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Storylines of family medicine Ⅻ:family medicine and the healthcare system

Family Medicine and Community Health 2024年第S3期12卷 109-118页

作者： William B Ventres Leslie A Stone Jeannette e South-Paul Kendall M Campbell Aerial R Petty Hima ekanadham Kurt C Stange Rebecca S etz William L Miller robert L Ferrer Marianna Kong Thomas Bodenheimer Roger Strasser Sharon C M Reece Joshua Freeman John M Westfall Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Meharry Medical College NashvilleTennesseeUSA Family Medicine University of Texas Medical Branch at Galveston School of MedicineGalvestonTexasUSA Family Medicine Residency Program New York-Presbyterian Columbia University Medical CenterNew YorkNew YorkUSA Center for Family and Community Medicine Columbia University Vagelos College of Physicians and SurgeonsNew YorkNew YorkUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA Family Medicine and Population Health Virginia Commonwealth University School of MedicineRichmondVirginiaUSA Family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA University of South Florida Morsani College of Medicine TampaFloridaUSA Family and Community Medicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA Family and Community Medicine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Northern Ontario School of Medicine University SudburyOntarioCanada Family Medicine Baylor Scott and White HealthTempleTexasUSA Family Medicine University of Kansas School of MedicineKansas CityKansasUSA DARTNet Insitute AuroraColoradoUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅻ:Family medicine and the future of the healthcare system’,authors address the following themes:‘Leadership in family medicine’,‘Becoming an academic family physician’,‘Advocare—our call to act’,‘The paradox of primary care and three simple rules’,‘The quadruple aim—melding the patient and the health system’,‘Fit-for-purpose medical workforce’,‘Universal healthcare—coverage for all’,‘The futures of family medicine’and‘The 100th essay.’May readers of these essays feel empowered to be part of family medicine’s exciting future.

关键词： system illustration family

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Interactions and effects on Cysteine Synthase Activity of Aminooxyacetate and Boc-Aminooxyacetate on the Bioherbicides <i>Colletotrichum truncatum</i>and <i>Alternaria cassia</i>and Their Weed Hosts

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American Journal of Plant Sciences 2021年第5期12卷 759-770页

作者： robert e. hoagland Kangetsu Hirase C. Douglas Boyette Crop Production Systems Research Unit USDA-ARS Stoneville USA Functional Chemicals Laboratory Mitsui Chemicals Chiba Japan Biological Control of Pests Research Unit USDA-ARS Stoneville USA

Aminooxyacetate (AOA) is a pyridoxal phosphate antagonist that inhibits various plant enzymes (including transaminases) which require pyridoxal phosphate as a cofactor and it exhibits phytotoxic and herbicidal properties. We examined AOA and its analog, N-t-butoxycarbonyl-AOA (Boc-AOA) for phytotoxicity, interactions with weed pathogens (bioherbicides), and effects on an important pyridoxal requiring enzyme, cysteine synthase (CS, E.C. 4.***.99.8). Studies were performed on two weeds, i.e., hemp sesbania [Sesbania exaltata (Raf.) Rybd. Ex A.W. Hill] and sicklepod (Senna obtusifolia), and two pathogens, (Colletotrichum truncatum and Alternaria cassiae), that are bioherbicidal agents against hemp sesbania and sicklepod, respectively. Pathogenicity tests, and assays for extractable, and in vitro CS activities were utilized. Phytotoxicity bioassays indicated that the bulky te="font-family:Verdana;">-butoxycarbonyl moiety substitution on the AOA molecule did not substantially hinder expression of biological activity of Boc-AOA in these tests. Generally, spray application of the compounds to young dark-grown seedlings caused little growth effects, but root-feeding of the chemicals reduced growth

关键词： Aminooxyacetate Bioherbicide Cysteine Synthase Pyridoxal Phosphate Antagonist Sicklepod Senna obtusifolia Hemp Sesbania Sesbania exaltata Transaminase

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Lipid nanoparticles deliver mRNA to the blood-brain barrier

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Nano Research 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avraham Shakked Randi Calkins Sebastian Rudden Camille Jones Jessie Doan Bora Jang elisa Schrader echeverri Ryan Zenhausern Liming Lian David Loughrey Hannah e.Peck Rachelle Wiese Dorothy Koveal Philip J.Santangelo James e.Dahlman George C.Woodruff School of Mechanical engineering Georgia Institute of TechnologyAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical engineering Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticles(LNPs)have delivered RNA to hepatocytes in patients after intravenous *** clinical data support efforts to design LNPs that transfect cells in the central nervous system(CNS).However,delivery to the CNS has been difficult,in large part because quantifying on-target delivery alongside common off-target cell types in adult mice remains *** we report methods to isolate different cell types from the CNS,and subsequently present mRNA delivery readouts using a liver-detargeted *** data suggest that LNPs without targeting ligands can transfect cerebral endothelial cells in mice after intravenous *** the difficulty of crossing the blood-brain barrier,they also underscore the value of quantifying delivery in the CNS with cell-type resolution instead of whole-tissue resolution.

关键词： lipid nanoparticle mRNA nanomedicine central nervous system blood-brain barrier

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A rare inter-haplotypic recombination at the S-locus contributed to the loss of self-incompatibility in trifoliate orange

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Plant Communications 2024年第9期5卷 16-20页

作者： Jianbing Hu Furong Guo Zezhen Du Peng Chen Chunmei Shi Jinzhi Zhang Junli Ye Xiuxin Deng robert M.Larkin Wenbiao Jiao Zongcheng Lin Maurice Bosch Lijun Chai National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070P.R.China Hubei Hongshan Laboratory Wuhan 430070P.R.China Horticultural Institute Hunan Academy of Agricultural SciencesChangsha 410125P.R.China Institute of Biological Environmental and Rural Sciences(IBERS)Aberystwyth UniversityAberystwyth SY233FLUK

Dear editor,In trans-specific S-haplotypes,crossover recombination at the S-locus,which controls self-incompatibility,has been thought to be highly ***,we discovered a previously unreported super S haplotype,derived from a rare inter-haplotypic recombination event,that contained two complete suites of functional S-RNase and SLF genes and could break the SI response in trifoliate orange through“self-recognition”within the same pollen.

关键词： orange crossover trifolia

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Hydrologic Time Scale:A Fundamental Stream Characteristic

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Journal of earth Science 2022年第5期33卷 1291-1297页

作者： robert e.Criss Department of earth and Planetary Sciences Washington University in St.LouisSt.LouisMO63130USA

A new,fundamental catchment attribute called the hydrologic time scaleτgoverns the rate of delivery of runoff to a particular site,and is equal to∫Qdt/∫|dQ|,where Q is discharge and t is *** value ofτfor any gauged site is readily calculated from tabulated discharge data by replacing the integrals with *** quantity,coupled with the square root of catchment area,√A,form a coordinate pair that embodies the characteristic time and length scales for any catchment,which govern its flow *** fitting constants used in several unit hydrograph models are simple multiples ofτ,so knowledge ofτallows rapid calibration of these models for the particular site,facilitating flow prediction from rainfall *** ofτreflect many different landscape attributes,but for multiple sub-basins in watersheds with homogeneous land use and lithologic conditions,they correlate linearly with √*** ratio √A/τprovides a characteristic velocity that is high for channelized,floodprone rivers,for flashy urban streams with high impervious cover,and for sites downstream of hydropower *** with low velocities are resistant to flooding,as their landscapes have a greater ability to delay the delivery of runoff by retention,detention,and infiltration into the groundwater system.

关键词： unit hydrograph time constant flash floods impervious cover urban streams flashiness hydrogeology

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Genomic Stability of Palmer amaranth Plants Derived by Macro-Vegetative Propagation

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American Journal of Plant Sciences 2014年第21期5卷 3302-3310页

作者： Neal Dwaine Teaster robert edward hoagland US Department of Agriculture-Agricultural Research Service Crop Production Systems Research Unit Stoneville USA

qPCR (quantitative polymerase chain reaction) and random amplified polymorphic DNA (RAPD) were utilized to investigate genetic stability of Palmer amaranth cloned plants over 10 generations. DNA from original parent Palmer amaranth plants (grown from seeds) was re-analyzed using qPCR, and confidence levels for determining ΔΔCt (threshold crossing) values were established. ANOVA was used to determine variation (margin of error) of these ΔΔCt values. This margin of error was applied to qPCR analysis of DNA from eight individual parent plants and their descendants (10th generation) so that possible differences in ePSPS (5-enolpyruvylshikimate-3-phosphate synthase) gene copy number could be ascertained. This method (and the associated error) indicated a lack of agreement in ΔΔCt values of DNA from plants of these two generations. qPCR analysis showed that in five out of eight clones, ePSPS gene copy number varied more than the calculated error (P = 0.05). A second technique to monitor genetic stability, RAPD was used to determine possible changes in genomic DNA due to extended cloning of these regenerated plants. RAPD analysis showed that four out of the eight clones differed when the profiles of the two generations were compared. Results show that qPCR and RAPD analysis point to the fact that several Palmer amaranth clones experienced changes in genome structure over 10 generations. Although the glyphosate resistance trait was retained, results suggest that during cloning studies, the genetic stability of macro-vegetatively propagated lines should be monitored.

关键词： Amaranthus palmeri ePSPS Gene Copy Number Glyphosate-Resistant Weeds Palmer amaranth Pigweed qPCR RAPD

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Kudzu Response to Foliar Applied Herbicides

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American Journal of Plant Sciences 2015年第7期6卷 856-863页

作者： Mark A. Weaver robert e. hoagland C. Douglas Boyette United States Department of Agriculture Agricultural Research Service Southern Weed Science Research Unit Stoneville USA

Chemical control is presently the most cost-effective means to control kudzu;however, some of the herbicides labeled for kudzu control have substantial non-target toxicity, poor selectivity, high cost, long soil persistence, high soil mobility and/or high use rates. The present study evaluated other herbicides for efficacy in suppressing aboveground kudzu biomass in replicated field trials at three sites over two years. A single application of aminopyralid, triclopyr or metsulfuron resulted in at least 90% kudzu suppression in the following season at two locations. After a second year of treatment those herbicides and fluroxypyr produced at least 90% kudzu suppression, and 100% kudzu control was reached on some test plots. Glyphosate, glufosinate and mesotrione were less effective in controlling kudzu. Given the rapid growth potential of kudzu, complete eradication should be pursued. None of the herbicides evaluated in the present study could reliably achieve eradication of mature kudzu with two applications, so additional control efforts would be required.

关键词： Herbicidal Control Invasive Species Pueraria montana var. lobata Weed Control

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Risk stratification prior to major hepatectomy

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 898-900页

作者： Daniel C.Osei-Bordom robert P.Sutcliffe Liver Unit Queen Elizabeth HospitalBirminghamUK

Post-hepatectomy liver failure(PHLF)is an uncommon but potentially life-threatening complication after major hepatic *** mild cases of PHLF are self-limiting,clinically significant PHLF[International Study Group of Liver Surgery(ISGLS)grades B or C]may be associated with multi-organ failure and sepsis and carries a high *** is no proven treatment for PHLF,and its management is essentially supportive,including timely diagnosis and treatment of septic or vascular complications and organ support for associated renal,respiratory or cardiovascular *** the absence of any evidence-based interventions that may improve PHLF outcomes,liver surgeons have focussed on preoperative risk assessment and development of risk mitigation *** dominant risk factors for PHLF are extent of resection and background liver function,which have been incorporated into several risk scores(1,2).Patients who undergo resection or four or more segments(i.e.,right hemihepatectomy or extended left/right hemihepatectomy)or those with underlying liver disease(e.g.,fibrosis,cirrhosis or chemotherapy-associated liver disease)are at particular risk of PHLF.

关键词： Prediction models liver resections post-hepatectomy liver failure(PHLF)

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efficacy Improvement of a Bioherbicidal Fungus Using a Formulation-Based Approach

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American Journal of Plant Sciences 2016年第16期7卷 2349-2358页

作者： Clyde D. Boyette robert e. hoagland Kenneth C. Stetina USDA-ARS Biological Control of Pests Research Unit Stoneville MS USA USDA-ARS Crop Production Systems Research Unit Stoneville MS USA

Greenhouse experiments were conducted to determine the effects of an invert (water-in-oil) emulsion (Ie) on dew period duration and dew delay of Colletotrichum coccodes for biocontrol of the problematic weed, eastern black nightshade (Solanum ptycanthum). Dew periods of 4, 8, or 12 h provided 10%, 25%, and 40% control of eastern black nightshade plants, respectively, when C. coccodes (Strain NRRL 15,547) spores were applied in water + Tween 80 surfactant 12 days after inoculation, but a minimum of 16 h of dew was required to achieve ~95% plant mortality. In contrast, at these same intervals of dew, 95%, 100% and 100% mortality occurred, respectively, when fungal spores were formulated in the Ie. even in the absence of dew, 60% mortality and 70% dry weight reductions of plants was achieved with the fungus/Ie formulation Delaying dew by 2 h after inoculation did not significantly reduce weed control or plant dry weight reductions when plants were inoculated with the fungus either in the aqueous or in the Ie formulation. However, when dew was delayed for 4, 8, or 12 h, only 60%, 50%, and 25% mortality, respectively, of plants receiving the aqueous spore treatment occurred. In contrast, 95%, 90%, and 90% weed mortality occurred after the same dew delays of plants receiving the fungus/ Ie treatments. These results demonstrate that formulating C. coccodes spores in an invert emulsion greatly improves the bioherbicidal potential of this fungus. Furthermore, results suggest that this formulation may render pathogens previously rejected for development as bioherbicides due to restrictive dew requirements more efficacious for use in controlling their target weeds.

关键词： Colletotrichum coccodes Solanum ptycanthum Bioherbicide Invert emulsion Formulation

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应用双层探测器光谱CT及三物质分离算法进行肝脏脂肪定量

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国际医学放射学杂志 2024年第4期 501-502页

作者： e.Demondion O.ernst A.Louvet B.robert G.Kafri e.Langzam 常雪

摘要目的以MRI作为参考标准，在大型病人队列中评估通过双层探测器光谱CT(DL-CT)的三物质分离算法测量肝脏脂肪含量的可行性。方法回顾性纳入104例病人，每

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