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Optimising soft tissue in-growth in vivo in additive layer manufactured osseointegrated transcutaneous implants

Biomaterials Translational 2022年第4期3卷 243-249页

作者： Elena Giusto Gordon Blunn roberta ferro de godoy Chaozong Liu Catherine Pendegrass Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalStanmoreUK Barts and the London School of Medicine and Dentistry Queen Mary University LondonLondonUK School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouthUK Writtle University College WrittleUK

Osseointegrated transcutaneous implants could provide an alternative and improved means of attaching artificial limbs for amputees,however epithelial down growth,inflammation,and infections are common failure modalities associated with their *** overcome these problems,a tight seal associated with the epidermal and dermal adhesion to the implant is *** could be achieved with specific biomaterials(that mimic the surrounding tissue),or a tissue-specific design to enhance the proliferation and attachment of dermal fibroblasts and *** intraosseous transcutaneous amputation prosthesis is a new device with a pylon and a flange,which is specifically designed for optimising soft tissue *** the flange has been fabricated using traditional machining techniques,however,the advent of additive layer manufacturing(ALM)has enabled 3-dimensional porous flanges with specific pore sizes to be used to optimise soft tissue integration and reduce failure of osseointegrated transcutaneous *** study aimed to investigate the effect of ALM-manufactured porous flanges on soft tissue ingrowth and attachment in an in vivo ovine model that replicates an osseointegrated percutaneous *** 12 and 24 weeks,epithelial downgrowth,dermal attachment and revascularisation into ALM-manufactured flanges with three different pore sizes were compared with machined controls where the pores were made using conventional *** pore sizes of the ALM flanges were 700,1000 and 1250μ*** hypothesised that ALM porous flanges would reduce downgrowth,improve soft tissue integration and revascularisation compared with machined *** results supported our hypothesis with significantly greater soft tissue integration and revascularisation in ALM porous flanges compared with machined controls.

关键词： in-vivo model ITAP orthopaedic implants osseointegrated transcutaneous implants

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Surgical Preparation of a Permanent Carotid Transposition in Sheep

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Surgical Science 2011年第7期2卷 402-405页

作者： Liana V. Gouvêa Ernane P. F. Novais Ceci R. Leite Fábio H. B. Ximenes Ricardo M. Almeida R. B. Molás J. G. C. Palermo C. E. V. Silva Jose R. J. Borges Eduardo M. M. Lima roberta ferro godoy 不详

In large animal research, when frequent sampling of arterial blood is needed, the carotid artery transposition is the most used technique. The objective of this paper is to describe a new technique for carotid artery transposition in sheep and evaluate its effectiveness using the echo-Doppler ultrasound. The animals enrolled in this study had their carotid surgically elevated to the subcutaneous level, by suturing underneath muscles sternocephalic and brachiocephalic. None of the animals that underwent the procedure in this study had trans- or postoperative complications. Six months after the suture removal, all animals presented patent ca-rotids by echo-Doppler ultrasound. This is an easy and safe procedure for carrying out experiments that re-quire the collection of arterial blood.

关键词： Blood Gas Analysis Eco-Doppler Experimental Surgery

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IFN-γ upregulates membranous and soluble PD-L1 in mesothelioma cells: potential implications for the clinical response to PD-1/PD-L1 blockade

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Cellular & Molecular Immunology 2020年第4期17卷 410-411页

作者： Maria Pia Pistillo roberta Carosio Barbara Banelli Anna Morabito Luca Mastracci Paola ferro Serena Varesano roberta Venè Alessandro Poggi Silvio Roncella Tumor Epigenetics Unit IRCCS Ospedale Policlinico San Martino16132 GenoaItaly Department of Surgical Sciences and Integrated Diagnostics(DISC) University of Genoa16132 GenoaItaly Anatomic Pathology IRCCS Ospedale Policlinico San Martino16132 GenoaItaly Histopathology and Cytopathology Division Azienda Sanitaria Locale 519121 La SpeziaItaly Molecular Oncology and Angiogenesis Unit IRCCS Ospedale Policlinico San Martino16132 GenoaItaly AIL Associazione italiana contro le leucemielinfomi e mieloma19121 La SpeziaItaly

Programmed death-ligand-1(PD-L1)plays a crucial role in the suppression of the antitumor immune response upon interaction with programmed cell death protein-1(PD-1)on cytotoxic T ***-L1 is constitutively expressed on antigen-presenting cells or tumor ***,PD-L1 has been detected by immunohistochemistry in a variety of tumors,including malignant pleural mesothelioma(MPM),in which it has emerged as a predictive biomarker for PD-1/PD-L1 immune checkpoint blockers(ICBs).1,2 PD-L1 expression on tumor cells can be upregulated by several factors including the interferon gamma(IFN-γ)cytokine produced by tumor-infiltrating lymphocytes(TILs).3 In MPM cells,it has been reported that IFN-γupregulates PD-L1 mRNA expression due to the activation of the interferon regulatory factor 1(IRF1)transcription factor,4 but no data have been shown regarding cell surface PD-L1 that is functionally relevant for its contact with PD-1-positive cells.

关键词： interferon death pleural

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Evaluation of the Potential of Araucaria angustifolia Seeds as Source of Oligosaccharides, Resistant Starch and Growth of Probiotic Bacteria

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Food and Nutrition Sciences 2024年第10期15卷 921-940页

作者： Rossana Catie Bueno de godoy Celia Lúcia de Luces Fortes Ferreira Jaqueline Moura Nadolny Haíssa roberta Cardarelli Fernanda Pereira Santos Magali Leonel Embrapa Forestry Colombo Brazil Department of Food Technology Federal University of Viosa (UFV) Viosa Brazil School of Chemical Engineering The University of Queensland (UQ) Brisbane Australia Department of Food Technology Center for Technology and Regional Development Federal University of Paraiba Joo Pessoa Brazil Postgraduation Program in Food Science and Technology Department of Food Engineering Technology Center Federal University of Paraiba Joo Pessoa Brazil Tropical Roots and Starches Center Paulista State University (UNESP) Botucatu Brazil

“Pinhão”, the seed of Araucaria angustifolia, is an important food, being part of the eating habits of Indigenous communities. In this study, we evaluated the oligosaccharide content, resistant starch and the growth of probiotic bacteria. GF4 (1-fructofuranosylnystose) was the main fructo-oligosaccharides found, in higher contents compared to other food sources. Maltooligosaccharides (MOS) represented the main part of the oligosaccharides profile of Brazilian pine seeds. In descending order of importance was maltoheptaose (G7), maltohexose (G6) and maltotriose (G3). The starches from the variety Sanct josephi presented the highest amount of resistant starch that could stimulate probiotic strains, mainly B. breve and L. plantarum, and may have a prebiotic effect, potentially promoting health benefits. This study advances the understanding of the chemical composition of the main portion of the “pinhão” enhancing awareness of its potential as a healthy food source, contributing to different uses and indirectly with the species preservation.

关键词： Maltooligosaccharides Fructooligosaccharides Resistant Starch B. breve L. plantarum

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Heavy Metals in Soil and Salad in the Proximity of Historical ferroalloy Emission

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Journal of Environmental Protection 2012年第5期3卷 374-385页

作者： roberta Ferri Filippo Donna Donald R. Smith Stefano Guazzetti Annalisa Zacco Luigi Rizzo Elza Bontempi Neil J. Zimmerman Roberto G. Lucchini Department of Experimental and Applied Medicine University of Brescia Brescia Italy INSTM and Chemistry for Technologies Laboratory University of Brescia Brescia Italy Microbiology and Environmental Toxicology University of California Santa Cruz USA Public Health Service Reggio Emilia Italy School of Health Sciences Purdue University West Lafayette USA

Emissions of manganese (Mn), lead (Pb), iron (Fe), zinc (Zn), copper (Cu) from ferro-alloy operations has taken place in Valcamonica, a pre-Alp valley in the province of Brescia, Italy, for about a century until 2001. Metal concentrations were measured in the soil of local home gardens and in the cultivated vegetables. Soil analysis was carried out using a portable X-Ray Fluorescence (XRF) spectrometer in both surface soil and at 10 cm depth. A subset of soil samples (n = 23) additionally was analysed using the modified BCR sequential extraction method and ICP-OES for intercalibration with XRF (XRF Mn = 1.33 * total OES Mn – 71.8;R = 0.830, p Lactuca sativa and Chichorium spp.) were analyzed with a Total Reflection X-Ray Fluorescence (TXRF) technique. Vegetable and soil metal measurements were performed in 59 home gardens of Valcamonica, and compared with 23 gardens from the Garda Lake reference area. Results indicate significantly higher levels of soil Mn (median 986 ppm vs 416 ppm), Pb (median 46.1 ppm vs 30.2 ppm), Fe (median 19,800 ppm vs 13,100 ppm) in the Valcamonica compared to the reference area. Surface soil levels of all metals were significantly higher in surface soil compared to deeper soil, consistent with atmospheric deposition. Significantly higher levels of metals were shown also in lettuce from Valcamonica for Mn (median 53.6 ppm vs 30.2) and Fe (median 153 vs 118). Metals in Chichorium spp. did not differ between the two areas. Surface soil metal levels declined with increasing distance from the closest ferroalloy plant, consistent with plant emissions as the source of elevated soil metal levels. A correlation between Mn concentrations in soil and lettuce was also observed. These data show that historic ferroalloy plant activity, which ended nearly a decade before this study, has contributed to the persistence of increased Mn levels in locally grown vegetables. Further research is needed to assess whether this increase can lead to adverse effects i

关键词： Heavy Metals ferroalloy Plant Soil Vegetables XRF ICP-OES

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