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Fungal.Diversity 2014年第1期64卷 165-179页

作者： Brendan P.Hodkinson Bibiana Moncada robert l.cking Perel.an School.of Medicine University of PennsylvaniaBRB 1046A421 Curie BlvdPhiladelphiaPA 19104USA l.cenciatura en Biol.gía Universidad Distrital Francisco Joséde CaldasCra.4 No.26B-54Torre de LaboratoriosHerbarioBogotáColombia Science&Education Integrative Research Center&Collections CenterThe Field Museum1400 South Lake Shore DriveChicagoIL 60605USA

We present a revised mol.cul.r phyl.geny of higher Basidiomycota focusing on l.pidostromataceae based on the l.rge subunit(28S)of the nucl.ar ribosomal.rDNA(nul.U),with additionl.data from the transl.tion el.ngation factor 1 al.ha 1(TEF1)and the RNA pol.merase II second l.rgest subunit(RPB2)*** resul.s suggest that l.pidostromataceae is best recognized in a separate order,l.pidostromatal.s ordo novum,within subcl.ss ***,the internal.topol.gy of l.pidostromataceae,correl.ting with thal.us features,indicates that three genera,instead of a singl. genus,shoul. be *** therefore introduce the genera Ertzia genus novum and Sul.bacheromyces genus novum for l.pidostroma akagerae and ***,*** addition,the new species *** *** is described for Mexican material.previousl. identified as *** photobionts of Sul.bacheromyces and l.pidostroma were identified using mol.cul.r data of the l.rge subunit of the ribul.se 1,5-bisphosphate carboxyl.se/oxygenase(rbcl.gene,reveal.ng a possibl. undescribed genus in Trebouxiophyceae and the first report of l.chenization for the genus Bracteacoccus in Chl.rophyceae.

关键词： Agarical.s Amyl.corticial.s Athel.al.s Auricul.rial.s Bl.ST Bol.tal.s Dictyonema Dipl.sphaera Gl.eophyl.al.s l.chenomphal.a Marchandiomphal.na Mul.icl.vul.

Serel.xin increases the antifibrotic action of rosigl.tazone in a model.of hepatic fibrosis

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Worl. Journal.of Gastroenterol.gy 2017年第22期23卷 3999-4006页

作者： robert G Bennett Ronda l.Simpson Frederick G Hamel Research Service Nebraska-Western Iowa Health Care System Department of Internal.Medicine University of Nebraska Medical Center

To determine the effect of combined serel.xin and rosigl.tazone treatment on establ.shed hepatic *** fibrosis was induced in mice by carbon tetrachl.ride administration for 6 wk, or vehicl. al.ne (nonfibrotic mice). For the final.2 wk, mice were treated with rosigl.tazone, serel.xin, or both rosigl.tazone and serel.xin. Serum l.ver enzymes and rel.xin l.vel. were determined by standard methods. The degree of l.ver col.agen content was determined by histol.gy and immunohistochemistry. Expression of type I col.agen was determined by quantitative PCR. Activation of hepatic stel.ate cel.s was assessed by al.ha-smooth muscl. actin (SMA) l.vel.. l.ver peroxisome prol.ferator activated receptor-gamma coactivator 1 al.ha (PGC1α) was determined by Western *** of mice with CCl.sub>4 resul.ed in hepatic fibrosis as evidenced by increased l.ver enzyme l.vel. (Al. and AST), and increased l.ver col.agen and SMA. Monotherapy with either serel.xin or rosigl.tazone for 2 wk was general.y without effect. In contrast, the combination of serel.xin and rosigl.tazone resul.ed in significantl. improved Al. l.vel. (P l.l.ver col.agen content as determined by Sirius red staining reveal.d that onl. combination treatment was effective in reducing total.l.ver col.agen (P l.s were supported by immunohistochemistry for type I col.agen, in which onl. combination treatment reduced fibril.ar col.agen l.vel. (P l.vel.of hepatic stel.ate cel. activation was modestl., but significantl., reduced by serel.xin treatment al.ne, but combination treatment resul.ed in significantl. l.wer SMA l.vel.. Final.y, whil. hepatic fibrosis reduced l.ver PGC1α l.vel., the combination of serel.xin and rosigl.tazone resul.ed in restoration of PGC1α protein *** combination of serel.xin and rosigl.tazone treatment for 2 wk was effective in significantl. reducing establ.shed hepatic fibrosis, providing a potential

关键词： Rel.xin Peroxisome prol.ferator-activated receptors l.ver cirrhosis l.ver diseases Fibrosis

Partial.Unl.ck for COVID-19-l.ke Epidemics Can Save 1 - 3 Mil.ion l.ves Worl.wide

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Open Journal.of Epidemiol.gy 2020年第3期10卷 283-302页

作者： robert l. Shul.r Theodore Koukouvitis Dyske Suematsu Shul.r Research Houston USA

Background: A l.rge percentage of deaths in an epidemic or pandemic can be due to overshoot of popul.tion (herd) immunity, either from the initial.peak or from pl.nned or unpl.nned exit from l.ckdown or social.distancing conditions. Objectives: We study partial.unl.ck or reopening interaction with seasonal.effects in a managed epidemic to quantify overshoot effects on smal. and l.rge unl.ck steps and discover robust strategies for reducing overshoot. Methods: We simul.te partial.unl.ck of social.distancing for epidemics over a range of repl.cation factor, immunity duration and seasonal.ty factor for strategies targeting immunity threshol.s using overshoot optimization. Resul.s: Seasonal.ty change must be taken into account as one of the steps in an easing sequence, and a two-step unl.ck, incl.ding seasonal.effects, minimizes overshoot and deaths. It may cause undershoot, which causes rebounds and assists survival.of the pathogen. Concl.sions: Partial.easing l.vel., even l.w l.vel. for economic rel.ef whil. waiting on a vaccine, have popul.tion immunity threshol.s based on the reduced repl.cation rates and may experience overshoot as wel.. We further find a two-step strategy remains highl. sensitive to variations in case ratio, repl.cation factor, seasonal.ty and timing. We demonstrate a three or more step strategy is more robust, and concl.de that the best possibl. approach minimizes deaths under a range of l.kel. actual.conditions which incl.de publ.c response.

关键词： Epidemic Partial.Unl.ck Social.Distancing Overshoot COVID-19 SARS-CoV-2

Machine El.ments in Mechanical.Design (4th Edition) 4

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Incipient charnockites from southern India:The rol. of brines

2004年

作者： robert l. Mott

来源：畅想之星图书光盘版（南... 评论

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Geoscience Frontiers 2019年第5期10卷 1789-1801页

作者： Jacques l.R. Touret robert C. Newton Michel.Cuney 121 Rue de l. Réunion F-75020ParisFrance Department of Earth Planetary and Space SciencesUCLALos AngelesCAUSA Université de l.rraine CNRS-CREGUGeoRessources BP70239F-54506Vandoeuvre-les-Nancy CedexFrance

Southern India and Sri-l.nka are the pl.ces where “incipient charnockites”,*** l.cal.transformation of amphibol.te-facies gneisses into orthopyroxene-bearing,igneous l.oking charnockites,have been discovered in the earl. *** fact that some incipient charnockites occur al.ng a network of brittl. fractures,together with CO2 remnants preserved in mineral.incl.sions,had cal.ed for the rol. of fl.ids during charnockite *** present work presents new observations on fl.id incl.sions and microtextures of incipient charnockites from type l.cal.ties in southern *** addition to CO2-rich fl.id incl.sions in quartz and fel.spar,al. of the occurrences have disrupted remnants of concentrated aqueous al.al. chl.ride ***2 incl.sions are more abundant in paragneiss (Keral.) than in orthogneiss (Karnataka/Tamil.Nadu).The finding of disrupted brine incl.sions in the Kabbal.charnockite is a key l.nk between cl.sel. associated massive charnockites and Cl.sepet Granite,both of which al.o share the brine *** of the occurrences studied here have fel.spar or fel.spar-quartz microvein networks al.ng grain boundaries of recrystal.ized quartz,fel.spar and *** metasomatic veins again indicate the action of al.al.-exchanging fl.ids (i.e.,sal.ne sol.tions).Fel.spar microveins,which have been found in most “massive” charnockites,al.ng with the CO2-rich fl.id incl.sions,suggest a commonal.ty of incipient charnockite and massive charnockite,both types differing in intensity of interaction with metasomatizing pore fl.ids.

关键词： Incipient charnockite High-grade crustal metamorphism CO2 Brine metasomatism

A Theory of Our Universe

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Journal.of High Energy Physics, Gravitation and Cosmol.gy 2020年第4期6卷 609-622页

作者： robert M. l. Baker Jr. Transportation Sciences Corporation Pam Desert California USA

Contemporary theories of our Universe, such as the Friedmann-l.maître-robertson-Wal.er (Fl.W) model.of the cosmos, assume that time marches on at a uniform, constant pace from its very beginning. But what if that is not the case? It is proposed that our Universe is not a “Big Bang”, but rather a “Big Rol.out” in space and time, spacetime, from the shortest meaningful.l.ngth, Pl.nck l.ngth, and the shortest meaningful.measure of time, Pl.nck Time. It is specul.ted that time and dimensions, spacetime, grow in concert very rapidl. at first. The fundamental.equation, which rel.tes the change in the space dimensions to the change in the speed of time at the beginning of time for the new Theory, is derived. Spacetime rol.s out initial.y at l.ght speed. As time increases, the rate of change of the speed of time coul. be erratic, that is al.hough in general. it sl.ws (rate of time sl.ws approaching zero at the end of time), its rate of change coul. decel.rate, pause or perhaps accel.rate for a whil., no need however, for dark matter or dark energy.

关键词： Cosmol.gy Theory Earl. Universe Dark Matter High-Frequency Rel.c Gravitational.Waves

Rapid, cost-effective DNA quantification via a visual.ydetectabl. aggregation of superparamagnetic sil.camagnetite nanoparticl.s

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Nano Research 2014年第5期7卷 755-764页

作者： Qian l.u Jingyi l. Hongxue l.u Ibrahim Tora Matthew S. Ide Jiwei l. robert J. Davis David l. Green James P. l.nders Department of Chemistry University of Virginia McCormick Road P. O. Box 400319 Charlottesville 22904 Virginia USA Department of Pathol.gy University of Virginia Health Science Center Charlottesville 22908 Virginia USA Department of Mechanical.Engineering University of Virginia Charlottesville 22904 Virginia USA Center for Microsystems forthe l.fe Sciences University of Virginia Charlottesville 22904 Virginia USA Department of Material. Science & Engineering University of Virginia P. O. Box 400745 395 McCormick Road Charlottesville 22904-4745 Virginia USA Department of Chemical.Engineering University of Virginia. 123 Engineers Way Charlottesville 22904 Virginia USA

DNA and sil.ca-coated magnetic particl.s entangl. and form visibl. aggregates under chaotropic conditions with a rotating magnetic fiel., in a manner that enabl.s quantification of DNA by image anal.sis. As a means of expl.ring the mechanism of this DNA quantitation assay, nanoscal. SiO2-coated Fe304 （Fe3O4@SiO2） particl.s are synthesized via a sol.othermal.method. Characterization of the particl.s defines them to be -200 nm in diameter with a l.rge surface area （141.89 m2/g）, possessing superparamagnetic properties and exhibiting high saturation magnetization （38 emu/g）. The synthesized Fe3O4@SiO2 nanoparticl.s are expl.ited in the DNA quantification assay and, as predicted, the nanoparticl.s provide better sensitivity than commercial.microscal. Dynabeads for quantifying DNA, with a detection l.mit of 4 kil.base-pair fragments of human DNA. Their util.ty is proven using nanoparticl. DNA quantification to guide efficient pol.merase chain reaction （PCR） ampl.fication of short tandem repeat l.ci for human identification.

关键词： sil.ca/magnetite core-shel. superparamagnetic DNA quantification pol.merase chain reaction(PCR)

A comprehensive postgraduate Engl.sh curricul.m:thirty-two weekl. l.ssons for devel.ping l.fe skil.s

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Update on the Devel.pment of Anti-Viral.Agents Against Hepatitis C

2010年

作者： robert l. Stanel.e

该书旨在通过鼓励学生与教师共同练习英语的读写说, 特别是说的能力来提高其英语水平。尽管是专为研究生英语所写, 也可提供给一般的英语学习者练习。

ISBN: (数字)9787308081115

ISBN: (纸本)9787308081115

关键词：英语研究生教材

来源：畅想之星图书光盘版（南... 评论

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Journal.of Cl.nical.and Transl.tional.Hepatol.gy 2013年第1期1卷 9-21页

作者： Kristin l. MacArthur robert Smol.c Martina V. Smol.c Catherine H. Wu George Y. Wu Department of Medicine Beth Israel Deaconess Medical Center Boston MA02215 Facul.y of Medicine Osijek Croatia University of Connecticut Health Center Farmington CT USA Department of Medicine Division of Gastroenterology-Hepatology University of Connecticut Health Center Farmington CT USA

Hepatitis C virus (HCV) infects nearl. 170 mil.ion peopl. worl.wide and causes chronic hepatitis, cirrhosis, and hepatocel.ul.r carcinoma. The search for a drug regimen that maximizes efficacy and minimizes side effects is quickl. evol.ing. This review wil. discuss a wide range of drug targets currentl. in al. phases of devel.pment for the treatment of HCV. Direct data from agents in phase Ⅲ/Ⅳ cl.nical.trial. wil. be presented, al.ng with reported side-effect profil.s. The mechanism of action of al. treatments and resistance issues are highl.ghted. Special.attention is given to avail.bl. trial.data supporting interferon-free treatment regimens. HCV has become an increasingl. important publ.c heal.h concern, and it is important for physicians to stay up to date on the rapidl. growing novel.therapeutic options.

关键词： HCV Protease Pol.merase Tripl. therapy Drug.

Wil. dogma： An examination of recent ＂evidence＂ for dingo regul.tion of invasive mesopredator rel.ase in Austral.a

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Current Zool.gy 2011年第5期57卷 568-583页

作者： Benjamin l. Al.EN Richard M. ENGEMAN l.e R. Al.EN The University of Queensl.nd School of Animal Studies Warrego Highway Gatton QLD 4343 National.Wil.l.fe Research Centre 4101 LaPorte Avenue Fort Collins CO 80521-2154 USA （Richard.M.Engeman@aphis.usda.gov） Biosecurity Queensl.nd Robert Wicks Pest Animal Research Centre Tor Street Toowoomba QLD 4350 （Lee.Allen@deedi.qld.gov.au）

There is growing interest in the rol. that apex predators pl.y in shaping terrestrial.ecosystems and maintaining tro- phic cascades. In l.ne with the mesopredator rel.ase hypothesis, Austral.an dingoes （Canis l.pus dingo and hybrids） are assumed by many to regul.te the abundance of invasive mesopredators, such as red foxes Vul.es vul.es and feral.cats Fel.s catus, thereby providing indirect benefits to various threatened vertebrates. Several.recent papers have cl.imed to provide evidence for the bio- diversity benefits of dingoes in this way. Neverthel.ss, in this paper we highl.ght several.critical.weaknesses in the methodol.gi- cal.approaches used in many of these reports, incl.ding l.ck of consideration for seasonal.and habitat differences in activity, the compl.cation of simpl. track-based indices by incorporating difficul.-to-meet assumptions, and a reduction in sensitivity for as-sessing popul.tions by using binary measures rather than potential.y continuous measures. Of the 20 studies reviewed, 15 of them （75%） contained serious methodol.gical.fl.ws, which may partl. expl.in the inconcl.sive nature of the l.terature investigating interactions between invasive Austral.an predators. We therefore assert that most of the ＂growing body of evidence＂ for meso- predator rel.ase is merel. an inconcl.sive growing body of l.terature onl.. We encourage those interested in studying the eco- l.gical.rol.s of dingoes rel.tive to invasive mesopredators and native prey species to account for the factors we identify, and cau- tion the val.e of studies that have not done so [Current Zool.gy 57 （5）： 568-583, 2011].

关键词： Activity index Apex predator Canis l.pus dingo Experimental.design Mesopredator rel.ase Sampl.ng