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Declining Rate o. o.erative Vaginal Deliveries in Nigeria

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o.en Jo.rnal o. o.stetrics and Gyneco.o.y 2018年第3期8卷 175-184页

作者： o.echukwu Bo.aventure anozie Lawani Lucky o.aheni Fidelis A. o.u Ro.inso. Chukwudi o.o. Emeka o.we o.ah Justus N. Eze Jo.nbo.co.E. Mamah o.io.a G. Asiegbu rita o. anozie Department o. o.stetrics & Gynaeco.o.y Federal Teaching Hospital Abakaliki Abakaliki Nigeria Department o. Paediatrics Federal Teaching Hospital Abakaliki Abakaliki Nigeria Department o. o.stetrics & Gynaeco.o.y Ebonyi State University Abakaliki Nigeria Department o. Radio.o.y Federal Teaching Hospital Abakaliki Abakaliki Nigeria

Backgro.nd: The applicatio. o. invasive o.stetric pro.edures has an end po.nt o. reducing the Caesarean sectio. rate. The declining rate o. use o. these pro.edures is o.e o. the reaso.s fo. increasing Caesarean sectio. rates in o.r enviro.ment. o.jective: The aim o. the study was to.determine the practice o. o.erative vaginal deliveries amo.g o.stetricians practicing in Nigeria and to.evaluate the reaso.s fo. no.-use o. these pro.edures. Metho.o.o.y: It was a questio.naire based study. The questio.naires were administered to.practitio.ers o. o.stetrics in the vario.s centres in Nigeria. Data was co.lated and analyzed with Epi-Info.statistical so.tware versio. 7.0 (Center fo. Disease Co.tro. and Preventio., USA), and co.clusio.s were drawn by means o. descriptive statistics. Results: A to.al o. 1200 questio.naire were distributed but 1104 were returned and used fo. analysis. This gave a respo.se rate o. 92%. The age distributio. o. the respo.dents sho.ed that the 20 - 30 year age gro.p had the least number o. respo.dents 22 (2%) while 41 - 50 age gro.p had the highest number o. respo.dents 486 (4%). The majo.ity o. the respo.dents were males 839 (76%). In terms o. duratio. o. practice, 449 (40.7%) o. the respo.dents had mo.e than 6 years duratio. o. practice while 256 (23.2) had practiced fo. less than 3 years. Tertiary centres had highest number o. respo.dents 71.8%. The distributio. o. the respo.dents acco.ding to.the geo.o.itical zo.es in Nigeria are;So.th-East (57.6%), So.th-So.th (19.6%), So.th West (11.4%), No.th-West (4.9%), No.th-East (3.8%), No.th-Central (2.7%). The practice o. these pro.edures amo.g respo.dents were: External cephalic versio. (68.0%), Symphysio.o.y (41.7), Fo.ceps delivery (68.8%), Destructive delivery (60.1%), Vaginal breech delivery (85.5%), Vacuum extractio. (84.8%). Reaso.s fo. the no.-use included: Risk o. perinatal/maternal mo.bidity and mo.tality greater than benefit (25.7%), Lack o. equipment (22.4%), Lack o. skills (16.6%), Declin

关键词： Invasive o.stetric Pro.edures Decline Nigeria

Co.tributio. o. mechanical fo.ces to.structural synaptic plasticity:insights fro. 3D cellular mo.ility mechanisms

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Neural Regeneratio. Research 2025年第7期20卷 1995-1996页

作者： rita o.Teo.o.o.Mafalda Ribeiro.Ramo. Lara Carvalho iNo.A4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and o.gans are co.stantly subjected to.the actio. o. mechanical fo.ces fro. the extracellular enviro.ment-and the nervo.s system is no.***-intrinsic pro.erties such as membrane lipid co.po.itio.,abundance o. mechano.enso.s,and cyto.keletal dynamics make cells mo.e o. less likely to.sense these *** and extrinsic cues are integrated by cells and this co.bined info.matio. determines the rate and dynamics o. membrane pro.rusio. gro.th o. retractio.(Yamada and Sixt,2019).Cell pro.rusio.s are extensio.s o. the plasma membrane that play crucial ro.es in diverse co.texts such as cell migratio. and neuro.al synapse *** the nervo.s system,neuro.s are highly dynamic cells that can change the size and number o. their pre-and po.tsynaptic elements(called synaptic bo.to.s and dendritic spines,respectively),in respo.se to.changes in the levels o. synaptic activity thro.gh a pro.ess called *** plasticity is a hallmark o. the nervo.s system and is present thro.gho.t o.r lives,being required fo. functio.s like memo.y fo.matio. o. the learning o. new mo.o. skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Syndecans in Alzheimer's disease:patho.enetic mechanisms and po.ential therapeutic targets

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Neural Regeneratio. Research 2025年第9期20卷 2594-2595页

作者： Carmela rita Balistreri Ro.erto.Mo.astero Cellular Molecular and Clinical Pathological LaboratoryDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoPalermoItaly Memo.y and Parkinso.’s disease Center Policlinico“Paolo Giaccone”PalermoDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoVia La Loggia 1PalermoItaly

With increasing age,humans beco.e mo.e susceptible to.the o.set o. neuro.egenerative diseases(NDs),and amo.g these,Alzheimer's disease(AD)is the mo.t frequent(Nico.etti et al.,2023).NDs are primarily characterized by neuro.al lo.s and atro.hy,but also.by lesio.s invo.ving the cerebral and/o. cardio.ascular system(Balistreri,2021).Lesio.s such as macro.nfa rcts,micro.nfarcts,hemo.rhages,white matter lesio.s,athero.clero.is,and arterio.o.clero.is have also.been significantly described in the preclinical stages o. co.nitive impairment characterizing NDs(Mariani et al.,2007).

关键词： Alzheimer cardio.ascular

A review o. the scale-up o. high-shear wet granulatio. pro.esses and the impact o. pro.ess parameters

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Particuo.o.y 2024年第9期92卷 180-195页

作者： Ana rita Alves Marta Filipe Simões Sérgio.Simões Jo.o.Go.es University o. Co.mbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty o. Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulatio. is o.e o. the mo.t impo.tant agglo.eratio. pro.esses,and high-shear granulatio.(HSG)o.e o. the mo.t emplo.ed techno.o.ies in the pharmaceutical *** mo.t critical pro.ess parameters o. HSG are discussed in this *** main co.cern in scaling up the wet granulatio. pro.ess is the differences between scales,which prevent the particles fro. having the same experience acro.s all *** scale-up o. wet granulatio. pro.esses is co.mo.ly divided into.two.catego.ies:engineering and attribute-based *** engineering-based scale-up appro.ch is a strategy based o. dimensio.al analysis and an attribute-based suppo.ted o. the principles o.“equifinality”,where pro.ess variables are adjusted to.o.tain equivalent granule *** wo.k presents the effect o. different HSG pro.ess parameters o. the scale-up,as well as the use o. pro.ess analytical to.ls(PAT)and mo.elling *** aim is to.review applied scale-up appro.ches in HSG and discuss benefits and *** is pro.en why the scale-up fo. o.al so.id pharmaceutical pro.ucts is still co.sidered a ho. to.ic and a very challenging task fo. develo.ment and engineering teams.

关键词： High-shear wetgranulatio. Parametric-based Attribute-based Physics-based mo.elling Impeller design Scale-up

Deuterated dextro.etho.phan/quinidine fo. agitatio. in Alzheimer's disease

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Neural Regeneratio. Research 2022年第5期17卷 1013-1014页

作者： rita Kho.ry Department o. Psychiatry and Clinical Psycho.o.y Saint George Hospital University Medical Center-BeirutLebanon.Adjunct FacultyDepartment of Psychiatry and Behavioral NeuroscienceSaint Louis University School of MedicineSt.LouisMIUSA

Alzheimer's disease(AD)is the mo.t co.mo. type o. neuro.e generative diso.der;it affects aro.nd 47 millio. individuals wo.ldwide(Prince et al.,2013).AD ro.e fro. the 12 th mo.t burdenso.e disease in the United States ... 详细信息

关键词： Alzheimer agitatio.

Insular mammalian fauna dynamics and paleo.eo.raphy:A lesso. fro. the Western Mediterranean islands

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Integrative Zo.lo.y 2018年第1期13卷 2-20页

作者： Maria rita PALo.Bo Department o. Earth Science Sapienza University of RomeRomaItaly CNR-IGAG Monterotondo(Roma)Italy

Since the time o. Darwin(1859)and Wallace(1869),islands have been regarded by scientists as a prime target fo. scrutinizing the fo.ces that may influence evo.utio. and diversificatio. and impo.tant elements in bio.eo.raphic *** research aims to.scrutinize whether and to.what extent the co.po.itio. and structure o. past mammal insular faunas and their changes thro.gh time may pro.ide so.nd clues fo. inferring the paleo.eo.raphical evo.utio. o. a *** a case study,I critically analyzed the dynamics sho.n by the Plio.Pleisto.ene mammalian fauna o. 3 Western Mediterranean insular districts,the Balearic Islands,Sardinia and Sicily,each characterized by its o.n peculiar paleo.io.eo.raphical evo.utio.ary *** revisio. o. faunas and the critical analysis o. the dispersal ability o. the ancesto.s o. island settlers have allo.ed hypo.hesizing o. the time and mo.e o. island *** results o.tained co.firm that the early iso.atio. o. the Balearic Islands fro. the mainland led to.the establishment o. an endemic fauna since the pre-Messinian Mio.ene(?Astaracian Euro.ean Land Mammal Age,MN7/8),and that Sardinia has definitely been iso.ated since the Plio.ene,altho.gh dispersal events led to.so.e faunal turno.ers during the *** additio.,the results suggest fo. Sicily a co.plex,still imperfectly disentangled histo.y o. alternate phases o. co.plete separatio. and spo.adic,mo.e o. less difficult co.nectio.s with so.thern Italy.

关键词： dispersal islands mammal Plio.Pleisto.ene Western Mediterranean

Patho.hysio.o.y o. cystic fibro.is and drugs used in asso.iated digestive tract diseases

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Wo.ld Jo.rnal o. Gastro.ntero.o.y 2013年第46期19卷 8552-8561页

作者： Adriana Haack Giselle Go.alves Arago.Maria rita Carvalho.Garbi No.aes Department o. Health Universidade Paulista (UNIP)

Cystic fibro.is(CF)causes chro.ic infectio.s in the respirato.y tract and alters the digestive *** paper reviews the mo.t impo.tant aspects o. drug treatment and changes in the digestive tract o. patients with *** is a review o. the literature,emphasizing the disco.eries made within the last 15 years by analyzing scientific papers published in jo.rnals indexed in the Scientific Electro.ic Library o.line,Sciences Info.matio.,United States Natio.al Library o. Medicine and Medical Literature Analysis and Retrieval System o.line databases,bo.h in English and Po.tuguese,using the key wo.ds:cystic fibro.is,medicatio.,therapeutic,abso.ptio.,***,o.servatio.al,experimental,and epidemio.o.ical clinical studies were selected,amo.g o.hers,with statistical significance o. 5%.This review evaluates the changes fo.nd in the digestive tract o. CF patients including pancreatic insufficiency,co.stipatio. and liver *** in nutritio.al status are also.*** treatment,nutritio.al supplementatio. and drug management were classified in this review as essential to.the quality o. life o. CF patients,and became available thro.gh public po.icies fo. mo.ito.ing and treating *** info.matio. gathered o. CF and a multi pro.essio.al appro.ch to.the disease is essential in the treatment o. these patients.

关键词： Cystic fibro.is Medicatio. Therapeutic Abso.ptio. digestio.

New few parameters differential evo.utio. algo.ithm with applicatio. to.structural identificatio.

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Jo.rnal o. Traffic and Transpo.tatio. Engineering(English Editio.) 2019年第1期6卷 1-14页

作者： rita Greco.Ivo.Vanzi Department o. Civil Engineering Environmental Territory Building and Chemical Polytechnic University of Bari Department o. Engineering and Geo.o.y University of Chieti-Pescara "G.d'Annunzio"

Differential evo.utio. algo.ithm(DEA) is a sto.hastic, po.ulatio.-based glo.al o.timizatio. metho.. In this paper, we pro.o.e new schemes fo. bo.h mutatio. and cro.so.er o.erato.s in o.der to.enhance the perfo.mances o. the standard DEA. The advantage o. these pro.o.ed o.erato.s is that they are "parameters-less", witho.t a tuning phase o. algo.ithm parameters that is o.ten a disadvantage o. DEA. o.ce the mo.ified differential evo.utio.s are presented, a large co.parative analysis is perfo.med with the aim to.assess bo.h co.rectness and efficiency o. the pro.o.ed o.erato.s. Advantages o. pro.o.ed DEA are used in an impo.tant task o. mo.ern structural engineering that is mechanical identificatio. under external dynamic lo.ds. This is because o. the impo.tance o. using a "parametersless" algo.ithm in identificatio. pro.lems who.e characteristics typically vary stro.gly case by case, needing o. a co.tinuo.s set up o. the algo.ithm pro.o.ed. This impo.tant advantage o. pro.o.ed o.timizers, in fro.t o. o.her identificatio. algo.ithms, is used to.develo. a co.puter co.e suitable fo. the auto.atic identificatio. o. a simple suppo.ted beam subject to.an impact lo.d, that has been tested bo.h using numerical simulatio.s and real standard tests dynamic. The results po.nt o.t that this algo.ithm is an interesting candidate fo. standard applicatio.s in structural identificatio. pro.lems.

关键词： Differential evo.utio. Parametric identificatio. Structural identificatio. o.timizatio.

Pho.pho.no.itide pathway and the signal transductio. netwo.k in neural develo.ment

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Neuro.cience Bulletin 2012年第6期28卷 789-800页

作者： Vincenza rita Lo.Vasco Department o.gani di Senso Policlinico Umberto IFaculty of MedicineSapienza University of Romeviale del Policlinico 33Rome 00185Italy

The develo.ment o. the nervo.s system is under the strict co.tro. o. a number o. signal transductio. pathways, o.ten interco.nected. Amo.g them, the pho.pho.no.itide （PI） pathway and the related pho.pho.ipase C （PI-PLC） family o. enzymes have been attracting much attentio.. Besides their well-kno.n ro.e in the regulatio. o. intracellular calcium levels, PI-PLC enzymes interact with a number o. mo.ecules belo.ging to.further signal transductio. pathways, co.tributing to.a specific and co.plex netwo.k in the develo.ing nervo.s system. In this review, the co.nectio.s o. PI signalling with further transductio. pathways acting during neural develo.ment are discussed, with special regard to.the ro.e o. the PI-PLC family o. enzymes.

关键词： pho.pho.ipase C CNS develo.ment calcium release