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From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?

Neural Regeneration Research 2022年第5期17卷 933-936页

作者： rita caridade silva Helena Sofia Domingues António J.Salgado Fábio G.Teixeira Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabBraga/GuimarãesPortugal

Parkinson's disease is the second most prevalent neurodegenerative disorder ***,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic *** treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal ***,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's *** instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell *** the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative ***,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based *** cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic *** approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's ***,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease.

关键词： disease-modifying strategies mesenchymal stem cells N-acetylcysteine neuroprotection Parkinson's disease stem cells secretome

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Laser texturing of piston ring for tribological performance improvement

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Friction 2023年第10期11卷 1895-1905页

作者： rita FERREIRA Óscar CARVALHO Luís SOBRAL Sandra CARVALHO Filipe silva CMEMS-UMinho University of MinhoGuimarães 4800058Portugal LABBELS-Associate Laboratory Guimarães 4800058Portugal CEMMPRE-Center for Mechanical Engineering Materials and ProcessesUniversity of CoimbraRua Luís Reis SantosCoimbra 3030-788Portugal MAHLE Componentes de MotoresS.A.Núcleo Industrial de MurtedeCantanhede 3060-372Portugal

The radial surface coating layer of compression piston rings is used to improve their wear resistance during the internal combustion engine ***,at top dead centers,the friction coefficient of the piston ring–cylinder liner pair is detrimental to the engine’s tribological *** this work,dimples with different texture dimensions and densities were tested in a home-developed *** friction coefficient was measured for all samples,and for those with the best results,their wear resistance was *** texture with an aspect ratio of 0.25 and a density area of 15%reported the best tribological results.

关键词： piston ring surface texture friction wear

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MULTIOBJECTIVE ROUTING IN MULTISERVICE MPLS NETWORKS WITH TRAFFIC SPLITTING-A NETWORK FLOW APPROACH

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Journal of Systems Science and Systems Engineering 2015年第4期24卷 389-432页

作者： rita Girao-silva Jose Craveirinha Joao Climaco M.Eugenia Captivo Department of Electrical and Computer Engineering University of Coimbra Polo ⅡPinhal de Marrocos P-3030-290 Coimbra Portugal Institute of Computers and Systems Engineering of Coimbra(INESC-Coimbra)R.Antero de Quental 199 P-3000-033 Coimbra Portugal Centro de Investigacao Operacional Faculdade de CienciasUniversidade de Lisboa Campo GrandeBloco C6Piso 4 P-1749-016 Lisboa Portugal

A multiobjective routing model for Multiprotocol Label Switching networks with multiple service types and traffic splitting is presented in this paper. The routing problem is formulated as a multiobjective mixed-integer program, where the considered objectives are the minimization of the bandwidth routing cost and the minimization of the load cost in the network links with a constraint on the maximal splitting of traffic trunks. Two different exact methods are developed for solving the formulated problem, one based on the classical constraint method and another based on a modified constraint method. A very extensive experimental study, with results on network performance measures in various reference test networks and in randomly generated networks, is also presented and its results are discussed.

关键词： Routing models multiobjective optimization telecommunication networks network flowapproach traffic splitting

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Adaptation of forest management to climate change as perceived by forest owners and managers in Belgium

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Forest Ecosystems 2017年第1期4卷 22-32页

作者： rita Sousa-silva Quentin Ponette Kris Verheyen Ann Van Herzele Bart Muys Ku Leuven Department of Earth and Environmental Sciences Celestijnenlaan 200E Box 24113001 Leuven Belgium Earth and Life Institute Environmental Sciences Universite catholique de Louvain Croix du Sud 2 Box L7.05.091348 Louvain-la-Neuve Belgium. Forest & Nature Lab Ghent University Geraardsbergsesteenweg 267 9090 Melle-Gontrode Belgium. Nature & Society Research Group Research Institute for Nature and Forest (INBO) Kliniekstraat 25 B-1070 Brussels Belgium. Forest Institute (EFIMED) Sant Pau Historical Site Sant Leopold Pavilion Carrer Sant Antoni Maria Claret 167 08025 Barcelona Spain.

Background： Climate change is likely to cause significant modifications in forests. Rising to this challenge may require adaptation of forest management, and therefore should trigger proactive measures by forest managers, but it is unclear to what extent this is already happening. Methods： The survey carried out in this research assesses how forest stakeholders in Belgium perceive the role of their forest management in the context of climate change and the impediments that limit their ability to prepare and respond to these changes. Results： Respondents indicated strong awareness of the changing climate, with more than two-thirds （71%） expressing concern about the impacts of climate change on their forests. However, less than one-third of the respondents （32 %） reported modifying their management practices motivated by climate change. Among the major constraints limiting their climate red,ted ~ctions, lack of ic^formation was considered the most important for managers of both public and private forests. Conclusions： Knowledge transfer is an essential condition for research to lead to innovation. Improving the communication and demonstration of possible solutions for climate change adaptation is therefore likely to be the most effective strategy for increasing their adoption.

关键词： Adaptation Adoption Belief Stakeholders Internet survey Logistic regression

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Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation

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Asian Journal of Andrology 2017年第5期19卷 526-532页

作者： Rheure Alves-Lopes Karla B Neves Marcondes AB silva Vania C Olivon Silvia G Ruginsk Jose Antunes-Rodrigues Leandra NZ Ramalho rita C Tostes Fernando silva Carneiro Department of Pharmacology Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto SP Brazil Department of Physics and Chemistry Faculty of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo Ribeirao Preto SP Brazil Department of Physiological Sciences Biomedical Sciences InstituteFederal University of Alfenas Alfenas MG Brazil Department of Physiology Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto SP Brazil Department of Pathology and Legal Medicine Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto SP Brazil

Androgen deficiency is strongly associated with erectile dysfunction （ED）. Inadequate penile arterial blood flow is one of the major causes of ED. The blood flow to the corpus cavernosum is mainly derived from the internal pudendal arteries （IPAs）; however, no study has evaluated the effects of androgen deprivation on IPA＇s function. We hypothesized that castration impairs IPAs reactivity and structure, contributing to ED. In our study, Wistar male rats, 8-week-old, were castrated and studied 30 days after orchiectomy. Functional and structural properties of rat IPAs were determined using wire and pressure myograph systems, respectively. Protein expression was determined by Western blot and immunohistochemistry. Plasma testosterone levels were determined using the IMMULITE 1000 Immunoassay System. Castrated rats exhibited impaired erectile function, represented by decreased intracavernosal pressure/mean arterial pressure ratio. IPAs from castrated rats exhibited decreased phenylephrine- and electrical field stimulation （EFS）-induced contraction and decreased acetylcholine- and EFS-induced vasodilatation. IPAs from castrated rats exhibited decreased internal diameter, external diameter, thickness of the arterial wall, and cross-sectional area. Castration decreased nNOS and α-actin expression and increased collagen expression, p38 （Thr180/ryr182） phosphorylation, as well as caspase 3 cleavage. In conclusion, androgen deficiency is associated with impairment of IPA reactivity and structure and increased apoptosis signaling markers. Our findings suggest that androgen deficiency-induced vascular dysfunction is an event involving hypotrophic vascular remodeling of IPAs.

关键词： androgen castration internal pudendal artery

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Ingredients from integral valorization of Isabel grape to formulate goat yogurt with stimulatory effects on probiotics and beneficial impacts on human colonic microbiota in vitro

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Food Science and Human Wellness 2023年第4期12卷 1331-1342页

作者： Francyeli Araújo silva rita de Cássia Ramos do Egypto Queiroga Evandro Leite de Souza Glenise Bierhalz Voss Maria Manuela Estevez Pintado Margarida Angélica da silva Vasconcelos Department of Nutrition Federal University of PernambucoRecife 50670-420Brazil Department of Nutrition Health Sciences CenterFederal University of ParaíbaJoão Pessoa 58050-585Brazil Universidade Católica Portuguesa CBQF-Centro de Biotecnologia e Química Fina-Laboratório AssociadoEscola Superior de BiotecnologiaPorto 4169-005Portugal

Isabel grape(IG)products have high contents of phenolic compounds and fiber recognized for their positive impacts on microorganisms associated with health benefits to *** study evaluated the effects of goat yogurts formulated with ingredients from IG integral valorization on the growth and metabolism of different probiotic strains,as well as on the population of selected bacterial groups and metabolic activity of human colonic microbiota in *** yogurts with IG ingredients(IGI)stimulated the growth of tested Lactobacillus and Bifidobacterium probiotic strains during a 48-h cultivation,as well as decreased the pH values and enhanced the organic acid *** yogurts with IGI increased the population of Lactobacillus *** Bifidobacterium *** a 24-h in vitro colonic fermentation.A stable Firmicutes:Bacteroidetes ratio close to 1 was found in media with goat yogurt formulations during the colonic fermentation,being similar to the effect caused by *** yogurt formulations with IGI caused increased production of short-chain fatty acids and sugar consumption during colonic *** yogurts with IGI should be a valuable strategy for development of novel added-value foods with beneficial effects on gut microbiota and human health.

关键词： Goat dairy product Grape Beneficial microorganisms Gut microbiota Modulatory effects

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Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease

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Neural Regeneration Research 2023年第7期18卷 1450-1456页

作者： Tamara Andrea Alarcón Sarah Martins Presti-silva Ana Paula Toniato Simões Fabiola Mara Ribeiro rita Gomes Wanderley Pires Department of Physiological Sciences Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Laboratory of Molecular and Behavioral Neurobiology Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Department of Biochemistry and Immunology Institute o Biological SciencesUniversidade Federal de Minas GeraisAvenida Antônio CarlosBelo HorizonteBrazil

Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 ***’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic *** addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-*** it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s *** addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative *** such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s *** enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating *** this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic *** describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease.

关键词： acetylcholine brain-derived neurotrophic factor dopamine environment enrichment gamma-aminobutyric acid glial cell line-derived neurotrophic factor glutamate molecular mechanisms Parkinson’s disease

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Can microcalcifications' characteristics predict the risk of breast cancer metastasis to bone?

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Journal of Cancer Metastasis and Treatment 2019年第4期4卷 31-37页

作者： rita Bonfiglio Manuel Scimeca Alessandro Polidori Clara Nazzaro Giselda De silva ElenaBonanno Department of Experimental Medicine University of Rome“Tor Vergata”Via Montpellier 1Rome 00133Italy Department of Biomedicine and Prevention University of Rome“Tor Vergata”Via Montpellier 1Rome 00133Italy San Raffaele University Via di Val Cannuta 247Rome 00166Italy Assing S.p.a Via Edoardo Amaldi 14Monterotondo 00015Italy Diagnostica Medica’&“Villa dei Platani” Neuromed GroupAvellino 83100Italy

Aim: To correlate the microcalcifications' characteristics, such as morphology and elemental compositions, with the occurrence of bone metastatic lesions at 5 years from diagnosis. Methods: In this retrospective study, we enrolled 70 patients from which we collected one breast biopsy each. From each biopsy, paraffin serial sections were obtained to perform histological classifications, immunohistochemical analyses and Energy Dispersive X-ray evaluation. Results: Microcalcifications analysis showed a significant association between the presence of calcium crystals made of magnesium substituted hydroxyapatite and the development of bone metastasis from 5 years from diagnosis. No significant association was observed by evaluation the morphological appearance of microcalcifications. Immunohistochemical analysis displayed a significant association between the expression of bone morphogenetic proteins 2 and pentraxin-3, two osteoblast induction factors, and the formation of bone metastatic lesions. Conclusion: Results here reported highlighted the possible use of breast microcalcifications as a negative prognostic marker of bone metastatic diseases. In particular, the association between elemental composition of breast microcalcifications and the formation of bone lesions can lay the foundation for the development of new in vivo diagnostic tools based on the analysis of microcalcifications and capable to predict the formation of bone metastasis.

关键词： Microcalcifications breast cancer bone metastasis breast osteoblast-like cells bone morphogenetic proteins 2 pentraxin-3

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Motivations for and barriers to innovation in non-profit organizations: The case of nursing homes in Northern Portugal

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International Journal of Innovation Studies 2024年第1期8卷 25-44页

作者： Ana rita Gonçalves Lopes Aldina Isabel de Azevedo Correia Alexandra Maria da silva Braga Center for Research and Innovation in Business Sciences and Information Systems School of Management and TechnologyPolitecnico do PortoRua do Curral-Margaride4610-156 FelgueirasPortugal

To contribute to the empirical literature on innovation in non-profit organizations,this study examines innovation in Private Social Solidarity Institutions with social responses for the elderly in Northern *** enriches the literature by clarifying the concept of innovation applied to non-profit organizations,which represents a perspective different from the business ***,it is important to support the innovation decisionmaking process in similar non-profit *** this study,the population was surveyed through questionnaires based on the PUBLIN research project,which has already been applied in different countries,and the targets were employees of organizations with social responses for the *** sample is small,with 28 respondent institutions and 51 employees,but it is representative,as it includes institutions from all districts in Northern *** study employed a quantitative approach,particularly factor analysis,multiple linear regression,and correlation analyses,using scales already applied in other dimensions of the social sector,to understand the effect of each innovation dimension/determinant on creativity and innovation in nonprofit *** results show that in these organizations with social responses for the elderly,learning orientation,risk-taking,and job satisfaction have a positive impact on innovation.

关键词： Determinants of innovation non-profit organizations social responses for the elderly Northern Portugal

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The functional complex network approach to foster forest resilience to global changes

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Forest Ecosystems 2019年第3期6卷 194-209页

作者： Christian Messier Jürgen Bauhus Frederik Doyon Fanny Maure rita Sousa-silva Philippe Nolet Marco Mina Núria Aquilué Marie-Josée Fortin Klaus Puettmann Département des sciences naturelles and Institut des sciences de la forêt tempérée (ISFORT) Université du Québec en Outaouais(UQO)58 rue PrincipaleRiponQC J0V 1V0 Canada Centre d’étude de la forêt Université du Québec à Montréal (UQAM)Case postale 8888succursale Centre-VilleMontréalQC H3C 3P8Canada Chair of Silviculture Institute of Forest SciencesUniversity of FreiburgTennenbacherstr.479106 FreiburgGermany Swiss Federal Institute for Forest Snow and Landscape Research WSLBirmensdorfSwitzerland Department of Ecology and Evolution University of TorontoTorontoON M5S 3B2Canada Department of Ecosystems and Society Oregon State UniversityCorvallisOR 97331USA

Human impacts on Earth's ecosystems have greatly intensified in the last decades. This is reflected in unexpected disturbance events, as well as new and increasing socio-economic demands, all of which are affecting the resilience of forest ecosystems worldwide and the provision of important ecosystem services. This Anthropocene era is forcing us to reconsider past and current forest management and silvicultural practices, and search for new ones that are more flexible and better at dealing with the increasing uncertainty brought about by these accelerating and cumulative global changes. Here, we briefly review the focus and limitations of past and current forest management and silvicultural practices mainly as developed in Europe and North America. We then discuss some recent promising concepts, such as managing forests as complex adaptive systems, and approaches based on resilience, functional diversity, assisted migration and multi-species plantations, to propose a novel approach to integrate the functionality of species-traits into a functional complex network approach as a flexible and multi-scale way to manage forests for the Anthropocene. This approach takes into consideration the high level of uncertainty associated with future environmental and societal changes. It relies on the quantification and dynamic monitoring of functional diversity and complex network indices to manage forests as a functional complex network. Using this novel approach, the most efficient forest management and silvicultural practices can be determined, as well as where, at what scale, and at what intensity landscape-scale resistance, resilience and adaptive capacity of forests to global changes can be improved.

关键词： forest management North America Ecosystem services

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