Oligodendrocyte ablation as a tool to study demyelinating diseases

作     者：Ahdeah Pajoohesh-Ganji Robert H.Miller 

作者机构：Department of Anatomy and Regenerative Biology The George Washington University School of Medicine and Health Sciences 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第6期

页      面：886-889页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported in part by Genentech 

主　　题：inflammation autoimmune ablation unclear infiltration accompanied briefly myelin impairment neuronal 

摘      要：Multiple sclerosis（MS） is an autoimmune mediated neurodegenerative disease characterized by demyelination and oligodendrocyte（OL） loss in the central nervous system and accompanied by local inflammation and infiltration of peripheral immune cells. Although many risk factors and symptoms have been identified in MS, the pathology is complicated and the cause remains unknown. It is also unclear whether OL apoptosis precedes the inflammation or whether the local inflammation is the cause of OL death and demyelination. This review briefly discusses several models that have been developed to specifically ablate oligodendrocytes in an effort to separate the effects of demyelination from inflammation.