检索结果-南通市图书馆

Predictive immune biomarkers: an unattainable chimera?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2018年第8期15卷 740-742页

作者： Anna Maria Trotta roberto Pacelli Stefania Scala Functional Genomics Istituto Nazionale per lo Studio e la Cura dei TumoriFondazione‘G.Pascale’Via SemmolaNaplesItaly Dipartimento di Scienze Biomediche Avanzate.UniversitàFederico II.Via Pansini NaplesItaly

Immune checkpoint blockade(ICB)with antibodies interfering with cytotoxic T lymphocyte antigen 4(CTLA-4)and the programmed cell death 1(PD-1)protein tremendously revolutionized therapy for advanced ***,the activity of such agents(ipilimumab and nivolumab)is limited to a 10–45%response rate in the context of unselected populations with advanced solid *** common cancer types have demonstrated a very low frequency of response(breast,prostate and colon cancers),and heterogeneous responses have been observed between distinct tumors within the same *** to broad clinical applicability include identifying patients most likely to benefit from checkpoint inhibitors and overcoming resistance to *** immune response is a dynamic and constantly evolving process due primarily to patient-dependent factors,including genetic and tumor microenvironment(TME)features,and secondarily to treatment interventions.

关键词： immune colon likely

Radiofrequency ablation of locally advanced pancreatic adenocarcinoma:An overview

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第28期16卷 3478-3483页

作者： Mirko D’Onofrio Emilio Barbi roberto Girelli Enrico Martone Anna Gallotti roberto Salvia Paolo Tinazzi Martini Claudio Bassi Paolo Pederzoli roberto Pozzi Mucelli Department of Radiology University Hospital G.B.RossiUniversity of Verona Department of Radiology Hospital"Casa di Cura Pederzoli"-Peschiera Department of Surgery Hospital"Casa di Cura Pederzoli"-Peschiera Department of Surgery University Hospital G.B.RossiUniversity of Verona

Radiofrequency ablation(RFA)of pancreatic neoplasms is restricted to locally advanced,non-resectable but nonmetastatic *** of pancreatic tumors is nowadays an ultrasound-guided procedure performed during laparotomy in open *** ultrasound covers the mandatory role of staging,evaluation of feasibility,guidance and monitoring of the *** types of needle can be *** first aim in the evaluation of RFA as a treatment for locally advanced pancreatic ductal adenocarcinoma,in order of evaluation but not of importance,is to determine the feasibility of the *** second aim is to establish the effect of RFA on tumoral mass in terms of necrosis *** most important aim,third in order of evaluation,is the potential improvement of quality of life and survival ***,only a few studies assess the feasibility of the *** present paper is an overview of RFA for pancreatic adenocarcinoma.

关键词： Radiofrequency ablation Pancreatic adenocarcinoma Intraoperative ultrasound Contrast-enhanced ultrasound Perfusion computed tomography

Assessment of compressive strength of jet grouting by machine learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 102-111页

作者： Esteban Diaz Edgar Leonardo Salamanca-Medina roberto Tomas Departamento de Ingeniería Civil Escuela Politécnica SuperiorUniversidad de AlicanteP.O.Box 99E-03080AlicanteSpain

Jet grouting is one of the most popular soil improvement techniques,but its design usually involves great uncertainties that can lead to economic cost overruns in construction *** high dispersion in the properties of the improved material leads to designers assuming a conservative,arbitrary and unjustified strength,which is even sometimes subjected to the results of the test *** present paper presents an approach for prediction of the uniaxial compressive strength(UCS)of jet grouting columns based on the analysis of several machine learning algorithms on a database of 854 results mainly collected from different research *** selected machine learning model(extremely randomized trees)relates the soil type and various parameters of the technique to the value of the compressive *** the complex mechanism that surrounds the jet grouting process,evidenced by the high dispersion and low correlation of the variables studied,the trained model allows to optimally predict the values of compressive strength with a significant improvement with respect to the existing ***,this work proposes for the first time a reliable and easily applicable approach for estimation of the compressive strength of jet grouting columns.

关键词： Jet grouting Ground improvement Compressive strength Machine learning

Unusual retention behavior of omeprazole and its chiral impurities B and E on the amylose tris(3-chloro-5-methylphenylcarbamate)chiral stationary phase in polar organic mode

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2018年第4期8卷 234-239页

作者： Rosella Ferretti Leo Zanitti Adriano Casulli roberto Cirilli Centro nazionale per il controllo e la valutazione dei farmaci Istituto Superiore di Sanita Viale Regina Elena 299 00161 Rome Italy European Union Reference Laboratory for the Parasites Istituto Superiore di Sanita Viale Regina Elena 299 00161 Rome Italy World Health Organization Collaborating Centre for the Epidemiology Detection and Control of Cystic and Alveolar Echinococcosis (In Animals and Humans) Istituto Superiore di Sanita Viale Regina Elena 299 00161 Rome Italy

Recent reports have demonstrated that the new commercially available immobilized-type chiral stationary phases（CSPs） containing amylose tris（3-chloro-5-methylphenylcarbamate）（ACMPC） as a selector exhibit not only an exceptionally high enantioselectivity in high-performance liquid chromatography（HPLC） but they are also applicable to a wide range of chiral analytes. Herein, we report the results obtained in the HPLC analysis of omeprazole and its impurities B and E on the ACMPC-based Chiralpak IG-3 CSP（CSP） under polar organic conditions. A systematic evaluation of the retention characteristics of the selected benzimidazole chiral probes was carried out by changing the composition of the mobile phase and the column temperature. It is worth emphasizing that the high affinity of both enantiomers of all analytes recorded in pure methanol mode dramatically decreased incorporating small volumes of either basic or acid additives in the mobile phase. Unspecified sites of the IG-3 CSP presumably involved in strong and non-stereoselective H-bonding contacts with chiral analytes are assumed responsible for the unproductive retention process.

关键词： Chiralpak IG-3 Retention Enantioselective HPLC Omeprazole Column temperature Basic/acid additives

AFM Measurements and Tip Characterization of Nanoparticles with Different Shapes

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanomanufacturing and Metrology 2022年第2期5卷 127-138页

作者： roberto Bellotti Gian Bartolo Picotto Luigi Ribotta Istituto Nazionale di Ricerca Metrologica(INRiM) Strada delle Cacce 9110135TorinoItaly Politecnico di Torino Corso Duca degli Abruzzi 2410129TorinoItaly

Unambiguous identification of the measurement methodologies is fundamental to reduce the uncertainty and support traceability of particle shape and size at the nanoscale. In this work, the critical aspects in atomic force microscopy measurements, that is, drawbacks on sample preparation, instrumental parameters, image pre-processing, size reconstruction, and tip enlargement, are discussed in reference to quantitative dimensional measurements on different kinds of nanoparticles (inorganic and biological) with different shapes (spherical, cylindrical, complex geometry). Once the cross-section profile is extracted, top-height measurements on isolated nanoparticles of any shape can be achieved with sub-nanometer accuracy. Lateral resolution is affected by the pixel size and shape of the probe, causing dilation in the atomic force microscopy image. For the reconstruction of critical sizes of inorganic non-spherical nanoparticles, a geometric approach that considers the nominal shape because of the synthesis conditions is presented and discussed.

关键词： Nanoparticles(NPs) Atomic force microscopy(AFM) Size reconstruction Spherical shape Complex shape AFM probe Uncertainty

A comprehensive analysis of future solar energy potential variations using a CMIP6 multi-model ensemble approach in Colombia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clean Energy 2024年第4期8卷 79-89页

作者： Heli AArregocés roberto Rojano Daiver Pinto Pimienta Grupo de Investigación GISA Facultad de IngenieríaUniversidad de La GuajiraRiohachaColombia Grupo Procesos Fisicoquímicos Aplicados Facultad de IngenieríaUniversidad de Antioquia SIU/UdeACalle 70 No.52–21MedellínColombia Grupo Desarrollo de Estudios y Tecnologías Ambientales del Carbono(DESTACAR) Facultad de IngenieríaUniversidad de La GuajiraRiohachaColombia

Climate change is predicted to significantly impact solar energy generation,which is particularly concerning given that photovoltaic(PV)energy is critical to the global transition to clean energy in underdeveloped *** study analyses the PV potential variations in Colombia using a Coupled Model Intercomparison Project Phase 6(CMIP6)multi-model ensemble approach under two shared socio-economic pathway scenarios for the near(2025-50)and far(2051-2100)*** the near-future period,the Pacific,Andean and Orinoquía regions are expected to experience a decrease in PV potential ranging from 10%to 23%for all shared socio-economic *** will be particularly noticeable during the March/April/May and June/July/August *** the other hand,CMIP6 estimations indicate a 1-4%increase in PV potential across the Amazon region during the June/July/August and September/October/November *** the far future,it has been projected that the Pacific,Andean and Orinoquía regions may experience a significant decline in solar power generation due to increased cloud cover and reduced *** decrease in PV potential during the June/July/August season could range from 8%to 27%for all considered scenarios,with the Pacific region being the most *** Pacific region is projected to experience a decrease ranging from 10%to 35%for all *** is worth noting that there are noticeable differences in PV potential across various regions,which can result in changes in cloud cover and atmospheric ***,the study provides valuable insights into the PV potential in Colombia and highlights the importance of considering regional variations and climate change scenarios in future energy planning.

关键词： photovoltaic potential CMIP6 solar photovoltaic energy climate change Colombia

Climate migrants’survival threatened by“C”shaped anthropic barriers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2020年第1期15卷 32-39页

作者： Luca BUTIKOFER Weihong JI roberto SACCHI Marco MANGIACOTTI School of Natural and Computational Sciences Massey UniversityNew Zealand Department of Earth and Environmental Science University of Pavia PaviaItaly

Despite studies on range shifts being abundant,the problem of dispersal barriers limiting climate migrants’movement is yet to be fully included into any modeling *** this reason,we introduce a novel concept whereby the interplay of range shifts and dispersal barriers of a particular spatial configuration can threaten the persistence of populations under a climate change *** named this concept“C-trap,”based on the topographic shape of such *** elaborating on the theoretical features of C-traps,we provide a simple method that combines environmental data and future climate projections to locate them *** use this method to determine where high C-trap densities have the potential to further threaten the conservation of endangered,endemic animals across the world’s terrestrial realm,in a climate change *** methodology detected potential C-traps for the study system,with areas of high density mostly located in east Europe,south Asia and North ***,finer-scale analyses are required to assess the magnitude of the threat *** barriers add an additional dimension to range shift studies and can ultimately prevent otherwise successful climate migrants from tracking their climatic *** methodology presented here is simple and flexible enough to be adapted to a wide range of taxa and locations as well as the fast development of range shift ***,we encourage researchers to include the effects of anthropogenic dispersal barriers in range shifts models and in the planning of effective conservation strategies with reference to climate change.

关键词： anthropogenic climate change land cover range shift trap

Temperature and eluent composition effects on enantiomer separation of carvedilol by high-performance liquid chromatography on immobilized amylose-based chiral stationary phases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2019年第5期9卷 324-331页

作者： Cristina Panella Rosella Ferretti Adriano Casulli roberto Cirilli Centro Nazionale peril Controllo e la Valutazione dei Farmaci Istituto Superiore di Sanita Viale Regina Elena 299 00161 Rome Italy European Union Reference Laboratory for the Parasites Istituto Superiore di Sanita Viale Regina Elena 299 00161 Rome Italy World Health Organization Collaborating Centre for the Epidemiology Detection and Control of Cystic and Alveolar Echinococcosis (in Animals and Humans) Istituto Superiore di Sanita Viale Regina Elena 299 00161 Rome Italy

Carvedilol is a chiral drug with potent antihypertensive and antianginal activities. Although it is clinically used as a racemic mixture, its enantiomers show different pharmacokinetic and pharmacodynamic profiles. Here, the direct chiral separation of racemic drug by high performance liquid chromatography using two immobilized-type amylose-based chiral stationary phases is presented. Some chromatographic parameters, such as retention and selectivity, were determined under multimodal eluent conditions and different temperatures. A temperature-dependent inversion of the elution order of enantiomers was observed in the operative temperature range of chiral chromatographic support. Finally, an effective direct enantioselective method was successfully applied to the separation of the enantiomers of carvedilol on a semipreparative scale.

关键词： Chiralpak^(■) IG-3 Enantioselective HPLC Carvedilol Column temperature Isoenantioselective temperature Semipreparative enantioseparation

A high aspect ratio surface micromachined accelerometer based on a SiC-CNT composite material

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2024年第2期10卷 219-230页

作者： Jiarui Mo Shreyas Shankar roberto Pezone Guoqi Zhang Sten Vollebregt Laboratory of Electronic Components Technology and Materials(ECTM)Department of MicroelectronicsDelft University of TechnologyDelftThe Netherlands

Silicon carbide(SiC)is recognized as an excellent material for microelectromechanical systems(MEMS),especially those operating in challenging environments,such as high temperature,high radiation,and corrosive ***,SiC bulk micromachining is still a challenge,which hinders the development of complex SiC *** address this problem,we present the use of a carbon nanotube(CNT)array coated with amorphous SiC(a-SiC)as an alternative composite material to enable high aspect ratio(HAR)surface *** using a prepatterned catalyst layer,a HAR CNT array can be grown as a structural template and then densified by uniformly filling the CNT bundle with LPCVD *** electrical properties of the resulting SiC-CNT composite were characterized,and the results indicated that the electrical resistivity was dominated by the *** demonstrate the use of this composite in MEMS applications,a capacitive accelerometer was designed,fabricated,and *** fabrication results showed that the composite is fully compatible with the manufacturing of surface micromachining *** Young’s modulus of the composite was extracted from the measured spring constant,and the results show a great improvement in the mechanical properties of the CNTs after coating with *** accelerometer was electrically characterized,and its functionality was confirmed using a mechanical shaker.

关键词： composite surface electrical