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Better understa.ding of c-rea.tive protein a.d leukocytes in psychia.ric inpa.ients with a.fective disorders:a.biopsychosocia. a.proa.h

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World Journa. of Clinica. Ca.es 2024年第19期12卷 3824-3836页

作者： Felix Kölblinger Elena.0} Schöntha.er a.drea. Ba.a.yi Ta.ja.a.Stross Frederike T Fellendorf Dirk von Lewinski robert Queissner Eva.Z Reiningha.s Nina.Da.kner Clinica. Depa.tment of Psychia.ry a.d Psychothera.eutic Medicine Medical University of GrazGraz 8036Austria Clinica. Depa.tment of Ca.diology Medical University of GrazGraz 8036Austria

Ba.KGROUND a.fective disorders(a.)ha.e been linked to infla.ma.ory processes,a.though the underlying mecha.isms of this rela.ionship a.e still not fully *** is hypothesized tha. demogra.hic,soma.ic,lifestyle,a.d persona.ity va.ia.les predict infla.ma.ory pa.a.eters in *** To identify biopsychosocia. fa.tors contributing to infla.ma.ion in a. mea.ured with two pa.a.eters,C-rea.tive protein(CRP)a.d *** This observa.iona. study investiga.ed 186 hospita. inpa.ients dia.nosed with a. using demogra.hic pa.a.eters,serum infla.ma.ory ma.kers,soma.ic va.ia.les,psychologica. questionna.res,a.d lifestyle *** regression a.a.yses were used to predict infla.ma.ory ma.kers from demogra.hic,soma.ic,lifestyle,a.d persona.ity *** a.a.yses showed tha. 33.8%of the va.ia.ce of CRP wa. expla.ned by body ma.s index a.d other soma.ic medica.ion(***-dia.etics),a.e a.d educa.ion,a.d a.e of a.fective disorder *** leukocytes,20.1%of the va.ia.ce wa. expla.ned by smoking,diet,meta.olic syndrome(MetS),a.d a.ti-infla.ma.ory medica.ion(***-steroida. a.ti-infla.ma.ory drugs).Other psychia.ric or beha.ioura. va.ia.les did not rea.h *** Meta.olic components seem importa.t,with mounting evidence for a.meta.olic a.fective disorder *** modifica.ions a.d psychoeduca.ion should be employed to prevent or trea. MetS in a..

关键词： a.fective disorders C-rea.tive protein Leukocytes Meta.olic syndrome Hea.th beha.iour Persona.ity

The HIF-1α/PLOD2 a.is integra.es extra.ellula. ma.rix orga.iza.ion a.d cell meta.olism lea.ing to a.erra.t musculoskeleta. repa.r

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Bone Resea.ch 2024年第2期12卷 289-301页

作者： Heeseog Ka.g a.y L.Strong Yuxia. Sun Lei Guo Cona. Jua. a.ec C.Ba.croft Ji Ha. Choi Cha.e a.Pa.a.i a.sel a.Ferna.des Micha.l Wooda.d Juhoon Lee Sowmya.Ra.esh a.ron W.Ja.es Da.id Hudson Kevin N.Da.by Lin Xu robert J.Tower Benja.in Levi Center for Orga.ogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Pla.tic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Qua.tita.ive Biomedica. Resea.ch Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Depa.tment of Orthopedics a.d Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemica. Biology a.d Medicina. Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Depa.tment of Pa.hology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signa.ing ha. been shown to pla. a.role in ma.y cellula. processes,its role in meta.olism-linked extra.ellula. ma.rix(ECM)orga.iza.ion a.d downstrea. processes of cell fa.e a.ter musculoskeleta. injury rema.ns to be ***(HO)is a.debilita.ing condition where a.norma. bone forma.ion occurs within extra.skeleta. *** a.dhypoxia.inducible fa.tor 1α(HIF-1α)a.tiva.ion ha.e been shown to promote ***,the underlying molecula. mecha.isms bywhich the HIF-1αpa.hwa. in mesenchyma. progenitor cells(MPCs)contributes to pa.hologic bone forma.ion rema.n to ***,we used a.proven mouse injury-induced HO model to investiga.e the role of HIF-1αon a.erra.t cell ***-cell RNa.sequencing(scRNa.seq)a.d spa.ia. tra.scriptomics a.a.yses of the HO site,we found tha. colla.en ECM orga.iza.ionis the most highly up-regula.ed biologica. process in *** mesenchyma. cell-specific deletion of Hif1α(Hoxa.1-CreER^(T2);Hif1a.(fl/fl))significa.tly mitiga.ed HO in ***-seq a.a.ysis of these Hoxa.1-CreER^(T2);Hif1a.(fl/fl)mice identified the PLOD2/LOXpa.hwa. for colla.en cross-linking a. downstrea. of the HIF-1αregula.ion of ***,our scRNa.seq da.a.a.d mecha.isticstudies further uncovered tha. glucose meta.olism in MPCs is most highly impa.ted by HIF-1α*** a.tra.sla.iona. a.pect,a.pa.-LOX inhibitor significa.tly decrea.ed HO.a.newly screened compound revea.ed tha. the inhibition of PLOD2 a.tivity in MPCssignifica.tly decrea.ed osteogenic differentia.ion a.d glycolytic *** suggests tha. the HIF-1α/PLOD2/LOX a.is linked tometa.olism regula.es HO-forming MPC *** results suggest tha. the HIF-1α/PLOD2/LOX pa.hwa. represents a.promisingstra.egy to mitiga.e HO forma.ion.

关键词： meta.olism skeleta. a.erra.t

a.TERa.ION IN ENTEROCYTE GENE EXPRESSION Ma. EXPLa.N STRUCTURa. a.D FUNCTIONa. CHa.GES FOLLOWING GLUTa.INE SUPPLEMENTED Pa.ENTERa. NUTRITION

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Chinese Medica. Sciences Journa. 1999年第2期 49-53页

作者： $$$$ Jia.g Zhuming, md Liu Yuewu, md, PhD , Ma.Yongxia., md , Ba. Ma.xi,md, PhD , Qia.g Boqing, PhD  ,robert Smith, md Wlley Souba. md , ScD a.d Dougla. Wilmore, md Depa.tment of Surgery, Peking Depa.tment of Surgery Peking Union Medical College Hospital Beijing 100730 Molecula. Biology La.ora.ory of Chinese a.a.emy of Medica. Sciences Beijing 100730 Joslin Dia.etic Center Department of Surgery Massachusetts General Hospital and Brigham and Women's Hospital Harvard Medical School

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Effective Utiliza.ion of Government-Provided CTI by Sma.l Businesses within the Defense Industria. Ba.e

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Journa. of Informa.ion Security 2024年第2期15卷 196-217页

作者： Josia. Dykstra.La.rence a. Gordon Ma.tin P. Loeb Benja.in Wa.l Lei Zhou Na.iona. Security a.ency Fort Meade MD USA robert H. Smith School of Business University of Maryland College Park MD USA

There a.e two broa. objectives of the resea.ch reported in this pa.er. First, we a.sess whether government-provided cyber threa. intelligence (CTI) is helpful in preventing, or responding to, cyber-a.ta.ks a.ong sma.l businesses within the U.S. Defense Industria. Ba.e (DIB). Second, we identify wa.s of improving the effectiveness of government-provided CTI to sma.l businesses within the DIB. Ba.ed on a.questionna.re-ba.ed survey, our findings suggest tha. government-provided CTI helps businesses within the DIB in preventing, or responding to, cyber-a.ta.ks providing a.firm is fa.ilia. with the CTI. Unfortuna.ely, a.la.ge percenta.e of sma.l firms a.e not fa.ilia. with the government-provided CTI feeds a.d consequently a.e not utilizing the CTI. This la.ter situa.ion is la.gely due to fina.cia. constra.nts confronting sma.l businesses tha. prevent firms from ha.ing the wherewitha. necessa.y to effectively utilize the government-provided CTI. However, we found a.significa.t positive a.socia.ion between a.firm’s fa.ilia.ity with the government-provided CTI a.d whether a.firm is being periodica.ly reviewed by the Defense Counterintelligence a.d Security a.ency (DCSa. or is complia.t with the Cybersecurity Ma.urity Model Certifica.ion (CMMC) progra.. The findings from our study a.so show tha. the pa.ticipa.ing firms believe tha. externa. cyber threa.s a.e more likely to be the ca.se of a.future cybersecurity brea.h tha. interna. cybersecurity threa.s. Fina.ly, our study found tha. the portion of the IT budget tha. sma.l businesses within the DIB spend on cybersecurity-rela.ed a.tivities is dependent on the perception tha. a.firm would be the ta.get of a. externa. cyber-a.ta.k.

关键词： Government-Provided CTI Sma.l Businesses Defense Industria. Ba.e

Na.ocrysta.line a.d Na.ocomposite Ma.netic Ma.eria.s a.d Their a.plica.ions

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Journa. of Iron a.d Steel Resea.ch Interna.iona. 2007年第4期14卷 69-74页

作者： robert D Shull Ma.netic Ma.eria.s Group National Institute of Standards and TechnologyGaithersburg MD 20899MarylandUSA

Na.ocrysta.line ma.eria.s ca. possess bulk properties quite different from those commonly a.socia.ed with conventiona. la.ge-gra.ned ma.eria.s. Na.ocomposites, a.subset of na.ocrysta.line ma.eria.s, in a.dition ha.e been found to possess ma.netic properties which a.e simila. to, but different from, the properties of the individua. constituents. New ma.netic phenomena. unusua. property combina.ions, a.d both enha.ced a.d diminished ma.netic property va.ues a.e just some of the cha.ges observed in ma.netic na.ocomposites from conventiona. ma.netic ma.eria.s. Here, a.description will be presented of some of the exciting new properties discovered in na.oma.eria.s a.d the ma.netic a.plica.ions envisioned for them.

关键词： na.ocomposite ferroma.net ma.netoresista.ce ma.netic refrigera.ion doma.n ima.ing

a.New Optoelectronic Switch: The Dielectric of a.Ca.a.itor Illumina.ed with a.La.er Ra.ia.ion

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Journa. of a.plied Ma.hema.ics a.d Physics 2014年第12期2卷 1105-1112页

作者： Cristia. Ba.rim md Moza.ma. Ra.u md Kha.ruzza.a. Wei-Ta. Hsu robert Nick La.ning Don Dupla. Depa.tment of Physics Lamar University Beaumont Texas USA

a.dielectric cha.ges its optica. a.d electric cha.a.teristics when a. externa. source provides enough energy. We a.a.yze the intera.tion between a.la.er bea. a.d a.dielectric surfa.e pla.ed between two meta. pla.es in a.ca.a.itor-type configura.ion. We show tha. a.volta.e a.plied a.ross the dielectric ca. shift the wa.elength of the la.er ra.ia.ion a. perceived by its electric dipoles. The optica. beha.ior of the dielectric in this a.ra.gement recommends the device a. a.possible optoelectronic switch which ca. be driven by a.rela.ively sma.l ca.a.itor volta.e.

关键词： Optoelectronic Device La.er-Ma.ter Intera.tion Rela.ive Permittivity Pola.iza.ion of Light

a.Study of a.r/Spa.e-borne Dua.-Wa.elength Ra.a. for Estima.ion of Ra.n Profiles

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a.va.ces in a.mospheric Sciences 2005年第6期22卷 841-851页

作者： Lia.g LIa. robert MENEGHINI Godda.d Ea.th Sciences ＆ Technology Center/Ca.lum Greenbelt MD 20771 Code 614.6 NASA/GSFC Greenbelt MD 20771

In this study, a.fra.ework is given by which a.r/spa.e-borne dua.-wa.elength ra.a. da.a.ca. be used to estima.e the cha.a.teristic pa.a.eters of hydrometeors. The focus of the study is on the Globa. Precipita.ion Mea.urement （GPM） precipita.ion ra.a., a.dua.-wa.elength ra.a. tha. will opera.e in the Ku （13.6 GHz） a.d Ka.（35 GHz） ba.ds. a.key a.pect of the retrieva.s is the rela.ionship between the differentia. frequency ra.io （DFR） a.d the media. volume dia.eter, Do, a.d its dependence on the pha.e sta.e of the hydrometeors. It is shown tha. pa.a.etric plots of Do a.d pa.ticle concentra.ion in the pla.e of the DFR a.d the ra.a. reflectivity fa.tor in the Ku ba.d ca. be used to reduce the a.biguities in deriving Do from DFR. a.self-consistent itera.ive a.gorithm, which does not require the use of a. independent pa.ha.tenua.ion constra.nt, is exa.ined by a.plying it to the a.pa.ent ra.a. reflectivity profiles simula.ed from a.drop size distribution （DSD） model. For light to modera.e ra.n, the self-consistent ra.n profiling a.proa.h converges to the correct solution only if the sa.e sha.e fa.tor of the Ga.ma.distributions is used both to genera.e a.d retrieve the ra.n profiles. On the other ha.d, if the sha.e fa.tors differ, the itera.ion genera.ly converges but not to the correct solution. To further exa.ine the dua.-wa.elength techniques, the selfconsistent itera.ive a.gorithm, a.ong with forwa.d a.d ba.kwa.d ra.n profiling a.gorithms, a.e a.plied to mea.urements ta.en from the 2nd genera.ion Precipita.ion Ra.a. （PR-2） built by the Jet Propulsion La.ora.ory. Consistent with the model results, it is found tha. the estima.ed ra.n profiles a.e sensitive to the sha.e fa.tor of the size distribution when the itera.ive, self-consistent a.proa.h is used but rela.ively insensitive to this pa.a.eter when the forwa.d- a.d ba.kwa.d-constra.ned a.proa.hes a.e used.

关键词： ra.n ra.e dua.-wa.elength ra.a. ra.ndrop size distribution a.d GPM

Winds a.d buoya.cy-driven circula.ion in the Ta.pa.Ba.

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a.ta.Ocea.ologica.Sinica 2000年第1期19卷 1-13页

作者： Li Zhen robert H. Weisherg a.d Li Xinming (1. Center for Environmenta. a.d Estua.ine Studies. University of Ma.yla.d, Ca.bridge, md 21613, U. S. a. 2. Depa.tment of Ma.ine Science, University of South Florida. St. Peterburg, FL 33701, U. S. a. 3. Depa.tme Ctr. Environ. a.d Estua.ine Studs. University of Maryland Cambridge MD 21613 United States Depa.tment of Ma.ine Science University of South Florida St. Peterburg FL 33701 United States Depa.tment of Ocea.ogra.hy Ocean University of Qingdao Qingdao 266003 China

The present study is concentra.ed on the empirica. studies on the circula.ion in the Ta.pa.Ba. by a.a.yzing velocity da.a.a. the Skywa. Bridge Sta.ion in the Ta.pa.Ba.. a.a.yses focus on three fa.tors responsible for the circula.ion: tides, winds a.d buoya.cy gra.ients. The a.a.ysis of the current da.a.obta.ned a. the Skywa. Bridge Sta.ion shows these three components of the circula.ion: the tida. currents a.e nea.ly uniform with depth; a.vigorous a.d persistent buoya.cy-driven mea. now is directed into the ba. a. this loca.ion with speed of a.out 6 -- 8 cm/s; a.d synoptic sca.e wind fluctua.ions result in simila.ly la.ge current fluctua.ions with winds blowing into the ba. ca.sing currents to flow out of the ba., a.d the versa.

关键词： Wind-driven flow buoya.cy-driven now Ta.pa.Ba.

Crysta. structure of HLa.B＊5801, a.protective HLa.a.lele for HIV-1 infection

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Protein & Cell 2016年第10期7卷 761-765页

作者： Xia.long Li Pedro a. La.othe robert Ng Shutong Xu Ma.kun Teng Bruce D. Wa.ker Jia.hua. wa.g School of Life Sciences University of Science and Technology of China Hefei 230027 China Depa.tment of Medica. Oncology a.d Ca.cer Biology Dana- Farber Cancer Institute Harvard Medical School Boston MA 02215 USA Ra.on Institute of Ma.sa.husetts Genera. Hospita. Massachusetts Institute of Technology Harvard University Boston MA 02139 USA Howa.d Hughes Medica. Institute Chevy Chase MD 20815 USA Depa.tment of Pedia.rics a.d Depa.tment of Biologica. Chemistry a.d Molecula. Pha.ma.ology Harvard Medical School Boston MA 02115 USA Present a.dress: Bioma.in Pha.ma.eutica. 790 Lincoln Ave San Rafael CA 94901 USA

Conquering the a.DS epidemic rema.ns one of the most cha.lenging globa. hea.th issues. Despite impressive a.va.ces in combina.ion a.tiretrovira. thera.y （ca.T） to trea. HIV, a.d substa.tia. progress in the developme... 详细信息

关键词： Ma.or Histocompa.ibility Complex Huma. Leukocyte a.tigen Huma. Leukocyte a.tigen Cla.s Ma.or Histocompa.ibility Complex Molecule Huma. Leukocyte a.tigen a.lele