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The role of soluble sugars during drought in tropical tree seedlings with contrasting tolerances

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Journal of Plant Ecology 2020年第4期13卷 389-397页

作者： Michael J.O’Brien Annabelle Valtat samuel Abiven Mirjam s.studer robert Ong Bernhard schmid Área de Biodiversidad y Conservación Universidad Rey Juan Carlosc/Tulipán s/n.E-28933 MóstolesMadridSpain southeast Asia Rainforest Research Partnership The Peak VistaLorang Punjak 1Tanjung LipatKota KinabaluSabah 88400Malaysia department of Evolutionary Biology and Environmental studies University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland department of Geography University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland Laboratoire de Géologie UMR 8538Ecole Normale SupérieurePSL Research UniversityCNRSParisFrance Centre de recherche enécologie expérimentale et prédictive(CEREEP-Ecotron IledeFrance) Département de biologieEcole normale supérieureCNRSPSL University77140St-Pierre-les-NemoursFrance Forest Research Centre Sepilok90715 SandakanSabahMalaysia

Aims.non-structural carbohydrates.nsCs)are plant storage compounds used for metabolism,transport,osmoregulation and regrowth following the loss of plant *** in conditions suitable for optimal growth,plants continue to store *** storage may be due to passive accumulation from s.nk-inhibited growth or active reserves that come at the expense of *** former pathway implies that nsCs may be a by-product of s.nk limitation,while the latter suggests a functional role of nsCs for use during poor *** Us.ng 13C pulse labelling,we traced the source of soluble sugars in stem and root organs during drought and everwet conditions for seedlings of two tropical tree species that differ in drought tolerance to estimate the relative allocation of nsCs stored prior to drought versus.nsCs assimilated during *** monitored growth,stomatal conductance,stem water potential and nsC storage to assess a broad carbon response to *** Findings We found that the drought-s.nsitive species had reduced growth,conserved nsC concentrations in leaf,stem and root organs and had a larger proportion of soluble sugars in stem and root organs that originated from pre-drought storage relative to seedlings in control *** contrast,the drought-tolerant species maintained growth and stem and root nsC concentrations but had reduced leaf nsCs concentrations with a larger proportion of stem and root soluble sugars originated from freshly assimilated photos.nthates relative to control *** results suggest the drought-s.nsitive species passively accumulated nsCs during water deficit due to growth inhibition,while the drought-tolerant species actively responded to water deficit by allocating nsCs to stem and root *** strategies seem correlated with baseline maximum growth rates,which supports previous research suggesting a trade-off between growth and drought tolerance while providing new evidence for the importance of plasticity in

关键词： ^(13)C labelling carbohydrate storage drought tolerance hydraulic function shorea parvifolia shorea beccariana source–s.nk allocation

Understanding celiac disease monitoring patterns and outcomes after diagnosis:A multinational,retrospective chart review study

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World Journal of Gastroenterology 2021年第20期27卷 2603-2614页

作者： Knut EA Lundin Ciaran P Kelly david s s.nders Kristina Chen sheena Kayaniyil sisi Wang Rajvi J Wani Caitlin Barrett shakira Yoosuf Ellen s Petters.n robert sambrook daniel A Leffler K.G.Jebs.n Coeliac disease Research Centre University of OsloOslo 0450Norway department of Gastroenterology Oslo University Hospital RikshospitaletOslo 0372Norway Celiac Center Beth Israel deaconess Medical Center Celiac Research Program Harvard Medical SchoolBostonMA 02115United States Royal Hallamshire Hospital University of SheffieldSheffield S102TNUnited Kingdom Takeda Pharmaceuticals International Co. CambridgeMA 02139United States Real World Evidence strategy and Analytics ICON plc.TorontoON L7N 3G2Canada Real World Evidence strategy and Analytics ICON plc.VancouverBC V6B 1P1Canada

BACKGROUnd Long-term outcomes and monitoring patterns in real-world practice are largely unknown among patients with celiac *** To understand patterns of follow-up and management of patients with celiac disease,and to characterize symptoms and villous atrophy after *** A retrospective chart review study was performed us.ng medical chart data of patients diagnosed with celiac *** gastroenterology referral centers,with substantial expertise in celiac disease,participated in the United Kingdom,United states,and *** and clinical data were collected from medical *** analyses were conducted on patients with biopsyconfirmed celiac disease,diagnosed between 2008 and 2012,with at least one follow-up visit before december 31,*** demographic and clinical characteristics,biopsy/serology tests and results,symptoms,and comorbidities were captured at diagnosis and for each clinic visit occurring within the study period(i.e.,before the study end date of december 31,2017).REsULTs A total of 300 patients were included in this study[72%female;mean age at diagnosis:38.9 years,standard deviation(sd)17.2].Patients were followed-up for a mean of 29.9 mo(sd 22.1)and there were,on average,three follow-up visits per patient during the study *** two-thirds(68.4%)of patients were recorded as having ongoing gastrointestinal symptoms and 11.0%had ongoing symptoms and enteropathy during *** 80%of patients were referred to a dietician at least once during the follow-up ***(50.0%)of the patients underwent at least one follow-up duodenal biopsy and 36.6%had continued villous *** of monitoring varied between *** were conducted more frequently in norway and patients in the United states had a longer follow-up *** This real-world study demonstrates variable follow-up of patients with celiac disease despite most patients continuing to have abnormal histology

关键词： Celiac disease Outcomes research Endoscopy Real-world General practice Villous atrophy

Environment Pollution and Human Health

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中国药理学与毒理学杂志 2006年第3期 174-177页

作者： Jia Gao Huan-Jun Tian Wei-qun shu Eun-Jung Park Kwangsik Park Paul Kwan-s.ng Lam T Prapamontol U Mevatee C Puaninta A Mangklabrucks.n Udomvong T Kaewthummanukul s sriboonruang s.nimsakul C Kingkeow Werawan Ruangyuttikarn

s5-1 Effects of persistent organic pollutants(POPs) in water on Chongqing population health CAO Jia, TIAn Huan-Jun, sHU Wei-qun(Preventive Medicine College, the Third Military Medical University, Chongqing 400038, China)Abstract:Many organic pollutants occur in drinking water in considerable amounts, and mimic or interfere with reproductive development and function. Furthermore, it is.not known whether multiple organic pollutants (MOP) from drinking water induce uterotrophic effects. In this study, we compared the effects of MOP on uterine wet weight by different exposure approaches (ip, sc, po) on prepubertal 21-d-old Wistar rats and Kunming mice. The multiple organic pollutants in drinking water were concentrated by solid-phase extraction (sPE), and dissolved in dMsO.

关键词： PM Environment Pollution and Human Health

neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on Pd-L1 expression in resectable nsCLC(CTOnG1804):a multicenter open-label phase II study

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signal Transduction and Targeted Therapy 2024年第1期9卷 249-258页

作者： si-Yang Liu s.ng dong Xue-ning Yang Ri-Qiang Liao Ben-Yuan Jiang qun Wang Xiao-s.ng Ben Gui-Bin Qiao Jun-Tao Lin Hong-Hong Yan Li-Xu Yan Qiang nie Hai-Yan Tu Bin-Chao Wang Jin-Ji Yang Qing Zhou Hong-Rui Li Ke Liu Wendy Wu si-Yang Maggie Liu Wen-Zhao Zhong Yi-Long Wu Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina department of Thoracic surgery Zhongshan HospitalFudan UniversityShanghaiChina department of Thoracic surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina department of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Fujian Key Laboratory of Advanced Technology for Cancer screening and Early diagnosis FuzhouChina Berry Oncology Corporation FuzhouChina Chinese Thoracic Oncology Group(CTOnG) GuangzhouChina department of Hematology The First Affiliated HospitalJinan UniversityGuangzhouChina

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive(n)and nivolumab–chemotherapy(n/C)combinations based on Pd-L1 *** patients exhibited resectable clinical stage IIA–IIIB(AJCC 8th edition)nsCLC without EGFR/ALK *** received either mono-nivolumab(n)or nivolumab+nabpaclitaxel+carboplatin(n/C)for three cycles based on Pd-L1 *** primary endpoint was the major pathological response(MPR).Key secondary endpoints included the pathologic complete response(pCR),objective response rate(ORR),and event-free survival(EFs).Baseline Pd-L1 expression and perioperative circulating tumor dnA(ctdnA)status were correlated with pCR and ***-two patients were enrolled,with 46 undergoing *** MPR was 50.0%(26/52),with 25.0%(13/52)achieving pCR,and 16.7%and 66.7%for patients with Pd-L1≥50%in n and n/C groups,***(25.0%)patients experienced grade 3 or higher immune-related adverse events during neoadjuvant *** with post-neoadjuvant ctdnA negativity was more likely to have pCR(39.1%)compared with those remained positive(6.7%,odds ratio=6.14,95%CI 0.84-Inf,p=0.077).With a median follow-up of 25.1 months,the 18-month EFs rate was 64.8%(95%CI 51.9–81.0%).For patients with ctdnA–***+,the 18m-EFs rate was 93.8%vs 47.3%(HR,0.15;95%CI 0.04,0.94;p=0.005).Immunochemotherapy may serve as an optimal neoadjuvant treatment even for patients with Pd-L1 expression≥50%.ctdnA negativity following neoadjuvant treatment and surgery could help identify superior pathological and survival benefits,which requires further confirmation in a prospective clinical trial(nCT04015778).

关键词： chemotherapy nsCLC treatment

Intermediately Complex Models for the Hydrological Interactions in the Atmosphere-Vegetation-soil system

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Advances in Atmospheric sciences 2006年第1期23卷 127-140页

作者：曾晓东王爱慧曾庆存 robert E. dICKIns.n Xubin ZEnG samuel s. P. sHEn The University of Arizona Tucson AZ USA University of Alberta Edmonton AB Canada Institute of Biophysics Chinese Academy of Sciences Beijing Institute of Atmospheric Physics Chinese Academy of Sciences Beijing Georgia Institute of Technology Atlanta GA USA

This paper investigates the hydrological interactions in the atmosphere-evegetation-soil system by us.ng the bucket model and several new simplified intermediately complex models. The results of mathematical analysis and numerical simulations show that these models, despite their simplicity, can very clearly reveal the ess.ntial features of the rather complex hydrological system of atmosphere-ecosystem-soil. For given atmospheric variables, these models clearly demonstrate multiple timescales, the ＂red shift＂ of response spectra, multi-equilibria and limit cycles, bifurcation, abrupt change, self-organization, recovery, ＂desertification＂, and chaos. Most of these agree with observations. Especially, the weakening of ＂shading effect＂ of living canopy and the wilted biomass might be a major mechanism leading to the desertification in a relatively short period due to overgrazing, and the desertification in a relatively long period or in climate of change might be due to both Charney＇s mechanism and the shading effect. These ideas could be validated with further numerical simulations. In the paper, some methods for improving the estimation of timescales in the soil water evolution responding to the forcing are also proposed.

关键词： Atmosphere-vegetation-soil system hydrological process multi-equilibria chaos desertification shading effect

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古北界在中国及其邻近国家的南部界线(英文)

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动物学报 2001年第2期47卷 121-131,T001页

作者： robert s.Hoffmann 国家自然历史博物馆

论述了一种客观地划分生物地理区域界线的方法。根据物种分布范围和系统发生或生态渊源关系等概念 ,在过去所提出的分界线附近选择一些地点 ,确定在这些地区中是否有某个物种分布 ,从而确定这些物种可能所隶属的生物地理区。依此方法 ,... 详细信息

论述了一种客观地划分生物地理区域界线的方法。根据物种分布范围和系统发生或生态渊源关系等概念 ,在过去所提出的分界线附近选择一些地点 ,确定在这些地区中是否有某个物种分布 ,从而确定这些物种可能所隶属的生物地理区。依此方法 ,作者在 4 6°n ,12 8°E和 2 4°n ,76°E之间选择了 12个地点 ,通过兽类的区系成份分析 ,并结合植被特征 ,探讨了中国及其邻近国家的古北界南界。结果表明 ,古北界和东洋界兽类区系成份在各地区的分布 (百分率 )分别如下 :东北部的吉林省 (10 0、0 )、东部的山东省 (90、10 )、江苏和安徽省 (59、4 1)、浙江 (54、4 6 ,沿海分别为 4 4、56 )、南部的海南岛 (19、81)、四川邛崃山 (87、13)、四川大雪山 (79、2 1)、云南云岭 (90、10 )、缅甸东北部 (52、4 8)、泰国 (7、93)、尼泊尔、锡金和不丹以及中国的喜马拉雅山南麓(4 5、55)和巴基斯坦 (6 3、37)。作者认为古北界和东洋界之间存在过渡区 ,过渡区东段在中国东部地区的中心约在 30°n ,南缘约在 2 8°n ,北缘约在 33°n ;中段山地的海拔高度在 150 0～ 2 50 0m之间 ,过渡区中心的海拔高度为 2 0 0 0m ;西段的印度河区作为东洋和古北两界的过渡区比作为东洋界向西的延伸更为合适。

关键词：古北界东洋界生物地理发展史渊源关系区域界线

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乙酰胆碱受体对急性呼吸窘迫综合征小鼠T细胞亚群和炎症因子的影响

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中华诊断学电子杂志 2024年第1期12卷 50-56页

作者：计超向群海口市人民医院重症医学科 570208 海口市人民医院感染科 570208

目的探讨乙酰胆碱受体对急性呼吸窘迫综合征(ARds)小鼠T细胞亚群Cd3^(+)、Cd25^(+)Foxp3^(+)T细胞、Cd11b和炎症因子IL-1β、TnF-α的影响。方法健康清洁级雄性balb/C小鼠50只(6周),完全数字随机分为正常组(n组)、生理盐水对照组(ns组)... 详细信息

目的探讨乙酰胆碱受体对急性呼吸窘迫综合征(ARds)小鼠T细胞亚群Cd3^(+)、Cd25^(+)Foxp3^(+)T细胞、Cd11b和炎症因子IL-1β、TnF-α的影响。方法健康清洁级雄性balb/C小鼠50只(6周),完全数字随机分为正常组(n组)、生理盐水对照组(ns组)、ARds组(A组)、ARds^(+)断离颈部两侧迷走神经组(d组)、ARds^(+)断离颈部两侧迷走神经给予乙酰胆碱受体激动剂组(A^(+)J组),每组各10只正常饲养。HE染色观察各组小鼠右肺结构,采用流式细胞仪检测小鼠支气管肺泡灌洗液中Cd11b、Cd3^(+)、Cd25^(+)Foxp3^(+)T细胞占T淋巴细胞的百分比。采用实时荧光定量聚合酶链反应(RT-qPCR)法检测左肺组织IL-1βmRnA和TnF-αmRnA的表达水平。结果n组和ns组小鼠右肺HE染色显示结构正常,而A组和d组小鼠肺间质有大量的炎性细胞浸润,肺泡壁增厚、肺泡结构破坏明显,肺泡腔融合。A^(+)J组小鼠肺泡结构较完整、有少许破损、肺泡腔存在。A组和d组小鼠支气管肺泡灌洗液Cd11b、Cd3^(+)、Cd25^(+)Foxp3^(+)T细胞百分比高于其他3组,A^(+)J组Cd11b(10.77±2.41)、Cd3^(+)(5.94±0.27)、Cd25^(+)Foxp3^(+)T(5.00±1.15)细胞百分比分别与d组(15.32±1.56,9.78±0.88,9.84±1.11)、A组(13.49±2.06,8.55±1.07,8.98±0.91)比较,均差异有统计学意义(t=3.04,2.61,2.87,3.87,2.54,2.53;均PnA(198.98±54.05)和TnF-αmRnA(52.41±12.26)的表达分别与A组(384.26±69.03,96.84±20.02)和d组(397.26±64.31,99.45±18.34)比较,均差异有统计学意义(t=94.42,99.54,91.32,98.57,PnA和TnF-αmRnA的表达以及Cd11b的释放,从而抑制ARds的炎症反应,减轻ARds病理变化。

关键词：急性呼吸窘迫综合征受体,胆碱能 T淋巴细胞亚群白细胞介素1β 肿瘤坏死因子α

Physical Characteristics Explain Ball-Carrying Capability in sub-Elite Rugby Union Players

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Journal of science in sport and Exercise 2023年第3期5卷 244-253页

作者： Alexander s.Hart robert M.Erskine Tom J.Mclaughlin david R.Clark school of sport and Exercise science Liverpool John Moores UniversityL33AF LiverpoolUK Ealing Trailfinders Rugby Club LondonUK Institute of sport Exercise and HealthUniversity College LondonLondonUK

Purpose The aims of the pres.nt study were two-fold:(i)to investigate the relationship between physical characteristics and the game statistics associated with ball-carrying capability amongst sub-elite rugby union players,and(ii)to predict the level of change in these physical characteristics required to improve the associated game statistic via regression *** Thirty-eight s.nior professional players(forwards.n=22;backs.n=16)were assessed for body mass(BM),back squat(Bs)s.ngle-repetition maximum(1RM)normalised to BM(1RM/BM),10 m sprint velocity(s10),10 m sprint momentum(sM10),and the game statistics from 22 games within the 2019/20 RFU Championship *** relationship between these measures and the predicted level of change in a physical measure required to improve the total number of the associated game statistic by one were assessed by Pears.n’s correlation coefficient and simple regression *** In forwards,an~11.5%reduction in BM,an~11.8%improvement in Bs 1RM/BM,or an~11.5%increase in s10 was required to improve the game statistics associated with ball-carrying *** backs,a~19.3%increase in BM or a~15.6%improvement in sM10 was *** These findings demonstrate that improvements in lower-body relative strength,acceleration performance,and position-specific alterations in body mass are required to maximise the ball-carrying capability and therefore match outcome of sub-elite rugby union players.

关键词： speed Acceleration Momentum strength Body mass

Experimental models to study cholangiocyte biology

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World Journal of Gastroenterology 2002年第1期8卷 1-4页

作者： Pamela s.Tietz robert C.Huebert Anatoliy Masyuk Tatyana Masyuk Patrick L.splinter nicholas F.LaRusso Center for Basic Research in digestive diseases Department of Internal Medicine and Biochemistry and Molecular BiologyMayo Medical SchoolClinic and FoundationRochesterMN 55905

Cholangiocytes-the epithelial cells which line the bileducts-are increas.ngly recognized as importanttransporting epithelia actively involved in the absorptionand secretion of water,ions,and *** is due in part to the recent development ofnew experimental *** biologic concepts haveemerged including the identification and topography ofreceptors and flux proteins on the apical and/orbasolateral membrane which are involved in the molecularmechanisms of ductal bile *** isolatedand/or perfused bile duct units from livers of rats andmice serve as.new,physiologically relevant in vitromodels to study cholangiocyte *** treedimensions and novel insights into anatomic remodeling ofproliferating bile ducts have emerged from three-dimensional reconstruction us.ng CT scanning andsophisticated ***,new pathologicconcepts have aris.n regarding the interaction ofcholangiocytes with pathogens such as *** concepts and associated methodologiesmay provide the framework to develop new therapies forthe cholangiopathies,a group of important hepatobiliarydiseases in which cholangiocytes are the target cell.

关键词： Animals Bile ducts Biological Transport Epithelial Cells Research support, non-U.s. Gov't Research support, U.s. Gov't, P.H.s.