreversibly damage structure and function of brain *** can result in serious brain damage,with memory and behavior disorders,or even fatal oncologic or neurodegenerative *** used treatments and drugs are mostly targeting biochemical processes of cell apoptosis,radiation toxicity,neuroinflammation,and conditions such as cognitive-behavioral disturbances or others that result from the radiation *** most drugs,the side effects and potential toxicity are also to be ***,many agents have not been approved for clinical use *** this review,we focus on the latest and most effective agents that have been used in animal and also in the human research,and clinical *** could have the potential therapeutical use in cases of radiation damage of central nervous system,and also in prevention considering their radioprotecting effect of nervous tissue.

关键词： antioxidants biomedical neuroprotectants central nervous system ionizing radiation neuroprotection radiation injury radiomitigators radioprotectants radioprotection therapeutics

Biotechnology of the multipurpose tree species Arbutus unedo:a review

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Journal of Forestry Research 2022年第2期33卷 377-390页

作者： João Martins Glória Pinto Jorge Canhoto Centre for Functional Ecology Department of Life SciencesUniversity of CoimbraCoimbraPortugal Centre for Environmental and Marine Studies Department of BiologyUniversity of AveiroAveiroPortugal

Arbutus unedo L.(strawberry tree,Ericaceae)is a woody species with a circum-Mediterranean *** has considerable ecological relevance in southern European forests due to its resilience to abiotic and biotic *** edible red berries are used in the production of traditional products,including an expensive *** compounds extracted from the species have bioactive prop-erties used by the cosmetic and pharmaceutical *** strawberry tree has gone from a neglected species to become a highly valuable crop with large cultivated areas in southern European and North African *** to an increasing demand from farmers for plants with improved features,researchers have been trying to improve this spe-cies through conventional and biotechnological tools,focus-ing mainly on population analysis using molecular markers,in vitro cloning,tolerance to biotic and abiotic stresses,and intraspecific crosses to obtain genotypes with new *** objective of this review is to gather and update information about the species and make it available to researchers and *** research areas that are considered a priority for this species are highlighted.

关键词： Breeding Chemical profiling Ericaceae Microbiome Micropropagation

Is there a potential of circulating miRNAs as biomarkers in rheumatic diseases?

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Genes & Diseases 2023年第4期10卷 1263-1278页

作者： Klára Prajzlerová Ladislav Senolt Mária Filková Institute of Rheumatology Prague 12800Czech Republic Department of Rheumatology First Faculty of MedicineCharles UniversityPrague 12800Czech Republic

t MicroRNAs(miRNAs)are small non-coding single-stranded RNAs of about 22 nucle-otides in length that act as post-transcriptional regulators of gene *** on the complementarity between miRNA and target mRNA,cleavage,destabilization,or transla-tional suppression of mRNA occurs within the RISC(RNA-induced silencing complex).As gene expression regulators,miRNAs are involved in a variety of biological *** of miRNAs and their target genes contribute to the pathophysiology of many diseases,including autoimmune and inflammatory *** are also present extracellularly in their sta-ble form in body *** incorporation into membrane vesicles or protein complexes with Ago2,HDL,or nucleophosmin 1 protects them against ***-free miRNAs can be deliv-ered to another cell in vitro and maintain their functional ***,miRNAs can be considered mediators of intercellular *** remarkable stability of cell-free miRNAs and their accessibility in body fluid makes them potential diagnostic or prognostic bio-markers and potential therapeutic *** we provide an overview of the potential role of circulating miRNAs as biomarkers of disease activity,therapeutic response,or diagnosis in rheumatic *** circulating miRNAs reflect their involvement in the pathogenesis,while for plenty,their pathogenetic mechanisms remain to be *** miRNAs described as biomarkers were also shown to be of therapeutic potential,and some miRNAs arealready tested in clinical trials.

关键词： Biomarker Diagnosis miRNA Rheumatic diseases Therapy

Endurance exercise and gut microbiota:A review

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Journal of Sport and Health Science 2017年第2期6卷 179-197页

作者： Núria Mach Dolors Fuster-Botella Health Science Department International Graduate Institute of the Open University of Catalonia (UOC) Barcelona 08035 Spain Animal Genetics and Integrative Biology unit (GABI) INRA AgroParis Tech Univesity of Paris-Saclay Jouy-en-Josas 78350 France

Background: The physiological and biochemical demands of intense exercise elicit both muscle-based and systemic responses. The main adaptations to endurance exercise include the correction of electrolyte imbalance, a decrease in glycogen storage and the increase of oxidative stress, intestinal permeability, muscle damage, and systemic inflammatory response. Adaptations to exercise might be influenced by the gut microbiota, which plays an important role in the production, storage, and expenditure of energy obtained from the diet as well as in inflammation,redox reactions, and hydration ***: A systematic and comprehensive search of electronic databases, including MEDLINE, Scopus, Clinical ***, Science Direct,Springer Link, and EMBASE was done. The search process was completed using the keywords: "endurance", "exercise", "immune response","microbiota", "nutrition", and "probiotics".Results: Reviewed literature supports the hypothesis that intestinal microbiota might be able to provide a measureable, effective marker of an athlete's immune function and that microbial composition analysis might also be sensitive enough to detect exercise-induced stress and metabolic disorders. The review also supports the hypothesis that modifying the microbiota through the use of probiotics could be an important therapeutic tool to improve athletes' overall general health, performance, and energy availability while controlling inflammation and redox ***: The present review provides a comprehensive overview of how gut microbiota may have a key role in controlling the oxidative stress and inflammatory responses as well as improving metabolism and energy expenditure during intense exercise.

关键词： Endurance Exercise Immune response Microbiota Nutrition Probiotics

The first case report of Leishmania(leishmania) chagasi in Panthera leo in Brazil

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Asian Pacific Journal of Tropical Biomedicine 2011年第3期1卷 249-250页

作者： Magyda AA Dahroug Arleana BPF Almeida Valéria RF Sousa Valéria Dutra Luciana D Guimares César E Soares Luciano Nakazato roberto L de Souza Federal University of Mato Grosso Ar.Fernando Correa da Costa s/n78060-900CuiabáMTBrasil

We reported here the first known case of natural infection of a lion(Panthera leo-Linnaeus,1738) with Leishmania(Leithmania) chagasi(***) in *** specimen was created by a circus handler in the state of Mato Grosso and was donated to the zoological park of the Federal University of Mato *** by *** was detected using a PCR-RFLP *** was known that the domestic felids can act as reservoir of infection of *** in endemic areas, making it important that studies demonstrate their participation in the epidemiological chain. We demonstrate in this work that wild animals can have an important role in the epidemiological chain and must be considered in order to plan methods of control of this zoonosis.

关键词： Panthera leo Leishmania(leishmania) chagasi PCR-RFLP

Key elements determining the intestinal region-specific environment of enteric neurons in type 1 diabetes

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World Journal of Gastroenterology 2023年第18期29卷 2704-2716页

作者： Mária Bagyánszki Nikolett Bódi Department of Physiology Anatomy and NeuroscienceFaculty of Science and InformaticsUniversity of SzegedSzeged H-6726Hungary

Diabetes,as a metabolic disorder,is accompanied with several gastrointestinal(GI)symptoms,like abdominal pain,gastroparesis,diarrhoea or *** and complex enteric nervous system damage is confirmed in the background of these diabetic motility *** anatomical length of the GI tract,as well as genetic,developmental,structural and functional differences between its segments contribute to the distinct,intestinal region-specific effects of *** observations support and highlight the importance of a regional approach in diabetes-related enteric *** large and microvessels are essential for the blood supply of enteric *** morpho-functional linkage exists between enteric neurons and enteroglia,however,there is also a reciprocal communication between enteric neurons and immune cells on which intestinal microbial composition has crucial *** this point of view,it is more appropriate to say that enteric neurons partake in multidirectional communication and interact with these key players of the intestinal *** interplays may differ from segment to segment,thus,the microenvironment of enteric neurons could be considered strictly *** goal of this review is to summarize the main tissue components and molecular factors,such as enteric glia cells,interstitial cells of Cajal,gut vasculature,intestinal epithelium,gut microbiota,immune cells,enteroendocrine cells,prooxidants,antioxidant molecules and extracellular matrix,which create and determine a gut region-dependent neuronal environment in diabetes.

关键词： Enteric neurons Neuronal environment Gut region specificity Type 1 diabetes,Hyperglycemia Microbiota-gut interactions

Soil moisture content as a predictor of soil disturbance caused by wheeled forest harvesting machines on soils of the Western Carpathians

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Journal of Forestry Research 2017年第2期28卷 283-289页

作者： Michal Allman Martin Jankovsk Valéria Messingerov Zuzana Allmanov Department of Forest Harvesting Logistics and AmeliorationsFaculty of ForestryTechnical University in ZvolenT.G.Masaryka 24960 53 ZvolenSlovakia

Limiting surface soil disturbance caused by forest harvesting machines is an important task and is influenced by the selection of efficient and reliable predictors of such disturbance. Our objective was to determine whether soil moisture content affects soil load bearing capacity and the formation of ruts. Measurements were conducted in six forest stands where various machines operated. We measured the formation of ruts along skid trails in connection with varying soil moisture content. Soil moisture content was determined through the gravimetric sampling method. Our results showed that severe（rut depth16–25 cm） to very severe disturbance（rut depth [26 cm）occurred in forest stands where the instantaneous soil moisture exceeded its plasticity limits defined through Atterberg limits. Atterberg limits of soil plasticity ranged from 26 to 32 % in individual stands. Regression and correlation analysis confirmed a moderately strong relationship（R = 0.52; p ／ 0.05） between soil moisture content and average rut depth. This confirmed that soil moisture is a suitable and effective predictor of soil disturbance.

关键词： disturbance moisture machines stands plasticity harvesting predictor moderately operated limits