检索结果-南通市图书馆

Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 211-212页

作者： risak. onodera Tomohiro Hayashi Tatsuo Nakamura Kaori Aibeb Kohei Tahara Hirofumi Takeuchi Gifu Pharmaceutical University 1-25-4 Daigaku-nishiGifu 501-1196Japan FANCL Corporation 12-13 Kamisinano Totsuka-kuYokohamaKanagawa 244-0806Japan

Oral bioavailability of drug is limited by the factors such as the membrane permeability, the solubility, the dissolution rate and so on (1)In case of a poorly water-soluble drug, its solubility and dissolution rate is a critical factor for its oral *** various techniques for enhancing solubility or dissolution properties, physical modification of drug products such as reducing the particle size is one of common approaches [2].

关键词： PureNano^(■) Silymarin Hydroxypropyl cyclodextrin Crystallization

维普期刊数据库

P53-mediated cell cycle arrest and apoptosis through a caspase-3-independent,but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第7期28卷 1057-1066页

作者： Shin-ichi TASHIRO Satoshi onodera Mutsuhiko MINAMI Takashi IKEJIMA Department of Clinical and Biomedical Sciences Showa Pharmaceutical University Tokyo 194-8543Japan Department of ImmunologyYokohama City University School of Medicine Yokohama 235-0004Japan China-Japan Research Institute of Medical Pharmaceutical Sciences Shenyang Pharmaceutical UniversityShenyang 110016China

Aim:To study the caspase-3-independent mechanisms in oridonin-induced MCF-7human breast cancer cell apoptosis in ***:The viability of oridonin-treated MCF-7 cells was measured by MTT （thiazole blue） *** cellswith condensed nuclei were visualized by phase contrast ***-mal DNA fragmentation was assayed by agarose gel *** apoptoticratio was determined by lactate dehydrogenase *** cycle alternation andmitochondrial membrane potential were measured by flow cytometric ***,Bcl-2,caspase-3,caspase-9,heat shock protein （Hsp）90,p53,p-p53,p21,Poly（ADP-ribose） polymerase （PARP）,and the inhibitor of caspase-activated DNase（ICAD） protein expressions were detected by Western blot ***:Oridonin inhibited cell growth in a time-and dose-dependent *** cyclewas altered through the upregulation of p53 and p21 protein ***-caspase inhibitor Z-VAD-fmk and calpain inhibitor Ⅱ both decreased cell *** DNA fragmentation and the downregulation of ΔΨmitweredetected in oridonin-induced MCF-7 cell apoptosis,which was involved in apostmitochondrial caspase-9-dependent *** Bcl-2 and Hsp90expression levels and increased Bax and p21 expression levels were positivelycorrelated with elevated levels of phosphorylated p53 ***,PARP was partially cleaved by calpain rather than by ***:DNAdamage provoked alternations in the mitochondrial and caspase-9 pathways aswell as p53-mediated cell cycle arrest,but was not related to caspase-3 activity inoridonin-induced MCF-7 cells.

关键词： oridonin MCF-7 cells cell cycle arrest apoptosis p53 caspase-9 caspase-3 calpain mitochondrial pathway

Hybridized Nano-Structure Composed of Metal and Polydiacetylene

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

复旦学报（自然科学版） 2005年第5期44卷 821-822页

作者： H. Oikawa A. Masuharat T. onodera H. Kasai H. Nakanishi Nanomaterials Lab. National Institute for Materials Science Tsukuba 305 - 0044 Japan IMRAM Tohoku University Sendai 980 - 8577 Japan CREST Japan Science and Technology Agency Tokyo 110-0015 Japan

Polydiacetylene (PDA) is one of the promising candidates for organic third-order nonlinear optical (NLO) material, due to fast optical responsibility and easy processability in comparison with semiconductors etc. The magnitude of NLO property, however, is not still sufficient for the devices applications. Neeves, et al[1] theoretically predicted the enhancement of NLO property for core-shell type hybridized nanocrystal (NC) composed of PDA and metal. In the present study, we have prepared the two kinds of core-shell type hybridized nano-structure, and investigated their optical properties.

关键词：金属纳米结构聚乙烯丁二炔纳米晶体表面胞质基因

Hybridized Nano-Structure Composed of Metal and Polydiacetylene

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

复旦学报(自然科学版) 2005年第5期 211-212页

作者： H. Oikawa,A. Masuhara,T. onodera,H. Kasai,H. Nakanishi Nanomaterials Lab. National Institute for Materials Science Tsukuba 305-0044 Japan CREST Japan Science and Technology Agency Tokyo 110-0015 Japan IMRAM Tohoku University Sendai 980-8577 Japan CREST Japan Science and Technology Agency Tokyo 110-0015 Japan Nanomaterials Lab. National Institute for Materials Science Tsukuba 305-0044 Japan CREST Japan Science and Technology Agency Tokyo 110-0015 Japan IMRAM Tohoku University Sendai 980-8577 Japan CREST Japan Science and Technology Agency Tokyo 110-0015 Japan IMRAM Tohoku University Sendai 980-8577 Japan CREST Japan Science and Technology Agency Tokyo 110-0015 Japan

Ferroelectricity in Layered Perovskites as a Model of Ultra-Thin Films

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Condensed Matter Physics 2016年第3期6卷 224-243页

作者： Masanori Fukunaga Masaki Takesada Akira onodera Department of Physics Hokkaido University Sapporo Japan

The instability of thin ferroelectric films is discussed based on the close similarity of dielectric properties between bulk Bi-layered perovskites and thin BaTiO3 films. The dielectric properties of pseudo-two-dimensional layered perovskites suggest that the bulk layered ferroelectric is a good model of ultra-thin ferroelectric film with a few perovskite units, free from any misfit lattice strain. It seems plausible that the ferroelectric interaction is still prominent but shows a crossover from ferroelectric to antiferroelectric along the unique c-axis (perpendicular to the film plane);with decreasing thickness, the ferroelectricity appears within the plane, which results in so-called “canted ferroelectricity”. An extra relaxation mode induced by surface effect of thin films correlates with soft mode, which results in a new intermediate phase between the paraelectric and ferroelectric phases. These evidences may indicate no critical thickness even for ferroelectric ultra- thin films.

关键词： Ferroelectricity Layered Oxide Perovskite Thin Film Size Effect

Activation of extracellular signal-regulated kinase during silibinin-protected,isoproterenol-induced apoptosis in rat cardiac myocytes is tyrosine kinase pathway-mediated and protein kinase C-dependent

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第6期28卷 803-810页

作者： Shin-ichi TASHIRO Satoshi onodera Fumiaki UCHIUMI Takashi IKEJIMA Department of Clinical and BiomedicalSciences Showa Pharmaceutical UniversityTokyo 194-8543Japan Department of Gene Regulation Faculty of Pharmaceutical SciencesTokyo University of ScienceChiba 278-8510Japan China-Japan Research Institute of Medieal and Pharmaceutical Sciences Shenyang Pharmaceutical UniversityShenyang 110016China

Aim:To investigate the mechanism of silibinin-protected isoproterenol-inducedapoptosis in rat cardiac ***:The viability of rat cardiac myocyteswas measured by MTT *** apoptotic ratio was measured by terminaldeoxynucleotidyl transferase-mediated dUTP nick *** kinase C(PKC) activity assay was carried out according to the instructions of the PepTagnon-radioactive protein kinase C assay *** blot analysis was used toevaluate the level of Ras,Raf-1 and mitogen-activated protein kinase (MAPK)***:The protective effects of silibinin were significantly sup-pressed by inhibitors,including genistein,manumycin A and GW5074 [inhibitorsfor protein tyrosine kinases (PTK),Ras and Raf-1,respectively].The exposure ofrat cardiac myocytes to isoproterenol alone caused decreased PKC activity,whichwas prevented by pretreatment with silibinin ***,the increased expression of Ras and Raf-1 activated by silibinin were blocked bythe PKC inhibitor,*** addition,the extracellularly responsive kinase(ERK) inhibitor,PD98059,suppressed silibinin-protected apoptosis,whereas thep38 MAPK inhibitor,SB203580,protected cardiac myocytes from isoproterenol-induced injury,and the c-Jun N-terminal kinase (JNK) inhibitor,SP600125 had noprotective ***,Western blot analysis showed that the expres-sion of phosphorylated ERK was increased by silibinin,the expression of phos-phorylated p38 MAPK was decreased and total ERK,p38,JNK and phosphory-lated JNK MAPK did not change after treatment with both isoproterenol ***,pretreatment of cardiac myocyte with PKC,Ras and Rafinhibitors significantly blocked ERK ***:Silibinin issuggested to protect isoproterenol-induced rat cardiac myocyte apoptosis byactivating the tyrosine kinase pathway,PKC and MAPK pathways.

关键词： silibinin rat cardiac myocytes tyrosine kinase: protein kinase C mitngen-activated protein kinases

Effect of False Windows on Light Exposure and Sleep Quality in Hospitalized Patients

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Health 2023年第4期15卷 281-288页

作者： Hiroki onodera Mitsuru Ida Masahiko Kawaguchi Department of Medical Technology Center Nara Medical University Hospital Kashihara Japan Department of Anesthesiology Nara Medical University Kashihara Japan

Purpose: We aimed to investigate the effects of installing false windows next to hospital beds without windows on the amount of light received by patients and their sleep quality. Methods: The study included patients admitted to the Department of Neurology at our hospital between September 2020 and August 2021. An Actigraph device was fitted to patients’ wrist and their beds to measure the amount of light received and sleep quality. Patients were divided into three groups: bed with a window, aisle bed with a false window, and aisle bed without a window. Mean sleep efficiency (%), mean steps (per day), and the amount of light (lux) received by the patients and beds were measured. Results: Valid data were obtained for 48 participants (median age, 66.5 years). There were 23 patients in beds with a window, 13 patients in aisle beds without a false window, and 12 in aisle beds with a false window. No statistically significant differences were found in terms of mean sleep efficiency, number of steps taken, and the amount of light received by the patients (P > 0.05);however, difference in the mean amount of light received by the beds at the location of the bed was statistically significant (P Conclusion: The amount of light that the patient receives is not necessarily affected by the location of the bed or the presence of a false window.

关键词： Actigraph False Window Sleep Efficiency

Developing a Higher-Cycled Product Design CAE Model： The Evolution of Automotive Product Design and CAE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

通讯和计算机（中英文版） 2013年第10期10卷 1292-1306页

作者： Kakuro Amasaka Takehiro onodera Takahito Kozaki School of Science and Engineering Aoyama Gakuin University Kanagawa-ken 252-5258 Japan Graduate School of Science and Engineering Aoyama Gakuin University Kanagawa-ken 252-5258 Japan

Hydrogeochemical Assessment of Metals Contamination in an Urban Drainage System: A Case Study of Osogbo Township, SW-Nigeria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Water Resource and Protection 2009年第3期1卷 164-173页

作者： Moshood N. TIJANI Shinichi onodera 不详

With increasing urban population, attention had been focused on environmental degradation of urban drain-age system with respect to trace/heavy metal contaminations. Such concerns underlie the ever-increasing impacts of urbanization and industrial activities on urban watershed in the developing regions of the world, especially in areas with inadequate land-use plan and poor waste disposal and management practices. Hence, this study highlights the hydrogeochemical assessment of surface water and bottom-sediment samples from an urban drainage system in Osogbo Township, SW-Nigeria with respect to trace metals contaminations. The results show that the surface water samples have generally low TDS with average value of 362mg/l, while the average dissolved concentrations of the trace metals (Cu, Pb, Zn, Ni, As and Cr) vary from 0.01 to 0.5mg/l. Cu, Cr and As exhibit concentrations similar to the local background concentrations (LBC) in the pristine stream water with low single metal contamination factor (CF ≈ 1). Pb, Zn and Ni are 5 folds enriched with contamination factor (CF) of >5 indicating moderate to high contamination. For the sediment phase, the adsorbed concentrations of the trace metals (Cu, Pb, Zn, Ni, As, Cr and Co) vary between 0.1 to 3.1mg/kg. These represent about 1 to 3% of the respective total metal concentrations with average values of 18.2– 533.4mg/kg. Also low anthropogenic factor, AF (0.002 to 0.08) and mostly negative values (–5 to –15) of Mueller’s geo-accumulation index (Igeo) for adsorbed metal contents in the sediments suggest dominant geo-genic controls. However, the total metals concentrations in the sediment phase have high estimated AF of 1.1 to 9.3 and positive values of the estimated Igeo (0.9–2.0) and metal contamination index (MCI) of 2.5–8.3. All these suggest a medium to high level enrichment (of 2 to 10 factor) for most of the metals with respect to the local background concentration (LBC) in the basement bedrock units (with the excepti

关键词： Urban Drainage System Heavy Metals Contamination Bioavailability Water Quality Stream Sediments

Remote-Plasma-Assisted Deposition of Pentacene Layer Using Atomic-Hydrogen

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Crystallization Process and Technology 2014年第1期4卷 14-19页

作者： Satoshi Yamauchi Takatoshi Minakuchi Miyuki onodera Department of Biomolecular Functional Engineering Ibaraki University Hitachi Japan

Pentacene thin layers were deposited on Si with the native oxide at 80°C by remote-plasma-assisted deposition (RPAD) using hydrogen-plasma cell to supply atomic hydrogen radicals. The deposition rate was increased by RPAD comparing to that by non-excited hydrogen gas supply whereas thermal evaporation rate of pentacene from crucible was same in the both process. DFM and XRD studies showed the grain laterally grew in the thin film phase with the size above 10 μm by RPAD. First-principles molecular orbital calculations suggested pentacene is evaporated from crucible as the trimer or larger cluster but atomic hydrogen penetrated into the cluster enhances cracking of pentacene clusters to the monomer.

关键词： Remote-Plasma-Assisted Deposition Pentacene Hydrogen Plasma Atomic Hydrogen