检索结果-南通市图书馆

Incidence of brain metastasis in patients with esophageal carcinoma

World Journal of Gastroenterology 2011年第19期17卷 2407-2410页

作者： Ron S Smith robert C miller Department of Radiation Oncology Andreas Cancer Center-Mayo Health SystemMankatoMN 56002United States Department of Radiation Oncology Mayo ClinicRochesterMN 56002United States

AIM:To determine the incidence of brain metastasis in a contemporary group of patients with carcinoma of the ***:Retrospective analysis of 53 patients with esophageal carcinoma who received radiotherapy as a component of treatment between 1998 and 2007,including patient and tumor characteristics,and subsequent diagnosis of brain *** association between the histological type of esophageal cancer and the incidence of brain metastasis was assessed using Fisher's exact ***:Forty-four of the fifty-three patients in this study had adenocarcinoma and nine had squamous cell carcinoma,ranging from stage ⅡA-Ⅳ*** treatment was surgery with neoadjuvant chemoradiotherapy (trimodality therapy) in 19% of patients;chemoradiotherapy in 42%;and surgery and adjuvant radiotherapy in 7%.Twenty-five percent of patients inthis study received palliative *** overall incidence of brain metastasis in this cohort was 13%.Adenocarcinoma was the primary tumor histology in all of the patients who developed brain metastasis,representing an incidence of 16% in this *** patients with squamous cell carcinoma received trimodality *** association between histology and brain metastasis was not statistically ***:The incidence of brain metastasis in this contemporary cohort of patients with esophageal carcinoma is higher than previously reported and was confined to those with adenocarcinoma.

关键词： Brain metastasis Esophageal carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oligodendrocyte ablation as a tool to study demyelinating diseases

引用

Neural Regeneration Research 2016年第6期11卷 886-889页

作者： Ahdeah Pajoohesh-Ganji robert H.miller Department of Anatomy and Regenerative Biology The George Washington University School of Medicine and Health Sciences

Multiple sclerosis（MS） is an autoimmune mediated neurodegenerative disease characterized by demyelination and oligodendrocyte（OL） loss in the central nervous system and accompanied by local inflammation and infiltration of peripheral immune cells. Although many risk factors and symptoms have been identified in MS, the pathology is complicated and the cause remains unknown. It is also unclear whether OL apoptosis precedes the inflammation or whether the local inflammation is the cause of OL death and demyelination. This review briefly discusses several models that have been developed to specifically ablate oligodendrocytes in an effort to separate the effects of demyelination from inflammation.

关键词： inflammation autoimmune ablation unclear infiltration accompanied briefly myelin impairment neuronal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Myelin repair and functional recovery mediated by neural cell transplantation in a mouse model of multiple sclerosis

引用

Neuroscience Bulletin 2013年第2期29卷 239-250页

作者： Lianhua Bai Jordan Hecker Amber Kerstetter robert H.miller Department of Neurosciences Center for Translational NeuroscienceCase Western Reserve University School ofMedicine The Key Laboratory Third Military Medical University Southwest Hospital

Cellular therapies are becoming a major focus for the treatment of demyelinating diseases such as multiple sclerosis （MS）, therefore it is important to identify the most effective cell types that promote myelin repair. Several components contribute to the relative benefits of specific cell types including the overall efficacy of the cell therapy, the reproducibility of treatment, the mechanisms of action of distinct cell types and the ease of isolation and generation of therapeutic populations. A range of distinct cell populations promote functional recovery in animal models of MS including neural stem cells and mesenchymal stem cells derived from different tissues. Each of these cell populations has advantages and disadvantages and likely works through distinct mechanisms. The relevance of such mechanisms to myelin repair in the adult central nervous system is unclear since the therapeutic cells are generally derived from developing animals. Here we describe the isolation and characterization of a population of neural cells from the adult spinal cord that are characterized by the expression of the cell surface glycoprotein NG2. In functional studies, injection of adult NG2~ cells into mice with ongoing MOG3~_~5-induced experimental autoimmune encephalomyelitis （EAE） enhanced remyelination in the CNS while the number of CD3＋ T cells in areas of spinal cord demyelination was reduced approximately three-fold. In vivostudies indicated that in EAE, NG2＊ cells stimulated endogenous repair while in vitro they responded to signals in areas of induced inflammation by differentiating into oligodendrocytes. These results suggested that adult NG2~ cells represent a useful cell population for promoting neural repair in a variety of different conditions including demyelinating diseases such as MS.

关键词： NG2 glycoprotein myelin oligodendro-cytes experimental autoimmune encephalomyelitis multiple sclerosis remyelination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adjuvant chemoradiotherapy for resected pancreas cancer

引用

World Journal of Gastrointestinal Surgery 2010年第11期2卷 373-380页

作者： Matthew Iott Michelle Neben-Wittich J Fernando Quevedo robert C miller Department of Radiation Oncology Mayo ClinicRochesterMN 55905United States Division of Medical Oncology Mayo ClinicRochesterMN 55905United States

The purpose of this article is to review pertinent literature assessing the evidence regarding adjuvant chemoradiotherapy for adenocarcinoma of the pancreas following curative *** review looks at randomized controlled studies with the emphasis on adjuvant *** assessing the evidence from the studies reviewed in this article,the trials have been grouped according to the positive or negative results for or against adjuvant *** addition,data from two large,single-institution studies affirming the role for adjuvant chemoradiotherapy has been *** the evidence from all of the randomized studies is important in shaping current practice recommendations for adjuvant therapy of surgically resected pancreas *** chemoradiotherapy following surgery is the current approach at many cancer treatment centers in the United *** Europe,chemotherapy alone is the preferred adjuvant ***,the type of adjuvant treatment recommended remains controversial due to conflicting study *** debate will likely *** practice should be based on the weight of evidence available at this time,which is in favor of adjuvant chemotherapy with chemoradiotherapy.

关键词： Pancreas cancer Radiotherapy Chemotherapy Adjuvant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicting nesting habitat of Northern Goshawks in mixed aspen-lodgepole pine forests in a high-elevation shrub-steppe dominated landscape

引用

Open Journal of Ecology 2013年第2期3卷 109-115页

作者： robert A. miller Jay D. Carlisle Marc J. Bechard Dena Santini Idaho Bird Observatory Department of Biological Sciences Boise State University Boise USA Minidoka Ranger District Sawtooth National Forest USDA Forest Service Burley USA Raptor Research Center Department of Biological Sciences Boise State University Boise USA

We developed a habitat suitability model for predicting nest locations of breeding Northern Goshawks (Accipiter gentilis) in the high-elevation mixed forest and shrub-steppe habitat of south-central Idaho, USA. We used elevation, slope, aspect, ruggedness, distance-to-water, canopy cover, and individual bands of Landsat imagery as predictors for known nest locations with logistic regression. We found goshawks prefer to nest in gently-sloping, east-facing, non-rugged areas of dense aspen and lodgepole pine forests with low reflectance in green (0.53 - 0.61 μm) wavelengths during the breeding season. We used the model results to classify our 43,169 hectare study area into nesting suitability categories: well suited (8.8%), marginally suited (5.1%), and poorly suited (86.1%). We evaluated our model’s performance by comparing the modeled results to a set of GPS locations of known nests (n = 15) that were not used to develop the model. Observed nest locations matched model results 93.3% of the time for well suited habitat and fell within poorly suited areas only 6.7% of the time. Our method improves on goshawk nesting models developed previously by others and may be applicable for surveying goshawks in adjacent mountain ranges across the northern Great Basin.

关键词： Accipiter gentilis Breeding Ecology Habitat Idaho Nest Model Northern Goshawk

来源：

维普期刊数据库评论