Immunomodulatory biomaterials against bacterial infections:Progress,challenges,and future perspectives

作     者：Shutao Zhang Hongtao Yang Minqi Wang Diego Mantovani Ke Yang Frank Witte Lili Tan Bing Yue Xinhua Qu 

作者机构：Department of Bone and Joint SurgeryDepartment of OrthopedicsRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200001China School of Engineering MedicineBeihang UniversityBejjing 100191China Laboratory for Biomaterials and BioengineeringCanada Research Chair 1 in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-MaterialsEngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineL aval UniversityQuebec CityQC G1V 0A6Canada Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Department of ProsthodonticsGeriatic Dentistry and Craniomandibular DisordersCharite Medical UniversityAssmannshauser Strasse 4-614197 BerlinGermany 

出 版 物：《The Innovation》 (创新（英文）)

年 卷 期：2023年第4卷第6期

页      面：101-114页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：National Natural Science Foundation of China(grant nos.32222042,82225031,82172464,82172453,and 81972086) Shanghai Rising-Star Pro-gram(21QA1405500) Program of Shanghai Excellent Academic Leader(grant no.22XD1401900) 

主　　题：infections biomaterials modulator 

摘      要：Bacterial infectious diseases are one of the leading causes of death *** with the use of multiple antibiotic treatment strategies,4.95 million people died from drug-resistant bacterial infections in *** 2050,the number of deaths will reach 10 milion *** increasing mortality may be partly due to bacterial heterogeneity in the infection microenvironment,such as drug-resistant bacteria,biofilms,persister cells,intracellular bacteria,and small colony *** addition,the complexity of the immune microenvironment at different stages of infection makes biomaterials with direct antimicrobial activity unsatisfactory for the longterm treatment of chronic bacterial *** increasing mortality may be partly attributed to the biomaterials failing to modulate the active antimicrobial action of immune ***,there is an urgent need for effective alternatives to treat bacterial ***,the development of immunomodulatory antimicrobial biomaterials has recently received considerable interest;however,a comprehensive review of their research progress is *** this review,we focus mainly on the research progress and future perspectives of immunomodulatory antimicrobial biomaterials used at different stages of ***,we describe the characteristics of the immune microenvironment in the acute and chronic phases of bacterial ***,we highlight the immunomodulatory strategies for antimicrobial biomaterials at different stages of infection and their corresponding advantages and ***,we discuss biomaterial-mediated bacterial vaccines potential applications and challenges for activating innate and adaptive immune *** review will serve as a reference for future studies to develop next-generation immunomodulatory biomaterials and accelerate their translation into clinical practice.