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An Integrative Collaborative Project Approach to Climate-Change Resilience and Urban/Regional Sustainability for the Mexico-Lerma-Cutzamala Hydrological Region

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Open Journal of Civil Engineering 2022年第1期12卷 101-138页

作者： Timothy J. Downs Morgan Ruelle Nigel Brissett Ravi Hanumantha Marisa Mazari-Hiriart rob krueger Edward R. Carr International Development Community & Environment (IDCE) Department Clark University Worcester USA Institute of Ecology National Autonomous University of Mexico (UNAM) Ciudad Universitaria Coyoacán Mexico Environmental & Sustainability Studies Worcester Polytechnic Institute (WPI) Worcester USA Humanitarian Response and Development Lab (HURDL) George Perkins Marsh Institute Clark University Worcester USA

In a rapidly urbanizing world, the social, economic, and ecological complexities of cities require conceptual and operational innovations to enhance climate resilience and sustainability. We describe our Integrative Collaborative Project (ICP) approach to co-create climate resilience in the Mexico-Lerma-Cutzamala Hydrological Region (MLCHR). In recent years, it has suffered from frequent natural disasters, and under climate change scenarios, the intensity and frequency of extreme events, including severe floods, droughts, heat waves and landslides are expected to increase. ICPs are framed as socio-technical capacity building enterprises, with networks operating at multiple scales. The approach differs from other integrative efforts, which tend to be top-down with scant civil society co-ownership, and focus on limited aspects like indicators/assessment, or institutional capacity building. We reimagine all operational stages, from creative thinking, through ethos and concept, assessment, planning, project design, implementation and management, and monitoring and evaluation. The design of ICPs is informed by six integrative domains: 1) project ethos, concept, and framing;2) sectors, topics, and issues;3) spatial and temporal scales;4) stakeholder interests, relationships and capacities;5) knowledge types, models and methods;and 6) socio-technical capacities and networks. Empirically, the approach is based on participatory development practices, pilot project work tackling sustainable water and sanitation in Mexico, and a synthesis of rich experiential knowledge spanning 20 years. The theoretical basis considers a pragmatic knowledge frame, socio-technical transitions literature, and education for social transformation. We describe forward-looking operational details of the Pilot ICP for the Mexico-Lerma-Cutzamala Hydrological Region, with our three-university partnership as catalyst, and a new breed of socio-technical enterprise organization as a key partner, engaging

关键词： Climate-Change Resilience Sustainable Development Urban Regional Mexico City

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Genomic Mutations Within the Host Microbiome: Adaptive Evolution or Purifying Selection

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Engineering 2023年第1期20卷 96-102页

作者： Jiachao Zhang rob Knight School of Food Science and Engineering Hainan UniversityHaikou 570228China Department of Pediatrics University of California San DiegoLa JollaCA 92093USA Center for Microbiome Innovation Jacobs School of EngineeringUniversity of California San DiegoLa JollaCA 92093USA Department of Bioengineering University of California San DiegoLa JollaCA 92093USA Department of Computer Science and Engineering University of California San DiegoLa JollaCA 92093USA

Next-generation sequencing technology has transformed our ability to assess the taxonomic composition functions of host-associated microbiota and microbiomes. More human microbiome research projects—particularly those that explore genomic mutations within the microbiome—will be launched in the next decade. This review focuses on the coevolution of microbes within a microbiome, which shapes strain-level diversity both within and between host species. We also explore the correlation between microbial genomic mutations and common metabolic diseases, and the adaptive evolution of pathogens and probiotics during invasion and colonization. Finally, we discuss advances in methods and algorithms for annotating and analyzing microbial genomic mutations.

关键词： Gut microbiota Genomic mutations Adaptive evolution Purifying selection Single-nucleoti de variants

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Interference Suppression and Jitter Elimination Ability-Based Adaption Tracking Guidance for robotic Fishes

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 126-137页

作者： Dongfang Li Jie Huang rob Law Xin Xu Limin Zhu Edmond Q.Wu IEEE the School of Electrical Engineering and Automation Fuzhou University the Key Laboratory of System Control and Information Processing Ministry of Education the School of Electrical Engineering and Automation Fuzhou University 5G+Industrial Internet Institute Fuzhou University the University of Macau the College of Mechatronics and Automation National University of Defense Technology the School of Mechanical Engineering Shanghai Jiao Tong University the Department of Computer Science and Engineering Shanghai Jiao Tong University

This work presents an adaptive tracking guidance method for robotic fishes. The scheme enables robots to suppress external interference and eliminate motion jitter. An adaptive integral surge line-of-sight guidance rule is designed to eliminate dynamics interference and sideslip issues. Limited-time yaw and surge speed observers are reported to fit disturbance variables in the model. The approximation values can compensate for the system's control input and improve the robots' tracking ***, this work develops a terminal sliding mode controller and third-order differential processor to determine the rotational torque and reduce the robots' run jitter. Then, Lyapunov's theory proves the uniform ultimate boundedness of the proposed method. Simulation and physical experiments confirm that the technology improves the tracking error convergence speed and stability of robotic fishes.

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Poverty reduction through the development of inclusive food value chains

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Journal of Integrative Agriculture 2021年第4期20卷 964-978页

作者： rob VOS Andrea CATTANEO International Food Policy Research Institute(IFPRI) WashingtonD.C.20007USA Food and Agriculture Organization of the United Nations(FAO) Rome 00153Italy

Propelled by urbanization,rising incomes,and changing diets,food markets have been expanding in Africa and South Asia,creating the vast potential for job and income opportunities along food supply chains and,hence,for poverty *** novel coronavirus(COVID-19)that spread to a pandemic in early 2020 provokes enormous setbacks to this ***,however,should provide lessons regarding the importance of resilient and inclusive food *** responses to COVID-19 should consider interventions towards that end and leverage the opportunities provided by food markets growth as economies recover from the present economic *** paper assesses options of how this could be done by facilitating the better functioning and interconnectedness of the many small and medium-sized enterprises that are proliferating along the"hidden middle"of food value chains in storage,logistics,transportation,and wholesale and retail *** also explores how policies can help smallholder farmers connect to this"hidden middle"in more gainful ways and help them climb out of poverty as well.

关键词： poverty food security and hunger food supply chains South Asia sub-Saharan Africa

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Ecological networks and greenways in Europe: reasoning and concepts

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Journal of Environmental Sciences 2003年第2期15卷 173-181页

作者： rob H.G. Jongman Wageningen UR Expertise Group on Environmental Sciences

The paper gives an overview of approaches towards ecological networks throughout Europe. It does not intend to present a complete picture, but to highlight common developments within countries and regions and show common principles and differences between countries and regions that have to be taken into account when developing a joint European initiative. Countries or regions that have not been included can be active in the same way, but information was not accessible to the authors for different reasons. This overview shows the comparable trends in decline of landscapes and the diversity in approaches to biodiversity conservation and nature conservation planning. Understanding the differences and common issues are of utmost importance to generalise common principles and to understand the way neighbours and other European partners approach problems.

关键词： ecological networks greenways biodiversity land use change homogenisation fragmentation

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Oxygen and Iron-and Steelmaking:Best Friends and Arch-Enemies

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Journal of Iron and Steel Research International 2011年第S2期18卷 16-27页

作者： BOOM rob Materials innovation institute M2i Department of Materials Science and EngineeringDelft University of TechnologyDelftThe Netherlands

Ironmaking is the art of removal the arch-enemy oxygen from iron ore by means of carbon reduction and thus producing hot *** is the art of removing carbon from liquid hot metal by means of best friend pure oxygen,followed by alloying and deoxidation-where oxygen returns to be the ***-metallic particles in steel such as oxides can have a detrimental effect on the steel product properties in terms of formability,strength and surface *** overview of the battle for clean steel production is given based on the experience of the author in industry as well as university research.

关键词： ironmaking carbon-oxygen equilibrium steelmaking deoxidation tundish metallurgy casting clean steel

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Mechanical circulatory support in cardiogenic shock and post-myocardial infarction mechanical complications

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Journal of Geriatric Cardiology 2022年第2期19卷 130-136页

作者： Daniel rob Jan Bělohlávek nd Department of Medicine-Department of Cardiovascular Medicine First Faculty of MedicineCharles University and General University HospitalPragueCzech Republic

Despite advanced therapies,the mortality of patients with myocardial infarction(MI)complicated by cardiogenic shock(CS)remains around 50%.Mechanical complications of MI are rare nowadays but associated with high mortality in patients who present with *** treatment strategies and mechanical circulatory support(MCS)devices have been increasingly used to improve the grim prognosis of refractory *** article discusses current evidence regarding the use of MCS in MI complicated by CS,ventricular septal rupture,free wall rupture and acute mitral *** selection should be tailored according to the cause and severity of *** MCS initiation and multidisciplinary team cooperation is mandatory for good *** associated bleeding remains a major complication and an obstacle to better *** prospective randomized trials will improve current knowledge regarding MCS indications,timing,and patient selection in the coming years.

关键词： mortality infarction rupture

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RNA interference with DNA polymerase and synthesis

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Science China Chemistry 2014年第7期57卷 954-960页

作者： ABDUR rob GAN JianHua HUANG Zhen Department of Chemistry Georgia State University

RNA can catalyze and participate in many chemical and biochemical reactions. Non-coding RNAs （ncRNA） can regulate cellular transcription and translation reactions. We have demonstrated biochemically that RNA can also interfere with DNA polymerization via transforming DNA polymerase into deoxyribonucleoside triphosphate diphosphatase （dNTP-DPase）. RNA, even with six nucleotides, can transform DNA polymerase into dNTP-DPase, and the dNTP-DPase activity causes the hydrolysis of dNTPs into dNMPs and pyrophosphate. Moreover, we have found that DNA polymerases from several families generally have similar RNA-dependent dNTP-DPase activity. We have also observed that in the presence of RNA, when the dNTP concentrations are relatively low, and that the dNTP-DPase activity can deplete dNTPs and interfere with DNA polymerization Thus, we have discovered for the first time that in the presence of RNA, DNA polymerase can behave as a diphosphatase and inhibit DNA synthesis when dNTP quantity is low. These in vitro observations might imply a plausible role of RNA in vivo, such as suppressing DNA synthesis during a resting phase （Go） of the cell cycle, when RNA quantity is high and dNTP quantity is low.

关键词： RNA interference alternative activity of DNA polymerase non-coding RNA deoxyribonucleoside triphosphatediphosphatase DNA polymerization and synthesis

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Synthetic lethal approaches to target cancers with loss of PTEN function

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Genes & Diseases 2023年第6期10卷 2511-2527页

作者： Ayse Ertay rob MEwing Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK

Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3 ) into phosphatidylinositol 4,5-bisphosphate (PIP2 ). The function of PTEN is regulated by different mechanisms and inactive PTEN results in aggressive tumor phenotype and tumorigenesis. Identifying targeted therapies for inactive tumor suppressor genes such as PTEN has been challenging as it is difficult to restore the tumor suppressor functions. Therefore, focusing on the downstream signaling pathways to discover a targeted therapy for inactive tumor suppressor genes has highlighted the importance of synthetic lethality studies. This review focused on the potential synthetic lethality genes discovered in PTEN-inactive cancer types. These discovered genes could be potential targeted therapies for PTEN-inactive cancer types and may improve the treatment response rates for aggressive types of cancer.

关键词： Cancer PTEN Synthetic lethality Tumour suppressor gene WDHD1

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On ethics,the pursuit of knowledge,truth and status in the hallowed halls of academe

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Integrative Zoology 2013年第3期8卷 223-231页

作者： John S.BUCKERIDGE rob WATTS Earth&Oceanic Systems Group RMIT UniversityMelbourneVictoriaAustralia

Advancement in academe is largely on the basis of research output;that is,refereed journal *** paper first explores pressures on academics,especially emerging researchers,when English is not a first *** assess why,when faculty members rush to improve their station that they may elect to circumvent ethical protocols to accelerate their promotion and *** resulting unethical behavior includes plagiarism and forms of duplication such as *** is then given to the wider implications of both plagiarism and the theft of intellectual property,and the role these have played in the development of individuals,the university and society.

关键词： ethics plagiarism promotion publication social evolution

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