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Connexin 43 hemichannels protect bone loss during estrogen deficiency

Bone Research 2019年第2期7卷 183-194页

作者： Liang Ma Rui Hua Yi Tian Hongyun Cheng roberto jose fajardo joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang Department of Orthopaedics Jinan Central Hospital Affiliated to Shandong UniversityJinanShandongChina Department of Biochemistry and Structural Biology UT Health San AntonioSan AntonioTX 78229USA Department of Orthopedics UT Health San AntonioSan AntonioTX 78229USA Department of Biomechanical Engineering University of Texas at San AntonioSan AntonioTX 78249USA

Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone *** 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and *** showed here that estrogen deficiency reduced Cx43 expression and HC *** determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were *** results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty ***,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 *** data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency.

关键词： hemichannels protect estrogen deficiency

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A Two-Player Coalition Cooperative Scheme for the Bodyguard Allocation Problem

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Journal of Computer Science & Technology 2018年第4期33卷 823-837页

作者： jose Alberto Fernandez-Zepedu Daniel Brubeck-Salcedo Daniel fajardo-Delgado Hector Zatarain-Aceves Department of Computer Science Center for Scientific Research and Higher Education of Ensenada Ensenada BC 22860 Mexico Department of Systems and Computation Instituto Technol6gico de Ciudad Guzmdn Guzmdn JAL 49100 Mexico

We address the bodyguard allocation problem （BAP）, an optimization problem that illustrates the conflict of interest between two classes of processes with contradictory preferences within a distributed system. While a class of processes prefers to minimize its distance to a particular process called the root, the other class prefers to maximize it; at the same time, all the processes seek to build a communication spanning tree with the maximum social welfare. The two state-of-the-art algorithms for this problem always guarantee the generation of a spanning tree that satisfies a condition of Nash equilibrium in the system; however, such a tree does not necessarily produce the maximum social welfare. In this paper, we propose a two-player coalition cooperative scheme for BAP, which allows some processes to perturb or break a Nash equilibrium to find another one with a better social welfare. By using this cooperative scheme, we propose a new algorithm called FFC-BAPs for BAP. We present both theoretical and empirical analyses which show that this algorithm produces better quality approximate solutions than former algorithms for BAP.

关键词： bodyguard allocation problem coalitional game graph algorithm Nash equilibrium

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Predictors of Performance of the Maritime Academy of Asia and the Pacific （MAAP） in the OIC Navigational Watch Licensure Examination

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Journal of Shipping and Ocean Engineering 2015年第2期5卷 88-101页

作者： jose Manabat Barlis Jr. josefin Datu fajardo III Math and Sciences Courses Maritime Academy of Asia and the Pacific Philippines

Abstract： The study aimed to assess the predictors of performance administered by the Philippine Regulation Commission （PRC） in the licensure examination of Maritime Academy of Asia and the Pacific （MAAP） for Academic Year 2007-2011. Specifically, this also aimed to answer the following questions： demographic profile of the maritime graduates, the college related factors, administrative related factors, the level of scholastic achievement of the graduates, and the performance of the graduates in the licensure examination. A total of one hundred seventy three （173） graduates of MAAP from Class 2007-2011 were utilized as the respondents for the study. The study found out that the results of pre board examination and scholastic achievement of the graduates had significant effect on the performance of the graduates in O.I.C Navigational Watch Licensure Examination. Other variables found out to have no significant effect on the result of the licensure examination of the graduates. Therefore, the null hypotheses that the demographic profile of the graduates, college related factors, and administrative related factors has no significant effect on scholastic the achievement of the students were accepted. However, the null hypothesis that scholastic achievement of the students has no significant effect on the performance in maritime licensure examination was rejected. The same way, the null hypothesis that the demographic profile of the graduates, college related factors and the administrative related factors has no significant effect on the performance in Officer in Charge--Navigational Watch licensure Examination were accepted.

关键词： Regimental Training Licensure Examination Maritime Academy of Asia and the Pacific Scholastic Achievement Philippine Regulation Commission (PRC) Administrative Related Factors College related factors

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Workplace Risk Prevention in Public Building Projects in Mexico

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Journal of Building Construction and Planning Research 2014年第4期2卷 217-226页

作者： Romel G. Solis-Carcano jose A. Gonzalez-fajardo Enrique de J. Ayora-Sosa College of Engineering Autonomous University of Yucatan Merida Mexico

The importance of risk prevention in the workplace during the construction of public infrastructure projects is particularly relevant due to the large number of workers involved as well as the frequency and severity of the accidents. The aim of this work was to conduct an exploratory study of workplace risk prevention in the construction of public work projects in Mexico. The methodology was based on a case study which included an exploration of the attitudes assumed by the civil servants working for the government agency, regarding workplace risk prevention, and the observation of construction processes in a sampling of projects. The results show that the regulations are not fully adhered to during the stages of project planning and contracting for the work. During project designing, the inclusion of criteria regarding workplace risk prevention is relegated, and during public tendering, the experience of the contractor in risk prevention and workplace safety plans are not taken into account. Consequently, as one might expect from the above, during the construction processes, it was possible to observe that only about half of the prevention requirements applicable in the workplace were actually complied with.

关键词： Prevention Workplace Risks Construction Public Works Supervision

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Transesterification Reaction of Waste Cooking Oil and Chicken Fat by Homogeneous Catalysis

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Journal of Chemistry and Chemical Engineering 2014年第7期8卷 736-743页

作者： Ignacio Contreras Andrade Jonathan Parra Santiago jose Ricardo Sodre joseph Sebastian Pathiyamattom Carlos Alberto Guerrero-fajardo Doctor Chemical Engineering Universidad Autonoma de Sinaloa Culiacan Rosales 80040 Mexico Chemical Engineering (C) Universidad Nacional de Colombia Bogota 11001 Colombia Doctor Mechanical Engineering Coordenador Programa de Pos-Graduaao em Engenharia Mecdnica Pontificia Universidade Catolica de Minas Gerais Belo Horizonte 30130 Brazil Center for Energy Research Universidad Nacional Autonoma de Mexico Temixco 62580 Mexico Chemical Engineering and Mechanical Universidad Nacional de Colombia Bogota 11001 Colombia

In the last years, biodiesel production has been on a steady increase due to it is renewable and biodegradable fuel. The process to obtain biodiesel can be carried out using different raw materials. It is conlmonly performed by transesterification reaction of vegetable oils with methanol and using a homogeneous or heterogeneous catalyst. This work seeks to compare the results produced in transesterification of wasted cooking oil and chicken fat by homogeneous catalysis with NaOH. Due to in each case triglyceride comes from different raw materials, operation conditions differ slightly, which is more evident in the values used for the temperature. For chicken fat was used temperature variations between 35 ℃ and 55 ℃, varying catalyst in percentages between 0.3% and 0.7% with a molar ratio 6：1 in all cases and a reaction time of I h. Likewise, the conditions used in the tmnsesterification process of waste cooking oil were temperature between 50 ℃ and 60 ℃ with a molar ratio 6/1 and 9/1 for alcohol and oil, and catalyst percentage between 0.5% and 0.7% by weight. The yields obtained were between 78% and 94%, or 83% and 95%, for chicken fat and wasted cooking oil, respectively.

关键词： Biodiesel transesterification homogeneous catalysis cooking oil chicken fat.

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Biodiesel Production by Enzymatic Catalysis Process Using Two Analytical Ways： Gas Chromatography and Total Glycerol Determination

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Journal of Chemistry and Chemical Engineering 2014年第7期8卷 717-726页

作者： Ignacio Contreras Andrade Jonathan Parra Santiago jose Ricardo Sodre joseph Sebastian Pathiyamattom Carlos Alberto Guerrero-fajardo Doctor Chemical Engineering Universidad Autonoma de Sinaloa Culiacan 80040 Mexico Chemical Engineering (C) Universidad Nacional de Colombia Bogota11001 Colombia Coordinator of the Postgraduate Program in Mechanical Engineering Pontifical Catholic University of Minas Gerais BeloHorizonte 30130 Brazil Center forEnergy Research Universidad Nacional Autonoma de Mexico Temixco 62580 Mexico Chemical Engineering and Mechanical Universidad Nacional de Colombia Bogota 11001 Colombia

Currently, biodiesel is presented as one of the best alternatives for gradually replacing the use of fossil fuels, but it has some factors that make it economically impractical if it does not have a government support. For this reason, research efforts focused on this area have been responsible for optimizing the process of biodiesel production by different catalytic routes to achieve greater efficiency at a lower cost. In this case, the biggest problem has been the high cost generated by an investigation, which in many occasions is the main factor to decide if an investigation could be carried out. Trying to reduce these costs, in the current study, we are using a technique of glycerol quantification by volumetric methods and comparing obtained results with the chromatographic method, which is conventionally used and comparatively much more expensive. Biodiesel employee was obtained by an enzymatic catalysis process varying one of three process variables：oil：alcohol molar ratio, temperature and proportion of catalyst. The numerical differences obtained between the two quantification methods generated relative errors lower than 10%, resulting in some occasions lower than 1%. By gas chromatography analysis the best yield was obtained at the same conditions of the volumetric method, a temperature of 45 ℃, an oil：alcohol ratio 1：4 and 8 wt.% of catalyst, but a yield of 95.5% and 97.1%, respectively. Due to the high precision of gas chromatography, this method is used to carry out a surface response analysis obtaining as ideal operating conditions a temperature of 43.5 ℃, 8.9 wt.%. of catalyst and an oil：alcohol ratio 1：4.

关键词： Biodiesel production glycerol determination gas chromatography enzymatic catalysis.

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Effect of music therapy on short-term psychological and physiological outcomes in mechanically ventilated patients:A randomized clinical pilot study

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Journal of Intensive Medicine 2024年第4期4卷 515-525页

作者： Mark Ettenberger Rosangela Casanova-Libreros josefina Chávez-Chávez jose Gabriel Cordoba-Silva William Betancourt-Zapata Rafael Maya Lizeth Alexa Fandino-Vergara Mario Valderrama Ingrid Silva-fajardo Sandra Milena Hernández-Zambrano SONO-Centro de Musicoterapia BogotáColombia Vice-Rectorate for Research Fundación Universitaria de Ciencias de la SaludBogotáColombia Department of Biomedical Engineering University of Los AndesBogotáColombia Department of Rehabilitation Sociedad de Cirugía de Bogotá Hospital de San JoséBogotáColombia Faculty of Nursing Fundación Universitaria de Ciencias de la SaludBogotáColombia

Background:Elevated anxiety levels are common in patients on mechanical ventilation(MV)and may challenge *** suggests music-based interventions may reduce anxiety during ***,studies inves-tigating specific music therapy techniques,addressing psychological and physiological well-being in patients on MV,are ***:This three-arm randomized clinical pilot study was conducted with MV patients admitted to the intensive care unit(ICU)of Hospital San Joséin Bogotá,Colombia between March 7,2022,and July 11,*** were divided into three groups:intervention group 1(IG1),music-assisted relaxation;intervention group 2(IG2),patient-preferred therapeutic music listening;and control group(CG),standard *** main outcome measure was the 6-item State-Anxiety *** outcomes were:pain(measured with a visual analog scale),resilience(measured with the Brief Resilience Scale),agitation/sedation(measured with the Richmond Agitation-Sedation Scale),vital signs(including heart rate,blood pressure,oxygen saturation,and respiratory rate),days of MV,extubation success,and days in the ***,three patients underwent electroencephalography during the ***:Data from 23 patients were analyzed in this *** age range of the patients was 24.0-84.0 years,with a median age of 66.0 years(interquartile range:57.0-74.0).Of the 23 patients,19 were female(82.6%).No statistically significant differences between the groups were observed for anxiety(P=0.330),pain(P=0.624),resilience(P=0.916),agitation/sedation(P=0.273),length of ICU stay(P=0.785),or vital signs.A statistically significant difference between the groups was found for days of MV(P=0.019).Electroencephalography mea-surements showed a trend toward delta and theta band power decrease for two patients and a power increase on both beta frequencies(slow and fast)in the frontal areas of the brain for one ***:In this pilot study,music therapy did not sig

关键词： Music therapy Mechanical ventilation Intensive care unit Anxiety Pain

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