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Effect of different lens status on intraocular pressure elevation in patients treated with anti-vascular endothelial growth factor injections

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 79-84页

作者： Amir Sternfeld rita Ehrlich Dov Weinberger Assaf Dotan Department of Ophthalmology Rabin Medical Center Beilinson HospitalPetach Tikva 4941402Israel Sackler Faculty of Medicine Tel Aviv UniversityRamat AvivTel Aviv 6997801Israel

AIM: To assess the effect of lens status on sustained intraocular pressure(IOP) elevation in patients treated intravitreally with anti-vascular endothelial growth factor(VEGF) agents. METHODS: Data were retrospectively collected for all patients treated with intravitreal injections of anti-VEGF medication at a tertiary medical center in July 2015. Findings were analyzed by lens status during 6 months' follow-up. The main outcome measure was a sustained increase in IOP(≥21 mm Hg or change of ≥6 mm Hg from baseline on ≥2 consecutive visits, or addition of a new IOPlowering medication during follow-up). RESULTS: A total of 119 eyes of 100 patients met the study criteria: 40 phakic, 40 pseudophakic, and 39 pseudophakic after Nd:YAG capsulotomy. The rate of sustained IOP elevation was significantly higher in the postcapsulotomy group(23.1%) than in the phakic/pseudophakic groups(8.1%;P=0.032), with no statistically significant differences among the 3 groups in mean number of injections, either total(P=0.82) or by type of anti-VEGF mediation(bevacizumab: P=0.19;ranibizumab: P=0.13), or mean follow-up time(P=0.70). CONCLUSION: Nd:YAG capsulotomy appears to be a risk factor for sustained IOP elevation in patients receiving intravitreal anti-VEGF injections. This finding has important implications given the growing use of anti-VEGF treatment and the irreversible effects of elevated IOP.

关键词： anti-VEGF injections cataract surgery intraocular pressure Nd:YAG capsulotomy

Efficacy assessment of peracetic acid in the removal of synthetic 17α-ethinyl estradiol contraceptive hormone in wastewater

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Journal of Environmental Sciences 2020年第3期32卷 1-8页

作者： rita Maurício Flávia Semedo rita Dias Joao P.Noronha Leonor Amaral Michiel A.Daam Antonio P.Mano Mário S.Diniz CENSE Center for Environmental and Sustainability ResearchNOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal Department of Environmental Sciences and Engineering NOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal REQUIMTE/FCT NOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal Biotox Lab UCIBIODepartment of ChemistryNOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal

Increasing concerns have been raised on endocrine disrupting chemicals like the sex hormone 17 a-ethinylestradiol(EE2),the more since traditional wastewater(WW) treatments appear to be ineffective for their *** efficacy of the relatively novel disinfectant peracetic acid(PAA) in EE2 removal was evaluated,as well as its potential effects on WW quality *** treatments tested for EE2 removal were also evaluated in terms of toxicity,through the determination of biochemical responses(antioxidant enzymes,lipid peroxidation and vitellogenin induction) using zebrafish(Danio rerio) as a biological *** contact times less than 20 min appeared insufficient regardless of the PAA dose tested,but a 100% EE2 removal was attained at a PAA concentration of 15 mg/L with a contact time of20 *** suspended solids,chemical oxygen demand and pH in PAA treatments remained well within levels set in European legislation for WW ***2 induced signific ant increased vitellogenin(VTG) levels in both female and male fish,indic ating increased estrogenic activity,especially in males suggesting an endocrine disruption *** the addition of PAA(15 mg/L),however,VTG levels in both sexes returned to control *** this PAA treatment showed increased levels of the antioxidant enzyme catalase,the lipid peroxidation levels were similar or even lower than in *** the results suggest that the use of PAA appears a promising way forward as a less toxic alternative to chlorine disinfection with high efficiency in the removal of EDC like EE2.

关键词： EE2 Wastewater treatment Zebrafish Biomarkers

Perception and Higher Education in China

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Perception and Higher Education in China

作者： rita Nagy 华东师范大学

学位级别：硕士

本文探究了留学经历对在华留学生对东道国认知的影响。近年来,来华学习的留学生日益增多,其对东道国的认知及影响这些认知的因素十分值得关注。基于对现有文献的研究,我们可知“认知”是一种内在的固有文化约束。因此,本文的研究范围仅... 详细信息

本文探究了留学经历对在华留学生对东道国认知的影响。近年来,来华学习的留学生日益增多,其对东道国的认知及影响这些认知的因素十分值得关注。基于对现有文献的研究,我们可知“认知”是一种内在的固有文化约束。因此,本文的研究范围仅限于匈牙利的在华留学生。为了了解他们对中国文化和政治价值观的看法,本文采取了问卷调查和半结构化访谈的方式。结果表明,在华留学生对中国的总体印象明显高于普通大众,在中国的留学经历对他们对中国的认知起到了积极的影响。本文认为,留学经历及在高等学府所受教育促使留学生对东道国——中国形成更加积极正面的看法。

关键词：认知留学生文化价值观政治价值观

Rifampicin quinone pretreatment improves neuronal survival by modulating microglia inflammation induced by α-synuclein

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Neural Regeneration Research 2020年第8期15卷 1473-1474页

作者： Leonardo Acuna Natalia S.Corbalán rita Raisman-Vozari Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Universidad Nacional de Salta(UNSa)SaltaArgentina Institut du Cerveau et de la Moelleépinière(ICM) Inserm U 1127CNRS UMR 7225Sorbonne UniversitéParisFrance

The World Health Organization has predicted that neurodegenerative diseases affecting the motor function will become the second most prevalent cause of death in the next 20 *** therapies can result from three main sources:synthetic compounds,natural products,and existing ***’s disease(PD)is a common neurodegenerative disease affecting 1–3%of the adult population over 50 years of age *** is initially characterized by the death of dopaminergic neurons in the substantia nigra pars compact and later by the widespread loss of nondopaminergic neurons,including those in the cortex.

关键词： inflammation death drugs

Two-level supply chain models with imperfect quality items when demand influences price and marketing promotion

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Journal of Management Analytics 2022年第4期9卷 480-495页

作者： rita Yadav Sarla Pareek Mandeep Mittal Mahesh Kumar Jayaswal Department of Mathematics and Statistics Banasthali VidyapithBanasthaliIndia Department of Mathematics Amity Institute of Applied SciencesAmity University Uttar PradeshNoidaIndia

The present paper studies a supply chain model with items that are of imperfect quality and with the assumption that end demand is responsive to price and promotion *** seller delivers items to the buyer in a *** an inspection process,it is observed that few articles produced are not of perfect *** defects might be the result of common operations or static *** defective items are then collected and are sold at a lower/discounted *** this paper,supply chain models are developed to approve the interaction among the players,in the supply chain *** interaction between the players is demonstrated by non-cooperative and cooperative game theoretical *** non-cooperative approach,optimal solutions are attained by game theoretic approaches named as Seller–Stackelberg and Buyer–*** the cooperative approach,a Pareto efficient solution is *** the last,numerical illustrations with sensitivity scrutiny are presented to support the theory of the present paper.

关键词： game theory imperfect quality items supply chain co-operative game non-cooperative games

Mucosa-associated bacteria in two middle-aged women diagnosed with collagenous colitis

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World Journal of Gastroenterology 2012年第14期18卷 1628-1634页

作者： rita J Gustafsson Bodil Ohlsson Cecilia Benoni Bengt Jeppsson Crister Olsson Department of Clinical Sciences Gastroenterology SectionSkne University HospitalLund University20502 MalmSweden Department of Surgery Skne University HospitalLund University20502 MalmSweden Food Technology Engineering and Nutrition Lund University22100 LundSweden

AIM:To characterize the colon microbiota in two women histologically diagnosed with collagenous colitis using a culture-independent ***:Biopsies were taken from the ascending colon and the total DNA was *** bacterial primers were used to amplify the bacterial 16S rRNA *** amplicons were then cloned into competent Escherichia coli *** clones were sequenced and identified by comparison to known ***:The clones could be divided into 44 different *** microbiota was dominated by Firmicutes and *** phylotypes werefound in both patients and constituted 47.5% of the total number of *** these,the most dominating were clones similar to Bacteroides cellulosilyticus,Bacteroides caccae,Bacteroides thetaiotaomicron,Bacteroides uniformis and Bacteroides dorei within *** similar to Faecalibacterium prausnitzii and Clostridium citroniae were also found in both ***:A predominance of potentially pathogenic Bacteroides spp.,and the presence of clones showing similarity to Clostridium clostridioforme were found but the overall colon microbiota showed similarities to a healthy *** for collagenous colitis other than an adverse bacterial flora must also be considered.

关键词： Microscopic colitis Collagenous colitis Lymphocytic colitis Colonic microbiota 16S rRNA sequencing

A first comparison of bone histomorphometry in extant domestic horses(Equus caballus)and a Pleistocene Indian wild horse(Equus namadicus)

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Integrative Zoology 2020年第6期15卷 448-460页

作者： Marco ZEDDA Vijay SATHE Prateek CHAKRABORTY Maria rita PALOMBO Vittorio FARINA Department of Veterinary Medicine University of SassariItaly Department of AIHC&Archaeology Deccan College Postgraduate and Research InstitutePuneIndia CNR-IGAG c/o Department of Earth SciencesSapienza UniversityRomaItaly

The microstructural features of the tissue of long bones subjected to different biomechanical stresses could be a helpful tool for a better understanding of locomotor behavior in extant and extinct mammals,including ***,few researches have attempted to describe the bone tissue of extinct *** our study,we analyze and compare the histomorphometric features of the bone tissue in extant modern horses,Equus caballus,and Equus namadicus,a Pleistocene Indian extinct wild *** number,position,and size of the osteons and Haversian canals of the bone tissue,classifiable as dense Haversian tissue,were considered for the *** results obtained highlight some differences between the analyzed species,*** having fewer and bigger osteons than *** microstructural differences may depend on the different lifestyles and environmental conditions characterizing the two *** results obtained suggest that comparing the biomechanical properties of extinct and modern horse species may provide indirect information on their paleoenvironment.

关键词： bone tissue Equus caballus Equus namadicus histomorphometry horse

Desmosterol, the main sterol in rabbit semen： distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility

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Asian Journal of Andrology 2010年第6期12卷 862-870页

作者： Evangelia Mourvaki Raffaella Cardinali rita Roberti Alessandro Dal Bosco Cesare Castellini Department of Applied Biology Section of Animal Science University of Perugia Perugia 06100 Italy Department of Internal Medicine Section of Biochemistry University of Perugia Perugia 06122 Italy

Sterols are essential components of the cell membrane lipid bilayer that include molecules such as cholesterol and desmosterol, which are significantly found in the spermatozoa of several animal species. However, the presence of desmosterol in rabbit semen has never been investigated. The aims of this study were to characterize the sterol composition of subfractions of ejaculated rabbit semen and evaluate the in vitro effects of sterol on the spermatozoa acrosome reaction and motility. Two sterols, occurring prevalently in the free form （94.3%）, were identified in whole semen collected from 10 fertile New Zealand White rabbits, specifically desmosterol （58.5% of total sterols） and cholesterol （35.9% of total sterols）. Desmosterol was the predominant sterol found in all subfractions of rabbit semen, varying from 56.7% （in the prostatic secretory granules, PSGs） to 63.8% （in the seminal plasma）. Spermatozoa contained an intermediate proportion of desmosterol （59.8%）, which was asymmetrically distributed between the heads （52.0% of the total content of sterols） and the tails （81.8%）. Results showed that both desmosterol and cholesterol can be transferred from the PSGs to the spermatozoa and are equally effective in inhibiting in vitro spermatozoa capacitation at a concentration higher than 1 mg L^-1. In contrast, neither desmosterol nor cholesterol had a significant effect on spermatozoa motility. Thus, it was concluded that, the various fractions of rabbit seminal fluid differ from each other in sterol composition and quantity, probably due to their different functional properties, and these fractions may undergo significant sterol changes depending on the stage of spermatozoa capacitation.

关键词： acrosome reaction cholesterol desmosterol motility prostatic secretory granules rabbit seminal plasma spermatozoa head spermatozoa tail

A porous puckered V_(2)O_(5) polymorph as new high performance cathode material for aqueous rechargeable zinc batteries

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Journal of Energy Chemistry 2021年第10期30卷 459-468,I0012页

作者： Dauren Batyrbekuly Barbara Laïk Jean-Pierre Pereira-Ramos Zhumabay Bakenov rita Baddour-Hadjean Institut de Chimie et des Matériaux Paris Est(ICMPE) UMR 7182 CNRS et UniversitéParis Est Créteil2 rue Henri Dunant94320 ThiaisFrance School of Engineering National Laboratory AstanaNazarbayev University53 Kabanbay Batyr AvenueAstana 010000Kazakhstan

Aqueous rechargeable zinc batteries are getting increasing attention for large-scale energy storage owing to their advantages in terms of cost,environmental friendliness and ***,the layered puckeredγ’-V_(2)O_(5) polymorph with a porous morphology is firstly introduced as cathode for an aqueous zinc battery system in a binary Zn^(2+)/Li^(+)*** Zn‖γ’-V_(2)O_(5) cell delivers high capacities of 240 and190 mAh g^(-1) at current densities of 29 and 147 mA g^(-1),respectively,and remarkable cycling stability in the 1.6 V-0.7 V voltage window(97%retention after 100 cycles at 0.15 A g^(-1)).The detailed structural evolution during first discharge-charge and subsequent cycling is investigated using X-ray diffraction and Raman *** demonstrate a reaction mechanism based on a selective Li insertion in the1.6 V-1.0 V voltage *** involves a reversible exchange of 0.8 Li^(+)in γ’-V_(2)O_(5) and the same structural response as the one reported in lithiated organic ***,in the extended 1.6 V-0.7 V voltage range,this work puts forward a concomitant and gradual phase transformation from γ’-V_(2)O_(5) to zinc pyrovanadate Zn_(3)V_(2)O_(7)(OH)2.2 H_(2)O(ZVO)during *** mechanism involving the in-situ formation of ZVO,known as an efficient Zn and Li intercalation material,explains the high electrochemical performance here reported for the Zn‖γ’-V_(2)O_(5) *** work highlights the peculiar layered-puckeredγ’-V_(2)O_(5) polymorph outperforms the conventionalα-V_(2)O_(5) with a huge improvement of capacity of 240 mAh g^(-1)vs 80 mAh g^(-1) in the same electrolyte and voltage window.

关键词： Vanadium pentoxide γ-V_(2)O_(5) Cathode Aqueous zinc battery High performance Layered structure Energy storage Renewable energy