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Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN T.ASGHAR z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： Peclet number

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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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Bake-Hardening Response of High martensite Dual-Phase Steel with Different morphologies and Volume Fractions

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Acta metallurgica Sinica(English Letters) 2014年第2期27卷 279-289页

作者： mustafa Trkmen Sleyman Gnd.z Department of metallurgy Kocaeli University Hereke Vocational School Department of manufacturing Engineering Technology FacultyKarabk University

Bake-hardening behaviour of carbon steel with different martensite morphologies and volume fraction was investigated. The specimens with fibrous and bulky martensite were prestrained in tension by 4%. After this, they were unloaded and bake hardened at 180 ℃ for 10-160 min. It was found that dual-phase steel samples which were bake hardened at 180 ℃ for 20 rain showed an increase in the yield stress （YS） and ultimate tensile stress （UTS） but a decrease in ductility. Further increase in the bake-hardening time of 80 or 160 min has reduced the YS and UTS, but increased the ductility. △σ （increase in stress due to bake hardening）, YS and UTS values are higher for the microstructure containing fibrous martensite compared to the microstructure-containing bulky martensite. It was also observed that at a given baking temperature Aa, YS and UTS increased by volume of martensite.

关键词： Dual-phase steel Bake hardening martensitic transformation

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Petro Gram: An excel-based petrology program for modeling of magmatic processes

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Geoscience Frontiers 2021年第1期12卷 81-92页

作者： mesut Günd.z Kürsad Asan Graduate School of Natural Sciences Mugla SıtkıKoçman UniversityTR-48000MuglaTurkey Geological Engineering Department Konya Technical UniversityTR-42250KonyaTurkey

Petro Gram is an Excel?based magmatic petrology program that generates numerical and graphical *** Gram can model the magmatic processes such as melting,crystallization,assimilation and magma mixing based on the trace element and isotopic *** program can produce both inverse and forward geochemical models for melting processes(*** model for batch,fractional and dynamic melting,and inverse model for batch and dynamic melting).However,the program uses a forward modeling approach for magma differentiation processes such as crystallization(EC:Equilibruim Crystallization,FC:Fractional Crystallization,IFC:Imperfect Fractional Crystallization and In-situ Crystallization),assimilation(AFC:Assimilation Fractional Crystallization,Decoupled FC-A:Decoupled Fractional Crystallization and Assimillation,A-IFC:Assimilation and Imperfect Fractional Crystallization)and magma *** of the most important advantages of the program is that the melt composition obtained from any partial melting model can be used as a starting composition of the crystallization,assimilation and magma *** addition,Petro Gram is able to carry out the classification,tectonic setting,multi-element(spider)and isotope correlation diagrams,and basic calculations including mg^#,Eu/Eu^*,εSrandεndwidely used in magmatic petrology.

关键词： PetroGram magmatic petrology Geochemical modeling Partial melting Crystallization Assimilation magma mixing

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Secondary endoresection for previously treated choroidal melanomas with a non-responsive course and persistent exudative retinal detachment

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 276-283页

作者： Ahmet Kaan Günd.z Ibadulla mirzayev Department of Ophthalmology Ankara University Faculty of MedicineAnkara 06590Turkey Private Eye Clinic Ankara 06590Turkey Department of Ophthalmology Dünyagoz HospitalAnkara 06540Turkey

AIm:To evaluate the results and complications of secondary endoresection via pars plana vitrectomy for choroidal melanoma and review the previously reported endoresection studies on the treatment of choroidal ***:The medical records of 6 patients with choroidal melanoma who underwent secondary endoresection between march 2012 and march 2020 were retrospectively *** indications for secondary endoresection were progressive or recurrent tumor and severe exudative retinal detachment after previous treatment with plaque radiotherapy/Cyberknife radiosurgery/transpupillary thermotherapy(TTT).RESULTS:Before endoresection,2 eyes had Iodine-125 plaque radiotherapy and TTT,1 eye had Ruthenium-106 plaque radiotherapy and TTT,1 eye had Cyberknife radiosurgery and TTT,1 eye had Cyberknife radiosurgery,and 1 eye had TTT *** visual acuity ranged from 20/63 to 20/1600(Snellen) and from 0.5 to 1.9(mean:1.1) on the log mAR *** mean tumor base diameters were 9.5×8.7 mm and the mean tumor thickness was 5.4 *** secondary endoresection,transient vitreous hemorrhage developed in 2(33.3%) eyes and retinal detachment in 1(16.7%) *** examination revealed epithelioid cell melanoma in 4(66.7%) eyes and mixed cell melanoma in 1(16.7%).melanoma cell type was not specified in 1(16.7%) *** a mean follow-up of 49.6 mo(range:16-90 mo),mean visual acuity did not improve and 1 eye was enucleated due to tumor *** visual acuity ranged from 20/63 to 20/1600(Snellen) and from 0.5 to 1.9(mean:1.2) on the log mAR *** patients with choroidal melanoma developed metastasis and eventually ***:Secondary endoresection seems to be an effective treatment option for globe salvage in choroidal melanoma not responsive to conventional treatment and displaying persistent exudative retinal *** was no visual acuity increase among the treated eyes but globe salvage was possible in most cases in this study.

关键词： endoresection choroidal melanoma metastasis pars plana vitrectomy recurrence

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Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen zhou Cathy z.Yang Karthik Venkudusamy Yessenia montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

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Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem Yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative medicine and Stem Cell Research&manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUnd Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-mSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-mSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

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Demographic features and histopathological diagnosis in primary eyelid tumors: results over 19 years from a tertiary center in Ankara, Turkey

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1287-1293页

作者： mehtap Arslantürk Eren Ahmet Kaan Günd.z Department of Ophthalmology Ankara University Faculty of MedicineAnkara 06620Turkey

AIm:To evaluate the demographic features,location,and histopathologic results in primary eyelid ***:We retrospectively reviewed the records of patients with primary eyelid tumor diagnosed and treated between November 1997 and June 2016 on our ***:Nine hundred and eleven lesions from 874 patients were included in this *** hundred and fortysix(51.0%)of the patients were females and 428(49.0%)were *** mean age was 51.0y(range:3 mo-94 y).The lesions were located in the upper eyelid(418 cases,45.9%),lower eyelid(378 cases,41.5%),medial canthus(89 cases,9.8%),and lateral canthus(26 cases,2.8%).Four hundred and seventy(51.6%)lesions were located on the right side and 441(48.4%)on the *** the eyelid lesions,666(73.1%)were benign,230(25.2%)malignant,and 15(1.6%)*** the eyelid tumors were classified according to their tissue or cell of origin,527(57.8%)of the lesions were found to be epidermal,171(18.8%)adnexal,131(14.4%)inflammatory and infectious,and 65(7.1%)*** most common benign lesions were squamous cell papilloma(139 lesions,15.2%),intradermal nevus(97 lesions,10.6%),epidermoid inclusion cysts(78 lesions,8.6%),seborrheic keratosis(60 lesions,6.6%),and inflammatory masses(59 lesions,6.5%).Basal cell carcinoma was the most common malignant tumor(191 lesions,21.0%)followed by squamous cell carcinoma(16 lesions,1.8%),sebaceous carcinoma(14 lesions,1.5%),and malignant melanoma(5 lesions,0.5%).CONCLUSION:In this study,73.1%of eyelid lesions are benign and the remaining 26.9%are premalignant and *** cell carcinoma is the most common tumor among all histopathological diagnosis followed by squamous papilloma.

关键词： eyelid tumors histopathology basal cell carcinoma squamous papilloma

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A Review of Piezoelectric Phenomena as a Key Characteristic of Wood

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Journal of Renewable materials 2024年第12期12卷 1985-2016页

作者： zeynep EdaÖzan Gökhan Günd.z Deniz Aydemir Department of Forest Industrial Engineering Faculty of ForestryBartin74100Turkey Department of Industrial Engineering Faculty of Engineering and Natural SciencesHatay31200Turkey

Piezoelectric materials convert mechanical energy into electrical energy,acting as renewable energy *** smart materials,they respond to environmental changes by altering their *** pressure is applied,their structure separates positive and negative charge centers,producing opposite charges on crystal *** generates an electric field and a measurable ***,a natural material,also exhibits piezoelectric *** piezoelectric effect of wood was first discovered by Russian scientists in 1940–***,in 1955,Fukada analyzed both the direct and inverse piezoelectric effect of wood and scientifically proved that this natural material has piezoelectric *** then,much research has been done on the piezoelectric effect of *** conducted between the 1960s and 1990s contributed to a deeper understanding of the piezoelectric properties of *** the 2000s,various methods have been developed to enhance wood’s piezoelectric performance using modern research techniques and advanced *** studies improve the understanding of wood’s piezoelectric properties and their potential *** research presents a chronological review of scientific studies from the discovery of the piezoelectric effect of wood to the present *** addition,the piezoelectric and electric potential behavior obtained from planted trees and academic studies on the energy generation purposes of wooden structures are comprehensively ***’s potential as a natural piezoelectric material is significant,particularly for renewable energy sources and smart material *** its piezoelectric properties aims to enhance energy harvesting,sensor performance,and other advanced technological applications.

关键词： Piezoelectric effects wood cellulose crystals electrical potential renewable energy sources

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Conversion of Andean montane forest to exotic forest plantation modifies soil physicochemical properties in the buffer zone of Ecuador's Podocarpus National Park

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Forest Ecosystems 2022年第6期9卷 802-812页

作者： Vinicio Carrion-Paladines Angel Benítez roberto García-Ruíz Departamento de Ciencias Biologicas y Agropecuarias Universidad Tecnica Particular de LojaSan Cayetano Alto s/nC.P.1101608LojaEcuador Departamento de Biología Animal Biología Vegetal y EcologíaSeccion de EcologíaUniversidad de JaenCampus Las LagunillasEdificio Ciencias Experimentales y de la Salud(B3)23071JaenSpain

Background:Andean montane forests(AmF)are biodiversity hotspots that provide fundamental hydrological services as well as carbon storage and *** recent decades,southern Ecuador AmFs have been seriously threatened by increased logging and conversion to forest plantations with exotic *** this context,our main objective was to evaluate the effects of AmF conversion to forest plantations on soil physicochemical properties in the buffer zone(Bz)of the Podocarpus National Park(PNP),in southern *** this purpose,random samples were taken at a depth of 0-10 cm in four plots in each contrast zone and analyzed for bulk density,porosity,textural class,leaf litter depth,soil pH,as well as the contents of organic matter(SOm),soil organic carbon(SOC),total nitrogen,and available phosphorus and ***:The results indicate that the conversion of AmFs produces an increase in bulk density and a decrease in SOm,SOC,and total nitrogen contents,thus modifying soil properties,which could result in a decrease in water regulation capacity and produce an increased risk of soil *** accelerates degradation processes,as well as threatens shortages of the drinking water ***:This study can help decision-makers to implement soil management plans in the Bz of the PNP,based on the implementation of new regulations,where the conservation of AmF is *** addition,it is recommended to apply environmental restoration strategies in the anthropized areas of the AmF,as well as in the areas with exotic eucalyptus and pine plantations.

关键词： Andean montane forests Land use conversion Edaphic properties

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