检索结果-南通市图书馆

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： rita O.Teodoro mafalda Ribeiro Ramos Lara Carvalho iNOVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Predictive-Analysis-based machine Learning model for Fraud Detection with Boosting Classifiers

在线全文

学校读者我要写书评

暂无评论

Computer Systems Science & Engineering 2023年第4期45卷 231-245页

作者： m.Valavan S.rita Department of Statistics Periyar UniversitySalemTamilnaduIndia

Fraud detection for credit/debit card,loan defaulters and similar types is achievable with the assistance of machine Learning(mL)algorithms as they are well capable of learning from previous fraud trends or historical data and spot them in current or future *** cases are scant in the comparison of non-fraudulent observations,almost in all the *** such cases detecting fraudulent transaction are quite *** most effective way to prevent loan default is to identify non-performing loans as soon as *** learning algorithms are coming into sight as adept at handling such data with enough computing *** this paper,the rendering of different machine learning algorithms such as Decision Tree,Random Forest,linear regression,and Gradient Boosting method are compared for detection and prediction of fraud cases using loan fraudulent *** model accuracy metric have been performed with confusion matrix and calculation of accuracy,precision,recall and F-1 score along with Receiver Operating Characteristic(ROC)curves.

关键词： Random forest decision tree logistic regression machine Learning gradient boosting method confusion matrix

mULTIOBJECTIVE ROUTING IN mULTISERVICE mPLS NETWORKS WITH TRAFFIC SPLITTING-A NETWORK FLOW APPROACH

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2015年第4期24卷 389-432页

作者： rita Girao-Silva Jose Craveirinha Joao Climaco m.Eugenia Captivo Department of Electrical and Computer Engineering University of Coimbra Polo ⅡPinhal de Marrocos P-3030-290 Coimbra Portugal Institute of Computers and Systems Engineering of Coimbra(INESC-Coimbra)R.Antero de Quental 199 P-3000-033 Coimbra Portugal Centro de Investigacao Operacional Faculdade de CienciasUniversidade de Lisboa Campo GrandeBloco C6Piso 4 P-1749-016 Lisboa Portugal

A multiobjective routing model for multiprotocol Label Switching networks with multiple service types and traffic splitting is presented in this paper. The routing problem is formulated as a multiobjective mixed-integer program, where the considered objectives are the minimization of the bandwidth routing cost and the minimization of the load cost in the network links with a constraint on the maximal splitting of traffic trunks. Two different exact methods are developed for solving the formulated problem, one based on the classical constraint method and another based on a modified constraint method. A very extensive experimental study, with results on network performance measures in various reference test networks and in randomly generated networks, is also presented and its results are discussed.

关键词： Routing models multiobjective optimization telecommunication networks network flowapproach traffic splitting

Analysis of genetic relationship among Arbutus unedo L. genotypes using RAPD and SSR markers

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2013年第2期24卷 227-236页

作者： Filomena Gomes rita Costa maria m. Ribeiro Elisa Figueiredo Jorge m. Canhoto CERNAS Departamento Florestal Escola Superior Agrária Coimbra INRB Instituto Nacional de Recursos Biológicos Departamento de Recursos Naturais e Desenvolvimento Sustentável Escola Superior Agrária Centre of Functional Ecology Department of Life Sciences University of Coimbra

The strawberry tree （Arbutus unedo L.） is an underutilized, drought tolerant, fire resistant species with a south western distribution in Europe, and with ecological and putative socio-economical impact in Portugal and mediterranean countries. Our aim was to develop an appropriate set of molecular markers to enable genetic diversity to be assessed and to fingerprint Arbutus unedo genotypes for breeding and conservation purposes in Portugal. Twenty-seven trees from a broad geographic range were screened with 20 random amplified polymorphic DNA （RAPD primers） and 11 microsatellite markers （SSR）. The RAPDs generated 124 bands, 57.3% of which were polymorphic, with an expected heterozygosity of 27%. We cross-amplified 11 SSR primers developed for Vaccinium spp., and 5 were found to be polymorphic in A. unedo, with 75% of expected heterozygosity, a number of alleles of 11.6, a null allele frequency of 7.6% and a polymorphic information content of 71%. Although the SSRs were more polymorphic and informative than the RAPDs, both markers displayed high genetic variability with the gathered data. No geographic pattern was observed in the genetic variation distribution based on both marker systems, and the lack of correlation between genetic and geographical matrices was confirmed by mantel tests. Likely, no correlation was found between pairwise SSR and RAPD band-sharing matrices. These results and their implications on A. unedo breeding and conservation programs are discussed.

关键词： Ericaceae fingerprinting geographic pattern molecular markers strawberry tree.

Efficacy assessment of peracetic acid in the removal of synthetic 17α-ethinyl estradiol contraceptive hormone in wastewater

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2020年第3期32卷 1-8页

作者： rita maurício Flávia Semedo rita Dias Joao P.Noronha Leonor Amaral michiel A.Daam Antonio P.mano mário S.Diniz CENSE Center for Environmental and Sustainability ResearchNOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal Department of Environmental Sciences and Engineering NOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal REQUImTE/FCT NOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal Biotox Lab UCIBIODepartment of ChemistryNOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal

Increasing concerns have been raised on endocrine disrupting chemicals like the sex hormone 17 a-ethinylestradiol(EE2),the more since traditional wastewater(WW) treatments appear to be ineffective for their *** efficacy of the relatively novel disinfectant peracetic acid(PAA) in EE2 removal was evaluated,as well as its potential effects on WW quality *** treatments tested for EE2 removal were also evaluated in terms of toxicity,through the determination of biochemical responses(antioxidant enzymes,lipid peroxidation and vitellogenin induction) using zebrafish(Danio rerio) as a biological *** contact times less than 20 min appeared insufficient regardless of the PAA dose tested,but a 100% EE2 removal was attained at a PAA concentration of 15 mg/L with a contact time of20 *** suspended solids,chemical oxygen demand and pH in PAA treatments remained well within levels set in European legislation for WW ***2 induced signific ant increased vitellogenin(VTG) levels in both female and male fish,indic ating increased estrogenic activity,especially in males suggesting an endocrine disruption *** the addition of PAA(15 mg/L),however,VTG levels in both sexes returned to control *** this PAA treatment showed increased levels of the antioxidant enzyme catalase,the lipid peroxidation levels were similar or even lower than in *** the results suggest that the use of PAA appears a promising way forward as a less toxic alternative to chlorine disinfection with high efficiency in the removal of EDC like EE2.

关键词： EE2 Wastewater treatment Zebrafish Biomarkers

Exploring the potential for an evolutionarily conserved role of the taste 1 receptor gene family in gut sensing mechanisms of fish

在线全文

学校读者我要写书评

暂无评论

Animal Nutrition 2022年第4期11卷 293-308页

作者： Anna rita Angotzi Esther Leal Sara Puchol José m. Cerdá-Reverter Sofia morais Department of Fish Physiology and Biotechnology Instituto de Acuicultura de Torre de la SalIATS-CSICTorre la Sal s/nRibera de Cabanes12595 CastellonSpain Lucta S.A. Innovation DivisionAnimal Science UnitUAB Research Park08193 BellaterraSpain

In this study,we investigated the transcriptional spatio-temporal dynamics of the taste 1 receptor(T1R)gene family repertoire in seabream(Sparus aurata[sa]),during larval ontogeny and in adult *** early larval development,sa T1R expression arises heterochronously,*** extraoral taste-related perception in the gastrointestinal tract(GIT)anticipates first exogenous feeding(at 9 days post hatching[dph]),followed by the buccal/intraoral perception from 14 dph onwards,supporting the hypothesis that the early onset of the molecular machinery underlying sa T1R expression in the GIT is not induced by food but rather genetically *** adulthood,we characterized the expression patterns of sa T1R within specific tissues(n=4)distributed in oropharingeal,GIT and brain regions substantiating their functional versatility as chemosensory signaling players to a variety of biological functions beyond oral taste ***,we provided for the first time direct evidences in fish for m RNA coexpression of a subset of sa T1R genes(mostly sa T1R3,*** common subunit of the heterodimeric T1R complexes for the detection of“sweet”and“umami”substances),with the selected gut peptides ghrelin(ghr),cholecystokinin(cck),hormone peptide yy(pyy)and proglucagon(pg).Each peptide defines the enteroendocrine cells(ECCs)identity,and establishes on morphological basis,a direct link for T1R chemosensing in the regulation of fish digestive ***,we analyzed the spatial gene expression patterns of 2 taste signaling components functionally homologous to the mammalian G(i)a subunit gustducin,namely sa G(i)a1 and sa G(i)a2,and demonstrated their co-localization with the sa T1R3in EECs,thus validating their direct involvement in taste-like transduction mechanisms of the fish *** conclusion,data provide new insights in the evolutionary conservation of gut sensing in fish suggesting a conserved role for nutrient sensors modulating entero-endocrine secretion.

关键词： Taste 1 receptor Fish larvae Gut nutrient sensing Gut peptides G(i)alpha protein subunits 1 and 2

Delaying clozapine: how long is too long?

在线全文

学校读者我要写书评

暂无评论

General Psychiatry 2020年第2期33卷 88-93页

作者： Tom Varghese m KS Jyothi KS Shaji Lekshmi rita Venugopal Department of Psychiatry Government Medical College ThrissurThrissurKeralaIndia Department of Psychiatry General Hospital KozhikodeKozhikodeKeralaIndia School of public health University of CaliforniaBerkeleyCaliforniaUSA

Background Although clozapine is the most effective drug for treatment-resistant schizophrenia,its use remains restricted in clinical practice in *** delay in initiating treatment with clozapine and its impact on disease outcome needs *** To identify the implications of delaying clozapine initiation in clinical outcomes among people with treatment-resistant *** Subjects with treatment-resistant schizophrenia,stabilised on clozapine monotherapy,were recruited from the outpatient clinic of a general hospital psychiatry unit offering tertiary care services in Thrissur district,Kerala,India.A retrospective cohort design was employed,and information on duration of illness,total duration of treatment and duration of treatment with clozapine was *** symptom status was measured using the Positive and Negative Syndrome *** associated with higher symptom scores were analysed using an independent sample f test,Spearman correlation and multiple linear *** Forty subjects stabilised on long-term clozapine therapy formed the study *** mean dose of clozapine used in the study population was 200 *** mean duration of antipsychotic treatment before starting clozapine was 89.3 months(7.4 years).The duration of treatment before starting clozapine was found to have a significant positive association with the total Positive and Negative Syndrome Scale score(correlation coefficient 0.40;p=0.01)and negative symptom score(correlation coefficient 0.33;p=0.04).The multiple regression analysis adjusting for covariates showed that the duration of treatment before starting clozapine was an independent factor associated with a higher negative symptom score in the Positive and Negative Syndrome Scale(slope p=0.05;p=0.02;R2=0.27).Conclusion Poor treatment outcomes in treatmentresistant schizophrenia could be secondary to a delay in initiating clozapine therapy.

关键词： clozapine starting treatment

Resin infiltration of deproteinised natural occlusal subsurface lesions improves initial quality of fissure sealing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2017年第2期9卷 117-124页

作者： Andrej m Kielbassa Ina Ulrich rita Schmidl Christoph Schuller Wilhelm Frank Vanessa D Werth Centre for Operative Dentistry Periodontology and Endodontology University of Dental Medicine and Oral Health Danube Private University (DPU) Krems Austria Department of Applied Genetics and Cell Biology UFT-Campus Tulln University of Natural Resources and Life Sciences (BOKU) Vienna Austria Centre for Preclinical Education Department of Biostatistics University of Dental Medicine and Oral Health Danube Private University (DPU) Krems Austria

The aim of this ex vivo study was to evaluate the infiltration capability and rate of microleakage of a low-viscous resin infiltrant combined with a flowable composite resin(RI/CR) when used with deproteinised and etched occlusal subsurface lesions(International Caries Detection and Assessment System code 2). This combined treatment procedure was compared with the exclusive use of flowable composite resin(CR) for fissure sealing. Twenty premolars and 20 molars revealing non-cavitated occlusal carious lesions were randomly divided into two groups and were meticulously cleaned and deproteinised using Na OCl(2%). After etching with HCl(15%), 10 premolar and 10 molar lesions were infiltrated(Icon/DmG; rhodamine B isothiocyanate(RITC)-labelled) followed by fissure sealing(G-?nial Flo/GC; experimental group, RI/CR). In the control group(CR), the carious fissures were only sealed. Specimens were cut perpendicular to the occlusal surface and through the area of the highest demineralisation(DIAGNOdent pen, Ka Vo). Using confocal laser-scanning microscopy, the specimens were assessed with regard to the percentage of caries infiltration, marginal adaption and internal integrity. Within the CR group, the carious lesions were not infiltrated. Both premolar(57.9% ± 23.1%) and molar lesions(35.3% ± 22.1%) of the RI/CR group were uniformly infiltrated to a substantial extent, albeit with significant differences(P = 0.034). moreover, microleakage(n = 1) and the occurrence of voids(n = 2) were reduced in the RI/CR group compared with the CR group(5 and 17 specimens,respectively). The RI/CR approach increases the initial quality of fissure sealing and is recommended for the clinical control of occlusal caries.

关键词： aprismatic enamel fissure sealing occlusal caries resin infiltration sodium hypochlorite

Identifying the validity domain of machine learning models in building energy systems

在线全文

学校读者我要写书评

暂无评论

Energy and AI 2024年第1期15卷 328-341页

作者： martin Rätz Patrick Henkel Phillip Stoffel rita Streblow Dirk müller RWTH Aachen University E.ON Energy Research CenterInstitute for Energy Efficient Buildings and Indoor ClimateMathieustraβe 10Aachen52074Germany

The building sector significantly contributes to climate *** improve its carbon footprint,applications like model predictive control and predictive maintenance rely on system ***,the high modeling effort hinders practical *** learning models can significantly reduce this modeling *** ensure a machine learning model’s reliability in all operating states,it is essential to know its validity *** states outside the validity domain might lead to extrapolation,resulting in unpredictable *** paper addresses the challenge of identifying extrapolation in data-driven building energy system models and aims to raise knowledge about *** that,a novel approach is proposed that calibrates novelty detection algorithms towards the machine learning *** novelty detection algorithms are identified through a literature review and a benchmark test with 15 candidates.A subset of five algorithms is then evaluated on building energy ***,on two-dimensional data,displaying the results with a novel visualization *** on more complex multi-dimensional use *** methodology performs well,and the validity domain could be *** visualization allows for a profound analysis and an improved understanding of the fundamental effects behind a machine learning model’s validity domain and the extrapolation regimes.

关键词： Extrapolation detection Validity domain Novelty detection machine learning Artificial neural network Data-driven model predictive control Building energy systems