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Very low calorie ketogenic diet and common rheumatic disorders:A case report

World Journal of Clinical Cases 2023年第9期11卷 1985-1991页

作者： Mariangela Rondanelli Zaira Patelli Clara Gasparri Francesca Mansueto Cinzia Ferraris Mara Nichetti Tariq A Alalwan Ignacio Sajoux roberto maugeri Simone Perna Department of Public Health Experimental and Forensic MedicineUnit of Human and Clinical NutritionIRCCS Mondino FoundationPavia 27100Italy Endocrinology and Nutrition Unit Azienda di Servizi alla Persona"Istituto Santa Margherita"University of PaviaPavia 27100Italy Food Education and Sport Nutrition Laboratory Department of Public HealthExperimental and Forensic MedicineUniversity of PaviaPavia 27100Italy Department of Biology College of ScienceUniversity of BahrainSakhir 32038Bahrain Chief Scientific Office Medical Department Pronokal GroupBarcelona 08001Spain Medical Direction PronoKal GroupSavigliano 12038Italy

BACKGROUND The scientific literature provides evidence that nutritional ketosis can be an important support in the treatment of pathologies in which inflammation is present,as recent studies have shown that ketone bodies have anti-inflammatory activity in numerous diseases,including rheumatic *** report the case of a 22-year-old woman with class I obesity and juvenile idiopathic arthritis who started treatment with a very low calorie ketogenic diet(VLCKD).CASE SUMMARY The patient was a 22-year-old woman diagnosed with juvenile idiopathic arthritis at age 4 years and with a body mass index(BMI)of 30.8 kg/m2,waist circumference(WC)80 cm,fat mass(FM)28.1 kg,free FM 45.7 kg,and visceral adipose tissue(VAT)3.5 kg,assessed on bioimpedance *** was treated using a commercial VLCKD weight-loss program(PNK®method);this program provides high-biological-value protein preparations and natural *** protein preparation contains 15 g protein,4 g carbohydrate,3 g fat,and 50 mg omega-3 docosahexaenoic acid,with an energy content of 90–120 *** four months on the program,the BMI was 28.6 kg/m2,WC 73 cm,FM 23.2 kg,free FM 41.9 kg,and VAT 2.9 *** VLCKD enabled the patient to reach her target weight and to reduce her joint pain and *** inflammatory indices also normalized.

关键词： Very low calorie ketogenic diet Inflammation PNK

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Role of pituitary adenylate cyclase-activating polypeptide in peripheral nerve regeneration:a cellular and molecular perspective

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Neural Regeneration Research 2024年第7期19卷 1429-1430页

作者： Grazia maugeri Velia D’Agata Section of Anatomy Histology and Movement SciencesDepartment of Biomedical and Biotechnological SciencesUniversity of CataniaCataniaItaly

Neuro regeneration is a very complex phenomenon characterized by the generation of new neurons and synapses,involving connections between adjacent cells and axonal *** supplies additional longterm resources to replace... 详细信息

关键词： replace functional regeneration

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Role of exercise in the brain:focus on oligodendrocytes and remyelination

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Neural Regeneration Research 2023年第12期18卷 2645-2646页

作者： Grazia maugeri Velia D'Agata Giuseppe Musumeci Section of Anatomy Histology and Movement SciencesDepartment of Biomedical and Biotechnological SciencesUniversity of CataniaCataniaItaly Research Center on Motor Activities(CRAM) University of CataniaCataniaItaly Department of Biology Sbarro Institute for Cancer Research and Molecular MedicineCollege of Science and TechnologyTemple UniversityPhiladelphiaPAUSA

The phrase“Mens sana in corpore sano”taken from Juvenal's Satires(127 a.C.)represents one of the best-known and most used sentences of all time,whose meaning in the modern age refers to the importance of physical activity for mental health and *** literature demonstrated the positive role of exercise in counteracting several diseases,such as diabetes,cardiovascular diseases,neurodegenerative diseases,cancers and age-related disorders including muscle atrophy,the reduction of aerobic capacity,bone and cartilage loss.

关键词： meaning such exercise

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Embedded fuzzing:a review of challenges,tools,and solutions

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Cybersecurity 2022年第4期5卷 1-18页

作者： Max Eisele Marcello maugeri Rachna Shriwas Christopher Huth Giampaolo Bella Safety Security and PrivacyRobert Bosch GmbHRenningenGermany Dept.of Math and Computer Science Universita degli Studi di CataniaCataniaItaly RBEl Robert Bosch GmbHBangaloreIndia.

Fuzzing has become one of the best-established methods to uncover software ***,the market of embedded systems,which binds the software execution tightly to the very hardware architecture,has grown at a steady pace,and that pace is anticipated to become yet more sustained in the near *** systems also beneft from fuzzing,but the innumerable existing architectures and hardware peripherals complicate the development of general and usable approaches,hence a plethora of tools have recently *** comes a stringent need for a systematic review in the area of fuzzing approaches for embedded systems,which we term'embedded fuzzing"for *** inclusion criteria chosen in this article are semi-objective in their coverage of the most relevant publication venues as well as of our personal *** review rests on a formal definition we develop to represent the realm of embedded *** continues by discussing the approaches that satisfy the inclusion criteria,then defines the relevant elements of comparison and groups the approaches according to how the execution environment is served to the system under *** resulting review produces a table with 42 entries,which in turn supports discussion suggesting vast room for future research due to the limitations noted.

关键词： Embedded systems Dynamic analysis Vulnerability mining Embedded security Software security

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Soil Uncertainties on Performance of Geotechnical Works

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Journal of Civil Engineering and Architecture 2010年第5期4卷 37-47页

作者： Michele maugeri Salvatore Grasso Department of Civil and Environmental Engineering University of Catania Catania 95125 Italy

Performance-Based Design （PBD） is a more rational approach, particularly in seismic environments. In this approach it is relevant the performance required to structures and to geotechnical works, as well as the geotechnical constitutive models used to predict the performance. The parameters of the constitutive models are related in turn to soil properties. So soil properties are a key point for Performance-Based Design. Questions arising are：（i） which are the more relevant soil properties to solve a specific PBD geotechnical problem？（ii） which are the more relevant model parameters and how they can be evaluated and/or correlated to soil properties？（iii） which is the role of the soil parameters uncertainty in Performance-Based Design？ An answer to these questions is given in this paper, outlining the potential offered by the new advanced in-situ and laboratory tests and discussing the performance required by some geotechnical works.

关键词： Performance Based Design (PBD) soil properties geotechnical works physical environment.

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Soil Liquefaction Hazard Evaluation by the New Seismic Dilatometer Marchetti Test （SDMT）

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Journal of Civil Engineering and Architecture 2010年第3期4卷 36-45页

作者： Salvatore Grasso Michele maugeri Department of Civil and Environmental Engineering University of Catania Italy

Soil liquefaction, and the permanent deformations that frequently result from it, have caused significant damage in past earthquakes. The procedures used in contemporary geotechnical earthquake engineering practice are generally based on simplified procedures for the evaluation of the liquefaction potential. The work describes a framework for performance-based earthquake engineering and its use in the development of a performance-based procedure for liquefaction hazard evaluation. The performance-based procedure will be used to show how consistent application of conventional procedures for evaluation of liquefaction potential can influence performance prediction. Implications for liquefaction-resistant design will also be discussed. The purpose is to summarize current procedures for practical prediction of liquefaction behavior, to describe recent advances in the understanding of liquefaction behavior, and to describe the incorporation of this improved understanding into new solutions for detailed modeling of soil liquefaction, Simplified procedures for evaluation of liquefaction hazards will be reviewed relatively briefly, with more details devoted to emerging knowledge about the mechanics of liquefiable soil behavior, and methods for incorporating those mechanics into improved models for performance prediction. In particular it focuses about the influence on the evaluation of Cyclic Resistance Ratio （CRR） by different in-situ tests （Cone Penetration Test （CPT）. Standard Penetration Test （SPT） and Seismic Dilatometer Marchetti Test （SDMT）） and by different shear waves velocity measurements （Down Hole D-H. Cross Hole C-H, Seismic Dilatometer Marchetti Test SDMT）.

关键词： Liquefaction Potential Index Seismic Dilatometer Marchetti Test (SDMT) Cyclic Resistance Ratio (CRR) Cyclic Stress Ratio (CSR).

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Technological advancements in the analysis of human motion and posture management through digital devices

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World Journal of Orthopedics 2021年第7期12卷 467-484页

作者： Federico Roggio Silvia Ravalli Grazia maugeri Antonino Bianco Antonio Palma Michelino Di Rosa Giuseppe Musumeci Department of Psychology Educational Science and Human MovementUniversity of PalermoPalermo 90144Italy Department of Biomedical and Biotechnological Sciences Human Anatomy and Histology SectionSchool of MedicineUniversity of CataniaCatania 95123Italy Department of Biology College of Science and TechnologyTemple UniversityPhiladelphiaPA 19122United States

Technological development of motion and posture analyses is rapidly progressing,especially in rehabilitation settings and sport ***,clear discrimination among different measurement systems is required to diversify their use as *** review aims to resume the currently used motion and posture analysis systems,clarify and suggest the appropriate approaches suitable for specific cases or *** currently gold standard systems of motion analysis,widely used in clinical settings,present several limitations related to marker placement or long procedure *** automated and markerless systems are overcoming these drawbacks for conducting biomechanical studies,especially outside ***,new posture analysis techniques are emerging,often driven by the need for fast and non-invasive methods to obtain high-precision *** new technologies have also become effective for children or adolescents with non-specific back pain and postural *** evolutions of these methods aim to standardize measurements and provide manageable tools in clinical practice for the early diagnosis of musculoskeletal pathologies and to monitor daily improvements of each ***,these devices and their uses are described,providing researchers,clinicians,orthopedics,physical therapists,and sports coaches an effective guide to use new technologies in their practice as instruments of diagnosis,therapy,and prevention.

关键词： Motion capture Gait analysis Inertial measurement unit Wearable devices Rasterstereography Posture

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Ground Motion and Site Effects on Performance-Based Design

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Journal of Civil Engineering and Architecture 2010年第7期4卷 34-41页

作者： Antonio Ferraro Salvatore Grasso Michele maugeri Department of Civil and Environmental Engineering University of Catania Italy

The objective of Performance-Based Earthquake Engineering （PBEE） is the analysis of performance objectives with a specified annual probability of exceedance. Increasingly undesirable performance is caused by increasing levels of strong ground motion having decreasing annual probabilities of exceedance. The development of this methodology includes three steps：（1） evaluation of the distribution of ground motion at a site; （2） evaluation of the distribution of system response; （3） evaluation of the probability of exceeding decision variables within a given time period, given appropriate damage measures. The work has taken a systematic approach to determine the impact of increasing levels of detail in site characterization on the accuracy of ground motion and site effects predictions. Complementary studies have investigated the use of the following models for evaluating site effects：（1） amplification factors defined on the basis of generalized site categories, （2） one-dimensional ground response analysis, and （3） two-dimensional ground response analysis for surface topography on ground motion. The paper provides a brief synthesis of ground motion and site effects analysis procedures within a Performance-Based Design framework. It focuses about the influence on the evaluation of site effects in some active regions by different shear waves velocity measurements Down Hole （D-H）, Cross Hole （C-H）, Seismic Dilatometer Marchetti Test （SDMT） and by different variation of shear modulus and damping ratio with strain level and depth from different laboratory dynamic tests for soil characterization： Resonant Column Test （RCT）, Cyclic Loading Torsional Shear Test （CLTST）.

关键词： Site effects Performance Based Design (PBD) ground motion soil non-linearity seismic response analysis

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The Role of Soil Investigation on Performance-based Design in Geotechnical Earthquake Engineering

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Journal of Civil Engineering and Architecture 2010年第2期4卷 33-40页

作者： Antonio Cavallaro Salvatore Grasso Michele maugeri Department of Civil and Environmental Engineering University of Catania Catania 95125 Italy

The spatial variability of geotechnical earthquake engineering critical parameters obtained by laboratory and in situ tests in the same area is affected by different measurements. The paper provides a brief synthesis of ground motion and site effects analysis procedures within a Performance-Based Design framework. In particular it focuses about the influence on the evaluation of site effects in some active regions by different shear waves velocity measurements （Down Hole D-H and Seismic Dilatometer Marchetti Test SDMT）. Moreover the variation of shear modulus and damping ratio with strain level and depth from different laboratory dynamic or cyclic tests for soil characterisation （Resonant Column Test RCT） was evaluated. The available data enabled one to compare the shear waves velocity profile obtained by laboratory and in situ tests （Cone Penetration Tests CPT） with empirical correlations proposed in literature.

关键词： Seismic Dilatometer Marchetti Test (SDMT) shear wave velocity St. Giuliano di Puglia (Italy) seismic response analysis.

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Development of a Soy-Based Synbiotic Beverage

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Food and Nutrition Sciences 2012年第8期3卷 1128-1135页

作者： Suzana Reis Evangelista Gislaine Ghiselli Francisco maugeri Filho Departamento de Ciência dos Alimentos Universidade Federal de Lavras Lavras Minas Gerias Brasil Departamento de Engenharia de Alimentos Faculdade de Engenharia de Alimentos Universidade Estadual de Campinas Campinas Sao Paulo Brasil

Nowadays consumers seek foods that not only provide basic nutrition but also contain compounds that contribute to health. Thus, different products have been designed to meet this demand, especially those with probiotic and prebiotic characteristics. This study aimed to evaluate different formulations of a soy-based synbiotic beverage. The composition and process conditions were defined using a Placket & Burman factorial design in which the independent variables were process temperature, concentrations of the soy hydrosoluble extract and fructooligosaccharides (FOS) and the initial concentration of the probiotics Bifidobaterium longum, Lactobacillus acidophilus, Lactobacillus paracasei subsp. Paracasei, Lactobacillus rhamnosus. Changes to the product by addition of sucrose, Streptococcus thermophilus and Lactobacillus delbrueckii subsp. Bulgaricus were also studied. Response parameters were: pH, cell concentration (plate counting), and quantification of fructooligosaccharides, acetic acid and lactic acid. The specific growth rate (μx) and change in cell count (Δx) were determined in each formulation. The soybean hydrosoluble extract was considered a good substrate for beverage production;FOS had a greater effect at lower concentrations. At the end of all fermentation tests the total probiotic count was greater than 7 log CFU/mL, meeting the legal requirements of a functional food. Lower temperatures were better for the growth of probiotics. The addition of sucrose resulted in a lower consumption of FOS by the fermenting microorganisms, while the presence of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus represented little change concerning the evaluated characteristics. Therefore, according to the results of this study, the production of a soy-based symbiotic fermented beverage can be performed using soybean hydrosoluble extract at 10% (w/v), fructooligosaccharides at about 3% (w/v), sucrose at 12% (w/v), and the process temperature should

关键词： Probiotics Prebiotics Soy Synbiotic Beverage Functional Food

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