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Vitreous microparticles contain apoptotic signals suggesting a diabetic vitreopathy

International Journal of Ophthalmology(English edition) 2022年第1期15卷 89-97页

作者： Harris Sultan rithwick rajagopal Prabakar Kumar Rao Kisha Deslee Piggott Michael A Paley Lynn Marisa Hassman Albert S.Li Brigid Marshall Rajendra Shridhar Apte John Hardesty Department of Ophthalmology Washington UniversitySt.LouisMO 63110USA Department of Medicine Division of RheumatologyWashington UniversitySt.LouisMO 63110USA Department of Ophthalmology and Visual Sciences University of Maryland School of MedicineBaltimoreMD 21201USA

AIM:To evaluate differences in microparticle profiles in vitreous samples between diabetic and non-diabetic eyes undergoing ***:Un-masked cross-sectional series of 34 eyes undergoing *** specimens were collected and processed to evaluate for membrane integrity(DAPI),apoptosis(Annexin-V),and endothelial-cell origin(V-Cadherin).A BD LSR II flow cytometer was used for analysis and standardized sub-micron-sized beads were used for size ***:Thirty-four specimens underwent *** levels of Annexin-V were found on microparticles from specimens in which blood had entered the vitreous(n=12)compared to those without blood(n=22;52.3%±30.7%vs 19.6%±27.2%,P=0.002).Patients with diabetes having surgery with hemorrhage(n=7)had greater expression of Annexin-V than those without hemorrhage(n=8;62.1%±31.7%vs 18.9%±20.9%,P=0.009).However,in patients with non-diabetic vitreous hemorrhage,the level of Annexin-V expression was not significantly different compared to other disease processes(38.6%±25.7%,n=5 vs 20.0%±30.9%,n=14,P=0.087).CONCLUSION:Increased expression of the apoptotic marker,Annexin-V is detected on vitreous microparticles in diabetes-related vitreous *** evaluating vitreous hemorrhage in patients without diabetes,the apoptotic signal is not significantly *** in patients with diabetes,and improvement in visual outcomes,may be related to the removal of a serumderived,pro-apoptotic *** investigation is warranted in order to identify the molecular characteristics of microparticles that regulate disease.

关键词： cell-derived microparticles vitrectomy vitreous diabetes mellitus apoptosis

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