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Determining the IgG concentrations in bovine colostrum and calf sera with a novel enzymatic assay

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Journal of Animal Science and Biotechnology 2019年第1期10卷 239-247页

作者： M.Drikic C.Windeyer S.Olsen y.fu L.Doepel J.De Buck Department Production Animal Health Faculty of Veterinary MedicineUniversity of Calgary

Background: Immune protection in newborn calves relies on a combination of the timing,volume and quality of colostrum consumed by the calf after *** quality colostrum with inadequate immunoglobulin concentration contributes to failed transfer of passive immunity in calves,leading to higher calf morbidity and ***,estimating colostrum quality and ensuring the transfer of passive immunity on farm is of critical ***,there are no on-farm tools that directly measure immunoglobulin content in colostrum or *** aim of this study was to apply a novel molecular assay,split trehalase immunoglobulin G assay(STIGA),to directly estimate immunoglobulin content in dairy and beef colostrum and calf sera,and to examine its potential to be developed as on-farm *** STIGA is based on a split version of trehalase TreA,an enzyme that converts trehalose into glucose,enabling the use of a common glucometer for signal *** a first study,60 dairy and64 beef colostrum and 83 dairy and 84 beef calf sera samples were tested with STIGA,and the resulting glucose production was measured and compared with radial immunodiffusion,the standard method for measuring immunoglobulin ***: Pearson correlation coefficients between the methods were determined and the sensitivity,specificity,and accuracy of the test were calculated for different colostrum quality and failed transfer of passive immunity cut-off *** correlations of the STIGA measured by colorimetric enzymatic reaction compared to radial immunodiffusion for dairy and beef colostrum were 0.72 and 0.73,respectively,whereas the correlations for dairy and beef sera were 0.9 and 0.85,***,STIGA was tested in a blinded study with fresh colostrum and serum samples where the correlation coefficient was 0.93 and 0.94,***,the performance of STIGA followed by glucometer readings resulted in correlations with radial immunodiffusion of 0.7 and

关键词： Cattle Colostrum Immunoglobulins Passive immunity Radial immunodiffusion Split trehalase

Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants

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Bioactive Materials 2022年第2期7卷 253-266页

作者： k.Sun R.fu X.W.Liu L.M.Xu G.Wang S.y.Chen Q.J.Zhai S.Pauly Institute of Materials Shanghai UniversityShanghai200444China Department of Neurology Tongren HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200336China Sports Medicine Department of Huashan Hospital Fudan UniversityShanghai200040China University of Applied Sciences Aschaffenburg Würzburger Straße 45D-63743AschaffenburgGermany

Implantation is an essential issue in orthopedic *** metallic glasses(BMGs),as a kind of novel materials,attract lots of attentions in biological field owing to their comprehensive excellent ***,we show that a Zr_(61)Ti_(2)Cu_(25)Al_(12)(at.%)BMG(Zr-based BMG)displays the best cytocompatibility,pronounced positive effects on cellular migration,and tube formation from in-vitro tests as compared to those of commercial-pure titanium and *** in-vivo micro-CT and histological evaluation demonstrate the Zr-based BMG can significantly promote a bone *** tests and digital reconstructed radiographs manifest a stimulated effect on early blood vessel formation from the Zr-based ***,the intimate connection and coupling effect between angiogenesis and osteogenesis must be effective during bone regeneration after implanting Zr-based *** gait analysis in rats after implanting Zr-based BMG demonstrates a tendency to decrease the pain level during recovery,simultaneously,without abnormal ionic accumulation and inflammatory *** suitable mechanical properties,we provide a realistic candidate of the Zr61Ti2Cu25Al12 BMG for biomedical applications.

关键词： Metallic glasses Bio-corrosion Biocompatibility Osteogenesis Angiogenesis

Interfacial Engineering of Polymer Blend with Janus Particle as Compatibilizer

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Chinese Journal of Polymer Science 2023年第4期41卷 500-515,I0005页

作者： Hai-Ling He fu-Xin Liang Institute of Polymer Science and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing100084China

Mixing two or more polymers to produce the“polymer alloy”is one of the most versatile and economical strategies for developing new polymeric *** compatibility between polymer components largely determines the comprehensive performance of polymer *** recently,a type of unique surface partitioned materials,Janus particles,has been proposed to act as a novel interfacial compatibilizer for polymer *** Janus particles integrates the amphipathicity of diblock copolymer and interfacial stabilization of nanoparticles,displaying a significant superiority in comparison with molecular compatibilizers for a wide range of polymer *** this review,we mainly focus on the compatibilizing effects of Janus nanofillers of various morphologies,including spherical,snowman-like,and two-dimensional nanosheets,on polymer *** shed light on the impacts of compatibilization of Janus particles on phase morphologies,mechanical properties,and functionalities of polymer *** review could provide a guidance for designing an effective Janus particle compatibilizer to develop high-performance polymer blends.

关键词： Janus particles Compatibilizer Polymer blend Interfacial engineering

functional roles of Mst3 in radial migration during the development of mouse cerebral cortex

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Functional roles of Mst3 in radial migration during the deve...

电感耦合等离子体离子注入内表面的数值仿真研究

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jacque P k IP Amy k y fu Nancy y IP Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience CenterThe Hong Kong University of Science and TechnologyClear Water Bay

＜正＞Objective Radial migration is critical for the lamination of cerebral cortex during early brain development. Whereas the migration of neurons requires a precise regulation of the organization and dynamics of cytoskeleton including microtubule and actin network,the underlying signaling mechanisms are not well *** the present study,we investigate the functional roles of a kinase Mst3 in radial migration during cortical *** The radial migration in mouse neocortex was investigated by in utero *** cone collapse assay in cultured hippocampal neurons was performed using confocal ***（1） We identified that Mst3, a serine/threonine kinase highly expressed in the developing mouse brain,regulates the neuronal differentiation. （2） Silencing of Mst3 by in utero electroporation resulted in a significant delay on the neuronal migration in the developing mouse neocortex.（2） kinase activity of Mst3 was essential for its functions in neuronal morphogenesis and migration.（3） Mst3 was co-localized with F-actin at the growth cones of cultured hippocampal neurons,and regulated actin *** kinase activity of Mst3 is important for neuronal morphogenesis and radial migration through modulation of actin dynamics.

关键词： mammalian Sterile 20-like kinase 3 Mst3 neuronal migration actin dynamics

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真空 2010年第4期47卷 82-86页

作者：汪志健田修波巩春志杨士勤 ricky fu 哈尔滨工业大学现代焊接生产技术国家重点实验室黑龙江哈尔滨150001 Department of Physics & Materials Science City University of Hong kong

本文采用Particle-in-cell模型对采用电感等离子体离子注入处理管内表面的动力学过程进行数值仿真研究,考察了电感线宽对管内电势分布、鞘层重叠、离子平均注入能量、剂量和角度等的影响。计算结果表明随着电感线宽的增加,电感线圈对等... 详细信息

本文采用Particle-in-cell模型对采用电感等离子体离子注入处理管内表面的动力学过程进行数值仿真研究,考察了电感线宽对管内电势分布、鞘层重叠、离子平均注入能量、剂量和角度等的影响。计算结果表明随着电感线宽的增加,电感线圈对等离子体鞘层扩展的钳制作用增强,管内的鞘层重叠系数下降,电感内的离子消耗速度下降。在鞘层内电场力的作用下,离子会发生聚集,离子聚集点的位置随着电感线宽的增加向外移动。研究结果还表明通过增加电感线宽可以进一步提高管内表面的离子平均注入能量。离子注入以接近垂直的角度注入到管内表面,虽然电感线圈会产生阴影效应,但管内表面的阴影可以通过管与电感线圈的相对运动来消除。

关键词：等离子体离子注入粒子模拟注入能量剂量

functional roles of melanocortin-4 receptor in hippocampal synapse

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Functional roles of melanocortin-4 receptor in hippocampal s...

HIGH RESOLUTION,REAL-TIME LINE-FIELD FOURIER-DOMAIN INTERFEROMETRy

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Amy k.y.fu Nancy y.IP Division of Life Science Molecular Neuroscience Center and State Key Laboratory of Molecular NeuroscienceThe Hong Kong University of Science and TechnologyClear Water Bay

＜正＞Objective Melanocortin-4 receptor（MC4R）,which belongs to the G-protein coupled receptor（GPCR） superfamily,is one of the five melanocortin receptors（MCRs）that is expressed abundantly in the central nervous ***4R is activated by various endogenous ligands including melanocyte stimulating hormone（MSH）,and adrenocorticotropin *** central melanocortin signaling in the hypothalamus-pituitary-adrenal axis system is critical for regulating various aspects of energy homeostasis and feeding *** MC4R is highly expressed in other brain regions such as cortex and hippocampus,the roles of MC4R in these regions remain *** this study,the functional role of MC4R in synapse plasticity in hippocampus is *** The regulation of MC4R protein in hippocampal neurons was examined using immunocytochemical analysis and Western blot *** function of MC4R in hippocampal neurons was studied by RNA interference using calcium phosphate ***（1）MC4R protein increases in rat hippocampus upon development and enriched at the synaptic compartment.（2）knockdown of MC4R in cultured rat hippocampal neurons results in a regulation in the density of dendritic spines,the sites where excitatory synapses reside.（3）Stimulation of MC4R increases the cAMP level in hippocampal *** MC4R regulates the synapse functions through modulating the morphology of dendritic spines.

关键词： Melanocortin-4 receptor cyclic AMP dendritic spines

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Journal of Innovative Optical Health Sciences 2012年第2期5卷 41-48页

作者： QING XIAO LING fu Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology 1037 Luoyu Rd. Wuhan 430074P.R.China key Laboratory of Biomedical Photonics of Ministry of Education Huazhong University of Science and Technology 1037 Luoyu Rd. Wuhan 430074P.R.China

To increase the application potential in manufacturing process,such as monitoring the processing performance,the profile measurement should be provided in real-time display and with high resolution *** propose a line-field Fourier-domain interferometric method(LFI),which combines the line-field microscope with spectral interferometer,for the surface cross-sectional profile measurement with no scan *** white light and objectives are employed to offer high axial and lateral resolution,*** our system setup,the measurement could be implemented in real-time display of 10 frame/s,and the resolutions of the LFI system in X;y,and Z directions are~8μm,~3.2μm,and~1.4μm,*** a demonstration,the cross-sectional profiles of a microfluidic chip are *** graphics processing unit is also used to accelerate the reconstruction algorithm to achieve the real-time display of the cross-sectional profiles.

关键词： Line-field Fourier-domain interferometry cross-sectional profile real-time

Significantly Enhanced Melt Memory Effect of Metallocene-made Isotactic Polypropylene Containing Talc

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Chinese Journal of Polymer Science 2024年第2期42卷 213-222,I0008页

作者： Hong-Wen Sun fu-Shan Wang yan Gao fu-Qing Wei Jia-Chun Feng State key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China Lanzhou Petrochemical Corporation of PetroChina Lanzhou730060China Lanzhou Petrochemical Research Center Petrochemical Research Institute of PetroChinaLanzhou730060China

The melt memory effect is a widely observed phenomenon in semi-crystalline polymers. In practical applications, various additives are usually introduced into polymers, which may affect their melt memory behavior. In this work, the effect of talc on the melt memory effect of metallocene-made isotactic polypropylene(M-PP) was investigated in detail by using the differential scanning calorimetry. The results indicated that the introduction of talc significantly strengthened the melt memory effect of M-PP. Specifically, the upper limit temperature of Domain II increased from 161 ℃ to 174 ℃, resulting in a substantial widening of the temperature range of Domain IIa from 1 ℃ to 14 ℃. Analysis of the crystal orientation of the M-PP containing talc cooled from various Ts suggested that the remarkably enhanced melt memory effect could be ascribed to the stabilization of oriented nuclei facilitated by talc. This stabilizing effect was likely attributable to the prefreezing effect or the sorption interaction between talc and the M-PP chains.

关键词： Metallocene-made isotactic polypropylene Talc Melt memory effect Crystal orientation

How faithfully can π be interpreted in SA?

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Science China(Information Sciences) 2013年第3期56卷 82-96页

作者： LONG Huan fu yuXi Basic Studies in Computing Science Department of Computer ScienceMOE-MS Key Laboratory for Intelligent Computing and Intelligent SystemsShanghai Jiao Tong University

The π calculus and the safe ambient calculus are two of the widely studied variants of process calculi in the field of concurrency *** former is the most classic model for mobile processes and the latter is well known for its nested ***,the relationship between these two models deserves further *** this paper,we reinvestigate this problem *** first give the strengthened encoding *** we propose the encoding of the synchronous π-calculus into the safe ambients *** encoding scheme is a generalization and improvement of Levi and Sangiorgi’s work when moving from the asynchronous π-calculus to the synchronous π-*** show the merits of the encoding by checking the mentioned criteria.

关键词： encoding expressiveness synchronous π-calculus safe ambients