检索结果-南通市图书馆

SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology

引用

Neural Regeneration Research 2022年第2期17卷 266-270页

作者： rita f.marques Kent E.Duncan Institute for Biochemistry and Molecular Biology Department of ChemistryUniversity of HamburgHamburgGermany Neuronal Translational Control Research Group Center for Molecular Neurobiology Hamburg(ZMNH)University Medical Center Hamburg-EppendorfHamburgGermany

Amyotrophic lateral sclerosis is the most common adult-onset neurodegenerative disease affecting motor neurons. Its defining feature is progressive loss of motor neuron function in the cortex, brainstem, and spinal cord, leading to paralysis and death. Despite major advances in identifying genes that can cause disease when mutated and model the disease in animals and cellular models, it still remains unclear why motor symptoms suddenly appear after a long pre-symptomatic phase of apparently normal function. One hypothesis is that age-related deregulation of specific proteins within key cell types, especially motor neurons themselves, initiates disease symptom appearance and may also drive progressive degeneration. Genome-wide in vivo cell-type-specific screening tools are enabling identification of candidates for such proteins. In this minireview, we first briefly discuss the methodology used in a recent study that applied a motor neuron-specific RNASeq screening approach to a standard model of TAR DNA-binding protein-43(TDP-43)-driven amyotrophic lateral sclerosis. A key finding of this study is that synaptogyrin-4 and pleckstrin homology domain-containing family B member 1 are also deregulated at the protein level within motor neurons of two unrelated mouse models of mutant TDP-43 driven amyotrophic lateral sclerosis. Guided by what is known about molecular and cellular functions of these proteins and their orthologs, we outline here specific hypotheses for how changes in their levels might potentially alter cellular physiology of motor neurons and detrimentally affect motor neuron function. Where possible, we also discuss how this information could potentially be used in a translational context to develop new therapeutic strategies for this currently incurable, devastating disease.

关键词： amyotrophic lateral sclerosis glucagon-like peptide-1 receptor motor neuron disease mouse model neurodegeneration phosphatidylserine pleckstrin homology domain synaptogyrin TAR DNA-binding protein-43 vesicle transport

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Ce-base mischmetal addition on the microstructure and mechanical properties of hot-rolled ZK60 alloy

引用

Journal of Magnesium and Alloys 2021年第3期9卷 995-1006页

作者： E.P.Silva R.H.Buzolin f.marques f.Soldera U.Alfaro H.C.Pinto Institute of Engineering Science and Technology(IECT)Federal University of Vales do Jequitinhonha e Mucuri(UFVJM)JanaúbaMGBrazil São Carlos School of Engineering(EESC) University of São Paulo(USP)Department of Materials EngineeringCEP 13563-120 São Carlos-SPBrazil Christian Doppler Laboratory for Design of high-performance alloys by thermomechanical processing Kopernikusgasse 24/I8010 GrazAustria Technische Universität Graz(TU Graz) Institute of Materials ScienceJoining and FormingKopernikusgasse 24/I8010 GrazAustria Institute of functional Materials Department of Materials Science and EngineeringSaarland UniversitySaarbrueckenGermany German Aerospace Center(DLR)Institute of Materials Research Linder Höhe51147 CologneGermany

Mg-Zn-Zr(ZK)alloys exhibit notably high mechanical strength amongst all magnesium alloy ***,due to the formation of low melting point Mg_3Zn_7-precipitates,these alloys are susceptible to hot cracking,thus compromising their metallurgical *** addition of rare earths to ZK alloys is an alternative to form higher melting point intermetallic compounds,speed up dynamic recrystallization,refine grain size,enhance corrosion resistance and extend the service temperature due to improved creep *** work deals with the effect of Ce-base mischmetal addition on the hot rolling behaviour of as-cast ZK60 *** microstructure investigation conducted using electron microscopy and X-Ray diffraction shows that precipitation of Mg_(7)Zn_(3) intermetallics occur during hot rolling,whereas no further precipitation is observed for the ZK60-Mm *** fragmentation of the intermetallic compounds occur during hot rolling and finer particles of Mg_(7)Zn_(3) are observed for the ZK60,whereas Mg_(7)Zn_(3) and Mg Zn_(2) Ce intermetallics are formed in the alloy modified with mischmetal addition.A higher fraction of dynamically recrystallized grains is observed for the ZK60-Mm in comparison to the *** recrystallization takes place in ZK60 with the formation of sub-grains near to the intermetallics and the addition of mischmetal promotes the occurrence of discontinuous recrystallization with the nucleation of new grains close to the *** mechanical strength and,in particular,the ductility of the hot-rolled alloys are notably improved when compared to the same alloys in the as-cast *** mechanical strength is,however,higher for the ZK60 *** solid solution strengthening,softer Mg Zn_(2) Ce intermetallics and more extensive recrystallization contribute to reduce the mechanical strength of *** in both alloys are initiated at coarse intermetallics and propagate through intermetallic-rich regions.

关键词： Magnesium alloys Hot rolling Mischmetal Recrystallization Microstructure Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preserving the literary past, looking to the future: the first Hong Kong Literature Database

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第11期6卷 1341-1347页

作者： MA Leo f.H. WONG rita LAU Paul University Library System The Chinese University of Hong Kong Hong Kong ChinaUniversity Library System The Chinese University of Hong Kong Hong Kong ChinaUniversity Library System The Chinese University of Hong Kong Hong Kong China

In the last two decades of the 20th century, there has been an increasing interest in and emphasis on the study of the Hong Kong literature in both the academic and general public in Hong Kong. Recognizing the emergent need of the resources on Hong Kong literature, the University Library System of the Chinese University of Hong Kong set up the Hong Kong Literature Database （the “Database”）, which was the first Chinese literature database in the Internet in 2000. The paper will examine how the database is constructed using XML technology andometadata schema, The database also employs Unicode UTf-8 as the internal code. A mapping table for traditional and simplified Chinese characters was created based on Unihan and is used behind the scene so that a user can either input traditional or simplified Chinese characters and retrieval will give both traditional and simplified Chinese characters. Currently 65% of journals use OCR technology so that full-text searching is possible. The Chinese OCR technology will be examined in greater detail. Special features of the Database such as, page-by-page browse mode, position-highlight for full-page newspaper, linking Table-Of-Contents and book jackets from the Library catalogue, etc. are described. The paper will also bring out the problem of massive downloading and compare the state-of-the-art technology and their shortcomings. This paper shows how the Hong Kong Literature Database facilitates future collaboration and data exchange by using open standard, shareable structure and the latest technology.

关键词： Hong Kong Literature Hong Kong Literature Database XML Metadata schema Database structure UnicodeUTf-8 OCR technology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mixed iridium-nickel oxides supported on antimony-doped tin oxide as highly efficient and stable acidic oxygen evolution catalysts

引用

Materials futures 2024年第1期3卷 165-180页

作者： Jonathan Ruiz Esquius Alec P LaGrow Haiyan Jin Zhipeng Yu Ana Araujo rita marques Adélio Mendes Lifeng Liu Clean Energy Cluster International Iberian Nanotechnology LaboratoryAv.Mestre JoséVeigaBraga 4715-330Portugal Carbon Science and Technology Institute INCAR-CSICFrancisco Pintado Fe 26Oviedo 33011Spain Scientific Imaging Section Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0412Japan Songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China Laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal.

Proton exchange membrane(PEM)water electrolysis represents a promising technology for green hydrogen production,but its widespread deployment is greatly hindered by the indispensable usage of platinum group metal catalysts,especially iridium(Ir)based materials for the energy-demanding oxygen evolution reaction(OER).Herein,we report a new sequential precipitation approach to the synthesis of mixed Ir-nickel(Ni)oxy-hydroxide supported on antimony-doped tin oxide(ATO)nanoparticles(IrNiyO_(x)/ATO,20 wt.%(Ir+Ni),y=0,1,2,and 3),aiming to reduce the utilisation of scarce and precious Ir while maintaining its good acidic OER *** tested in strongly acidic electrolyte(0.1 M HClO_(4)),the optimised IrNi1Ox/ATO shows a mass activity of 1.0 mAµgIr^(−1) and a large turnover frequency of 123 s^(−1) at an overpotential of 350 mV,as well as a comparatively small Tafel slope of 50 mV dec^(−1),better than the IrOx/ATO control,particularly with a markedly reduced Ir loading of only 19.7µgIr cm^(−2).Importantly,IrNi1O_(x)/ATO also exhibits substantially better catalytic stability than other reference catalysts,able to continuously catalyse acidic OER at 10 mA cm^(−2) for 15 h without obvious *** in-situ synchrotron-based x-ray absorption spectroscopy confirmed that the Ir^(3+)/Ir^(4+)species are the active sites for the acidic ***,the performance of IrNi1Ox/ATO was also preliminarily evaluated in a membrane electrode assembly,which shows better activity and stability than other reference *** IrNi1Ox/ATO reported in this work is a promising alternative to commercial IrO_(2) based catalysts for PEM electrolysis.

关键词： mixed oxides oxygen evolution reaction polymer electrolyte membrane antimony doped tin oxide membrane electrode assembly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Superconductivity in antiperovskites

引用

npj Computational Materials 2022年第1期8卷 1424-1433页

作者： Noah Hoffmann Tiago f.T.Cerqueira Jonathan Schmidt Miguel A.L.marques Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099HalleGermany CfisUC Department of PhysicsUniversity of CoimbraRua Larga3004-516CoimbraPortugal

We present a comprehensive theoretical study of conventional superconductivity in cubic antiperovskites materials with composition XYZ_(3) where X and Z are metals,and Y is H,B,C,N,O,and *** starting point are electron–phonon calculations for 397 materials performed with density-functional perturbation *** 43%of the materials are dynamically unstable,we discovered 16 compounds close to thermodynamic stability and with T_(c) higher than 5 *** these results to train interpretable machine-learning models,leads us to predict a further 57(thermodynamically unstable)materials with superconducting transition temperatures above 5 K,reaching a maximum of 17.8 K for ***,the models give us an understanding of the mechanism of superconductivity in *** combination of traditional approaches with interpretable machine learning turns out to be a very efficient methodology to study and systematize whole classes of materials and is easily extendable to other families of compounds or physical properties.

关键词： properties theory perovskite

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Searching for ductile superconducting Heusler X_(2)YZ compounds

引用

npj Computational Materials 2023年第1期9卷 919-927页

作者： Noah Hoffmann Tiago f.T.Cerqueira Pedro Borlido Antonio Sanna Jonathan Schmidt Miguel A.L.marques Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099 HalleGermany CfisUC Department of PhysicsUniversity of CoimbraRua Larga 3004-516 CoimbraPortugal Max-Planck-Institut für Mikrostrukturphysik Weinberg 2D-06120 HalleGermany

Heusler compounds attract a great deal of attention from researchers thanks to a wealth of interesting properties,among which is *** we perform an extensive study of the superconducting and elastic properties of the cubic(full-)Heusler family using a mixture of ab initio methods,as well as interpretable and predictive machine-learning *** analyzing the statistical distributions of these properties and comparing them to anti-perovskites,we recognize universal behaviors that should be common to all conventional superconductors while others turn out to be specific to the material *** total,we discover a total of eight hypothetical materials with critical temperatures above 10 K to be compared with the current record of T_(c)=4.7 K in this ***,we expect most of these materials to be highly ductile,making them potential candidates for the manufacture of wires and tapes for superconducting magnets.

关键词： ductile compounds superconducting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances and applications of machine learning in solidstate materials science

引用

npj Computational Materials 2019年第1期5卷 394-429页

作者： Jonathan Schmidt Mário R.G.marques Silvana Botti Miguel A.L.marques Institut für Physik Martin-Luther-Universität06120 Halle-WittenbergHalle(Saale)Germany Institut für festkörpertheorie und-optik Friedrich-Schiller-Universität JenaMax-Wien-Platz 107743 JenaGermany

One of the most exciting tools that have entered the material science toolbox in recent years is machine *** collection of statistical methods has already proved to be capable of considerably speeding up both fundamental and applied *** present,we are witnessing an explosion of works that develop and apply machine learning to solid-state *** provide a comprehensive overview and analysis of the most recent research in this *** a starting point,we introduce machine learning principles,algorithms,descriptors,and databases in materials *** continue with the description of different machine learning approaches for the discovery of stable materials and the prediction of their crystal *** we discuss research in numerous quantitative structure–property relationships and various approaches for the replacement of first-principle methods by machine *** review how active learning and surrogate-based optimization can be applied to improve the rational design process and related examples of *** major questions are always the interpretability of and the physical understanding gained from machine learning *** consider therefore the different facets of interpretability and their importance in materials ***,we propose solutions and future research paths for various challenges in computational materials science.

关键词： learning gained starting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Placing a Child for Adoption and the Myth of Maternal Love

引用

Journal of Health Science 2019年第5期7卷 295-302页

作者： rita Tropa marques Yara Ishara Ivonise fernandes da Motta Santa Casa da Misericordia de Lisboa Research Laboratory on Creativity and Psychic Development (LAPECRI)Avenida Professor Mello de Morais1721-Butanta Sao Paulo 05508-030Brazil Tribunal de Justica do Estado de Sao Paulo Research Laboratory on Creativity and Psychic Development (LAPECRI)Avenida Professor Mello de Morais1721-ButantaSao Paulo 05508-030Brazil Research Laboratory on Creativity and Psychic Development (LAPECRI) Department of Clinical PsychologyUniversity of Sao PauloAvenida Professor Mello de Morais1721-Butanta Sao Paulo 05508-030Brazil

The article discusses the circumstances of placing a child for adoption and its relation to the myth of maternal love. It examines the research related to this issue, questioning the idealization of motherhood expressed in the idea that every woman is “naturally” a mother. It also examines the justification commonly found in literature that perceives the act of placing a child for adoption as the result of difficulties associated with socioeconomic factors. It shows the relevance of the research on the subject involving different professionals who deal with this reality.

关键词： Myth of maternal love adoption motherhood

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

from regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?

引用

Neural Regeneration Research 2022年第5期17卷 933-936页

作者： rita Caridade Silva Helena Sofia Domingues António J.Salgado fábio G.Teixeira Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabBraga/GuimarãesPortugal

Parkinson's disease is the second most prevalent neurodegenerative disorder ***,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic *** treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal ***,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's *** instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell *** the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative ***,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based *** cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic *** approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's ***,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease.

关键词： disease-modifying strategies mesenchymal stem cells N-acetylcysteine neuroprotection Parkinson's disease stem cells secretome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

葡萄牙阿威罗大学孔子学院小学汉语教学现况调查分析

葡萄牙阿威罗大学孔子学院小学汉语教学现况调查分析

引用

作者： rita ISABEL marques PEREIRA（丽达）大连外国语大学

学位级别：硕士

本文主要分析当前阿威罗大学孔子学院管理体系下中文课程的特点、中文教学的开展情况和教学成果,概括总结孔子学院在海外汉语教学活动中所起到的作用。本项调查研究主要通过归纳目前在葡萄牙参与对外汉语教育的这一群体(学生、老师)的特... 详细信息

本文主要分析当前阿威罗大学孔子学院管理体系下中文课程的特点、中文教学的开展情况和教学成果,概括总结孔子学院在海外汉语教学活动中所起到的作用。本项调查研究主要通过归纳目前在葡萄牙参与对外汉语教育的这一群体(学生、老师)的特点,分析当前葡萄牙小学汉语教学的特殊性,对目前阿威罗大学孔子学院小学汉语教学项目提出建设性的教学建议并提供促进其教学管理工作发展的可行性数据信息。作者以葡萄牙阿威罗大学孔子学院小学汉语教学项目为调查对象,针对教学项目中的教学规模、学生人群、教师备课、课堂教学、教学效果、教辅人员反馈以及孔子学院的管理等方面,对项目进行全方位的调查研究。通过实地访谈、参与课程、调查问卷、文献研究以及数据分析等多种调研方法,以教师、学生及教学管理者为研究对象,对于课程的开展、运行及效果进行阶段性的考查。我们的调查主要是将语言与文化放在同样的高度审视,在语言教学的同时追溯其文化内涵。对外汉语教学中文化教学研究的问题从二十世纪八十年代开始逐渐得到了中国对外汉语教学界的重视。所以本文所阐述的大部分教学方法,均来自于实践教学课堂的数据和信息搜集,也是最接近目前葡萄牙小学汉语教学实际情况的信息。

关键词：葡萄牙孔子学院小学汉语教学

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：