检索结果-南通市图书馆

Promising applications of D-amino acids in periprosthetic joint infection

Bone Research 2023年第2期11卷 248-272页

作者： Matthew Caldwell Megan hughes Fei Wei Christopher Ngo Raven Pascua Abinaya Sindu Pugazhendhi Melanie j.Coathup Biionix Cluster&College of Medicine University of Central FloridaBlvdOrlandoFL32827USA School of Biosciences Cardiff UniversityCF103AT WalesUK Burnett School of Biomedical Sciences College of MedicineUniversity of Central Florida6900 Lake NonaBlvdOrlandoFL32827USA

Due to the rise in our aging population,a disproportionate demand for total joint arthroplasty(TjA)in the elderly is *** joint infection(PjI)represents one of the most challenging complications that can occur following TjA,and as the number of primary and revision TjAs continues to rise,an increasing PjI burden is *** advances in operating room sterility,antiseptic protocols,and surgical techniques,approaches to prevent and treat PjI remain difficult,primarily due to the formation of microbial *** difficulty motivates researchers to continue searching for an effective antimicrobial *** dextrorotatory-isoforms of amino acids(D-AAs)are essential components of peptidoglycan within the bacterial cell wall,providing strength and structural integrity in a diverse range of *** many tasks,D-AAs regulate cell morphology,spore germination,and bacterial survival,evasion,subversion,and adhesion in the host immune *** administered exogenously,accumulating data have demonstrated that D-AAs play a pivotal role against bacterial adhesion to abiotic surfaces and subsequent biofilm formation;furthermore,D-AAs have substantial efficacy in promoting biofilm *** presents D-AAs as promising and novel targets for future therapeutic *** their emerging antibacterial efficacy,their role in disrupting PjI biofilm formation,the disassembly of established TjA biofilm,and the host bone tissue response remains largely *** review aims to examine the role of D-AAs in the context of *** to date suggest that D-AA bioengineering may serve as a promising future strategy in the prevention and treatment of PjI.

关键词： prevention spite furthermore

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Isogeometric Collocation:A Mixed Displacement-Pressure Method for Nearly Incompressible Elasticity Dedicated to Professor Karl Stark Pister for his 95th birthday

引用

Computer Modeling in Engineering & Sciences 2021年第12期129卷 1125-1150页

作者： S.Morganti F.Fahrendorf L.De Lorenzis j.A.Evans T.j.R.hughes A.Reali Department of Electrical Computer and Biomedical EngineeringUniversita degli Studi di PaviaPavia27100Italy Institute of Applied Mechanics Technische Universitat BraunschweigBraunschweig38106Germany Department of Mechanical and Process Engineering Zurich8092Switzerland Department of Aerospace Engineering Sciences University of Colorado BoulderColorado80309USA Institute for Computational Engineering and Sciences The University of Texas at AustinTexas78712USA Department of Civil Engineering and Architecture Universita degli Studi di PaviaPavia27100Italy

We investigate primal and mixed u−p isogeometric collocation methods for application to nearly-incompressible isotropic *** primal method employs Navier’s equations in terms of the displacement unknowns,and the mixed method employs both displacement and pressure *** benchmarks for what might be considered acceptable accuracy,we employ constant-pressure Abaqus finite elements that are widely used in engineering *** a basis of comparisons,we present results for compressible *** the methods were completely satisfactory for the compressible ***,results for low-degree primal methods exhibited displacement locking and in general deteriorated in the nearly-incompressible *** results for the mixed methods behaved very well for two of the problems we studied,achieving levels of accuracy very similar to those for the compressible *** third problem,which we consider a“torture test”presented a more complex story for the mixed methods in the nearly-incompressible case.

关键词： Isogeometric analysis isogeometric collocation nearly-incompressible elasticity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stagnant lid tectonics:Perspectives from silicate planets,dwarf planets, large moons,and large asteroids

引用

Geoscience Frontiers 2018年第1期9卷 103-119页

作者： robert j.Stern Taras Gerya Paul j.Tackley Geosciences Department University of Texas at Dallas Department of Earth Sciences ETH-Zurich

To better understand Earth's present tectonic style-plate tectonics—and how it may have evolved from single plate(stagnant lid) tectonics, it is instructive to consider how common it is among similar bodies in the Solar System. Plate tectonics is a style of convection for an active planetoid where lid fragment(plate) motions reflect sinking of dense lithosphere in subduction zones, causing upwelling of asthenosphere at divergent plate boundaries and accompanied by focused upwellings, or mantle plumes;any other tectonic style is usefully called "stagnant lid" or "fragmented lid". In 2015 humanity completed a 50+ year effort to survey the 30 largest planets, asteroids, satellites, and inner Kuiper Belt objects,which we informally call "planetoids" and use especially images of these bodies to infer their tectonic activity. The four largest planetoids are enveloped in gas and ice(jupiter, Saturn, Uranus, and Neptune)and are not considered. The other 26 planetoids range in mass over 5 orders of magnitude and in diameter over 2 orders of magnitude, from massive Earth down to tiny Proteus; these bodies also range widely in density, from 1000 to 5500 kg/m^3. A gap separates 8 silicate planetoids with ρ = 3000 kg/m^3 or greater from 20 icy planetoids(including the gaseous and icy giant planets) with ρ = 2200 kg/m^3 or less. We define the "Tectonic Activity Index"(TAI), scoring each body from 0 to 3 based on evidence for recent volcanism, deformation, and resurfacing(inferred from impact crater density). Nine planetoids with TAI = 2 or greater are interpreted to be tectonically and convectively active whereas 17 with TAI <2 are inferred to be tectonically dead. We further infer that active planetoids have lithospheres or icy shells overlying asthenosphere or water/weak ice. TAI of silicate(rocky) planetoids positively correlates with their inferred Rayleigh number. We conclude that some type of stagnant lid tectonics is the dominant mode of heat loss and that plate tectonics

关键词： Stagnant lid Solar system Plate tectonics Planets Moons

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

c-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer

引用

World journal of Gastroenterology 2014年第26期20卷 8458-8470页

作者： Daniel Delitto Eva Vertes-George Steven j.hughes Kevin E Behrns jose G Trevino Department of Surgery University of Florida-Gainesville Department of Pathology University of Florida-Gainesville

Pancreatic ductal adenocarcinoma is the 4th leading cause of cancer deaths in the United States. The majority of patients are candidates only for palliative chemotherapy, which has proven largely ineffective in halting tumor progression. One proposed mechanism of chemoresistance involves signaling via the mesenchymal-epithelial transition factor protein (MET), a previously established pathway critical to cell proliferation and migration. Here, we review the literature to characterize the role of MET in the development of tumorigenesis, metastasis and chemoresistance, highlighting the potential of MET as a therapeutic target in pancreatic cancer. In this review, we characterize the role of c-Met in the development of tumorigenesis, metastasis and chemoresistance, highlighting the potential of c-Met as a therapeutic target in pancreatic cancer.

关键词： Pancreatic adenocarcinoma c-Met Chemoresistance Receptor tyrosine kinase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Subtypes of functional dyspepsia

引用

World journal of Gastroenterology 2006年第17期12卷 2667-2671页

作者： Georgina Baker robert j Fraser Graeme Young Department of Gastroenterology Repatriation General Hospital and Flinders Medical Centre Australia

Functional dyspepsia is a common clinical condition characterised by chronic or recurrent upper abdominal pain or discomfort commonly associated with a variety of associated gastrointestinal symptoms and a normal endoscopy. To standardise research-based approaches, an initial categorisation of into sub groups was agreed to, based on clusters of symptoms. However the early expectation that these subgroups would be associated with distinct pathophysiologies amenable to specific therapy has not been realised. A classification based on the most troublesome symptom has been suggested but the utility of this is also unclear. More recent data suggest that some of the pathophysiologic dysfunctions may be associated with specific symptoms and so provide a better tool for grouping patients. But this approach remains incomplete as current insights into the pathogenesis are still too limited for this to be satisfactory. In conclusion, no classification provides for an adequate treatment-based approach to the syndrome of functional dyspepsia. As a consequence treatment remains largely empiric.

关键词： Functional dyspepsia Classification Subtypes Symptoms Pathophysiology Management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diagnosis and treatment of heart failure with preserved left ventricular ejection fraction

引用

World journal of Cardiology 2020年第1期12卷 7-25页

作者： robert j Henning College of Public Health University of South Florida

Nearly six million people in United States have heart *** percent of these people have normal left ventricular(LV)systolic heart function but abnormal diastolic function due to increased LV myocardial *** commonly,these patients are elderly women with hypertension,ischemic heart disease,atrial fibrillation,obesity,diabetes mellitus,renal disease,or obstructive lung *** annual mortality rate of these patients is 8%-12%per *** diagnosis is based on the history,physical examination,laboratory data,echocardiography,and,when necessary,by cardiac *** with obesity,hypertension,atrial fibrillation,and volume overload require weight reduction,an exercise program,aggressive control of blood pressure and heart rate,and *** devices inserted into patients for pulmonary artery pressure monitoring provide early warning of increased pulmonary pressure and *** significant coronary heart disease is present,coronary revascularization should be considered.

关键词： Diastolic heart failure Myocardial stiffness Incomplete left ventricular relaxation Echocardiographic heart failure criteria Pulmonary artery pressure monitoring Drug treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Specifications of Targeting Heterochromatin Modifications in Plants

引用

Molecular Plant 2018年第3期11卷 381-387页

作者： jered M. Wendte robert j. Schmitz Department of Genetics University of Georgia Athens GA 30602 USA

Plants encode a diverse repertoire of DNA methyltransferases that have specialized to target cytosines for methylation in specific sequence contexts. These include the de novo methyltransferase, DOMAINS REARRANGED METHYLTRANSFERASE 2 （DRM2）, which methylates cytosines in all sequence contexts through an RNA-guided process, the CHROMOMETHYLASES （CMTs）, which methylate CHH and CHG cytosines （where H is A, T, or C）, and METHYLTRANSFERASE 1 （MET1）, which maintains methylation of symmetrical CG contexts. In this review, we discuss the sequence specificities and targeting of each of these pathways. In particular, we highlight recent studies that indicate CMTs preferentially target CWG or CWA/CAW motifs （where W is A or T）, and discuss how self-reinforcing feedback loops between DNA methyltransferases and histone modifications characteristic of heterochromatin specify targeting. Finally, the initiating events that lead to gene body methylation are discussed as a model illustrating how interde- pendent targeting of different silencing pathways can potentiate the establishment of off-target epialleles.

关键词： heterochromatin DNA methylation gene body methylation epiallele DNA methyltransferase,chromomethylase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Early developmental exposure to inorganic mercury does not alter affiliative behavior of adult prairie voles(Microtus ochrogaster)

引用

Integrative Zoology 2018年第6期13卷 761-768页

作者： Yue CHEN robert LEWIS j.Thomas CURTIS Department of Pharmacology and Physiology Oklahoma State University Center for Health SciencesTulsaOklahomaUK

Mercury chloride exposure through drinking water in adult male prairie voles(Microtus ochrogaster)has been shown to alter their social ***,we examined the potential disruption of adult social behavior in prairie voles that were exposed to 60 ppm mercury during early *** used a cross-fostering approach to test the effects of mercury exposure:(1)from conception until birth;(ii)from birth until weaning;and(iii)from conception until weaning,on adult affiliative *** and mercury-treated voles were given the option of remaining in an empty cage or affiliating with a same-sex conspecific in a 3-h choice *** found that early developmental mercury exposure had little if any effect on the reproductive success of breeder pairs or on affiliative behavior by either sex when subjects were tested as *** results suggest that,at least in the context of the behavior tested,the effects of early developmental exposure to mercury do not permanently alter adult prairie vole affiliative behavior,or do so in a way that is too subtle to be detected using the current testing paradigm.

关键词： behavioral testing metals toxicity social behavior prairie vole

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

How spiders practice aggressive and Batesian mimicry

引用

Current Zoology 2012年第4期58卷 620-629页

作者： Ximena j. NELSON robert R. jACKSON School of Biological Sciences University of Canterbury Private Bag 4800 Christchurch New Zealand International Centre of Insect Physiology and Ecology Thomas Odhiambo Campus EO. Box 30 Mbita Point Kenya

To understand communication, the interests of the sender and the receiver/s of signals should be considered sepa-rately. When our goal is to understand the adaptive significance of specific responses to specific signals by the receiver, questions about signal information are useful. However, when our goal is to understand the adaptive significance to the sender of generating a signal, it may be better to envisage the receiver＇s response to signals as part of the sender＇s extended phenotype. By making signals, a sender interfaces with the receiver＇s model of the world and indirectly manipulates its behaviour. This is especially clear in cases of mimicry, where animals use deceptive signals that indirectly manipulate the behaviour of receivers. Many animals adopt Batesian mimicry to deceive their predators, or aggressive mimicry to deceive their prey. We review examples from the lite-rature on spiders to illustrate how these phenomena, traditionally thought of as distinct, can become entangled in a web of lies .

关键词： Mimicry Communication Spider Deception Signal Search image

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Covering Your Bases： Inheritance of DNA Methylation in Plant Genomes

引用

Molecular Plant 2014年第3期7卷 472-480页

作者： Chad E. Niederhuth robert j. Schmitz Department of Genetics University of Georgia Athens GA 30602 USA

Cytosine methylation is an important base modification that is inherited across mitotic and meiotic cell divisions in plant genomes. Heritable methylation variants can contribute to within-species phenotypic variation. Few methylation variants were known until recently, making it possible to begin to address major unanswered questions： the extent of natural methylation variation within plant genomes, its effects on phenotypic variation, its degree of depend- ence on genotype, and how it fits into an evolutionary context. Techniques like whole-genome bisulfite sequencing （WGBS） make it possible to determine cytosine methylation states at single-base resolution across entire genomes and populations. Application of this method to natural and novel experimental populations is revealing answers to these long-standing questions about the role of DNA methylation in plant genomes.

关键词： DNA methylation epigenetics epiallele whole-genome bisulfite sequencing.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：