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DTBVis:An interactive visual comparison system for digital twin brain and human brain

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Visual Informatics 2023年第2期7卷 41-53页

作者： Yuxiao Li Xinhong Li Siqi Shen Longbin Zeng richen liu Qibao Zheng Jianfeng Feng Siming Chena School of Data Science Fudan UniversityChina Institute of Science and Technology for Brain-Inspired Intellignece Fudan UniversityChina School of Computer and Electronic Information Nanjing Normal UniversityChina

The digital twin brain(DTB)computing model from brain-inspired computing research is an emerging artificial intelligence technique,which is realized by a computational modeling approach of hardware and software.It can achieve various cognitive abilities and their synergistic mechanisms in a manner similar to the human brain.Given that the task of the DTB is to simulate the functions of the human brain,comparing the similarities and differences between the two is crucial.However,the visualization study of the DTB is still under-researched.Moreover,the complexity of the datasets(multilevel spatiotemporal granularity and different types of comparison tasks)presents new challenges to the analysis and exploration of visualization.Therefore,in this study,we proposed DTBVis,a visual analytics system that supports comparison tasks for the DTB.DTBVis supports iterative explorations from different levels and at different granularities.Combined with automatic similarity recommendation,and high-dimensional exploration,DTBVis can assist experts in understanding the similarities and differences between the DTB and the human brain,thus helping them adjust their model and enhance its functionality.The highest level of DTBVis shows an overview of the datasets from the brain,which is used for comparison and exploration of the function and structure of the DTB and the human brain.The medium level is used for the comparison and exploration of a designated brain region.The low level can analyze a designated brain voxel.We worked closely with experts of brain science and held regular seminars with them.Feedback from the experts indicates that our approach helps them conduct comparative studies of the DTB and human brain and make modeling adjustments of the DTB through intuitive visual comparisons and interactive explorations.

关键词： Brain Digital twin brain Visual analytics Comparative analysis

LTSA-LE:A Local Tangent Space Alignment Label Enhancement Algorithm

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Tsinghua Science and Technology 2021年第2期26卷 135-145页

作者： Chao Tan Genlin Ji richen liu Yanqiu Cao School of Computer Science and Engineering Southeast UniversityNanjing 210096 School of Computer Science and Technology Nanjing Normal UniversityNanjing 210023China

According to smoothness assumption,local topological structure can be shared between feature and label manifolds.This study proposes a new algorithm based on Local Tangent Space Alignment(LTSA)to implement the label enhancement process.In general,we first establish a learning model for feature extraction in label space and use a feature extraction method of LTSA to guide the reconstruction of label manifolds.Then,we establish an unconstrained optimization model based on the optimal theory presented in this paper.The model is suitable for solving problems with a large number of sample points.Finally,the experiment results show that the algorithm can effectively improve the training speed and multilabel dataset prediction accuracy.

关键词： smoothness assumption feature manifold label manifold unconstrained optimization

A Survey of Multi-Space Techniques in Spatio-Temporal Simulation Data Visualization

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Visual Informatics 2019年第3期3卷 129-139页

作者： Xueyi Chen Liming Shen Ziqi Sha richen liu Siming Chen Genlin Ji Chao Tan School of Computer Science and Technology Nanjing Normal UniversityNo.1 Wenyuan RoadQixia DistrictNanjingJiangsuPR China Fraunhofer Institute for Intelligent Analysis and Information Systems Germany University of Bonn Germany

The widespread use of numerical simulations in different scientific domains provides a variety of research opportunities.They often output a great deal of spatio-temporal simulation data,which are traditionally characterized as single-run,multi-run,multi-variate,multi-modal and multi-dimensional.From the perspective of data exploration and analysis,we noticed that many works focusing on spatiotemporal simulation data often share similar exploration techniques,for example,the exploration schemes designed in simulation space,parameter space,feature space and combinations of them.However,it lacks a survey to have a systematic overview of the essential commonalities shared by those works.In this survey,we take a novel multi-space perspective to categorize the state-ofthe-art works into three major categories.Specifically,the works are characterized as using similar techniques such as visual designs in simulation space(e.g,visual mapping,boxplot-based visual summarization,etc.),parameter space analysis(e.g,visual steering,parameter space projection,etc.)and data processing in feature space(e.g,feature definition and extraction,sampling,reduction and clustering of simulation data,etc.).

关键词： Simulation data visualization Spatio-temporal data visualization Comparative visualization

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探地数据可视化研究

计算机辅助设计与图形学学报 2015年第1期27卷 36-45页

作者：原达刘日晨袁晓如山东工商学院计算机科学与技术学院烟台264005 北京大学信息科学技术学院机器感知与智能教育部重点实验室北京100871

由于发展中国家经济增长的驱动,全球对石油、天然气体的需求在不断地增长,从而需要越来越纯熟的石油勘探技术.探地数据可视化在石油、天然气勘探过程中起着举足轻重的作用.文中主要从可视化的角度对探地数据的解释与展示进行了调研:首... 详细信息

由于发展中国家经济增长的驱动,全球对石油、天然气体的需求在不断地增长,从而需要越来越纯熟的石油勘探技术.探地数据可视化在石油、天然气勘探过程中起着举足轻重的作用.文中主要从可视化的角度对探地数据的解释与展示进行了调研:首先介绍了以二维切片为主的探地数据可视化方法,包括二维切片纹理映射、二维断层可视化;其次讨论了以三维体绘制技术为主的探地数据可视化方法;最后总结了解释性与叙述性可视化,以及基于Sketch的交互式可视化和领域知识辅助的可视化.

关键词：探地数据切片可视化体绘制解释性可视化

Some observational results of sea storm current

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Acta Oceanologica Sinica 2001年第2期20卷 299-308页

作者： Xiu richen, liu Aiju, Ye Hesong, Gu Yuhe, Xu Lanying (1. First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China 2. Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China) First Institute of Oceanography State Oceanic Administration Qingdao 266061 China

INTRODUCTIONDr. Hollister, a marine geologist of the Woods Hole Oceanographic Institution, first pointed out that there was ocean storm current in the ocean. He found out the wavy texture in the seabed core samples, and suggested that this wavy texture was caused by the high speed sea current in remote antiquity. He then suggested a bold hypothesis that there existed a benthic storm current near the ocean bottom, and presented this hypothesis at the IUGG conference held at San Francisco in 1963. Unfortunately, the attention was not drawn to the hypothesis at the conference, and the hypothesis was criticized as a sheer nonsense.

关键词： Sea storm current tidal storm current chaotic motion

淹水胁迫下6种北方花灌木光合特性及耐涝性评价

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植物生理学报 2024年第4期60卷 725-738页

作者：朱婧杨城刘思王茂良丛日晨孙宏彦北京市园林绿化科学研究院绿化植物育种北京市重点实验室城乡生态环境北京实验室北京100102 河北农业大学河北保定071001 涉县住房和城乡建设局城镇园林管理所河北邯郸056400 北京农学院北京102206

本研究以淹水胁迫0~15 d的重瓣榆叶梅、金钟花、水栒子、小花溲疏、圆锥绣球、欧洲荚蒾6种北方花灌木为试材,测定其根系生长、植株形态、光合气体交换和叶绿素荧光参数等变化。结果显示,重瓣榆叶梅、金钟花、水栒子、小花溲疏、圆锥绣球... 详细信息

本研究以淹水胁迫0~15 d的重瓣榆叶梅、金钟花、水栒子、小花溲疏、圆锥绣球、欧洲荚蒾6种北方花灌木为试材,测定其根系生长、植株形态、光合气体交换和叶绿素荧光参数等变化。结果显示,重瓣榆叶梅、金钟花、水栒子、小花溲疏、圆锥绣球5种花灌木根系干重、根总长、根表面积等根系指标随淹水时间的增加呈先增加后下降的趋势,欧洲荚蒾呈逐渐下降的趋势;6种花灌木的植物叶片的叶片含水率、比叶重、PSII最大光合效率(Fv/Fm)、单位反应中心吸收的光能(RC/ABS)以及潜在光合转化和利用能力(PI)等叶绿素荧光指标及净光合速率(Pn)、气孔导度(Gs)、胞间CO_(2)浓度(Ci)等光合指标较对照均减小。根据测定的指标通过主成分分析等对其耐涝性进行评价,结果表明,淹水胁迫导致植物根系发褐、腐烂;植株出现萎蔫、落叶甚至死亡;随着淹水时间的增加,6种花灌木出现不同程度的光合系统受损。主成分分析结果表明,淹水胁迫主要影响植物的根系,进一步影响植物光和系统,最终评价得出6种花灌木的耐涝性排序为欧洲荚蒾>金钟花>小花溲疏>水栒子>圆锥绣球>重瓣榆叶梅。

关键词：淹水胁迫根系变化形态特征光合特性叶绿素荧光特性花灌木

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铜基催化剂用于一氧化碳电还原为多碳产品

Science China Materials 2024年第6期67卷 1684-1705页

作者：赵雯刘娟王光滔王新天杨传举李剑王鋙葶孙晓莲林日琛左淦丞朱文磊 State Key Laboratory of Pollution Control and Resource Reuse Frontiers Science Center for Critical Earth Material CyclingState Key Laboratory of Pollution Control and Resource Reusethe Frontiers Science Center for Critical Earth Material CyclingSchool of the EnvironmentNanjing UniversityNanjing 210023China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceSchool of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 211189China Jiangsu Engineering Lab of Water and Soil Eco-remediation School of EnvironmentNanjing Normal UniversityNanjing 210023China

电化学二氧化碳还原(ECO_(2)R)是一种将碳和可再生能源的能量储存在多碳产品(C_(2+))的化学键中的有效途径.然而,反应涉及的复杂步骤为CO_(2)直接转化为C_(2+)设置了巨大的障碍.一种利用CO作为“中转站”,通过串联ECO_(2)R和电化学CO还... 详细信息

电化学二氧化碳还原(ECO_(2)R)是一种将碳和可再生能源的能量储存在多碳产品(C_(2+))的化学键中的有效途径.然而,反应涉及的复杂步骤为CO_(2)直接转化为C_(2+)设置了巨大的障碍.一种利用CO作为“中转站”,通过串联ECO_(2)R和电化学CO还原(ECOR)以提高生产C_(2+)的选择性和反应速率的策略引起了人们的广泛关注.本文总结了铜基电催化剂在ECOR中催化特定C_(2+)生成的设计策略.其次,从各个方面总结了催化剂工程的代表性设计策略,并介绍了电解反应器改进方面的最新进展.最后,阐述了该研究领域面临的主要挑战和未来前景.这些见解和观点将为铜基电催化剂的设计提供有益指导.

关键词： CO electroreduction Cu-based catalysts multi-car-bon products

Remodeling Isoprene Pyrophosphate Metabolism for Promoting Terpenoids Bioproduction

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Engineering 2023年第9期28卷 166-178页

作者： Xianhao Xu Xueqin Lv Shixiu Cui Yanfeng liu Hongzhi Xia Jianghua Li Guocheng Du Zhaofeng Li Rodrigo Ledesma-Amaro Jian Chen Long liu Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationJiangnan UniversityWuxi 214122China Science Center for Future Foods Ministry of EducationJiangnan UniversityWuxi 214122China richen Bioengineering Co. Ltd.Nantong 226000China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China Department of Bioengineering and Centre for Synthetic Biology Imperial College LondonLondon SW72AZUK

Terpenoids are the largest family of natural products.They are made from the building block isoprene pyrophosphate(IPP),and their bioproduction using engineered cell factories has received a great deal of attention.To date,the insufficient metabolic supply of IPP remains a great challenge for the efficient synthesis of terpenoids.In this work,we discover that the imbalanced metabolic flux distribution between the central metabolism and the IPP supply hinders IPP accumulation in Bacillus subtilis(B.subtilis).Therefore,we remodel the IPP metabolism using a series of genetically encoded two-input-multioutput(TIMO)circuits that are responsive to pyruvate or/and malonyl-CoA,resulting in an IPP pool that is significantly increased by up to four-fold.As a proof-of-concept validation,we design an IPP metabolism remodeling strategy to improve the production of three valuable terpenoids,including menaquinone-7(MK-7,4.1-fold),lycopene(9-fold),andβ-carotene(0.9-fold).In particular,the titer of MK-7 in a 50-L bioreactor reached 1549.6 mg·L^(-1),representing the highest titer reported so far.Thus,we propose a TIMO genetic circuits-assisted IPP metabolism remodeling framework that can be generally used for the synergistic fine-tuning of complicated metabolic modules to achieve the efficient bioproduction of terpenoids.

关键词： Terpenoids Genetic circuits Bacillus subtilis Isoprene pyrophosphate

4种木本园林植物水分胁迫生理响应及耐旱性评价

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分子植物育种 2023年第23期21卷 7867-7883页

作者：朱婧聂水刘思丛日晨王茂良孙宏彦北京市园林绿化科学研究院绿化植物育种北京市重点实验室城乡生态环境北京实验室北京100102 河北农业大学园林与旅游学院保定071001 河北省邯郸市涉县住房和城乡建设局城镇园林管理所邯郸056400 北京农学院园林学院北京102206

为了揭示水分胁迫对不同植物生理特性的影响,研究4种木本园林植物在不同水分胁迫条件下,植株形态、光合气体交换、叶绿素荧光等参数变化,并通过形态评分、主成分分析对它们的耐旱性进行评价。本研究以‘重瓣’榆叶梅(Amygdalus triloba ... 详细信息

为了揭示水分胁迫对不同植物生理特性的影响,研究4种木本园林植物在不同水分胁迫条件下,植株形态、光合气体交换、叶绿素荧光等参数变化,并通过形态评分、主成分分析对它们的耐旱性进行评价。本研究以‘重瓣’榆叶梅(Amygdalus triloba f.multiplex)、紫藤(Wisteria sinensis)、中华金叶榆(Ulmus pumila’Jinye’)和‘绚丽’海棠(Malus’Radiant’)二年生盆栽幼苗为试验材料,通过欠量灌溉法对其进行5个不同灌溉量、4个周期的水分胁迫,观测不同灌溉条件下各植物形态、光合和荧光等指标变化,并观察恢复灌溉1个月后植株生长状况。结果显示,水分胁迫后4种植物叶片出现不同程度的萎蔫、焦边及落叶的情况;叶片含水率、叶面积均随灌水量的减少及灌溉周期的增加而显著降低;净光合速率(A)显著下降并伴随着蒸腾速率(E)、气孔导度(Gs)和水分利用率(WUE)的下降;最大光合效率(Fv/Fm)变化不显著、光合性能指数(PIABS)随水分胁迫的加重而逐渐降低。通过对不同植物评价结果的综合比较和分析发现,4种木本园林植物中,中华金叶榆的耐旱性最强,‘重瓣’榆叶梅最弱。本研究旨在为园林植物造景及养护管理提供参考。

关键词：木本植物水分胁迫形态特征光合特性叶绿素荧光特性