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Neural Regeneration Research 2024年第9期19卷 1861-1862页

作者： robert.galinsky Laura Bennet Alistair J.Gunn The Ritchie Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Department of Obstetrics and Gynaecology Monash UniversityMelbourneVICAustralia Department of Physiology The University of AucklandAucklandNew Zealand

Mitigating preterm encephalopathy continues to be one of the greatest challenges in perinatal *** encephalopathy is associated with high mortality,serious morbidity,and significant socio-economic impacts on the individuals,their families,and public health sectors and welfare systems that last a *** cost of disability associated with preterm brain injury continues to *** of this injury,and disability,would significantly reduce this socioeconomic burden.

关键词： encephalopathy mortality hypoxic

Neuronal avalanches:Sandpiles of self-organized criticality or critical dynamics of brain waves?

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Frontiers of physics 2023年第4期18卷 337-348页

作者： Vitaly L.galinsky Lawrence R.Frank Center for Scientific Computation in Imaging University of California at San DiegoLa JollaCA 92037-0854USA Center for Functional MRI University of California at San DiegoLa JollaCA 92037-0677USA

Analytical expressions for scaling of brain wave spectra derived from the general nonlinear wave Hamiltonian form show excellent agreement with experimental“neuronal avalanche”*** theory of the weakly evanescent nonlinear brain wave dynamics[*** 2,023061(2020);*** Neurosci.32,2178(2020)]reveals the underlying collective processes hidden behind the phenomenological statistical description of the neuronal avalanches and connects together the whole range of brain activity states,from oscillatory wave-like modes,to neuronal avalanches,to incoherent spiking,showing that the neuronal avalanches are just the manifestation of the different nonlinear side of wave processes abundant in cortical *** a more broad way these results show that a system of wave modes interacting through all possible combinations of the third order nonlinear terms described by a general wave Hamiltonian necessarily produces anharmonic wave modes with temporal and spatial scaling properties that follow scale free power *** the best of our knowledge this has never been reported in the physical literature and may be applicable to many physical systems that involve wave processes and not just to neuronal avalanches.

关键词： nonlinear waves critical exponent Hamiltonian system neuronal avalanches critical dynamics

Glia and hemichannels: key mediators of perinatal encephalopathy

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Neural Regeneration Research 2018年第2期13卷 181-189页

作者： robert.galinsky Joanne O.Davidson Justin M.Dean Colin R.Green Laura Bennet Alistair J.Gunn Department of Physiology University of Auckland The Ritchie Centre Hudson Institute of Medical Research Department of Ophthalmology University of Auckland

Perinatal encephalopathy remains a major cause of disability, such as cerebral palsy. Therapeutic hypo- thermia is now well established to partially reduce risk of disability in late preterm/term infants. However, new and complementary therapeutic targets are needed to further improve outcomes. There is increasing evidence that glia play a key role in neural damage after hypoxia-ischemia and infection/inflammation. In this review, we discuss the role of astrocytic gap junction （connexin） hemichannels in the spread of neural injury after hypoxia-ischemia and/or infection/inflammation. Potential mechanisms of hemichannel medi- ated injury likely involve impaired intraceUular calcium handling, loss of blood-brain barrier integrity and release of adenosine triphosphate （ATP） resulting in over-activation of purinergic receptors. We propose the hypothesis that inflammation-induced opening of connexin hemichannels is a key regulating event that initiates a vicious cycle of excessive ATP release, which in turn propagates activation of purinergic receptors on microglia and astrocytes. This suggests that developing new neuroprotective strategies for preterm infants will benefit from a detailed understanding of glial and connexin hemichannel responses.

关键词： hypoxia-ischemia connexin hemichannels spreading injury connexin 43 astrocytes hypoxicischemic encephalopathy

Interleukin-1:an important target for perinatal neuroprotection?

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Neural Regeneration Research 2023年第1期18卷 47-50页

作者： Sharmony B.Kelly Elys Green Rod W.Hunt Claudia A.Nold-Petry Alistair J.Gunn Marcel F.Nold robert.galinsky The Ritchie Centre Hudson Institute of Medical ResearchMelbourneVictoriaAustralia Department of Obstetrics and Gynaecology Monash UniversityVictoriaAustralia Department of Pediatrics Monash UniversityVictoriaAustralia Monash Newborn Monash Children’s HospitalMelbourneAustralia Department of Physiology The University of AucklandAucklandNew Zealand

Perinatal inflammation is a significant risk factor for lifelong neurodevelopmental impairments such as cerebral *** clinical and preclinical evidence links the severity and pattern of perinatal inflammation to impaired maturation of white and grey matters and reduced brain *** pathways are involved in the pathogenesis of perinatal ***,studies of human and experimental perinatal encephalopathy have demonstrated a strong causative link between perinatal encephalopathy and excessive production of the pro-inflammatory effector cytokine *** this review,we summarize clinical and preclinical evidence that underpins interleukin-1 as a critical factor in initiating and perpatuating systemic and central nervous system inflammation and subsequent perinatal brain *** also highlight the important role of endogenous interleukin-1 receptor antagonist in mitigating interleukin-1-driven neuroinflammation and tissue damage,and summarize outcomes from clinical and mechanistic animal studies that establish the commercially available interleukin-1 receptor antagonist,anakinra,as a safe and effective therapeutic *** reflect on the evidence supporting clinical translation of interleukin-1 receptor antagonist for infants at the greatest risk of perinatal inflammation and impaired neurodevelopment,and suggest a path to advance interleukin-1 receptor antagonist along the translational path for perinatal neuroprotection.

关键词： brain inflammation interleukin-1 receptor antagonist interleukin-1 interleukin-1β neonatal encephalopathy neuroprotection preterm brain injury

Use of a device that applies external kneading-like force on the abdomen for treatment of constipation

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World Journal of Gastroenterology 2005年第13期11卷 1971-1975页

作者： Konstantinos Mimidis David galinsky Efraim Rimon Vassilios Papadopoulos Yehuda Zicherman Dimitrios Oreopoulos Democritus University of Thrace Faculty of Health Sciences Kaplan Medical Center ADM Ltd Toronto Western Hospital

AIM: To evaluate the efficacy of a recently developed device that applies kneading-like motion on the abdomen in improving constipation in elderly long-term care patients. METHODS: Thirty constipated elderly patients were randomly selected from two nursing homes. They were instructed to use the device once daily for 20 min. Rate of bowel movements, volume and consistency of stool and the use of laxantia were all recorded during a 3-wk baseline period and for 12-wk treatment period. Colonic transit time (CTT) was measured in 13 patients by radiopaque markers during the baseline and at the end of treatment. RESULTS: Bowel movement rate (BM/week) increased from 1.4±0.4 BM/wk during baseline to 3.9±0.8 BM/wk during treatment (P<5.0×10-7). Stool amount that was 'low' in 30 patients during baseline increased in 21 patients at the end of the study period (x2 = 19.048-P= 1.3×10-5). Stool consistency,that was 'hard' in 25 patients and 'soft' in 5 patients during baseline, ameliorated in 23 patients at the end of the study (only 2 patients referred 'hard' stool) (x2 = 21.043-P= 4.0×10-6). The mean baseline CTT measured was 92.3±32.3 h at baseline and decreased to 49.4±31.3 h during the study period (P = 0.000208). No side effects were observed during the study period. CONCLUSION: External mechanical vibration of the abdomen reduced CTT and helped to relieve severe constipation in elderly constipated patients.

关键词： Constipation Laxatives Colon transit time

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如何为自己发声（英文）

英语画刊(高中版) 2023年第36期 3-5页

作者： Adam galinsky

为自己发声并不是一件容易的事。社会心理学家亚当·加林斯基提出了如何得到你想要的东西,而又不让人觉得讨厌的方法。Speaking up is hard to do.I understood the true meaning of this phrase last year,when my wife and I became n...

为自己发声并不是一件容易的事。社会心理学家亚当·加林斯基提出了如何得到你想要的东西,而又不让人觉得讨厌的方法。Speaking up is hard to do.I understood the true meaning of this phrase last year,when my wife and I became new *** we took our child home from the hospital,we were unsure whether our baby was getting enough nutrients from *** wanted to call our pediatrician(儿科医生),but we also didn’t want to make a bad first impression or come across as crazy,neurotic *** we worried and waited.

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孩子必备的七种生存技能

作者： (美)艾伦·加林斯基(Ellen galinsky)

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痛苦少一些

经理人 2006年第12期 94-96页

作者： Harris Sondak Adam D.galinsky

分担责任的谈判很容易发生争执，谈判效率不高.

关键词：痛苦谈判效率责任

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怪诞关系学

作者： (美)亚当·加林斯基(Adam galinsky) (美)马利斯·施韦泽(Maurice Schweitzer)

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伦敦商学院竞标秘诀:拍卖中的策略

董事会 2007年第12期 97-97页

作者： Gillian Ku Adam galinsky Keith Murnighan 伦敦商学院西北大学克洛格管理学院

常识或许会阻止你在拍卖自己的好车或几乎全新的高级时装时，把起拍价定为1美元或者1便士。传统思想总是认为．要价高，售价才会高。但是这种思想未必正确。在诸如eBay等的网上拍卖中．你要是开价太高，甚至有反而受损的危险。伦敦商学... 详细信息

常识或许会阻止你在拍卖自己的好车或几乎全新的高级时装时，把起拍价定为1美元或者1便士。传统思想总是认为．要价高，售价才会高。但是这种思想未必正确。在诸如eBay等的网上拍卖中．你要是开价太高，甚至有反而受损的危险。伦敦商学院教授Gillian Ku和西北大学克洛格管理学院教授Adam galinsky和*** Murnighan最近的研究扭转了关于拍卖标价的传统思想。他们的研究表明．在网上拍卖中，从衬衫到地毯的一系列产品都表明．起价低比起价高更能促成最终的高售价。

关键词：网上拍卖伦敦商学院秘诀竞标传统思想高级时装 eBay 管理学院