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Methodological factors affecting gas and methane production during in vitro rumen fermentation evaluated by meta-analysis approach

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Journal of Animal Science and Biotechnology 2017年第1期8卷 236-247页

作者： Laura Maccarana Mirko Cattani Franco Tagliapietra Stefano Schiavon Lucia Bailoni roberto mantovani Department of Comparative Biomedicine and Food Science (BCA) University of Padova Viale dell'Universita 16 35020 Legnaro (PD) Italy Department of Agronomy Food Natural resources Animals and Environment (DAFNAE) University of Padova Viale dell'Universita 16 35020 Legnaro (PD) Italy

Effects of some methodological factors on in vitro measures of gas production（GP, mL/g DM）, CH4production（mL/g DM） and proportion（% CH4 on total GP） were investigated by meta-analysis. These factors were considered：pressure in the GP equipment（0 = constant; 1 = increasing）, incubation time（0 = 24; 1 = ≥ 48 h）, time of rumen fluid collection（0 = before feeding; 1 = after feeding of donor animals）, donor species of rumen fluid（0 = sheep; 1 =bovine）, presence of N in the buffer solution（0 = presence; 1 = absence）, and ratio between amount of buffered rumen fluid and feed sample（BRF/FS; 0 = ≤ 130 mL/g DM; 1 = 130–140 mL/g DM; 2 = ≥ 140 mL/g DM）. The NDF content of feed sample incubated（NDF） was considered as a continuous variable. From an initial database of 105 papers, 58 were discarded because one of the above-mentioned factors was not stated. After discarding 17 papers,the final dataset comprised 30 papers（339 observations）. A preliminary mixed model analysis was carried out on experimental data considering the study as random factor. Variables adjusted for study effect were analyzed using a backward stepwise analysis including the above-mentioned variables. The analysis showed that the extension of incubation time and reduction of NDF increased GP and CH4 values. Values of GP and CH4 also increased when rumen fluid was collected after feeding compared to before feeding（＋26.4 and ＋9.0 mL/g DM, for GP and CH4）,from bovine compared to sheep（＋32.8 and ＋5.2 mL/g DM, for GP and CH4）, and when the buffer solution did not contain N（＋24.7 and ＋6.7 mL/g DM for GP and CH4）. The increase of BRF/FS ratio enhanced GP and CH4production（＋7.7 and ＋3.3 mL/g DM per each class of increase, respectively）. In vitro techniques for measuring GP and CH4 production are mostly used as screening methods, thus a full standardization of such techniques is not feasible. However, a greater harmonization of analytical procedures（i.e., a reduction in the number of available protocols） would be usefu

关键词： Experimental factors Gas production In vitro rumen fermentation Meta-analysis Methane production

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Crystal Structure of the Arabidopsis thaliana L1L/ NF-YC3 Histone-fold Dimer Reveals Specificities of the LECl Family of NF-Y Subunits in Plants

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Molecular Plant 2017年第4期10卷 645-648页

作者： Nerina Gnesutta Dana Saad Antonio Chaves-Sanjuan roberto mantovani Marco Nardini Dipartimento di Bioscienze Università degli Studi di Milano Via Celoria 26 20133 Milan Italy

The NF-Y transcription factor is a heterotrimer formed by evolu- tionarily conserved subunits： NF-YA, NF-YB, and NF-YC. NF-YB and NF-YC harbor a histone fold domain （HFD）, structur- ally similar to that of nucleoso... 详细信息

关键词： NF-Y transcription factor heterotrimer evolutionarily conserved

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The Physical Universe and the Theoretical Value of Science:Reflections on the Thought of ***

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Journal of Philosophy Study 2023年第8期13卷 325-334页

作者： roberto mantovani Alessandro Prato University of Urbino UrbinoItaly University of Siena SienaItaly

The essay has two main *** first consists of discussing some literary and philosophical thoughts on the epistemological value of science by one of the most famous and celebrated poets in Italian literature,Giacomo *** poet firmly believes in the cognitive power of science,capable of revealing false beliefs with the light of ***,in his mature reflections,what will radically change will not be the value of scientific activity itself,always admirably accepted,but rather its true salvific *** was not a scientist,but he used the scientific culture of his time to critically address the great existential themes of man concerning nature and the *** had amply demonstrated a scientific culture since his youthful'History of Astronomy',which would reappear in many of his other literary *** deep and meditative reflections on the nature of finite and infinite space and time are a clear and fruitful testimony to ***,Giacomo writes icastically,reason alone is not enough;it needs *** second concerns a first reconstruction of the influence that the philosophy of Enlightenment had on Leopardi’s thought especially in relation to these topics:atheism,rejection of providentialism and anthropocentrism,the conception of nature,the question of the relationship between human and animal intelligence,the rejection of metaphysics,the importance of scientific knowledge.

关键词： Giacomo Leopardi Leopardi's philosophical thoughts Leopardi's scientific thoughts epistemological value of science materialism philosophy of Enlightenment metaphysics

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Glucose-lowering agents and reduced risk of incident non-alcoholic fatty liver disease:new insights

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 156-160页

作者： Alessandro mantovani Rosa Lombardi Andrea Dalbeni Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Unit of Internal Medicine and Metabolic Disease Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly Department of Pathophysiology and Transplantation Universitàdegli Studi di MilanoMilanItaly Section of General Medicine C and Liver Unit University and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly

Non-alcoholic fatty liver disease(NAFLD)is classically defined as the hepatic manifestation of metabolic syndrome(1).Histologically,NAFLD covers a range of conditions,spanning from simple steatosis to non-alcoholic steatohepatitis(NASH)and cirrhosis(2).At present,NAFLD is the most frequent chronic liver disease seen in clinical practice in high-income countries,as it affects nearly 30%of adults in the general population,up to 70%of patients with type 2 diabetes(T2DM)and almost all patients with obesity(2).

关键词： NAFLD liver hepatic

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Effect of silver in thermal treatments of Fe-Mn-C degradable metals:Implications for stent processing

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Bioactive Materials 2022年第6期7卷 30-41页

作者： Sergio Loffredo Sofia Gambaro Francesco Copes Carlo Paternoster Nicolas Giguere Maurizio Vedani Diego mantovani Laboratory for Biomaterials and Bioengineering Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-Materials EngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineLaval UniversityQuebec CityQC G1V 0A6Canada Department of Mechanical Engineering Politecnico di MilanoMilan20156Italy National Research Council Institute of Condensed Matter Chemistry and Technologies for Energy CNR-ICMATEGenoa16149Italy Quebec Metallurgy Center CMQ Trois-RivieresQCG9A 5E1Canada

Twinning-induced plasticity(TWIP)steels are considered excellent materials for manufacturing products requiring extremely high mechanical properties for various applications including thin medical devices,such as biodegradable intravascular *** is also proven that the addition of Ag can guarantee an appropriate degradation while implanted in human body without affecting its bioactive *** order to develop an optimized manufacturing process for thin stents,the effect of Ag on the recrystallization behavior of TWIP steels needs to be *** is of major importance since manufacturing stents involves several intermediate recrystallization annealing *** this work,the recrystallization mechanism of two Fe-Mn-C steels with and without Ag was thoroughly investigated by microstructural and mechanical *** was observed that Ag promoted a finer microstructure with a different texture evolution,while the recrystallization kinetics resulted *** presence of Ag also reduced the effectiveness of the recrystallization *** behavior was attributed to the presence of Ag-rich second phase particles,precipitation of carbides and to the preferential development of grains possessing a{111}orientation upon thermal *** prominence of{111}grains can also give rise to premature twinning,explaining the role of Ag in reducing the ductility of TWIP steels already observed in other ***,in vitro biological performances were unaffected by *** findings could allow the design of efficient treatments for supporting the transformation of Fe-Mn-C steels alloyed with Ag into commercial products.

关键词： Twinning Recrystallization Biomaterials Silver Steels

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Surface processing for iron-based degradable alloys:A preliminary study on the importance of acid pickling

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Bioactive Materials 2022年第5期7卷 166-180页

作者： Leticia Marin de Andrade Carlo Paternoster Pascale Chevallier Sofia Gambaro Paolo Mengucci Diego mantovani Laboratory for Biomaterials and Bioengineering Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-Materials EngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineLaval UniversityQuebec CityQCG1V 0A6Canada National Research Council Institute of Condensed Matter Chemistry and Technologies for Energy CNR-ICMATEGenoa16149Italy Polytechnic University of Marche Ancona60121Italy

The formation of a heterogeneous oxidized layer,also called scale,on metallic surfaces is widely recognized as a rapid manufacturing event for metals and their *** or total removal of the scale represents a mandatory integrated step for the industrial fabrication processes of medical *** biodegradable metals,acid pickling has already been reported as a preliminary surface preparation given further processes,such as ***,biodegradable medical prototypes presented discrepancies concerning acid pickling studies based on samples with less complex geometry(e.g.,non-uniform scale removal and rougher surface).Indeed,this translational knowledge lacks a detailed investigation on this process,deep characterization of treated surfaces properties,as well as a comprehensive discussion of the involved *** this study,the effects of different acidic media(HCl,HNO_(3),H_(3)PO_(4),CH_(3)COOH,H_(2)SO_(4) and HF),maintained at different temperatures(21 and 60℃)for various exposition time(15-240 s),on the chemical composition and surface properties of a Fe-13Mn-1.2C biodegradable alloy were *** in mass loss,morphology and wettability evidenced the combined effect of temperature and time for all *** in HCl and HF solutions favor mass loss(0.03-0.1 g/cm^(2))and effectively remove the initial scale.

关键词： Biodegradable metals Iron-based alloys Acid pickling Surface finishing Pre-treatment

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Proteomics as a tool to gain next level insights into photo-crosslinkable biopolymer modifications

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Bioactive Materials 2022年第11期7卷 204-220页

作者： Nele Pien Fabrice Bray Tom Gheysens Liesbeth Tytgat Christian Rolando Diego mantovani Peter Dubruel Sandra Van Vlierberghe Ghent University Polymer Chemistry and Biomaterials Research GroupCentre of Macromolecular Chemistry(CMaC)Krijgslaan 281 S4bis9000 GentBelgium Laval University Laboratory for Biomaterials and BioengineeringCRC-IPavillon PouliotQuebec G1V 0A6Canada Univ.Lille CNRSUSR 3290MSAPMiniaturisation pour la Synthese l’Analyse et la ProteomiqueF-59000LilleFrance

The distribution of photo-crosslinkable moieties onto a protein backbone can affect a biomaterial’s crosslinking behavior, and therefore also its mechanical and biological properties. A profound insight in this respect is essential for biomaterials exploited in tissue engineering and regenerative medicine. In the present work, photo-crosslinkable moieties have been introduced on the primary amine groups of: (i) a recombinant collagen peptide (RCPhC1) with a known amino acid (AA) sequence, and (ii) bovine skin collagen (COL BS) with an unknown AA sequence. The degree of substitution (DS) was quantified with two conventional techniques: an ortho-phthalic dialdehyde (OPA) assay and ^(1)H NMR spectroscopy. However, neither of both provides information on the exact type and location of the modified AAs. Therefore, for the first time, proteomic analysis was evaluated herein as a tool to identify functionalized AAs as well as the exact position of photo-crosslinkable moieties along the AA sequence, thereby enabling an in-depth, unprecedented characterization of functionalized photo-crosslinkable biopolymers. Moreover, our strategy enabled to visualize the spatial distribution of the modifications within the overall structure of the protein. Proteomics has proven to provide unprecedented insight in the distribution of photo-crosslinkable moieties along the protein backbone, undoubtedly contributing to superior functional biomaterial design to serve regenerative medicine.

关键词： (Photo-crosslinkable)biomaterials Chemical modifications Biomaterial characterization Proteomics Localization of functionalizations

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Rare horizontal transmission does not hide long-term inheritance of SINE highly conserved domains in the metazoan evolution

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Current Zoology 2016年第6期62卷 667-674页

作者： Andrea LUCHETTI Barbara mantovani Dipartimento di Scienze Biologiche Geologiche e Ambientali--Universit~ di Bologna Via Selmi 3 Bologna 40126Italy

Transposable elements (TEs) are self-replicating, mobile DNA sequences which constitute a significant fraction of eukaryotic genomes. They are generally considered selfish DNA, as their replication and random insertion may have deleterious effects on genome functionalities, although some beneficial effects and evolutionary potential have been recognized. Short interspersed elements (SINEs) are non-autonomous TEs with a modular structure: a small RNA-related head, a body, and a long interspersed element-related tail. Despite their high turnover rate and emergence, the body may retain highly conserved domains (HCDs) shared among divergent SINE families: in metazoans, at least nine HCD-SINEs have been recognized. Data mining on public molecular databases allowed the retrieval of 16 new HCD-SINE families from cnidarian, molluscs, arthropods, and vertebrates. Tracking the ancestry of HCDs on the metazoan phylogeny revealed that some of them date back to the Radiata-Bilateria split. Moreover, phylogenetic and age divergence analyses of the most ancient HCDs suggested that long-term vertical inheritance is the rule, with few horizontal transfer events. We suggest that the evolutionary conservation of HCDs may be linked to their potential to serve as recombination hotspots. This indirectly affects host genomes by maintaining active and diverse SINE lineages, whose insertions may impact (either positively or negatively) on the evolution of the genome.

关键词：动物进化结构域正弦水平传播保守 DNA序列传承自我复制

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Immunomodulatory biomaterials against bacterial infections:Progress,challenges,and future perspectives

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The Innovation 2023年第6期4卷 101-114页

作者： Shutao Zhang Hongtao Yang Minqi Wang Diego mantovani Ke Yang Frank Witte Lili Tan Bing Yue Xinhua Qu Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200001China School of Engineering Medicine Beihang UniversityBejjing 100191China Laboratory for Biomaterials and Bioengineering Canada Research Chair 1 in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-MaterialsEngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineL aval UniversityQuebec CityQC G1V 0A6Canada Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Department of Prosthodontics Geriatic Dentistry and Craniomandibular DisordersCharite Medical UniversityAssmannshauser Strasse 4-614197 BerlinGermany

Bacterial infectious diseases are one of the leading causes of death *** with the use of multiple antibiotic treatment strategies,4.95 million people died from drug-resistant bacterial infections in *** 2050,the number of deaths will reach 10 milion *** increasing mortality may be partly due to bacterial heterogeneity in the infection microenvironment,such as drug-resistant bacteria,biofilms,persister cells,intracellular bacteria,and small colony *** addition,the complexity of the immune microenvironment at different stages of infection makes biomaterials with direct antimicrobial activity unsatisfactory for the longterm treatment of chronic bacterial *** increasing mortality may be partly attributed to the biomaterials failing to modulate the active antimicrobial action of immune ***,there is an urgent need for effective alternatives to treat bacterial ***,the development of immunomodulatory antimicrobial biomaterials has recently received considerable interest;however,a comprehensive review of their research progress is *** this review,we focus mainly on the research progress and future perspectives of immunomodulatory antimicrobial biomaterials used at different stages of ***,we describe the characteristics of the immune microenvironment in the acute and chronic phases of bacterial ***,we highlight the immunomodulatory strategies for antimicrobial biomaterials at different stages of infection and their corresponding advantages and ***,we discuss biomaterial-mediated bacterial vaccines'potential applications and challenges for activating innate and adaptive immune *** review will serve as a reference for future studies to develop next-generation immunomodulatory biomaterials and accelerate their translation into clinical practice.

关键词： infections biomaterials modulator

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A microfluidic approach for development of hybrid collagen-chitosan extracellular matrix-like membranes for on-chip cell cultures

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Journal of Materials Science & Technology 2021年第4期63卷 54-61页

作者： Erica Rosella Nan Jia Diego mantovani Jesse Greener Laboratory Department of ChemistryLaval UniversityQuébecQCCanada Laboratory of Biomaterials and Bioengineering CRC-1Dept.Min-Met-Materials Eng&CHU de QuebecResearch CenterLaval UniversityQuébecQCCanada CHU de Quebec Research Centre Laval University10 rue de l’EspinayQuébecQC G1L 3L5Canada

To advance organ-on-a-chip development and other areas befitting from physiologically-relevant biomembranes,a microfluidic platform is presented for synthesis of biomembranes during gelation and investigation into their role as extracellular matrix *** this work,high-throughput studies of collagen,chitosan,and collagen-chitosan hybrid biomembranes were carried out to characterize and compare key properties as a function of the applied hydrodynamic conditions during ***,depending on the biopolymer material used,varying flow conditions during biomembrane gelation caused width,uniformity,and swelling ratio to be differently affected and ***,cell viability studies of seeded fibroblasts were conducted,thus showing the potential for biological applications.

关键词： matrix swelling showing

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