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Characterization of squash polysaccharide and the anti-diabetic effect on type 2 diabetic rat revealed by urine metabolomics analysis

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Food Science and Human Wellness 2024年第5期13卷 2937-2946页

作者： Li Liang Fuming Zhang Quanhong Li Baoguo Sun Yuyu Zhang robert j.Linhardt Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Key Laboratory of Flavor ChemistryBeijing Technology and Business University(BTBU)Beijing 100048China Departments of Chemical and Biological Engineering Chemistry and Chemical BiologyBiomedical Engineering and Biological ScienceCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroy 12180USA College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China China National Engineering Research Center for Fruit and Vegetable Processing Beijing 100083China

The present study reports the structural characteristics of 3 polysaccharide fractions(SPS-F1,SPS-F2 and SPS-F3)isolated and purified from ***-F1(molecular weight(Mw)=12.30 kDa)and SPS-F2(Mw=19.40 kDa)were likely to contain HG and RG-I domain of pectic polysaccharide,***-F2(Mw=270.4 kDa)was mainly composed of rhamnose,galactose and *** treatment with SPS decreased body weight gain,glucose and TG levels in type 2 diabetes ***,25 differential metabolites were identified based on urinary metabolomics analysis,which are crucial to the anti-diabetic effect of *** regulation of nicotinamide N-oxide,histamine,cis-aconitate,citrate,L-malic acid,3-(3-hydroxyphenyl)propanoic acid and N-acetyl-L-aspartic acid were mainly associated with energy metabolism,gut microbiota and *** of surface plasmon resonance revealed the binding kinetics with galectin-3(Gal-3)and fibroblast growth factor 2(FGF2).The K_(D)values of SPS-F2 and SPS-F3 to Gal-3 were 4.97×10^(-3)and 1.48×10^(-3)mol/L,indicating a weak binding *** 3 fractions showed moderate binding to FGF2 and the affinity was SPS-F3>SPS-F2>***,the metabolomics and SPR approach were proved to be a promising tool in exploring the anti-diabetes effects of SPS and provided a deep understanding of the mechanisms.

关键词： Polysaccharide Metabolomics Type 2 diabetes Surface plasmon resonance

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Conditional coherent risk measures and regime-switching conic pricing

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Probability, Uncertainty and Quantitative Risk 2021年第4期6卷 267-300页

作者： Engel john C Dela Vega robert j Elliott UniSA Business University of South AustraliaSA 5000 AdelaideAustralia Haskayne School of Business University of CalgaryCalgaryAlbertaT2N 1N4Canada

This paper introduces and represents conditional coherent risk measures as essential suprema of conditional expectations over a convex set of probability measures and as distorted expectations given a concave distortion function.A model is then developed for the bid and ask prices of a European-type asset by a conic *** price process is governed by a modified geometric Brownian motion whose drift and diffusion coefficients depend on a Markov *** bid and ask prices of a European-type asset are then characterized using conic quantization.

关键词： Conditional coherent risk measures Markov chains Regime-switching Conic finance European options Distortion functions Conic quantization

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Effects of L-arginine,guanidinoacetic acid and L-citrulline supplementation in reduced-protein diets on bone morphology and mineralization of laying hens

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Animal Nutrition 2023年第3期14卷 225-234页

作者： Hiep Thi Dao Amy F.Moss Emma j.Bradbury robert A.Swick School of Environmental and Rural Science Faculty of ScienceAgricultureBusiness and LawUniversity of New EnglandArmidaleNew South Wales2351Australia Faculty of Animal Science Vietnam National University of AgricultureTrau Quy TownGia Lam DistrictHanoi100000Vietnam Baiada Poultry Pty Limited Pendle HillNew South Wales2145Australia

The alterations in feed ingredients and the nutrient matrix to produce reduced-protein diets may affect bone morphology and mineralization in laying *** study was implemented to determine the effects of L-arginine(Arg),guanidinoacetic acid(GAA),and L-citrulline(Cit)supplementation to Argdeficient reduced-protein diets on bone morphology,strength,and mineralization status of laying *** housed Hy-Line Brown laying hens were evenly distributed to five dietary treatments with 25 replicates per treatment from 20 to 40 wk of *** consisted of a standard protein diet(17%crude protein,SP),a reduced-protein diet deficient in Arg(13%crude protein,RP),and RP supplemented with Arg(0.35%Arg,RP-Arg),GAA(0.46%GAA equivalent to 0.35%Arg,RP-GAA),or Cit(0.35%Cit equivalent to 0.35%Arg,RP-Cit)to reach the Arg level of SP *** fed the SP diet had similar bone weight,ash,length,width,Seedor index,breaking strength,and serum mineral concentration,but higher toe B level(P<0.001)compared to those fed the RP diet at wk *** fed the SP diet consumed more but also excreted more K and B compared to those fed the RP diet(P<0.01).Birds fed the SP diet had lower Cu digestibility(P=0.01)and higher B retention(P<0.01)compared to those offered the RP *** of Arg,GAA,and Cit to the RP diet increased relative femur weight and length(P<0.001).Citrulline supplementation also increased relative tibia and femur ash,and Zn digestibility(P<0.05).Supplementation of GAA to the RP diet decreased serum Ca,P,and Mg levels,decreased tibia Fe and Mg levels and toe Mg level,but increased Al,Fe,Zn,and Mn digestibility(P<0.05).The current findings demonstrated the capacity of laying hens to adapt to low mineral intake by increasing mineral ***,bone morphology and breaking strength,and serum mineral level in laying hens were not influenced by dietary CP *** Arg,GAA,or Cit supplementation were effective in improving bone morphology and

关键词： Ash Breaking strength Femur Low protein Minerals Digestibility

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Response of laying hens to L-arginine,L-citrulline and guanidinoacetic acid supplementation in reduced protein diet

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Animal Nutrition 2021年第2期7卷 460-471页

作者： Hiep Thi Dao Nishchal K.Sharma Emma j.Bradbury robert A.Swick School of Environmental and Rural Science Faculty of ScienceAgricultureBusiness and LawUniversity of New England2351New South WalesAustralia Faculty of Animal Science Vietnam National University of AgricultureTrau Quy TownGia Lam DistrictHanoiViet Nam Ridley AgriProducts Level 4565 Bourke StreetMelbourneVICAustralia

A study was conducted with Hy-Line Brown laying hens to examine the effects of reduced protein diet,deficiency of arginine(Arg),and addition of crystalline Arg,citrulline(Cit)and guanidinoacetic acid(GAA)as substitutes for *** performance,egg quality,serum uric acid,liver and reproductive organ weights,and energy and protein digestibility were measured using a completely randomized design with 5 *** were a standard diet(17%protein diet;SP),a reduced diet(13%protein diet deficient in Arg;RP)and RP with added Arg(0.35%,RP-Arg),GAA(0.46%equivalent to 0.35%Arg,RP-GAA)or Cit(0.35%,RP-Cit)to the level of *** was hypothesized that performance would decrease with Arg deficient RP diet and the addition of GAA or Cit in RP would allow birds to perform similar or greater than Arg-added RP *** experiment was conducted from 20 to 39 wk of age but the treatment effect was seen only after 29 wk of *** birds offered RP had reduced egg and albumin weights(P0.05).The birds offered RP-GAA decreased FI and egg production(P0.05).However,birds offered the RP-Cit diet tended to have higher Haugh unit(P=0.095)and lower shell breaking strength(P=0.088)compared to all other treatments while those offered RP-GAA had higher energy digestibility(P<0.05)than all other groups but *** limited performance response of hens fed RP with added Arg,GAA,or Cit may be due to deficiency of some other nutrients in RP such as phenylalanine,potassium or non-essential amino acids and other components of soybean meal in the diet.

关键词： Arginine Citrulline Guanidinoacetic acid Laying hen Reduced protein

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A Critical Review of the Evidence for M32 being a Compact Dwarf Satellite of M31 rather than a More Distant Normal Galaxy

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Chinese journal of Astronomy and Astrophysics 2008年第4期8卷 369-384页

作者： C. Ke-shih Young Malcolm j. Currie robert j. Dickens A-Li Luo Tong-jie Zhang National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Department of Physics University of Hong Kong Hong Kong China School of Physics University of New South Wales Sydney 2052 Australia Rutherford Appleton Laboratory Chilton Didcot Oxfordshire OX 11 0QX Great Britain Department of Astronomy Beijing Normal University Beijing 100875 China

Since Baade＇s photographic study of M32 in the mid 1940s, it has been accepted as an established fact that M32 is a compact dwarf satellite of M31. The purpose of this paper is to report on the findings of our investigation into the nature of the existing evidence. We find that the case for M32 being a satellite of M31 rests upon Hubble Space Telescope （HST） based stellar population studies which have resolved red-giant branch （RGB） and red clump stars in M32 as well as other nearby galaxies. Taken in isolation, this recent evidence could be considered to be conclusive in favour of the existing view. However, the conventional scenario does not explain M32＇s anomalously high central velocity dispersion for a dwarf galaxy （several times that of either NGC 147, NGC 185 or NGC 205） or existing planetary nebula observations （which suggest that M32 is more than twice as distant as M31） and also requires an elaborate physical explanation for M32＇s inferred compactness. Conversely, we find that the case for M32 being a normal galaxy, of the order of three times as distant as M31, is supported by：（1） a central velocity dispersion typical of intermediate galaxies, （2） the published planetary nebula observations, and （3） known scaling relationships for normal early-type galaxies. However, this novel scenario cannot account for the high apparent luminosities of the RGB stars resolved in the M32 direction by HST observations. We are therefore left with two apparently irreconcilable scenarios, only one of which can be correct, but both of which suffer from potentially fatal evidence to the *** suggests that current understanding of some relevant fields is still very far from adequate.

关键词： galaxies:individual M32 - galaxies distances and redshifts - galaxies dwarf- galaxies elliptical and lenticular, cD - galaxies fundamental parameters

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Revisiting rock classification to estimate rock mass properties

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journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 494-510页

作者： robert Bertuzzi Pells Sullivan Meynink North RydeNSW 2113Australia

This paper presents the results of ongoing research carried out by the author exploring methods to provide a more robust estimate of rock mass properties specifically for use in tunnel *** from various large-scale rock mass failures are introduced,including coal *** damage-initiation,spalling-limit approach is compared to the coal pillar *** comparisons of estimating the geological strength index(GSI)and relationships to estimate the Hoek-Brown failure criterion parameters,mb,s and a,are presented.

关键词： Rock mass properties HoekeBrown strength criterion Geological strength index(GSI) Tunnelling

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Back-analysing rock mass modulus from monitoring data of two tunnels in Sydney, Australia

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journal of Rock Mechanics and Geotechnical Engineering 2017年第5期9卷 877-891页

作者： robert Bertuzzi Pells Sullivan Meynink North Ryde NSW 2113 Australia School of Civil and Environmental Engineering University of New South Wales Kensington NSW 2052 Australia

This paper presents two case studies where the rock mass modulus and in situ stress are estimated from the monitoring data obtained during the construction of underground excavations in Sydney,*** case studies comprise the widening of existing twin road tunnels within Hawkesbury sandstone and the excavation of a large cavern within Ashfield *** back-analysis from detailed systematic monitoring has been previously published,this paper presents a relatively simple methodology to derive rock mass modulus and in situ stress from the relatively simple displacement data routinely recorded during tunnelling.

关键词： Back-analysis Rock mass modulus In situ stress Sydney tunnels

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Operations management for competitive advantage / Richard B. Chase, Nicholas j. Aquilano, F. robert jacobs. 9th ed.

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丛书名： The Irwin/McGraw-Hill series. Operations and decision sciences.

2001年

作者： Richard B. Chase Nicholas j. Aquilano F. robert jacobs.

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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X-ray Multiple Diffraction Topographic Imaging Technique For Growth History Study of Habit Modifying Impurity Doped Crystals

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Chemical Research in Chinese Universities 2004年第4期20卷 411-416页

作者： LAI X. MA C. K. j. robert M. C. Miller Institute of Particle Science and Engineering Department of Chemical Engineering University of LeedsInstitute of Particle Science and Engineering Department of Chemical Engineering University of LeedsInstitute of Particle Science and Engineering Department of Chemical Engineering University of LeedsCCLRC Daresbury Laboratory Daresbury Leeds LS2 9JT UKLeeds LS2 9JT UKLeeds LS2 9JT UKWarrington Cheshire WA4 4AD UK

A novel crystal characterization instrument has been built up in which a combination of X-ray multiple diffraction and X-ray topography is applied to enabling the cross-correlation between micro-crystallographic symmetry and its spatial dependence in relation to lattice defects. This facility is used to examine, in a self-consistent manner, growth sector-dependant changes to both the crystallographic structure and the lattice defects associated with the action of habit-modifying additives in a number of representative crystal growth systems. In addition, the new instrument can be used to probe micro-crystallographic aspects(such as distortion to crystal symmetry) and relate these in a spatially resolved manner to the crystal defect structure in crystals doped with known habit modifiers.

关键词： X-ray diffraction X-ray multiple diffraction X-ray topography Habit modification Crystal growth Growth defects

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Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D

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Protein & Cell 2010年第6期1卷 563-572页

作者： Anne jäkel Howard Clark Kenneth B.M.Reid robert B.Sim Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK University of Southampton School of MedicineDivision of Infection Inflammation&ImmunitySouthampton General HospitalSouthampton SO166YDUK MRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK

Surfactant proteins A(SP-A)and D(SP-D),both members of the collectin family,play a well established role in apoptotic cell recognition and *** in vitro data show that SP-A and SP-D interact with apoptotic neutrophils in a distinct ***-A and SP-D bind in a Ca^(2+)-dependent manner to viable and early apoptotic neutrophils whereas the much greater interaction with late apoptotic neutrophils is Ca^(2+)-*** surface molecules on the apoptotic target cells responsible for these interactions had not been identified and this study was done to find candidate target ***(MPO),a specific intracellular defense molecule of neutrophils that becomes exposed on the outside of the cell upon apoptosis,was identified by affinity purification,mass-spectrometry and western blotting as a novel binding molecule for SP-A and *** confirm its role in recognition,it was shown that purified immobilised MPO binds SP-A and SP-D,and that MPO is surface-exposed on late apoptotic ***-A and SP-D inhibit binding of an anti-MPO monoclonal Ab to late apoptotic *** microscopy confirmed that anti-MPO mAb and SP-A/SP-D colocalise on late apoptotic *** was identified as a further potential ligand for SP-A,and neutrophil defensin as a target for both proteins.

关键词： SP-A SP-D myeloperoxidase neutrophils flow cytometry mass spectrometry

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