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Geoscience Frontiers 2024年第4期15卷 411-426页

作者： Aifeng Liu Muhammad Imran Abdelmohsen A.Nassani rima h.binsaeed Khalid Zaman International Business School Shaanxi Normal UniversityXi’anChina Department of Economics The University of HaripurHaripur Khyber Pakhtunkhwa 22620Pakistan Department of Management College of Business AdministrationKing Saud UniversityP.O.Box 71115Riyadh 11587Saudi Arabia

Standards for Low-Carbon Energy Portfolios(LC-EPS)mandate that a certain percentage of a region's electricity generation originate from zero-or low-emissions *** 1995Q1 through 2020Q4,the study used the ARDL-Bounds testing technique to estimate coefficient parameters,Granger causality to draw causal inferences,and variance decomposition analysis to anticipate the factors that will have the greatest impact on carbon emissions in the US *** power significantly impacts carbon emissions,as seen by an inverted U-shaped environmental Kuznets curve,whereas long-term impact of innovation leads to lower *** the other hand,exports of sophisticated technology reduce carbon *** growth has a discernible effect on carbon emissions,nuclear power,innovation,and environmentally friendly ***-tech exports will likely impact carbon emissions most,followed by a demand for nuclear power,innovation,economic expansion,and sustainable finance for the next ten *** results give policymakers helpful insight into how the US economy may reduce carbon emissions and fight climate change via renewable energy and green finance.

关键词： Nuclear energy demand high technology exports Innovation Economic growth Green finance USA

Real-time monitoring the formation and decomposition processes of methane hydrate with Thz spectroscopy

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Science China(Physics,Mechanics & Astronomy) 2017年第1期60卷 72-73页

作者： XinYang Miao ShiNing Sun YiZhang Li Wei Wang rima Bao Kun Zhao Beijing Key Laboratory of Optical Detection Technology for Oil and Gas China University of Petroleum Beijing 102249 China

Gas hydrates are crystalline clathrate compounds comprised of hydrogen-bonded water cavities, consisting of guest molecules trapped in a lattice of polyhedral water cages under elevated pressures and low temperatures [1]. The structures of the gas hydrates are closely related to the types and sizes of the guest species, and three distinct structures, including cubic structure-I （sI）, hexagonal structure-h （sh）, are cubic structure-II （sII）, and known to form [2].

关键词： hexagonal crystalline trapped cubic hydrate guest sizes methane comprised bonded

Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells

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World Journal of Gastroenterology 2018年第10期24卷 1072-1083页

作者： Vaidotas Cesna Arturas Sukovas Aldona Jasukaitiene rima Naginiene Giedrius Barauskas Zilvinas Dambrauskas Saulius Paskauskas Antanas Gulbinas Department of Surgery Lithuanian University of Health Sciences Department of Obstetrics and Gynecology Lithuanian University of Health Sciences Institute for Digestive Research Lithuanian University of Health Sciences Neuroscience Institute Lithuanian University of Health Sciences

AIM To investigate the response to hyperthermia and chemotherapy, analyzing apoptosis, cytotoxicity, and cisplatin concentration in different digestive system cancer *** AGS(gastric cancer cell line), Caco-2(colon cancer cell line) and T3M4(pancreatic cancer cell line) were treated by cisplatin and different temperature setting(37 ℃ to 45 ℃) either in isolation, or in combination. Treatment lasted for one hour. 48 h after the treatment viability was evaluated by MTT, cell apoptosis by Annexin V-PE and 7 ADD flow cytometry. Intracellular cisplatin concentration was measured immediately after the treatment, using mass spectrometry. Isobologram analysis was performed to evaluate the mathematical combined effect of temperature and *** AGS cells were the most sensitive to isolated application of hyperthermia. hyperthermia, in addition to cisplatin treatment, did not provoke a synergistic effect at intervals from 37 ℃ to 41 ℃ in neither cancer cell line. however, a temperature of 43 ℃ enhanced cisplatin cytotoxicity for Caco-2 cells. Moreover, isobologram analysis revealed mathematical antagonistic effects of cisplatin and temperature combined treatment in AGS cells; variations between synergistic, additive, and antagonistic effects in Caco-2 cells; and additive and antagonistic effects in T3 M4 cells. Combined treatment enhanced initiation of cell apoptosis in AGS, Caco-2, and T3 M4 cells by 61%, 20%, and 19% respectively. The increase of intracellular cisplatin concentration was observed at 43 ℃ by 30%, 20%, and 18% in AGS, Caco-2, and T3 M4 cells, *** In addition to cisplatin, hyperthermia up to 43 ℃ does not affect the viability of cancer cells in a synergistic manner.

关键词： hyperthermal intraperitoneal chemotherapy Cisplatin hyperthermia Isobolograms Gastric cancer Pancreatic cancer Colon cancer

high frequency of the c.3207C>A (p.h1069Q) mutation in ATP7B gene of Lithuanian patients with hepatic presentation of Wilson's disease

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World Journal of Gastroenterology 2008年第38期14卷 5876-5879页

作者： Laimutis Kucinskas Jolanta Jeroch Astra Vitkauskiene Raimundas Sakalauskas Vitalija Petrenkiene Vaidutis Kucinskas rima Naginiene hartmut Schmidt Limas Kupcinskas Institute of Biology of Kaunas University of Medicine Mickeviiaus 9 Kaunas LT-44307 Lithuania Institute of Biomedical Research of Kaunas University of Medicine Eiveniu 4 Kaunas LT-50009 Lithuania Laboratory of Immunology and Genetics Kaunas University of Medicine Eiveniu 2 Kaunas LT-50009 Lithuania Department of Pulmonology and Immunology Kaunas University of Medicine Eiveniu 2Kaunas LT-50009 Lithuania Department of Gastroenterology Kaunas University of Medicine Eiveniu 2Kaunas LT-50009 Lithuania Department of human and Medical Genetics Faculty of Medicine Vilnius University Santariskiu 2Vilnius LT-08661 Lithuania Institute of Biomedical Research of Kaunas University of Medicine Eiveniu 4Kaunas LT-50009 Lithuania Department of hepatotransplanthology University of Munster Schlossplatz 2Munster D-48149 Germany Department of Gastroenterology Kaunas University of Medicine Eiveniu 2 Kaunas LT-50009 Lithuania

AIM： To investigate the prevalence of the ATP7B gene mutation in patients with hepatic presentation of Wilson＇s disease （WD） in Lithuania. METhODS： Eleven unrelated Lithuanian families, including 13 WD patients were tested. Clinically WD diagnosis was established in accordance to the Leipzig scoring system. Genomic DNA was extracted from whole venous blood using a salt precipitation method. Firstly, the semi-nested polymerase chain reaction （PCR） technique was used to detect the c.3207C〉A （p.h1069Q） mutation. Patients not homozygous for the c.3207C〉A （p.h1069Q） mutation were further analyzed. The 21 exons of the WD gene were amplified in a thermal cycler （Biometra T3 Thermocycler, G0ttingen, Germany）. Direct sequencing of the amplified PCR products was performed by cycle sequencing using fluorescent dye terminators in an automatic sequencer （Applied Biosystems, Darmstadt, Germany）. RESULTS： Total of 13 WD patients （mean age 26.4 years; range 17-40; male/female 3/10） presented with hepatic disorders and 16 their first degree relatives （including 12 siblings） were studied. Some of WD patients, in addition to hepatic symptoms, have had extrahepatic disorders （hemolytic anemia 3; Fanconi syndrome 1; neurophsychiatric and behavioural disorder 2）. Liver biopsy specimens were available in all of 13 WD patients （8 had cirrhosis; 1-chronic hepatitis; 3-acute liver failure, 1-1iver steatosis）. Twelve of 13 （92.3%） WD patients had the c.3207C〉A （***069Q） mutation, 6 of them in both chromosomes, 6 were presented as compound heterozygotes with additional c.3472-82delGGTTTAACCAT, c.3402delC, c.3121C〉T （***041W） or unknown mutations. For one patient with liver cirrhosis and psychiatric disorder （Leipzig score 6）, no mutations were found. Out of 16 first degree WD relatives, 11 （68.7%） were heterozygous for the c.3207C〉A （p.h1069Q） mutation. Two patients with fulminant WD died from acute liver failure and ii are in full remission under peniciilamine or zinc acetate treatment. Thr

关键词： Wilson disease ATP7B gene c.3207C〉A(p.h1069Q) mutation Cirrhosis Urine copper Copper in liver biopsies

Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques

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World Journal of Gastroenterology 2015年第16期21卷 4894-4902页

作者： Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim IFB Adiposity Diseases Leipzig University Medical Center Department of Medicine Neurology and DermatologyDivision of Gastroenterology and RheumatologyUniversity Hospital Leipzig Department of Diagnostic and Interventional Radiology University Hospital Leipzig Internistische hausarzt- und Diabetologische Schwerpunktpraxis Dr. Relke Department of Medicine Neurology and DermatologyDivision of Endocrinology and NephrologyUniversity Hospital Leipzig

AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver ***:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1h-MRS; only available for the diabetic cohort), and *** parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP ***:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the *** ASQ parameters showed differences between healthy controls and diabetic patients(Phe ASQ FD ratio(logarithmic)correlated with the CAP(r=-0.81,Ph-MRS(r=-0.43,P=0.004)*** FD ratio[CAPh advanced steatosis(ANOVA Phowever,none of the ASQ parameters showed a significant difference in patients with advanced fibrosis,as determined by TE and the NAFLD fibrosis score(P>0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver *** estimation with ASQ should be further evaluated in biopsy-controlled studies.

关键词： Transient elastography Non-alcoholic fatty liver disease Liver stiffness Fibrosis score Controlled attenuation parameter

骨形态发生蛋白15基因多态性与复发性葡萄胎和习惯性流产的相关性研究

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中国妇幼保健 2017年第11期32卷 2432-2435页

作者：王鹤 Ramesh Reddy Ngoc Minh Phuong Nguyen Seang L Tan rima Slim 广西医科大学附属肿瘤医院妇瘤科广西南宁530021 麦吉尔大学人类健康中心人类基因部加拿大蒙特利尔魁北克省H4A 3J1 麦吉尔大学人类健康中心妇产科加拿大蒙特利尔魁北克省H4A 3J1

目的探讨骨形态发生蛋白15(BMP15)基因多态性与复发性葡萄胎(RhMs)和习惯性流产(RSAs)的相关性。方法收集2012年10月-2013年9月在加拿大麦吉尔大学人类健康中心妇产科治疗的77例不同种族的RhMs和习惯性流产妇女的血液标本,采用基因外显... 详细信息

目的探讨骨形态发生蛋白15(BMP15)基因多态性与复发性葡萄胎(RhMs)和习惯性流产(RSAs)的相关性。方法收集2012年10月-2013年9月在加拿大麦吉尔大学人类健康中心妇产科治疗的77例不同种族的RhMs和习惯性流产妇女的血液标本,采用基因外显子测序分析患者BMP15基因的多态性,并采用蛋白功能预测软件预测各SNPs对BMP15蛋白功能的影响。结果在BMP15基因2个外显子中共检测到5个错义突变和1个插入突变。其中在外显子1中检测到2个错义突变(p.S5R和p.N103S);在外显子2中检测到3个错义突变(p.L148P,p.A180T,p.h200Y)和1个插入突变,(***263dup)。通过预测,p.L148P突变可能会严重影响BMP15蛋白的活性进而影响卵巢功能,而p.S5R突变的影响相对较小,其余SNPs对BMP15蛋白功能基本无影响。结论 BMP15基因突变除了可能与RhMs和习惯性流产妇女的卵泡生成障碍及卵巢功能早衰相关,还可能导致葡萄胎恶变。

关键词：骨形态发生蛋白15 基因多态性 RhMs 习惯性流产

Development of a Biopolymer by Chemical Modification of β-Cyclodextrin for Pharmaceutical Applications

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材料科学与工程（中英文A版） 2014年第7期4卷 209-215页

作者： Ghemit rima Baitiche Milad Makhloufi Abdesselam Faculty of Technology Ferhat Abbas University Sétif 19000 Algeria

The need for effective and safe therapeutic systems comply deliverances medication with the patient, led to the development of new tools and strategies. Cyclodextrins (CDs) are widely used as an excipient in many pharmaceutical forms. In this work, the β-cyclodextrin (β-CD) has been modified in order to serve as a vehicle for the design of capsules with diclofenac sodium (DCFNa) is the active ingredient. This modification is based on the crosslinking of the β-cyclodextrin by citric acid in the presence of a catalyst. Modulation parameters of the reaction were carried out by varying the content of the polyacid and used this in order to have the best reaction yield. The resulting matrix of this method was used to prepare the inclusion complexes with the drug. The characterization of these systems is performed by FTIR spectroscopy and XRD. Then, the release of DCFNa (packed in capsules), from native and cross-linked matrices in a simulated gastric and intestinal environment (ph = 1.2, t = 2 h) and (ph = 6.8, t = 6 h), was done. The kinetics of drug were studied and the dissolution profiles for the cross-linked and native β-CD were compared.

关键词：环糊精生物聚合物化学改性制药应用药物制备 FTIR光谱反应产率

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响应面优化羊肉负离子电场腌制工艺

食品与发酵工业 2020年第24期46卷 121-125页

作者：樊沙娜李斯琦刘彦秋白杨都日玛莎日娜内蒙古农业大学食品科学与工程学院内蒙古呼和浩特010018

该试验以羊肉为原料,将原料肉置于负离子电场中进行腌制,实验中以负离子电场强度、腌制温度、腌制时间为变量分析研究其对腌制羊肉中氧合肌红蛋白含量及相关指标的影响,利用Box-Behnken响应面法优化负离子电场腌制的工艺条件。结果表明... 详细信息

该试验以羊肉为原料,将原料肉置于负离子电场中进行腌制,实验中以负离子电场强度、腌制温度、腌制时间为变量分析研究其对腌制羊肉中氧合肌红蛋白含量及相关指标的影响,利用Box-Behnken响应面法优化负离子电场腌制的工艺条件。结果表明,负离子电场腌制羊肉的最佳工艺条件为:电场场强为3.34 kV、腌制温度为4℃、腌制时间为13 h,在此条件下预测的氧合肌红蛋白的含量为20.79%。综合考虑因素及实际生产条件,对最佳腌制工艺参数稍作调整后可得:负离子场强3 kV、腌制温度4℃、腌制时间13 h。经过验证试验,最佳工艺条件下可得到腌制肉中氧合肌红蛋白含量为(20.67±0.18)%。

关键词：羊肉负离子电场腌制氧合肌红蛋白响应面法

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非晶态FeSe超导材料制备与表征

微纳电子技术 2022年第10期59卷 1081-1089页

作者：詹鹏飞王俊焱刘逸宇王子佳吴海城宝日玛邢颖中国石油大学(北京)重质油国家重点实验室北京102249 中国石油大学(北京)新能源与材料学院北京102249 中国石油大学(北京)理学院北京102249

FeSe是铁基超导体家族中的重要一员,因其结构简单且物理内涵丰富而受到了极大的关注。关于各种维度的晶态FeSe超导电性研究已较为完备,而非晶态FeSe的制备与物性仍缺乏系统的研究。采用表面辅助气-固反应法,控制不同反应条件,成功制备... 详细信息

FeSe是铁基超导体家族中的重要一员,因其结构简单且物理内涵丰富而受到了极大的关注。关于各种维度的晶态FeSe超导电性研究已较为完备,而非晶态FeSe的制备与物性仍缺乏系统的研究。采用表面辅助气-固反应法,控制不同反应条件,成功制备了具有超导特性的非晶态FeSe。使用扫描电子显微镜(SEM)和能量散射谱仪(EDS)进行了样品形貌与化学元素组成表征。结果表明,在500~600℃内,随温度升高,样品的微米结构变得更为微细;Fe箔与Se粉末的距离对FeSe形貌影响明显;FeSe形貌对保温时长和温度梯度变化不敏感。X射线衍射(XRD)图中存在宽的漫衍射峰,证实了样品的非晶特性。通过磁学性能测量系统(MPMS)对样品进行了抗磁性测试,在约8.0 K下,样品表现出完全抗磁性;零温对应的下临界磁场强度(h_(c1)(0))约为66 Oe(1 A·m^(-1)=4π×10^(-3)Oe)。

关键词：铁基超导 FeSe 非晶态材料表面辅助气-固反应抗磁性