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糖尿病相关的足病的定义和标准(2023年更新版)

感染、炎症、修复 2024年第1期25卷 80-85页

作者： jaap j.van Netten Sicco A.Bus jan Apelqvist Pam Chen Vivienne Chuter robert Fitridge Frances Game robert j.hinchliffe Peter A.Lazzarini joseph Mills Matilde Monteiro-Soares Edgar j.G.Peters Katherine M.Raspovic Eric Senneville Dane K.Wukich Nicolaas C.Schaper on behalf of the International Working Group on the Diabetic Foot 张会峰(译) 许樟荣(审校) Department of Rehabilitation Medicine Amsterdam UMCLocation University of AmsterdamAmsterdamthe Netherlands Amsterdam Movement Sciences Program RehabilitationAmsterdamthe Netherlands Department of Endocrinology University Hospital of MalmöMalmöSweden joondalup Health Campus Ramsay HealthcareSydneyAustralia Faculty of Health University of TasmaniaHobartAustralia School of Health Sciences Western Sydney UniversitySydneyAustralia Faculty of Health and Medical Sciences University of AdelaideAdelaideAustralia Vascular and Endovascular Service Royal Adelaide HospitalAdelaideAustralia Department of Diabetes and Endocrinology University Hospitals of Derby and Burton NHS Foundation TrustDerbyUK Department of Vascular Surgery University of BristolBristolUK School of Public Health and Social Work Queensland University of TechnologyBrisbaneAustralia Allied Health Research Collaborative The Prince Charles HospitalBrisbaneAustralia Michael E.DeBakey Department of Surgery Division of Vascular Surgery and Endovascular TherapyBaylor College of MedicineHoustonTexasUSA Portuguese Red Cross School of Health–Lisbon LisbonPortugal MEDCIDS–Departamento de Medicina da Comunidade Informação e Decisão em Saúde Faculty of Medicine of the University of PortoPortoPortugal RISE@CINTESIS Faculty of Medicine Oporto UniversityPortoPortugal Department of Internal Medicine Amsterdam UMCVrije Universiteit AmsterdamSection of Infectious DiseasesAmsterdamthe Netherlands Department of Orthopaedic Surgery University of Texas Southwestern Medical CenterDallasTexasUSA Department of Infectious Diseases Gustave Dron Hospital Tourcoing Univ-lilleTourcoingFrance Div.Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtThe Netherlands 不详河南省人民医院内分泌科河南郑州450003 战略支援部队特色医学中心北京100101

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本... 详细信息

糖尿病相关的足病管理涉及多个学科,通用的专业词汇对于各学科间准确沟通交流至关重要。国际糖尿病足工作组(IWGDF)对相关文献进行了系统综述,构成了制定IWGDF指南的基础,并且明确了糖尿病相关的足病的一系列定义、标准及名词解释。本文介绍2023年IWGDF对这些定义和标准的更新,并建议在临床实践和研究中一致使用,以利于世界各地不同学科人员针对糖尿病相关的足病的专业性交流。

关键词：定义糖尿病糖尿病相关的足病国际糖尿病足工作组

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国际糖尿病足工作组:指南的发展和方法学——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分

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感染．炎症．修复 2019年第4期20卷 238-243页

作者： Sicco A.Bus jaap j.van Netten jan Apelqvist robert j.hinchliffe Benjamin A.Lipsky Nicolaas C.Schaper 无严同(译) 许樟荣(审校) Amsterdam UMC Department of Rehabilitation MedicineAcademic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands School of Clinical Sciences Queensland University of TechnologyBrisbaneAustralia Diabetic foot clinic Department of SurgeryZiekenhuisgroep TwenteAlmelo and HengeloThe Netherlands Department of Endocrinology University Hospital of MalmoMalmoSweden Bristol Centre for Surgical Research University of BristolUK Department of Medicine University of WashingtonSeattleUSA Green Templeton College University of OxfordUK Div.Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtThe Netherlands International Working Group on the Diabetic Foot(IWGDF) 四川省成都市第三人民医院四川成都 610031 战略支援部队特色医学中心北京 100101

糖尿病足不仅给患者带来巨大的折磨,还给社会带来沉重的经济负担。本指南是以目标为导向,以循证医学为依据,且在全球得到合理实施。践行国际糖尿病足病指南有良好的经济-效益比。国际糖尿病足工作组(IWGDF)从1999年起开始发布和更新国... 详细信息

糖尿病足不仅给患者带来巨大的折磨,还给社会带来沉重的经济负担。本指南是以目标为导向,以循证医学为依据,且在全球得到合理实施。践行国际糖尿病足病指南有良好的经济-效益比。国际糖尿病足工作组(IWGDF)从1999年起开始发布和更新国际指南。IWGDF在着眼于相关临床问题和结局、严谨的文献系统评价、最大可能给予明确而清晰的推荐及其依据的基础上发布了2019年版指南更新。相关推荐均基于推荐评估和评价系统(GRADE)。本文阐述《IWGDF:糖尿病足防治国际指南(2019)》(简称《IWGDF指南》)的制定过程。《IWGDF指南》中指南共6个部分,分别由6个国际专家组编写,从预防、减压、周围动脉病变、感染、创面愈合干预及糖尿病足溃疡分级6个方面提出推荐意见。IWGDF编辑委员会分别从上述6个方面制定了一系列的实践指南,每条推荐意见均经过IWGDF编辑委员会成员和相关领域国际专家的深入评估。我们相信,只要相关专业人员遵循2019版IWGDF指南推荐,并将这些推荐与本地具体情况相结合,就能够进一步改善糖尿病足的预防和治疗水平,同时也会减轻糖尿病足给全世界患者和社会所带来的负担。

关键词：指南发展推荐评估和评价系统国际糖尿病足工作组系统评价循证糖尿病足足溃疡

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国际糖尿病足工作组:糖尿病足防治实践指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分

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感染．炎症．修复 2019年第3期20卷 131-139页

作者： Nicolaas C.Schaper jaap j.van Netten jan Apelqvist Sicco A.Bus robert j.hinchliffe Benjamin A.Lipsky 无周秋红许景灿(译) 许樟荣(审校) Div.Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtThe Netherlands Amsterdam UMC Department of Rehabilitation MedicineAcademic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands School of Clinical Sciences Queensland University of TechnologyBrisbaneAustralia Diabetic foot clinic Department of SurgeryZiekenhuisgroep TwenteAlmelo and HengeloThe Netherlands Department of Endocrinology University Hospital of MalmoSweden Bristol Centre for Surgical Research University of BristolBristolUK Department of Medicine University of WashingtonSeattleUSA Green Templeton College University of OxfordOxfordUK International Working Group on the Diabetic Foot(IWGDF) 中南大学湘雅医院湖南长沙410008 战略支援部队特色医学中心北京100101

糖尿病足给全球糖尿病患者以及卫生保健系统带来沉重的负担。国际糖尿病足工作组(The International Working Group on the Diabetic Foot,IWGDF)自1999年起一直致力于制定基于循证的糖尿病足防治指南。2019年,在文献系统综述以及全球... 详细信息

糖尿病足给全球糖尿病患者以及卫生保健系统带来沉重的负担。国际糖尿病足工作组(The International Working Group on the Diabetic Foot,IWGDF)自1999年起一直致力于制定基于循证的糖尿病足防治指南。2019年,在文献系统综述以及全球多学科领域专家推荐意见的基础上,对IWGDF的所有指南进行了更新。本实践指南在IWGDF指南第六部分的基础上阐述了糖尿病足的预防、分类和治疗的基本原则。同时,阐述了如何基于这些原则从组织层面成功地预防与治疗糖尿病足,并提供了用于辅助糖尿病足筛查的附录(见附录1和附表1)。本实践指南针对的是全球参与糖尿病患者医疗照护的医务人员。全球大量的研究证实,实施这些防治原则与降低糖尿病相关的下肢截肢发生率有关。我们希望这些更新的实践指南能继续作为有效参考文件以帮助卫生保健人员减轻全球糖尿病足的负担。

关键词：糖尿病足足溃疡指南贯彻预防治疗

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Necrotic enteritis and antibiotic-free production of broiler chickens:Challenges in testing and using alternative products

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Animal Nutrition 2024年第01期16卷 288-298页

作者： robert j.Moore School of Science RMIT University

The global trend towards raising broiler chickens without the use of in-feed antibiotics(IFAs) means that there is an ongoing need to develop alternative treatments capable of delivering the benefits that IFAs previously provided. IFAs supported the productivity performance of chickens and played a key role in maintaining their health. Necrotic enteritis(NE) is an important disease of broilers that affects health,productivity, and welfare, and was previously well controlled by IFAs. However, with the reduction in IFA use, NE is resurgent in some countries. Vaccines and various feed additives, including pre-, pro-, and postbiotics, phytobiotics, fatty acids, and phage therapies have been introduced as alternative methods of NE control. While some of these feed additives have specific activity against the NE pathogen, Clostridium perfringens, most have the more general goal of reinforcing gut health. Extensive reviews of the effects of many of these feed additives on gut health have been published recently. Hence, rather than cover previously well reviewed areas of research this review focuses on the challenges and pitfalls in undertaking experimental assessment of alternative NE treatments and translating laboratory research to real world commercial production settings. The review is based on the author's particular experience,reading, thoughts, and analysis of the available information and inevitably presents a particular understanding that is likely to be at odds with others thinking on these issues. It is put forward to stimulate thinking and discussion on the issues covered.

关键词： Necrotic enteritis

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国际糖尿病足工作组:糖尿病足溃疡周围动脉病变诊断、预后与管理指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分

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感染．炎症．修复 2019年第4期20卷 195-206页

作者： robert j.hinchliffe Rachael O.Forsythe jan Apelqvist Ed j.Boyko robert Fitridge joon Pio Hong Konstantinos Katsanos joseph L.Mills Sigrid Nikol jim Reekers Maarit Venermo R.Eugene Zierler Nicolaas C.Schaper 无许樟荣(译) 冉兴无(审校) Bristol Centre for Surgical Research University of BristolBristolUK British Heart Foundation/University of Edinburgh Centre for Cardiovascular Science University of EdinburghEdinburghScotlandUK Department of Endocrinology University Hospital of MalmoSweden Seattle Epidemiologic Research and Information Centre-Department of Veterans Affairs Puget Sound Health Care System and the University of Washington SeattleWashingtonUSA Vascular Surgery The University of AdelaideAdelaideSouth AustraliaAustralia Asan Medical Center University of Ulsan SeoulKorea Patras University Hospital School of Medicine RionPatrasGreece SALSA(Southern Arizona Limb Salvage Alliance) University of Arizona Health Sciences CenterTucsonArizonaUSA Asklepios Klinik *** HamburgGermany Department of Vascular Radiology Amsterdam Medical CentreThe Netherlands Helsinki University Hospital University of HelsinkiFinland Department of Surgery University of WashingtonSeattleWashingtonUSA Div.Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtThe Netherlands International Working Group on the Diabetic Foot(IWGDF) 战略支援部队特色医学中心北京100101 四川大学华西医院四川成都610041

1999年以来,国际糖尿病足工作组(IWGDF)已经多次发表循证医学基础上的糖尿病足预防与管理指南。该指南是有关糖尿病足溃疡合并周围动脉病变(PAD)患者的诊断、预后和管理指南,更新了以前IWGDF指南的内容。高达50%的糖尿病足溃疡患者同时... 详细信息

1999年以来,国际糖尿病足工作组(IWGDF)已经多次发表循证医学基础上的糖尿病足预防与管理指南。该指南是有关糖尿病足溃疡合并周围动脉病变(PAD)患者的诊断、预后和管理指南,更新了以前IWGDF指南的内容。高达50%的糖尿病足溃疡患者同时患有PAD,这种病变使得患者截肢和心血管病变的风险明显增加。这类患者的诊断、预后和治疗明显地不同于那些没有PAD的糖尿病患者,但仅有很少的关于这类患者的高质量的研究强调了这点。我们遵循GRADE方法来提出临床问题并以至少包括患者-干预-比较-结局(PICO)形式说明重要结局,进行了系统的医学科学文献评价,写出推荐意见及其合理性。这类推荐是建立在系统文献评价的循证医学基础上的,没有证据时则在权衡利弊和患者选择、便宜性和干预的费用等因素后,采用专家的观点。这里我们发布更新的2019年糖尿病足溃疡合并PAD患者的有关PAD诊断、预后和管理的指南,以及一些需要未来特别关注的研究课题。

关键词：糖尿病足足溃疡指南周围动脉病变外科诊断预后血管病变

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Glycolysis and glucose metabolism as a target for bioenergetic and neuronal protection in glaucoma

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Neural Regeneration Research 2024年第8期19卷 1637-1638页

作者： Pete A.Williams robert j.Casson Department of Clinical Neuroscience Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden Ophthalmic Research Laboratories Discipline of Ophthalmology and Visual SciencesUniversity of AdelaideAdelaideAustralia

Vision is arguably our most valued sense,yet approximately 340 million people globally suffer blindness or moderate visual impairment,highlighting the need to further develop and advance treatments for ophthalmic *** refers to a group of ocular disorders united by a clinically characteristic optic neuropathy with associated retinal ganglion cell loss.

关键词： metabolism glaucoma globally

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Does MgSO_(4) protect the preterm brain?Dissecting its role in the pathophysiology of hypoxic ischemic encephalopathy

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Neural Regeneration Research 2024年第9期19卷 1861-1862页

作者： robert Galinsky Laura Bennet Alistair j.Gunn The Ritchie Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Department of Obstetrics and Gynaecology Monash UniversityMelbourneVICAustralia Department of Physiology The University of AucklandAucklandNew Zealand

Mitigating preterm encephalopathy continues to be one of the greatest challenges in perinatal *** encephalopathy is associated with high mortality,serious morbidity,and significant socio-economic impacts on the individuals,their families,and public health sectors and welfare systems that last a *** cost of disability associated with preterm brain injury continues to *** of this injury,and disability,would significantly reduce this socioeconomic burden.

关键词： encephalopathy mortality hypoxic

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Extracellular vesicles and angiotensin-converting enzyme 2 in COVID-19 disease

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BIOCELL 2024年第1期48卷 1-8页

作者： YU LIU robert j.KASPER NATALIE j.S.CHOI Department of Family and Community Medicine Northwestern University Feinberg School of MedicineChicagoIllinois

Extracellular vesicles(EVs)are membranous vesicular structures released from almost all eukaryotic cell types under different physiological or pathological *** evidence demonstrates that EVs can serve as mediators of intercellular communication between donor and recipient cells or microorganism-infected and noninfected *** disease 2019(COVID-19)disease is caused by infection of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)of host cells in the respiratory system and various extra-pulmonary tissue/organs,resulting in complications of multiple organ *** the cell surface receptor,angiotensin-converting enzyme 2(ACE2)mediates cellular entry of SARS-CoV-2 into the host cells in patients with *** studies have found that ACE2 can be released with EVs,which have been shown to interfere with the entry of the virus into host cells and thus may be involved in COVID-19 *** addition,ACE2,neprilysin(NEP),and thimet oligopeptidase(TOP)are the key enzymes that regulate angiotensin metabolism by converting angiotensin II or angiotensin I to angiotensin 1-7,the latter of which has protective effects in counterbalancing the harmful effects of angiotensin II in COVID-19 *** review summarizes the recent research progress regarding EV-associated ACE2,NEP,and TOP and the perspectives of their potential involvement in the pathophysiology of COVID-19 disease.

关键词： Extracellular vesicles COVID-19 Angiotensin converting enzyme 2 Thimet oligopeptidase

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Bioactive compounds in Hericium erinaceus and their biological properties:a review

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Food Science and Human Wellness 2024年第4期13卷 1825-1844页

作者： Yue Qiu Genglan Lin Weiming Liu Fuming Zhang robert j.Linhardt Xingli Wang Anqiang Zhang College of Food Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Zhejiang Biosan Biotech Co. Ltd.Hangzhou 310052China Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA Departments of Chemistry and Chemical Biology and Biomedical Engineering Biological ScienceCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA

Hericium erinaceus is a nutritious edible and medicinal fungi,rich in a variety of functional active ingredients,with various physiological functions such as antioxidation,anticancer,and enhancing *** is also effective in protecting the digestive system and preventing neurodegenerative *** this review paper,we summarize the sources,structures and efficacies of the main active components in *** fruiting body,mycelium,and culture media,and update the latest research progress on their biological activities and the related molecular *** on this information,we provide detailed challenges in current research,industrialization and information on the active ingredients of *** for future studies and new applications of *** are proposed.

关键词： Hericium erinaceus Bioactive compounds Biological activities Antioxidation Neuroprotection Immunoregulation

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Layer chicken microbiota:a comprehensive analysis of spatial and temporal dynamics across all major gut sections

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journal of Animal Science and Biotechnology 2024年第3期15卷 1056-1070页

作者： Yadav Sharma Bajagai Thi Thu Hao Van Nitish joat Kapil Chousalkar robert j.Moore Dragana Stanley Institute for Future Farming Systems Central Queensland UniversityRockhamptonQLD 4701Australia School of Science RMIT UniversityBundooraVIC 3083Australia School of Animal and Veterinary Sciences The University of AdelaideRoseworthySouth Australia 5371Australia

Background The gut microbiota influences chicken health,welfare,and productivity.A diverse and balanced microbiota has been associated with improved growth,efficient feed utilisation,a well-developed immune system,disease resistance,and stress tolerance in *** studies on chicken gut microbiota have predominantly focused on broiler chickens and have usually been limited to one or two sections of the digestive system,under con-trolled research environments,and often sampled at a single time *** extend these studies,this investigation examined the microbiota of commercially raised layer chickens across all major gut sections of the digestive system and with regular sampling from rearing to the end of production at 80 *** aim was to build a detailed picture of microbiota development across the entire digestive system of layer chickens and study spatial and temporal *** The taxonomic composition of gut microbiota differed significantly between birds in the rearing and pro-duction stages,indicating a shift after laying *** microbiota compositions were observed between proven-triculus and gizzard,as well as between jejunum and ileum,likely due to their anatomical ***-lus dominated the upper gut in pullets and the lower gut in older *** oesophagus had a high proportion of Proteobacteria,including opportunistic pathogens such as *** abundance of Gallibacterium increased after peak production in multiple gut *** was enriched in the late-lay phase compared to younger birds in multiple gut *** influenced microbial richness and diversity in different *** upper gut showed decreased diversity over time,possibly influenced by dietary changes,while the lower gut,specifi-cally cecum and colon,displayed increased richness as birds ***,age-related changes were inconsist-ent across all organs,suggesting the influence of organ-specific factors in micro

关键词： Chicken microbiota Gut microbiota Layers Spatial variation Temporal variation

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