Phosphoinositide pathway and the signal transduction network in neural development

作     者：Vincenza Rita Lo Vasco 

作者机构：Department Organi di SensoPoliclinico Umberto IFaculty of MedicineSapienza University of Romeviale del Policlinico 33Rome 00185Italy 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2012年第28卷第6期

页      面：789-800页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

主　　题：phospholipase C CNS development calcium release 

摘      要：The development of the nervous system is under the strict control of a number of signal transduction pathways, often interconnected. Among them, the phosphoinositide （PI） pathway and the related phospholipase C （PI-PLC） family of enzymes have been attracting much attention. Besides their well-known role in the regulation of intracellular calcium levels, PI-PLC enzymes interact with a number of molecules belonging to further signal transduction pathways, contributing to a specific and complex network in the developing nervous system. In this review, the connections of PI signalling with further transduction pathways acting during neural development are discussed, with special regard to the role of the PI-PLC family of enzymes.