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Tumor-associated Exosomes Are Involved in hepatocellular Carcinoma Tumorigenesis, Diagnosis, and Treatment

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Journal of Clinical and Translational hepatology 2022年第3期10卷 496-508页

作者： Hang Wang Liang Yu Peng Huang Yongxu Zhou Wangyang Zheng Nanfeng Meng risheng he Yi Xu Tey Sze Keong Yunfu Cui Department of hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina The Key Laboratory of Myocardial Ischemia Harbin Medical UniversityMinistry of EducationHarbinHeilongjiangChina Department of Pathology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

hepatocellular carcinoma(HCC)has become a challenging disease *** are still limitations in the diagnosis and treatment of HCC,and its high metastatic capacity and high recurrence rate are the main reasons for its poor *** ability of extracellular vesicles(EVs)to transfer functionally-active substances and their widespread presence in almost all body fluids suggest their unprecedented potential in the study of various *** unique physicochemical properties of EVs determine their potential as antitumor vaccines and drug *** the last decade,the study of EVs in HCC has evolved from a single hot topic to a system with considerable *** paper summarizes the role of EVs,especially exosomes,in the occurrence,metastasis and tumor immunity of HCC,reviews their applications in tumor diagnosis,prognosis and treatment,describes the pros and cons of these studies,and looks forward towards the future research directions of EVs in HCC.

关键词： Extracellular vesicles Exosome hepatocellular carcinoma Tumor formation and progression

基于数据建模的浙江省稀有血型信息共享系统构建与应用

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中国输血杂志 2024年第9期37卷 1068-1072页

作者：裘君娜孔长虹许先国徐烨彪王翠娥武恺莉何日盛浙江省血液中心浙江杭州310052

目的建立省级稀有血型库信息化管理平台,实现稀有血型的种类、献血者资料、血液库存等信息的互联互通和共享,提升稀有血型血液保障能力。方法采用鱼骨图,分析我省稀有血型管理在血站内部各业务环节以及血站间存在的信息壁垒。基于全省... 详细信息

目的建立省级稀有血型库信息化管理平台,实现稀有血型的种类、献血者资料、血液库存等信息的互联互通和共享,提升稀有血型血液保障能力。方法采用鱼骨图,分析我省稀有血型管理在血站内部各业务环节以及血站间存在的信息壁垒。基于全省统一的采供血业务系统和血液云平台,引入数据建模技术,通过需求分析和模型设计,构建稀有血型献血者、稀有血型血液数据库视图,并开发统一的查询平台,实现稀有血型信息的共享。结果系统对稀有血型信息进行了集成、检索和展示,实现在血站内部各业务环节、血站间信息的互联互通。截止目前,除RhD阴性血型外,已入库的红细胞稀有血型种类8种,覆盖7个血型系统,稀有血型献血者289人,稀有血液血液实体冻存红细胞216单位。结论基于数据建模开发的信息系统,提高了系统整体效率和协同性,同时也降低了系统开发运维的工作量,为数据的标准化管理和应用发展提供技术借鉴,也为建立健全全国性的稀有血型信息网络提供模式参考和示范应用。

关键词：稀有血型数据建模数据共享互联互通浙江

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加强安全管理提高安全生产水平

中国安全科学学报 2000年第6期10卷 73-78页

作者：何日升深圳市中南有色金属股份有限公司韶关冶炼厂安全环保处

搞好安全生产 ,防止事故 ,必须从加强企业的安全管理入手。本文提出采用有效的安全管理方法 ,建立和实施职业安全卫生管理体系标准 ,健全各项安全管理制度并狠抓落实。

关键词：安全管理安全生产企业职业安全卫生管理制度

Flower-like tin oxide membranes with robust three-dimensional channels for efficient removal of iron ions from hydrogen peroxide

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Chinese Journal of Chemical Engineering 2024年第1期65卷 1-7页

作者： risheng Shen Shilong Li Yuqing Sun Yuan Bai Jian Lu Wenheng Jing State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech UniversityNanjing 210009China National Energy Group Science and Technology Research Institute Co. Ltd.Nanjing 210023China

Membrane technology has become the mainstream process for the production of electronic grade hydrogen peroxide(H_(2)O_(2)).But due to the oxidation degradation of the organic membranes(***)by the strong oxidative radicals(e.g.OH)generated via the activation of H_(2)O_(2)by iron ions(Fe^(3+)),the short effective lifetime of membranes remains a *** nano tin oxide(SnO_(2))has great potential for the removal of Fe^(3+)in strongly oxidative H_(2)O_(2)because of its ability to stabilize H2O_(2)and preferentially adsorb Fe^(3+).herein,we have designed for the first time a flower-like robust SnO_(2)membrane on the ceramic support by in situ template-free one-step hydrothermal *** three-dimensional loose pore structure in the membrane built by interlacing SnO_(2)nanosheets endows the SnO_(2)membrane with a high specific surface area and abundant adsorption sites(AOH).Based on the coordination complexation and electrostatic attraction between the SnO_(2)surface and Fe^(3+),the membrane shows a high Fe3+removal efficiency(83%)and permeability(24 L·m^(-2)·h^(-1)·MPa^(-1))in H_(2)O_(2).This study provides an innovative and simple approach to designing robust SnO_(2)membranes for highly efficient removal of Fe^(3+)in harsh environments,such as strong oxidation conditions.

关键词： Hydrogen peroxide SnO_(2)membrane Adsorption Hydrothermal

Roles and Molecular Mechanisms of Biomarkers in hepatocellular Carcinoma with Microvascular Invasion: A Review

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Journal of Clinical and Translational hepatology 2023年第5期11卷 1170-1183页

作者： Xudong Zhao Yudan Wang Haoming Xia Shuqiang Liu Ziyue Huang risheng he Liang Yu Nanfeng Meng Hang Wang Junqi You Jinglin Li Judy Wai Ping Yam Yi Xu Yunfu Cui Department of hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Key Laboratory of Basic Pharmacology of Ministry of Education Zunyi Medical UniversityZunyiGuizhouChina Key Laboratory of Functional and Clinical Translational Medicine Fujian Province UniversityXiamen Medical CollegeXiamenFujianChina Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials Yancheng Teachers UniversityYanchengJiangsuChina Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang province HangzhouZhejiangChina Key Laboratory of Gastrointestinal Cancer(Fujian Medical University) Ministry of EducationSchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujianChina State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical GenomicsPeking University Shenzhen Graduate SchoolShenzhenGuangdongChina Key Laboratory of Intelligent Pharmacy and Individualized Therapy of Huzhou Department of PharmacyChangxing People’s HospitalChangxingZhejiangChina

hepatocellular carcinoma(HCC)being a leading cause of cancer-related death,has high associated mortality and recurrence *** has been of great necessity and urgency to find effective HCC diagnosis and treatment *** have shown that microvascular invasion(MVI)is an independent risk factor for poor prognosis after *** abnormal expression of biomacromolecules such as circ-RNAs,lncRNAs,STIP1,and PD-L1 in HCC patients is strongly correlated with *** of several markers mentioned in this review affects the proliferation,invasion,metastasis,EMT,and anti-apoptotic processes of HCC cells through multiple complex ***,these biomarkers may have an important clinical role and serve as promising interventional targets for *** this review,we provide a comprehensive overview on the functions and regulatory mechanisms of MVI-related biomarkers in HCC.

关键词： hepatocellular carcinoma Microvascular invasion Biomarkers Progress Molecular mechanism

Integrating Zeolite and Layered Double Hydroxide for Highly Selective Catalytic Production ofγ-Valerolactone

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CCS Chemistry 2024年第3期6卷 652-662页

作者： Mingkun Gao Guoju Yang Guangyuan he risheng Bai Jialiang Li Yinghao Liu Qiang Zhang Guangrui Chen Donghai Mei Jihong Yu State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryInternational Center of Future ScienceJilin UniversityChangchun 130012 School of Materials Science and Engineering Tiangong UniversityTianjin 300387

The production ofγ-valerolactone(GVL)from biomass derivatives levulinic acid(LA)based on acidbase metallic catalysts offers a sustainable pathway to the synthesis of valuable chemicals and ***,the development of efficient metallic catalysts with tunable Lewis acid–base and Brønsted acid sites remains a ***,for the first time,we integrated zeolite and layered double hydroxide(LDH),in a core–shell structure,wherein zeolite and CoFe-LDH provided the Brønsted acidic sites and Lewis acid sites,***,oxygen vacancies(OV_(x))acting as Lewis bases were generated on the surface of LDH via Ga *** efficient cascade catalytic reaction from LA to GVL was successfully achieved over the designed Beta@LDH-OVx catalyst,affording a superior conversion of LA(>99.9%)and an impressive selectivity to GVL(89.18%).Importantly,the“memory effect”of LDH endowed the catalyst with excellent regeneration of metal active *** functional theory calculations revealed that the introduced OVx facilitated the adsorption of carbonyl oxygen in LA and boosted the production of GVL through the synergistic effect of acid/base sites in the composite *** work presents a rational design route for the construction of multifunctional catalysts by coupling zeolites and LDHs for highly selective catalytic conversion of biomass.

关键词： zeolite layered double hydroxide oxygen vacancies biomass γ-valerolactone

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网球视频中记分牌的检测和定位

计算机应用与软件 2014年第7期31卷 156-159页

作者：何日升智敏内蒙古师范大学计算机与信息工程学院内蒙古呼和浩特010022

为了在网球视频中精确地检测和定位记分牌,在总结和分析网球记分牌特点基础上,提出角点区域直方图的概念并利用其进行记分牌的检测和定位。首先通过角点和角点区域直方图获得记分牌模板,其次根据自适应阈值进行模板匹配检测记分牌;最后... 详细信息

为了在网球视频中精确地检测和定位记分牌,在总结和分析网球记分牌特点基础上,提出角点区域直方图的概念并利用其进行记分牌的检测和定位。首先通过角点和角点区域直方图获得记分牌模板,其次根据自适应阈值进行模板匹配检测记分牌;最后利用滑动窗口对记分牌进行精确定位。实验结果表明该方法查全率和查准率都达到了99%以上,且对有一定透明度的记分牌也有明显的效果。

关键词：记分牌角点角点区域直方图阈值透明度

The 2023 M_(w)6.8 Adassil Earthquake(Chichaoua,Morocco)on a steep reverse fault in the deep crust and its geodynamic implications

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Earth and Planetary Physics 2024年第3期8卷 522-534页

作者： Billel Touati WangWang Gu SiDao Ni risheng Chu MinHan Sheng QingJie Xue Fouzi Bellalem Said Maouche Habibi Yahyaoui School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Geodesy and Earth’s Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Centre de Recherche en Astronomie Astrophysique et Géophysique(CRAAG)BP 63BouzaréahAlgiers 16340Algeria Geography and Territory Planning Natural Hazards and Territory Planning LaboratoryBatna 2 UniversityFesdisBatna 05000Algeria

The Mw 6.8 Adassil earthquake that occurred in the High Atlas on September 8,2023,was a catastrophic event that provided a rare opportunity to study the mechanics of deep crustal *** research aimed to decipher the rupture characteristics of the Adassil earthquake by analyzing teleseismic waveform data in conjunction with interferometric synthetic aperture radar(InSAR)observations from both ascending and descending *** analysis revealed a reverse fault mechanism with a centroid depth of approximately 28 km,exceeding the typical range for crustal *** result suggests the presence of cooler temperatures in the lower crust,which facilitates the accumulation of tectonic *** earthquake exhibited a steep reverse mechanism,dipping at 70°,accompanied by minor strike-slip *** the geotectonic framework of the High Atlas,known for its volcanic legacy and resulting thermal irregularities,we investigated the potential contributions of these factors to the initiation of the Adassil *** seismicity within the lower crust,away from plate boundaries,calls for extensive research to elucidate its implications for regional seismic hazard *** findings highlight the critical importance of studying and preparing for significant seismic events in similar geological settings,which would provide valuable insights into regional seismic hazard assessments and geodynamic paradigms.

关键词： Adassil earthquake seismogenic fault source depth interferometric synthetic aperture radar(InSAR) seismic waveform joint inversion

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佛教慈济功德会的圆形组织

佛学研究 2018年第2期 58-85页

作者：何日生佛教慈济慈善事业基金会文发处

一、慈济的组织结构与成员1.慈济在佛教历史中的角色(一)理想的再诠释与体现一千九百多年来,汉传佛教承袭印度佛教衍生出不同的宗派。佛教慈济功德会是佛教对当代社会的适应与开展,慈济的社会投入,强调'利他度己''利他到觉悟',通过'利... 详细信息

一、慈济的组织结构与成员1.慈济在佛教历史中的角色(一)理想的再诠释与体现一千九百多年来,汉传佛教承袭印度佛教衍生出不同的宗派。佛教慈济功德会是佛教对当代社会的适应与开展,慈济的社会投入,强调'利他度己''利他到觉悟',通过'利他而成佛'。他所代表的是,引领佛教逐渐从心性的升华与追求,转向以世俗社会的改造着手,达成自我生命与内在心灵永恒极致的成就与圆满。

关键词：慈济功德会静思精舍人间净土比丘尼