Roles and Molecular Mechanisms of Biomarkers in Hepatocellular Carcinoma with Microvascular Invasion: A Review

作     者：Xudong Zhao Yudan Wang Haoming Xia Shuqiang Liu Ziyue Huang Risheng He Liang Yu Nanfeng Meng Hang Wang Junqi You Jinglin Li Judy Wai Ping Yam Yi Xu Yunfu Cui 

作者机构：Department of Hepatopancreatobiliary SurgerySecond Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of PathologySchool of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Key Laboratory of Basic Pharmacology of Ministry of EducationZunyi Medical UniversityZunyiGuizhouChina Key Laboratory of Functional and Clinical Translational MedicineFujian Province UniversityXiamen Medical CollegeXiamenFujianChina Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic MaterialsYancheng Teachers UniversityYanchengJiangsuChina Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang provinceHangzhouZhejiangChina Key Laboratory of Gastrointestinal Cancer(Fujian Medical University)Ministry of EducationSchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujianChina State Key Laboratory of Chemical OncogenomicsKey Laboratory of Chemical GenomicsPeking University Shenzhen Graduate SchoolShenzhenGuangdongChina Key Laboratory of Intelligent Pharmacy and Individualized Therapy of HuzhouDepartment of PharmacyChangxing People’s HospitalChangxingZhejiangChina 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2023年第11卷第5期

页      面：1170-1183页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Hong Kong Scholars Program(Grant No.XJ2020012) Beijing Xisike Clinical Oncology Research Foundation(Grant No.Y-Young2022-0188) Medjaden Academy&Research Foundation for Young Scientists(Grant No.MJR20220903) Strengthening and Enhancing the Efficiency Plan of the Dominant and Characteristic Disciplines of Harbin Medical University(Grant No.HMUMIF-22008) Opening Project of State Key Laboratory of Chemical Oncogenomics,Opening Project of Key Laboratory of Basic Pharmacology of Ministry of Education,Zunyi Medicial University(Grant No.2022-449) Opening Research Fund of Key Laboratory of Gastrointestinal Cancer,Fujian Medical University,Ministry of Education(Grant No.FMUGIC-202203) Opening Project of Key Laboratory of Environment and Health,Ministry of Education(Grant No.2022GWKFJJ01) Opening Project of Key Laboratory of Functional and Clinical Translational Medicine,Fujian Province University(Grant No.XMMC-FCTM202205) Opening Project of Guangxi Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer(Grant No.GXEKL202204) Opening Project of Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang Province(Grant No.KFJJ-2022002) Opening Project of Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials(Grant No.JETNM202210) Thematic Research Support Scheme of State Key Laboratory of Liver Research,The University of Hong Kong(SKLLR/TRSS/2022/08) Opening Project of Key Laboratory of Intelligent Pharmacy and Individualized Therapy of Huzhou&Changxing Anti-cancer Association(NZKF-20230203) Opening Project of Fujian Provincial Key Laboratory of Innovative Drug Target Research(FJ-YW-2022KF03) 

主　　题：Hepatocellular carcinoma Microvascular invasion Biomarkers Progress Molecular mechanism 

摘      要：Hepatocellular carcinoma(HCC)being a leading cause of cancer-related death,has high associated mortality and recurrence *** has been of great necessity and urgency to find effective HCC diagnosis and treatment *** have shown that microvascular invasion(MVI)is an independent risk factor for poor prognosis after *** abnormal expression of biomacromolecules such as circ-RNAs,lncRNAs,STIP1,and PD-L1 in HCC patients is strongly correlated with *** of several markers mentioned in this review affects the proliferation,invasion,metastasis,EMT,and anti-apoptotic processes of HCC cells through multiple complex ***,these biomarkers may have an important clinical role and serve as promising interventional targets for *** this review,we provide a comprehensive overview on the functions and regulatory mechanisms of MVI-related biomarkers in HCC.