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Incident frailty and cognitive impairment by heart failure status in older patients with atrial fibrillation: the sAGE-AF study

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Journal of Geriatric Cardiology 2020年第11期17卷 653-658页

作者： Wei-Jia WAnG darleen Lessard Jane saczynski robert J Goldberg Alan s.Go Tenes Paul Ely Gracia david d McManus department of Medicine University of Massachusetts Medical SchoolWorcesterMAUSA department of Population and Quantitative Health sciences University of Massachusetts Medical SchoolWorcesterMAUSA department of Pharmacy and Health system sciences Northeastern UniversityBostonMAUSA division of Research Kaiser Permanente Northern CaliforniaOaklandCAUSA

Background Atrial fibrillation(AF) and heart failure(HF) frequently co-occur in older individuals. Among patients with AF, HF increases risks for stroke and death, but the associations between HF and incident cognition and physical impairment remain unknown. We aimed to examine the cross-sectional and prospective associations between HF, cognition, and frailty among older patients with AF. Methods The sAGE-AF(systematic Assessment of Geriatric Elements in AF) study enrolled 1244 patients with AF(mean age 76 years, 48% women) from five practices in Massachusetts and Georgia. HF at baseline was identified from electronic health records us.ng ICd-9/10 codes. At baseline and 1-year, frailty was assessed by Cardiovascular Health survey score and cognition was assessed by the Montreal Cognitive Assessment. Results Patients with prevalent HF(n = 463, 37.2%) were older, less likely to be non-Hispanic white, had less education, and had greater cardiovascular comorbidity burden and higher CHA2 ds2 VAsC and HAs-BLEd scores than patients without HF(all P's n multivariable adjusted regression models, HF(pres.nt vs. abs.nt) was associated with both prevalent frailty(adjusted odds ratio [a OR]: 2.38, 95% confidence interval [CI]: 1.64-3.46) and incident frailty at 1 year(a OR: 2.48, 95% CI: 1.37-4.51). HF was also independently associated with baseline cognitive impairment(a OR: 1.60, 95% CI: 1.22-2.11), but not with developing cognitive impairment at 1 year(a OR 1.04, 95%CI: 0.64-1.70). Conclusions Among ambulatory older patients with AF, the co-existence of HF identifies individuals with physical and cognitive impairments who are at higher short-term risk for becoming frail. Preventive strategies to this vulnerable subgroup merit consideration.

关键词： Atrial fibrillation Cognitive impairment Heart failure Frailty

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Large ferro-pyro-phototronic effect in 0.5Ba(Zr_(0.2)Ti_(0.8))O_(3)-0.5(Ba_(0.7)Ca_(0.3))TiO_(3)thin films integrated on silicon for photodetection

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Carbon Energy 2023年第6期5卷 1-10页

作者： JoséP.B.silva Katarzyna Gwozdz Luís s.Marques Mario Pereira Maria J.M.Gomes Judith L.MacManus‐driscoll robert L.Z.Hoye Centre of Physics of Universities of Minho and Porto(CF‐UM‐UP) University of MinhoBragaPortugal Laboratory of Physics for Materials and Emergent Technologies LapMETUniversity of MinhoBragaPortugal department of Quantum Technologies Faculty of Fundamental Problems of TechnologyWroclaw University of Science and TechnologyWroclawPoland department of Materials science and Metallurgy CambridgeUK Inorganic Chemistry Laboratory Department of ChemistryUniversity of OxfordOxfordUK department of Materials Imperial College LondonLondonUK

Coupling together the ferroelectric,pyroelectric,and photovoltaic characteristics within a s.ngle material is a novel way to improve the performance of *** this work,we take advantage of the triple multifunctionality shown by 0.5Ba(Zr_(0.2)Ti_(0.8))O_(3)-0.5(Ba_(0.7)Ca_(0.3))TiO_(3)(BCZT),as demonstrated in an Al/si/siOx/BCZT/ITO thin-film *** si/siOx acts as an n-type layer to form a metal-ferroelectric-insulator-semiconductor heterostructure with the BCZT,and with Al and ITO as *** photo-response of the device,with excitation from a violet laser(405 nm wavelength),is carefully investigated,and it is shown that the photodetector performance is invariant with the chopper frequency owing to the pyro-phototronic effect,which corresponds to the coupling together of the pyroelectric and photovoltaic ***,the photodetector performance was significantly better than that of the devices operating based only on the pyro-phototronic effect by a factor of 4,due to the pres.nce of ferroelectricity in the ***,after a poling voltage of−15 V,for a laser power density of 230mW/cm^(2)and at a chopper frequency of 400Hz,optimized responsivity,detectivity,and s.nsitivity values of 13.1mA/W,1.7×10^(10)Jones,and 26.9,respectively,are ***,ultrafast rise and fall times of 2.4 and 1.5μs,respectively,are obtained,which are 35,000 and 36,000 times faster rise and fall responses,respectively,than previous reports of devices with the ferro-pyro-phototronic *** is understood based on the much faster ferroelectric switching in ferroelectric thin films owing to the predominant 180°domains in a s.ngle direction out of plane.

关键词： ferroelectric ferro-pyro-phototronic effect photodetector polarization-controlled response

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资本市场与实体部门的金融风险溢出及宏观政策调控效果

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中央财经大学学报 2024年第4期 3-17页

作者：单敬群王浩楠浙江财经大学金融学院广东金融学院金融与投资学院

党的二十大报告强调守住不发生系统性风险底线。为有效监测我国资本市场与实体部门的金融风险溢出,本文通过TVP-VAR模型测度了金融风险动态溢出指数和吸收指数,利用有向网络拓扑结构考察金融风险主要溢出路径和特殊时期演变规律,再基于T... 详细信息

党的二十大报告强调守住不发生系统性风险底线。为有效监测我国资本市场与实体部门的金融风险溢出,本文通过TVP-VAR模型测度了金融风险动态溢出指数和吸收指数,利用有向网络拓扑结构考察金融风险主要溢出路径和特殊时期演变规律,再基于TVP-FAVAR模型实证研究宏观政策的金融风险溢出调控效果。研究表明,(1)金融风险溢出效应在2015年后增强,各资本市场与实体部门的风险溢出效应呈非线性。(2)在金融系统内,“股票市场→房地产市场”和“政府部门→企业部门”是主要的风险溢出路径,且次贷危机时期风险溢出效应显著增强,尤其是股票市场,新冠病毒感染疫情时期的风险溢出路径更为复杂。(3)从宏观政策调控效果看,次贷危机期间,提高货币市场利率、降低货币增速和提高法定存款准备金率对风险溢出的调控效果更显著,而疫情期间,财政政策和外汇干预政策的调控效果更显著。上述结果为防范化解金融风险和制定宏观政策提供参考依据。

关键词：资本市场实体部门吸收效应溢出效应宏观政策

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An experimental approach for investigating many-body phenomena in Rydberg-interacting quantum systems

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Frontiers of physics 2014年第5期9卷 571-586页

作者： C. s. Hofmann G. Gunter H. schempp n. L. M. Miiller A. Faber H. Busche M. robert-de-saint-Vincent s. Whitlock M. Weidemuller Physikalisches Institut Universitiit Heidelberg Im Neuenheimer Feld 226 69120 Heidelberg Germany Center for Free-Electron Laser science DESY Notkestrasse 85 22607 Hamburg Germany department of Physics University of Basel Klingelbergstrasse 82 4056 Basel Switzerland Joint Quantum Centre (JQC) durham-newcastle Department of Physics Durham University Rochester Building South Road Durham DH1 3LE United Kingdom

Recent developments in the study of ultracold Rydberg gases demand an adwanced level of experimental sophistication, in which high atomic and optical densities must be combined with excellent control of external fields and s.nsitive Rydberg atom detection. We describe a tailored experimental system used to produce and study Rydberg-interacting atoms excited from dense ultracold atomic gases. The experiment has been optimized for fast duty cycles us.ng a high flux cold atom source and a three beam optical dipole trap. The latter enables tuning of the atomic density and temperature over several orders of magnitude, all the way to the Bose--Einstein condensation transition. An elec- trode structure surrounding the atoms allows for precise control over electric fields and s.ngle-particle s.nsitive field ionization detection of Rydberg atoms. We review two experiments which highlight the influence of strong Rydberg---Rydberg interactions on different many-body systems. First, the Rydberg blockade effect is used to pre-structure an atomic gas prior to its spontaneous evolution into an ultracold plasma. second, hybrid states of photons and atoms called dark-state polaritons are studied. By looking at the statistical distribution of Rydberg excited atoms we reveal correlations between dark-state polaritons. These experiments will ultimately provide a deeper understanding of many-body phenomena in strongly-interacting regimes, including the study of strongly-coupled plasmas and interfaces between atoms and light at the quantum level.

关键词： ultracold Rydberg gases ultracold plasmas Bose-Einstein condensation atom-light interactions many-body interactions

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Angle-to-angle and spur-to-spur distance analysis with high-resolution optical coherence tomography

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Eye and Vision 2020年第1期7卷 399-411页

作者： robert Montés-Micó Pedro Tañá-Rivero salvador Aguilar-Córcoles María Ruiz-s.ntos María dolores Rodríguez-Carrillo Ramón Ruiz-Mesa Oftalvist Alicante and Jerez de la FronteraAlicanteSpain University of Valencia ValenciaSpain

Background:To measure angle-to-angle(ATA)and spur-to-spur(sTs)distances along six meridians us.ng highresolution swept-source optical coherence tomography(ss-OCT)and to compare those values with horizontal white-to-white(WTW)***:68 eyes from 68 patients were quantitatively assessed with the Anterion ss-OCT(Heidelberg Engineering,Heidelberg,Germany).ATA and sTs distances were measured with the ss-OCT’s B-scan in six cross-sectional images corresponding to the vertical(6-12 o’clock),1-7 o’clock,2-8 o’clock,horizontal(3-9 o’clock),4-10 o’clock and 5-11 o’clock *** was measured horizontally with the device’s infrared camera.A Pears.n correlation analysis was carried out to compare ATA and sTs distances with ***:The largest values were found for the vertical meridian and the shortest for the 2-8 o’clock meridian,both for ATA and sTs *** statistically significant differences were found between WTW,ATA and sTs along the horizontal meridian(p>0.1).However,ATA and sTs showed statistically significant differences elsewhere,except for the horizontal and the 2-8 o’clock meridians(p>0.05).Moreover,we found that ATA and sTs varied significantly depending on the meridian being assessed,except for ATA at 4-10 versus 3-9 o’clock and for sTs at 4-10 versus 3-9 o’clock and at 3-9 versus 2-8 o’clock(p>0.1).R^(2) values ranged from 0.49 to 0.75 for ATA and sTs at the different meridians,showing the best correlation at 3-9 o’clock meridian(0.64 and 0.75,respectively)and the worst at 6-12 o’clock meridian(R^(2)=0.49 for both ATA and sTs).Conclusions:ATA and sTs distances vary radially,thus showing that the anterior chamber is vertically ***,it is advisable to measure these two distances along the meridian to be used.

关键词： Angle-to-angle spur-to-spur White-to-white Optical coherence tomography swept-source Fourier domain

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Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?

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World Journal of Gastroenterology 2018年第17期24卷 1825-1838页

作者： Elia Moreno-Cubero robert T s.nchez del Arco Julia Pena-As.nsio Eduardo s.nz de Villalobos Joaquín Míquel Juan Ramón Larrubia Translational Hepatology Unit Guadalajara University HospitalUniversity of AlcaláGuadalajara 19002Spain Internal Medicine service Guadalajara University HospitalUniversity of AlcaláGuadalajara 19002Spain department of Biology of systems University of AlcaláAlcaláde Henares(Madrid)28805Spain department of Medicine and Medical specialties University of AlcaláAlcaláde Henares(Madrid)28805Spain

Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. nucleos(t)ide analogue(nA) treatment suppresses viral replication but does.not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated nA therapy discontinuation after several years of nA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is ess.ntial to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. s.nce antiviral immunity plays an ess.ntial role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe nA discontinuation in both groups.

关键词： Cd8 Lamivudine nucleos(t)ide analogues Tenofovir Chronic hepatitis B Entecavir hepatitis B virus Treatment cessation

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Expression of HIF-1α and Its Target Genes in the nanorana parkeri Heart：Implications for High Altitude Adaptation

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Asian Herpetological Research 2016年第1期7卷 12-20页

作者： Qiong ZHAnG Xingzhi HAn Yinzi YE robert H.s.KRAUs Liqing FAn Le YAnG Yi TAO Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China College of Life sciences Harbin Normal University Harbin 150025 Heilongjiang China College of Life sciences Hangzhou Normal University Hangzhou 311121 Zhejiang China department of Biology University of Konstanz Konstanz 78457 Germany Max Planck Institute for Ornithology Department of Migration and Immuno-Ecology Am Obstberg 1 Radoljzell 78315 Germany College of Agricultural and Animal Husbandry Tibet University Tibet 860000 China Tibet Plateau Institute of Biology Tibet 850001 China

Hypoxia-inducible factor 1 alpha（HIF-1α） and its target genes vascular endothelial growth factor（VEGF） and transferrins（TF） play an important role in native endothermic animals＇ adaptation to the high altitude environments. For ectothermic animals – especially frogs – it remains undetermined whether HIF-1α and its target genes（VEGF and TF） play an important role in high altitude adaptation, too. In this study, we compared the gene sequences and expression of HIF-1α and its target genes（VEGF and TF） between three nanorana parkeri populations from different altitudes（3008 m a.s.l., 3440 m a.s.l. and 4312 m a.s.l.）. We observed that the c dnA sequences of HIF-1A exhibited high sequence similarity（99.38%） among the three altitudinally separated populations; but with increas.ng altitude, the expression of HIF-1A and its target genes（VEGF and TF） increased significantly. These results indicate that HIF-1α plays an important role in n. parkeri adaptation to the high altitude, similar to its role in endothermic animals.

关键词： Hypoxia cold-temperature ectothermic animals nanorana parkeri high altitude vascular endothelial growth factor transferrins anura amphibia

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The Expression Plasticity of Hypoxia Related Genes in High-Altitude and Plains.nanorana parkeri Populations

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Asian Herpetological Research 2016年第1期7卷 21-27页

作者： Qiong ZHAnG Xingzhi HAn robert H.s.KRAUs Le YAnG Liqing FAn Yinzi YE Yi TAO Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China College of Life sciences Harbin Normal University Harbin 150025 Heilongjiang China department of Biology University of Konstanz 78457 Konstanz Germany Max Planck Institute for Ornithology Department of Migration and Immuno-Eeology Am Obstberg 1 Radolfzell 78315 Germany Tibet Plateau Institute of Biology Beijing West Street 19 Tibet 850001 China College of Agricultural and Animal Husbandry Tibet University Tibet 860000 China College of Life sciences Hangzhou Normal University Hangzhou 311121 Zhejiang China

For species that have a broad geographic distribution, adaptive variation may be attributable to gene expression plasticity. nanorana parkeri is an anuran endemic to the southern Tibetan Plateau where it has an extensive altitudinal range（2850 to 5100 m asl）. Low oxygen concentration is one of the main environmental characteristics of the Tibetan Plateau. Hypoxia-inducible factor α subunits（HIF-1α and HIF-2α, encoded by Endothelial PAs domain protein 1（EPAs1）） and associated genes（e.g., vascular endothelial growth factor（VEGF） and Erythropoietin（EPO）） play crucial roles in maintaining oxygen homeostasis. In this study, we compared the expression of HIF-1A, VEGF, EPAs1 and EPO mRnA between two populations of n. parkeri： one population inhabiting the native high altitudes, and the second living in, and being acclimated to, the lower plains（70 m asl）. The expression of HIF-1A, VEGF and EPAs1 mRnA in the high altitude population were significantly higher than in the acclimated population, whereas there was.no significant difference for EPO between two groups. Our results indicated that gene expression plasticity may make significant contributions to local adaptation of species that have broad altitudinal distributions. In addition, we deepen our understanding of the adaptive potential of this species by evaluating the experiments in the scope of its evolutionary history.

关键词： local adaptation ectotherms de-adaptation plasticity Qinghai-Tibetan plateau amphibians

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猕猴桃皮多酚对脂多糖应激Caco-2细胞抗氧化能力的影响

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食品科学 2024年第16期45卷 105-112页

作者：徐瑞屿薛沙牛鸿艳黄群周艳贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室贵州省生态食品创制工程研究中心贵州贵阳561113

目的:探讨猕猴桃皮多酚(kiwifruit peel polyphenols,KPP)对脂多糖(lipopolysaccharide,LPs)应激Caco-2细胞抗氧化能力的影响。方法:采用CCK-8法测定不同处理组Caco-2的细胞活力,荧光分光光度计测定活性氧和线粒体膜电位,分光光度计测... 详细信息

目的:探讨猕猴桃皮多酚(kiwifruit peel polyphenols,KPP)对脂多糖(lipopolysaccharide,LPs)应激Caco-2细胞抗氧化能力的影响。方法:采用CCK-8法测定不同处理组Caco-2的细胞活力,荧光分光光度计测定活性氧和线粒体膜电位,分光光度计测定超氧化物歧化酶(superoxide dismutase,sOd)活力和谷胱甘肽(glutathione,GsH)、丙二醛(malonaldehyde,MdA)含量,实时荧光定量聚合酶链式反应测定核红细胞2相关因子2(nuclear factor erythroid 2-related factor 2,nrf2)、Kelch样ECH相关蛋白1(Kelch-like ECH-associated protein 1,Keap1)、nAd(P)H:醌氧化还原酶1(nAd(P)H:quinone oxidoreductase 1,nQO1)、超氧化物歧化酶1(superoxide dismutase 1,s O d 1)、s O d 2基因的表达;蛋白印迹测定n r f 2、Ke a p 1及n Q O 1蛋白表达水平。结果:与L P s组相比,经50μg/mL KPP干预后细胞活力显著升高(PdA含量分别显著下降至1.82±0.28、5.08 nmol/mg(PsOd活力和GsH含量分别显著升高至52.57 U/mg和69.46μmol/g(Pnrf2、nQO1基因和蛋白表达(Pnrf2/nQO1信号通路提高Caco-2的抗氧化水平,缓解LPs应激造成的细胞损伤。

关键词：猕猴桃皮多酚脂多糖 Caco-2细胞抗氧化活性 nrf2通路

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sequential piezoresponse force microscopy and the‘small-data’problem

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npj Computational Materials 2018年第1期4卷 419-425页

作者： Harsh Trivedi Vladimir V.shvartsman Marco s.A.Medeiros robert C.Pullar doru C.Lupascu Institute for Materials science and Center for nanointegration duis order ferroic switching induced by sburg-Ess.n(CEnIdE) University of Duisburg-EssenEssenGermany CICECO–Aveiro Institute of Materials University of AveiroAveiroPortugal department of Materials and Ceramic Engineering University of AveiroAveiroPortugal

The term big-data in the context of materials science not only stands for the volume,but also for the heterogeneous.nature of the characterization *** is a common problem in combinatorial searches in materials science,as well as ***,these data-sets may well be‘small’in terms of limited step-size of the measurement *** to this limitation,application of higher-order statistics is.not effective,and the choice of a suitable unsupervised learning method is restricted to those utilizing lower-order *** an interesting case study,we pres.nt here variable magnetic-field Piezoresponse Force Microscopy(PFM)study of composite multiferroics,where due to experimental limitations the magnetic field dependence of piezoresponse is registered with a coarse *** efficient extraction of this dependence,which corresponds to the local magnetoelectric effect,forms the central problem of this *** evaluate the performance of Principal Component Analysis(PCA)as a simple unsupervised learning technique,by pre-labeling possible patterns in the data us.ng density Based Clustering(dBsCAn).Based on this combinational analysis,we highlight how PCA us.ng non-central second-moment can be useful in such cases for extracting information about the local material response and the corresponding spatial distribution.

关键词： dBsCAn problem utilizing

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