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Treatment, residual chlorine and season as factors affecting variability of trihalomethanes in small drinking water systems

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Frontiers of Environmental Science & Engineering 2015年第1期9卷 171-179页

作者： roberta DYCK Genevieve COOL Manuel RODRIGUEZ Rehan SADIQ School of Engineering University of British Columbia Okanagan Kelowna V1V 1V7 Canada Ecole superieure d'amenagement du territoire Universite Laval Quebec G1V 0A6 Canada

Seasonal variability in source water can lead to challenges for drinking water providers related to operational optimization and process control in treatment facilities. The objective of this study is to investigate seasonal variability of water quality in municipal small water systems （〈 3000 residents） supplied by surface waters. Residual chlorine and trihalomethanes （THM） were measured over seven years （2003-2009）. Comparisons are made within each system over time, as well as between systems according to the type of their treatment technologies. THM concentrations are generally higher in the summer and autumn. The seasonal variability was generally more pronounced in systems using chlorination plus additional treatment. Chloroform, total THM （TTHM） and residual chlorine concentrations were generally lower in systems using chlorination plus additional treatment. Conversely, brominated THM concentrations were higher in systems using additional treatment. Residual chlorine was highest in the winter and lowest in the spring and summer. Seasonal variations were most pronounced for residual chlorine in systems with additional treatment. There was generally poor correlation between THM concentrations and concentrations of residual chlorine. Further study with these data will be beneficial in finding determinants and indicators for both quantity and variability of disinfection byproducts and other water quality parameters.

关键词： drinking water residual chlorine seasonal variability small municipal systems treatment technologies trihalomethanes

Dose escalation of adalimumab as a strategy to overcome anti-drug antibodies:A case report of infantile-onset inflammatory bowel disease

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World Journal of Gastroenterology 2023年第38期29卷 5428-5434页

作者： Silvana Ancona Sara Signa Chiara Longo Giuliana Cangemi roberta Carfora Enrico Drago Alessandro La Rosa Marco Crocco Andrea Chiaro Paolo Gandullia Serena Arrigo Dipartimento di Neuroscienze RiabilitazioneOftalmologiaGenetica e Scienze Materno-Infantili(DINOGMI)Universitàdegli Studi di GenovaGenova 16126Italy Pediatric Gastroenterology and Endoscopy Unit IRCCS Istituto Giannina GasliniGenova 16147Italy Chromatography and Mass Spectrometry Section Central Laboratory of AnalysisIRCCS Istituto Giannina GasliniGenova 16147Italy

BACKGROUND Treatment of infantile-onset inflammatory bowel disease(IO-IBD)is often challenging due to its aggressive disease course and failure of standard therapies with a need for *** loss of response is frequently caused by the production of anti-drug antibodies,a well-known problem in IBD patients on biologic *** present a case of IO-IBD treated with therapeutic drug monitoring(TDM)-guided high-dose anti-tumor necrosis factor therapy,in which dose escalation monitoring was used as a strategy to overcome anti-drug *** SUMMARY A 5-mo-old boy presented with a history of persistent hematochezia from the 10th d of life,as well as relapsing perianal abscess and growth ***,anemia,and elevated inflammatory markers were also *** assessment revealed skip lesions with deep colic ulcerations,inflammatory anal sub-stenosis,and deep fissures with persistent abscess.A diagnosis of IO-IBD Crohn-like was *** patient was initially treated with oral steroids and *** the perianal abscess healed,adalimumab(ADA)was administered with concomitant gradual tapering of *** and biochemical steroid-free remission was achieved with good trough *** 3 mo,antibodies to ADA(ATA)were found with undetectable trough levels;therefore,we optimized the therapy schedule,first administering 10 mg weekly and subsequently up to 20 mg weekly(2.8 mg/kg/dose).After 2 mo of high-dose treatment,ATA disappeared,with concomitant high trough levels and stable clinical and biochemical remission of the *** TDM-guided high-dose ADA treatment as a monotherapy overcame ATA *** strategy could be a good alternative to combination therapy,especially in very young patients.

关键词： Infantile-onset inflammatory bowel disease Adalimumab Loss of response Dose escalation Anti-drug antibodies Case report

Senior fitness test manual / roberta E. Rikli, C. Jessie Jones.

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Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis

2013年

作者： roberta E. Rikli C. Jessie Jones.

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World Journal of Gastroenterology 2023年第22期29卷 3440-3468页

作者： Henrique Inhauser Riceti Magalhães Felipe Alexandre Machado roberta Figueiroa Souza Marcos Antônio Ferreira Caetano Vanessa Ribeiro Figliuolo Robson Coutinho-Silva Patricia Castelucci Department of Surgery School of Veterinary Medicine and Animal SciencesUniversity of São PauloSão Paulo 05508-270Brazil Department of Anatomy University of São PauloSão Paulo 05508-000Brazil Biophysics Institute Carlos Chagas Filho Federal University of Rio de JaneiroRio de Janeiro 21941-902Brazil

BACKGROUND The literature indicates that the enteric nervous system is affected in inflammatory bowel diseases(IBDs)and that the P2X7 receptor triggers neuronal ***,the mechanism by which enteric neurons are lost in IBDs is *** To study the role of the caspase-3 and nuclear factor kappa B(NF-κB)pathways in myenteric neurons in a P2X7 receptor knockout(KO)mouse model of *** Forty male wild-type(WT)C57BL/6 and P2X7 receptor KO mice were euthanized 24 h or 4 d after colitis induction by 2,4,6-trinitrobenzene sulfonic acid(colitis group).Mice in the sham groups were injected with *** mice were divided into eight groups(n=5):The WT sham 24 h and 4 d groups,the WT colitis 24 h and 4 d groups,the KO sham 24 h and 4 d groups,and the KO colitis 24 h and 4 d *** disease activity index(DAI)was analyzed,the distal colon was collected for immunohistochemistry analyses,and immunofluorescence was performed to identify neurons immunoreactive(ir)for calretinin,P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,and total NF-κ*** analyzed the number of calretinin-ir and P2X7 receptor-ir neurons per ganglion,the neuronal profile area(μm^(2)),and corrected total cell fluorescence(CTCF).RESULTS Cells double labeled for calretinin and P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,or total NF-κB were observed in the WT colitis 24 h and 4 d *** number of calretinin-ir neurons per ganglion was decreased in the WT colitis 24 h and 4 d groups compared to the WT sham 24 h and 4 d groups,respectively(2.10±0.13 vs 3.33±0.17,P<0.001;2.92±0.12 vs 3.70±0.11,P<0.05),but was not significantly different between the KO *** calretinin-ir neuronal profile area was increased in the WT colitis 24 h group compared to the WT sham 24 h group(312.60±7.85 vs 278.41±6.65,P<0.05),and the nuclear profile area was decreased in the WT colitis 4 d group compared to the WT sham 4 d group(104.63±2.49 vs 117.41±1.14,P<0.01).The number of

关键词： Cell death Enteric nervous system Gastroenterology Inflammatory bowel diseases P2X7 receptor Purinergic signaling

Iatrogenic atrial septal defects after transseptal puncture for percutaneous left atrial appendage occlusion and their hemodynamic effects

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Journal of Geriatric Cardiology 2022年第9期19卷 675-684页

作者： Ioannis Drosos roberta De Rosa Philipp C.Seppelt Sebastian Cremer Silvia Mas-Peiro Katrin Hemmann Jana Oppermann Recha Blessing Mariuca Vasa-Nicotera Andreas M.Zeiher Zisis Dimitriadis Division of Cardiology Department of Medicine IIIUniversity Hospital FrankfurtGoethe University Frankfurt am MainFrankfurtGermany German Center for Cardiovascular Research(DZHK) BerlinGermany Cardiopulmonary Institute(CPI) FrankfurtGermany Center of Cardiology University Medical Center MainzMainzGermany Di-vision of Cardiology and Intensive Care Department of Internal MedicineSt.Ansgar HospitalHöxterGermany

Background Percutaneous left atrial appendage occlusion(LAAO)requires puncture of the interatrial *** immediate hemodynamic effects of iatrogenic atrial septal defects(iASD)after LAAO have not been examined so *** aimed at evaluat-ing these effects through invasive measurements of pressure and oxygen ***,we assessed the incidence of per-sistent iASD at three *** Forty-eight patients scheduled for percutaneous LAAO were prospectively included in the *** and oxygen saturation were measured(1)in the right atrium(RA)before transseptal puncture,(2)in the left atrium(LA)through the transseptal sheath after transseptal puncture,(3)in the LA after removal of introducer sheath,and(4)in the RA after removal of introducer *** echocardiography was performed at three months to detect *** Pressure in the RA increased significantly after removing the introducer sheath(P=0.034),whereas no difference was found in oxygen saturation in the RA(P=0.623).Pressure measurement in the LA showed no significant difference after re-moving the introducer sheath(P=0.718).Oxygen saturation in the LA also showed no significant difference(P=0.129).Follow-up transesophageal echocardiogram at 3 months revealed a persistent iASD in 4 patients(8.5%).CONCLUSIONS Our study suggests that iASD after percutaneous LAAO does not result in significant shunts directly after the procedure,although a significant increase of mean right atrial pressure can be *** iASDs after percutaneous LAAO seem to be relatively rare at three months.

关键词： atrial septal puncture

Post-endoscopic retrograde cholangio-pancreatography pancreatitis:Is time for a new preventive approach?

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World Journal of Gastroenterology 2012年第34期18卷 4635-4638页

作者： Stella Tammaro roberta Caruso Francesco Pallone Giovanni Monteleone Division of Gastroenterology Azienda Ospedaliera Universitaria84131 SalernoItaly Department of Systems Medicine Division of GastroenterologyUniversity of Rome Tor Vergata00133 RomeItaly

Acute pancreatitis is the most common serious complication of endoscopic retrograde cholangio-pancre-atography (ERCP) and its incidence may exceed 25% in some high-risk patient subsets. In some patients, pancreatitis may follow a severe course with pancreatic necrosis, multiorgan failure, permanent disability and even death. Hence, approaches which minimize both the incidence and severity of post-ERCP pancreatitis are worth pursuing. Pancreatic stents have been used with some success in the prevention of post-ERCP, while so far pharmacological trials have yielded disappointing results. A recent multicenter, randomized, placebo-controlled, double-blind trial has shown that rectally administered indomethacin is effective in reducing the incidence of post-ERCP pancreatitis, the occurrence of episodes of moderate-to-severe pancreatitis and the length of hospital stay in high-risk patients. These results together with the demonstration that rectal administration of indomethacin is not associated with en-hanced risk of bleeding strongly support the use of this drug in the prophylaxis of post-ERCP pancreatitis.

关键词：内视镜后退 cholangiopancreatography endoscopic 以后后退 cholangiopancreatography 胰腺炎 Non-steroidal 反煽动性的药消炎痛胰腺炎预防

Nonalcoholic fatty liver disease: is the IFNL4 rs368234815 variant protective from liver damage?

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 209-211页

作者： Enrico Galmozzi roberta D'Ambrosio "A. M. and A. Migliavacca" Center for Liver Disease Division of Gastroenterology and HepatologyFondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoUniversità degli Studi di MilanoMilanItaly

Nonalcoholic fatty liver disease (NAFLD) consists of a spectrum of disorders characterized predominantly by hepatic steatosis in the absence of significant alcohol consumption, potentially evolving to nonalcoholic ste... 详细信息

关键词： damage liver NAFLD

Visible-light-driven intramolecular xanthylation of remote unactivated C(sp^(3))-H bonds

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Green Synthesis and Catalysis 2023年第4期4卷 350-354页

作者： Hang Chen Yang Zhou Panpan Lei Haifeng Wang Qiongjiao Yan roberta Properzi Wei Wang Linhai Jing Fener Chen Pharmaceutical Research Institute Wuhan Institute of TechnologyWuhan 430205China Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province China West Normal UniversityNanchong 637009China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs Shanghai 200433China Max-Planck-Institut für Kohlenforschung Mülheim an der Ruhr 45470Germany

Visible light-mediated site-specific C(sp^(3))-H xanthylation of amides has been accomplished using *** N-centered radicals generated by light initiation of N-xanthylamide substrates undergo 1,5-hydrogen atom transfer to form benzylic or alkyl radical intermediates under metal-and catalyst-free *** method exhibits a broad substrate scope,high functional group tolerance,and high ***,this strategy provides straightforward access to a range of derivatives through the subsequent elaboration of the xanthate group.

关键词： C-H functionalization 1,5-Hydrogen atom transfer Photocatalytic Site-specific Xanthylation

Individual Responses to Creatine Supplementation on Muscular Power is Modulated by Gene Polymorphisms in Military Recruits

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Journal of Science in Sport and Exercise 2023年第1期5卷 70-76页

作者： Daniele Mattos Caleb Guedes MSantos Scott CForbes Darren GCandow Douglas Rosa roberta Giovanini Busnardo Marcos Dornelas Ribeiro Dailson Paulucio Cynthia Chester Marco Machado Skeletal Muscle Physiology Study Group Universidade Iguaçu Campus VR Luiz Carlos Ferreira Tirado148Cidade NovaItaperunaRJ CEP 28300-000Brazil Laboratory of Human Movement Studies University Fondation of ItaperunaItaperunaRJBrazil Brazilian Army Institute of Biology Rio de JaneiroRJBrazil Biometrics Laboratory School of Physical Education and SportsFederal University of Rio de JaneiroRio de JaneiroBrazil Department of Physical Education Studies Faculty of EducationBrandon UniversityBrandonMBCanada Faculty of Kinesiology and Health Studies University of ReginaReginaSKCanada Laboratório de Virologia Molecular Depto de GenéticaInstituto de BiologiaUFRJRio de JaneiroBrazil

Purpose The aim was to explore five established SNPs(rs1815739,rs1805086,rs2700352,rs28497577,and rs28357094)that are known to modulate skeletal muscle protein kinetics in response to creatine *** A randomized,placebo-controlled,repeated measures design was ***(n=152)were rand-omized divided into one of two groups:CREA(20 g/day creatine monohydrate)or PLAC:(dextrose)for 7 *** were assessed,and participants were classified *** and after supplementation,anthropometrics(height and body mass)and performance measures(vertical jump,countermovement vertical jump,squat jump,abdominal crunches,and maximum push-ups)were *** CREA gained more body mass than PLAC(CREA:Δ0.864±0.06 kg;PLAC:Δ0.154±0.07 kg,P<0.001).In the CREA group,the presence of an A allele for the MYLK1 polymorphism was related to changes in countermovement jump height(P=0.027;effect size[d]=0.41)and leg power(P=0.040,effect size[d]=0.18).The total number of abdominal crunches after supplementation was influenced by treatments and SPP1 gene(P=0.041).A higher number of abdominal crunches was associated with the G allele in the CREA group and the TT genotype in the PLAC group(effect size[d]=0.04).Conclusion Collectively,short-term creatine supplementation increased body mass but was unable to alter muscle ***,following creatine supplementation,participants expressing A alleles in the MYLK1 polymorphism had a greater increase in jump height and leg power and participants expressing G alleles in the SPP1 gene had greater improve-ments in abdominal crunch performance.

关键词： SNP Creatine monohydrate Muscular power MYLK1 gene SPP1 gene