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Incidence of anastomotic stricture after Ivor-Lewis oesophagectomy using a circular stapling device

World Journal of Gastrointestinal Surgery 2019年第11期11卷 407-413页

作者： robert Tyler Amit Nair Meagan Lau James Hodson Rizwan Mahmood jan Dmitrewski department of Upper Gastrointestinal Surgery University Hospitals Birmingham NHS Foundation TrustBirmingham B152THUnited Kingdom Institute of Translational Medicine University Hospitals Birmingham NHS Foundation TrustBirmingham B152THUnited Kingdom department of Gastroenterology Russells Hall HospitalDudley DY12HQUnited Kingdom

BACKGROUND Benign oesophageal strictures carry a significant level of morbidity,causing burdensome symptoms impacting on quality of ***-oesophagectomy anastomotic stricture rates as high as 41%have been reported in the *** can require endoscopic dilatation,often multiple times to relieve *** aim of the present study was to determine a single surgeons stricture rate in a series of 2-stage Ivor-Lewis procedures,and to identify any independent risk factors in their *** To determine a single surgeons stricture rate in a series of 2-stage Ivor-Lewis procedures,and to identify any independent risk factors in their *** We performed a retrospective analysis of a prospectively collected database of Ivor-Lewis oesophagectomy performed from 2004-2018 to determine the stricture *** database comprised a single-surgeon series of open,two-stage oesophagectomies with a circular stapled intra-thoracic *** location,histology,neoadjuvant chemotherapy,stapler size,T-stage and R-status were analysed to see if they could predict stricture *** was defined as dysphagia requiring endoscopic *** with anastomotic leaks were excluded on the basis they would develop an anastomotic *** One hundred and seventy patients were collected in the *** were excluded on the basis of anastomotic leak,perioperative death and early *** hundred and fifty-four patients(119 males,35 females)with a mean age of 64±10 years were eligible for analysis.A total of 15 patients developed strictures a median of 99 d(interquartile range:84-133)after surgery,giving a Kaplan-Meier estimated stricture rate of 10%at one *** of the factors considered were found to be significantly associated with *** In this study the stricture rate was 10%,with the majority occurring in the first 100 d after *** significant independent factors were found in the deve

关键词： Oesophageal cancer Anastomosis Stricture Stapled Circular

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defective recovery of QT dispersion following transcatheter aortic valve implantation： frequency, predictors and prognosis

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Journal of Geriatric Cardiology 2015年第5期12卷 482-488页

作者： Rutger-jan Nuis Gokhan Turgut robert M van der Boon Nicolas M van Mieghem Sjoerd T Nauta Patrick W Serruys Ron T van Domburg Giulio Zuchelli Luc Jordaens Peter P de Jaegere department of Cardiology Erasmus University Medical Center Rotterdam the Netherlands department of Electrophysiology Erasmus Thoraxcenter Rotterdam the Netherlands department of Biostatistics Erasmus Thoraxeenter Rotterdam the Netherlands Division of Cardiovascular Diseases Azienda Ospedaliero-Universitaria Pisana Pisa Italy

Background Corrected QT dispersion （cQTD） has been correlated with non-uniform ventricular repolarisation and increased mortality. In patients with aortic stenosis, cQTD has been shown improved after surgical valve replacement, but the effects of transcatheter aortic valve implantation （TAVI） are unknown. Therefore, we sought to explore the frequency, predictors and prognostic effects of defective cQTD recovery at 6 months after TAVI. Methods A total of 222 patients underwent TAVI with the Medtronic-CoreValve System between November 2005 and january 2012. Patients who were on class Ⅰ or Ⅲ antiarrhythmics or on chronic haemodialysis or who developed atrial fibrillation, a new bundle branch block or became pacemaker dependent after TAVI were excluded. As a result, pre-, post- and follow-up ECG （median： 6 months） analysis was available in 45 eligible patients. defective cQTD recovery was defined as any progression beyond the baseline cQTD at 6 months. Results In the 45 patients, the mean cQTD was 47 ± 23 ms at baseline, 45 ±17 ms immediately after TAVI and 40 ± 16 ms at 6 months （15% reduction, P = 0.049）. Compared to baseline, cQTD at 6 months was improved in 60% of the patients whereas defective cQTD recovery was present in 40%. cQTD increase immediately after TAVI was an independent predictor of defective cQTD recovery at 6 months （per 10 ms increase; OR： 1.89, 95% CI： 1.15-3.12）. By univariable analysis, defective cQTD recovery was associated with late mortality （HR： 1.52, 95% CI： 1.05-2.17）. Conclusions despite a gradual reduction ofcQTD after TAVI, 40% of the patients had defective recovery at 6 months which was associated with late mortality. More detailed ECG analysis after TAVI may help to avoid late death.

关键词： Aortic stenosis Conduction abnormalities Left bundle branch block Predictors QT dispersion Transcatheter aortic valve implantation

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Does training and experience influence the accuracy of computed tomography colonography interpretation?

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World Journal of Gastroenterology 2014年第6期20卷 1574-1581页

作者： Greg Rosenfeld Yi Tzu Nancy Fu Brendan Quiney Hong Qian Darin Krygier Jacquie Brown Patrick vos Pari Tiwari Jennifer Telford Brian Bressler robert Enns Division of Gastroenterology Department of Medicine University of British Columbia St. Paul’s Hospital department of Radiology University of British Columbia St. Paul’s Hospital CHEOS St. Paul’s Hospital Division of Gastroenterology Department of Medicine University of British Columbia Royal Columbian Hospital

AIM: To evaluate the effect of experience on the accuracy rate of computed tomography colonography (CTC) interpretation and patient preferences/satisfaction for CTC and colonoscopy.

关键词： Computed tomography colonography Colonoscopy Colorectal neoplasia Colorectal cancer screening

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Chinese Medical Journal 2008年第13期121卷 1245-1246页

作者： Jaing Tang-Her Hsia Shao-Hsuan Chiu Cheng-Hsun Hou Jia-Woei Wang Chao-jan Chow robert Divisions of Hematology/Oncology Chang Gung Children's Hospital Chang Gung University Taoyuan Taiwan 333 China Critical Care Medicine Chang Gung Children's Hospital Chang Gung University Taoyuan Taiwan 333 China Infectious Disease Chang Gung Children's Hospital Chang Gung University Taoyuan Taiwan 333 China Medical Genetics Chang Gung Children's Hospital Chang Gung University Taoyuan Taiwan 333 China department of Diagnostic Radiology Chang Gung Children's Hospital Chang Gung University Taoyuan Taiwan 333 China StemCyte Taiwan National Cord Blood Center Linko Taiwan China

Malignant infantile osteopetrosis （MIOP） is .characterized by a lack of osteoclastic function,with disturbed bone building and remodeling. Most children with this disease die within the first decade of life of secondary consequence of bone marrow failure. Hematopoietic stem cell transplantation （HSCT） is the only curative therapy for MIOP,

关键词： STEM-CELL TRANSPLANTATION AUTOSOMAL RECESSIVE OSTEOPETROSIS

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Sensors, empowerment, and accountability: a Digital Earth view from East Africa

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International Journal of Digital Earth 2011年第4期4卷 285-304页

作者： Yola Georgiadou Benson Bana robert Becht robert Hoppe Justinian Ikingura Menno-jan Kraak Kate Lance Rob Lemmens Juma Hemed Lungo Michael McCall Gianluca Miscione Jeroen Verplanke Faculty of Geo-information Science and Earth Observation(ITC) University TwenteEnschedeThe Netherlands department of Political Science and Public Administration University Dar es SalaamTanzania Faculty of Management and Governance University TwenteEnschedeThe Netherlands School of Informatics and Communication Technologies University Dar es SalaamTanzania

Several innovative‘participatory sensing’initiatives are under way in East *** can be seen as local manifestations of the global notion of Digital *** initiatives aim to amplify the voice of ordinary citizens,improve citizens’capacity to directly influence public service delivery and hold local government *** popularity of these innovations is,among other things,a local reaction to the partial failure of the millennium development goals(MDGs)to deliver accurate statistics on public services in *** citizens,with access to standard mobile phones,can‘sense’via text messages and report failures in the delivery of local government *** public disclosure of these reports on the web and other mass media may pressure local authorities to take remedial *** this paper,we outline the potential and research challenges of a‘participatory sensing’platform,which we call a‘human sensor web.’Digital Africa’s first priority could be to harness continent-wide and national data as well as local information resources,collected by citizens,in order to monitor,measure and forecast MDGs.

关键词： human sensors empowerment accountability Digital Africa geobrowser water resources

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Neutrophil engagement and septic challenge in acute experimental pancreatitis in rats

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World Journal of Gastroenterology 2005年第41期11卷 6459-6465页

作者： Stanisiaw Ha Marek Dobosz jan J Kaczor robert Rzepko Ewa Aleksandrowicz-Wrona Zdzislaw Wajda Zbigniew ledzi■ski Jacek Krajewski department of General Endocrine and Transplant Surgery Medical University of Gdask Poland department of General and Gastroenterological Surgery St. Vincent a' Paulo Hospital of Gdynia Poland department of Bioenergetics J. niadecki University School of Physical Education in Gdask Poland department of Pathomorphology Medical University of Gdask Poland department of Clinical Nutrition Medical University of Gdask Poland Ⅱ department of General Gastroenterological and Endocrinological Surgery Medical University of Gdask Poland

AIM： To investigate the influence of neutrophil adhesion molecule blockade with rnonoclonal antibody （MoAb CD11b） and E. coli lipopolysaccharide （LPS） administration on experimental acute pancreatitis （AP）. METHODS： AP was induced by four ip injections of cerulein （Cn） at 1-h intervals. MoAb CD 11b and LPS were administered at the beginning of the experiment. RESULTS： The neutrophil count and chemiluminescence were diminished at the beginning of AP. The oxidative stress parameters were found within the pancreatic gland. MoAb CD 11b used for AP resulted in a significant reduction of pancreatic infiltration and pancreatitis oxidative stress parameters. Serum interleukin-6 （IL-6） was not detected in AP animals, whereas high serum IL-6 concentration was noted only in animals receiving LPS. CONCLUSION： Neutrophils are involved in pancreatic damage in the early stage of AP. Neutrophil infiltration reduction protects the pancreatic gland from destruction during AP. LPS does not change the early course of Cn pancreatitis in rats.

关键词： Acute pancreatitis Polymorphonuclear cells Immunomodulation Septic shock

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糖尿病相关的足病的定义和标准(2023年更新版)

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感染、炎症、修复 2024年第1期25卷 80-85页

作者： Jaap J.van Netten Sicco A.Bus jan Apelqvist Pam Chen Vivienne Chuter robert Fitridge Frances Game robert J.Hinchliffe Peter A.Lazzarini Joseph Mills Matilde Monteiro-Soares Edgar J.G.Peters Katherine M.Raspovic Eric Senneville Dane K.Wukich Nicolaas C.Schaper on behalf of the International Working Group on the Diabetic Foot 张会峰(译) 许樟荣(审校) department of Rehabilitation Medicine Amsterdam UMCLocation University of AmsterdamAmsterdamthe Netherlands Amsterdam Movement Sciences Program RehabilitationAmsterdamthe Netherlands department of Endocrinology University Hospital of MalmöMalmöSweden Joondalup Health Campus Ramsay HealthcareSydneyAustralia Faculty of Health University of TasmaniaHobartAustralia School of Health Sciences Western Sydney UniversitySydneyAustralia Faculty of Health and Medical Sciences University of AdelaideAdelaideAustralia Vascular and Endovascular Service Royal Adelaide HospitalAdelaideAustralia department of Diabetes and Endocrinology University Hospitals of Derby and Burton NHS Foundation TrustDerbyUK department of Vascular Surgery University of BristolBristolUK School of Public Health and Social Work Queensland University of TechnologyBrisbaneAustralia Allied Health Research Collaborative The Prince Charles HospitalBrisbaneAustralia Michael E.deBakey department of Surgery Division of Vascular Surgery and Endovascular TherapyBaylor College of MedicineHoustonTexasUSA Portuguese Red Cross School of Health–Lisbon LisbonPortugal MEDCIDS–departamento de Medicina da Comunidade Informação e decisão em Saúde Faculty of Medicine of the University of PortoPortoPortugal RISE@CINTESIS Faculty of Medicine Oporto UniversityPortoPortugal department of Internal Medicine Amsterdam UMCVrije Universiteit AmsterdamSection of Infectious DiseasesAmsterdamthe Netherlands department of Orthopaedic Surgery University of Texas Southwestern Medical CenterDallasTexasUSA department of Infectious Diseases Gustave Dron Hospital Tourcoing Univ-lilleTourcoingFrance Div.Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtThe Netherlands 不详河南省人民医院内分泌科河南郑州450003 战略支援部队特色医学中心北京100101

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本... 详细信息

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本文介绍2023年IWGDF对这些定义和标准的更新,并建议在临床实践和研究中一致使用,以利于世界各地不同学科人员针对糖尿病相关的足病的专业性交流。

关键词：定义糖尿病糖尿病相关的足病国际糖尿病足工作组

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Material-specific high-resolution table-top extreme ultraviolet microscopy

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Light(Science & Applications) 2022年第5期11卷 991-1000页

作者： Wilhelm Eschen Lars Loetgering Vittoria Schuster robert Klas Alexander Kirsche Lutz Berthold Michael Steinert Thomas Pertsch Herbert Gross Michael Krause Jens Limpert jan Rothhardt Institute of Applied Physics Abbe Center of PhotonicsFriedrich-SchillerUniversität JenaAlbert-Einstein-Str.1507745 JenaGermany HelmholtzInstitute Jena Fröbelstieg 307743 JenaGermany Leibniz Institute of Photonic Technology Albert-Einstein-Straße 907745 JenaGermany Fraunhofer Institute for Microstructure of Materials and Systems IMWS WalterHülse-Str.106120 HalleGermany Fraunhofer Institute for Applied Optics and Precision Engineering IOF Albert-Einstein-Str.707745 JenaGermany

Microscopy with extreme ultraviolet(EUV)radiation holds promise for high-resolution imaging with excellent material contrast,due to the short wavelength and numerous element-specific absorption edges available in this spectral *** the same time,EUV radiation has significantly larger penetration depths than *** thus enables a nano-scale view into complex three-dimensional structures that are important for material science,semiconductor metrology,and next-generation ***,we present high-resolution and material-specific microscopy at 13.5 nm *** combine a highly stable,high photon-flux,table-top EUV source with an interferometrically stabilized ptychography *** utilizing structured EUV illumination,we overcome the limitations of conventional EUV focusing optics and demonstrate high-resolution microscopy at a half-pitch lateral resolution of 16 ***,we propose mixed-state orthogonal probe relaxation ptychography,enabling robust phase-contrast imaging over wide fields of view and long acquisition *** this way,the complex transmission of an integrated circuit is precisely reconstructed,allowing for the classification of the material composition of mesoscopic semiconductor systems.

关键词： resolution ultraviolet extreme

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Does higher ploidy level increase the risk of invasion?A case study with two geo-cytotypes of Solidago gigantea Aiton(Asteraceae)

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Journal of Plant Ecology 2018年第2期11卷 317-327页

作者： David U.Nagy Szilvia Stranczinger Aliz Godi Anett Weisz Christoph Rosche jan Suda Mark Mariano robert W.Pal department of Ecology Institute of BiologyFaculty of SciencesUniversity of PécsH-7624 PécsIfjúság u.6Hungary department of Botany Institute of BiologyFaculty of SciencesUniversity of PécsH-7624 PécsIfjúság u.6Hungary Working Group:Plant Ecology Institute of Biology/Geobotany and Botanical GardenMartin Luther University Halle-WittenbergAm Kirchtor 1D-06108 HalleGermany department of Botany Faculty of ScienceCharles University in PragueBenátská2CZ-12801 PragueCzech Republic and Institute of BotanyThe Czech Academy of SciencesZámek 1CZ-25243 PruhoniceCzech Republic department of Biological Sciences Montana TechMontana Tech of the University of Montana1300 W Park StMT 59701 ButteUSA

Aims Understanding the role of genetics in biological invasions has become an important aspect for modern plant *** studies suggest that increased ploidy level benefits the success of an invasive species,but the basis for this phenomenon is not fully *** its native,North American range,Solidago gigantea has three geo-cytotypes comprising di-,tetra-and hexa-ploid populations,while in Europe,where it is highly invasive,*** stands are composed primarily of tetraploid *** study investigates whether North American hexaploids can induce a greater risk of invasion,due to their higher perfor-mance in a non-native range,as compared to the existing tetra-ploids of that *** We performed greenhouse and common garden experiments along with microsatellite analyses to test whether differences in chromo-some number and origin of the species mean superior fitness in the introduced *** Findings Genetic diversity was significantly higher in the native hexaploid popula-tions(A_(R)=6.04;H_(e)=0.7794),rather than the non-native tetraploid pop-ulations(A_(R)=4.83;H_(e)=0.6869).Furthermore,differentiation between geo-cytotypes was moderate(ρST=0.1838),which was also confirmed by their clear segregation in principal component analysis and structure analyses,proving their different genetic *** contrast to genetic diversity,the non-native tetraploid geo-cytotype performed better in the common garden experiment,implying that higher genetic diversity does not always mean better *** results suggest that native hexa-ploids do not present a greater risk,as assessed by their performance in the introduced range,when compared to the non-native tetraploids,as was suggested by previous ***,their introduction is still undesirable due to their different genetic structure,which,through hybridization,could give a new drive to the invasion of ***.

关键词： EiCA plant invasion microsatellite ecotype polyploidy

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Interaction of immunosuppressants with HCV antivirals daclatasvir and asunaprevir: combined effects with mycophenolic acid

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World Journal of Transplantation 2018年第5期8卷 156-166页

作者： Petra E de Ruiter Yashna Gadjradj robert J de Knegt Herold J Metselaar jan NM Ijzermans Luc JW van der Laan department of Surgery Erasmus MC-University Medical Center department of Gastroenterology and Hepatology Erasmus MC-University Medical Center

AIM To investigate the specific effects of immunosuppressants on the antiviral action of daclatasvir and *** The antiviral activity of daclatasvir(DCV) and asunaprevir(ASV) combined with immunosuppressants was tested using two in vitro models for hepatitis C virus(HCV) *** Tacrolimus, rapamycin and cyclosporine did not negatively affect the antiviral action of DCV or ASV. Mycophenolic acid(MPA) showed additive antiviral effects combined with these direct acting antivirals(DAAs). MPA induces interferon-stimulated genes(ISGs) and is a potent GTP synthesis inhibitor. DCV or ASV did not induce ISGs expression nor affected ISG induction by MPA. Rather, the combined antiviral effect of MPA with DCV and ASV was partly mediated via inhibition of GTP *** Immunosuppressants do not negatively affect the antiviral activity of DAAs. MPA has additive effect on the antiviral action of DCV and ASV. This combined benefit needs to be confirmed in prospective clinical trials.

关键词： Immunosuppressant Hepatitis C Daclatasvir Asunaprevir Liver Transplantation

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