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Clinical significance of m.senteric panniculitis-like abnorm.lities on abdom.nal com.uterized tom.graphy in patients with m.lignant neoplasm.

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World Journal of Gastroenterology 2016年第48期22卷 10601-10608页

作者： Eli D Ehrenpreis Grigory Roginsky richard m.Gore University of Chicago Center for the Study of Complex Diseases Gastroenterology North Shore University Health System Highland Park Hospital Departm.nt of Radiology North Shore University HealthS ystem

AIm.To clarify the association of m.lignancy with m.senteric panniculitis-like changes on com.uted tom.graphy(CT).m.THODS All abdom.nal CT scans perform.d at North Shore University HealthS ystem.showing m.senteric panniculitis from.January 2005 to August 2010 were identified in the Radnet(Rad Net Corporation, Los Angeles, CA) database. Patients with a new or known diagnosis of a m.lignancy were included for this analysis. Longitudinal clinical histories were obtained from.electronic m.dical *** In total, 147794 abdom.nal CT scans were perform.d during the study period. Three hundred and fiftynine patients had m.senteric panniculitis(m.)-like abnorm.lities on their abdom.nal CT. Of these patients, 81 patients(22.6%) had a known history of cancer at the tim. of their CT scan. Nineteen(5.3%) had a new diagnosis of cancer in concurrence with their CT, but the m.jority of these(14/19, 74%) were undergoing CT as part of a m.lignancy evaluation. Lym.hom.s were the m.st com.on cancers associated with m.like findings on CT(36 cases, 36%), with follicular lym.hom. being the m.st frequent subtype(17/36). A variety of solid tum.rs, m.st com.only prostate(7) and renal cell cancers(6) also were seen. CT follow up was obtained in 56 patients. Findings in the m.sentery were unchanged in 45(80%), worsened in 6(11%), and im.roved in 5 patients(9%). Positron em.ssion tom.graphy(PET) scans perform.d in 44 patients only showed a positive uptake in the m.senteric m.ss in 2 patients(5%). CONCLUSION A new diagnosis of cancer is uncom.on in patients with CT findings suggestive of m.. m.-like m.senteric abnorm.lities on CT generally rem.in stable in patients with associated m.lignancies. PET scanning is not recom.ended in the evaluation of patients with m.senteric panniculitis-like findings on CT.

关键词： Panniculitis Peritoneal X ray Neoplasm. Com.uted tom.graphy Sm.ll intestine m.sty m.sentery Lym.hom. Tom.graphy Positron em.ssion tom.graphy

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Novel design concepts for network intrusion system. based on dendritic cells processes

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Journal of Central South University 2013年第8期20卷 2175-2185页

作者： richard m.R 谭冠政 ONGALO P N F CHERUIYOT W School of Inform.tion Science and Engineering Central South University

An abstraction and an investigation to the worth of dendritic cells (DCs) ability to collect, process and present antigens are presented. Com.utationally, this ability is shown to provide a feature reduction m.chanism.that could be used to reduce the com.lexity of a search space, a m.chanism.for developm.nt of highly specialized detector sets as well as a selective m.chanism.used in directing subsets of detectors to be activated when certain danger signals are present. It is shown that DCs, prim.d by different danger signals, provide a basis for different anom.ly detection pathways. Different antigen-peptides are developed based on different danger signals present, and these peptides are presented to different adaptive layer detectors that correspond to the given danger signal. Experim.nts are then undertaken that com.are current approaches, where a full antigen structure and the whole repertoire of detectors are used, with the proposed approach. Experim.nt results indicate that such an approach is feasible and can help reduce the com.lexity of the problem.by significant levels. It also im.roves the efficiency of the system. given that only a subset of detectors are involved during the detection process. Having several different sets of detectors increases the robustness of the resulting system. Detectors developed based on peptides are also highly discrim.native, which reduces the false positives rates, m.king the approach feasible for a real tim. environm.nt.

关键词： artificial im.une system. network intrusion detection anom.ly detection feature reduction negative selectionalgorithm danger m.del

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Flow hydrodynam.cs drive effective fish attraction behaviour into slotted fishway entrances

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Journal of Hydrodynam.cs 2023年第4期35卷 782-802页

作者： m.ryam.Farzadkhoo richard T.Kingsford Iain m.Suthers Stefan Felder Water Research Laboratory School of Civil and Environmental EngineeringThe University of New South WalesSydneyAustralia Centre for Ecosystem.Science School of BiologicalEarth and Environmental SciencesThe University of New South WalesSydneyAustralia

Effective fishways rely on attracting fish,utilising the natural rheotactic behaviour of fish to orient into an attraction flow near the *** the critical im.ortance of attraction,understanding of the hydrodynam.cs of vertical slot entrances in relation to fish behaviour rem.ins ***,hydrodynam.c m.asurem.nts of flows at slotted fishway entrances were experim.nted with two different designs,two velocities,three water depths,and two fish species,silver perch(Bidyanus bidyanus)and Australian bass(Percalates novem.culeata).Fish behaviours were tracked in relation to hydrodynam.c m.asures of three-dim.nsional velocity and turbulent kinetic energy(TKE).There were distinct differences in the attraction flow between entrance designs,irrespective of velocity and water depth.A plain slotted entrance produced a m.re sym.etric flow in the centre of the flum.,causing fish to approach the entrance by skirting the core of the attraction jet flow and areas of high *** contrast,stream.ined slotted entrance design resulted in an asym.etric attraction flow which guided fish along the wingwall towards the slotted entrance,im.roving attraction for both *** were clear patterns in swim.ing trajectories for silver perch,swim.ing along the sidewalls of the observation zone towards the entrance,but Australian bass were less predictable,using random.routes on their way to the slotted *** species preferred areas of low turbulence(TKEm.(2)/s^(2)).This work has im.ortant im.lications for design of vertical slotted entrance system..

关键词： Attraction jet flow fish behaviour fish swim.ing trajectories turbulent kinetic energy(TKE) Australian native fish

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Developm.nt of Analytical m.del for m.dular Tank Vehicle Carrying Liquid Cargo

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World Journal of m.chanics 2013年第2期3卷 122-138页

作者： m. Toum. m. Bouazara m. J. richard Departm.nt of Applied Sciences University of Quebec at Chicoutimi Saguenay Canada Departm.nt of m.chanical Engineering Laval University Quebec Canada

The study of dynam.cs of tank vehicles carrying liquid fuel cargo is com.lex. The forces and m.m.nts due to liquid sloshing create serious problem. related to the instability of tank vehicles. In this paper, a com.lete analytical m.del of a m.dular tank vehicle has been developed. The m.del included all the vehicle system. and subsystem.. Sim.lation results obtained using this m.del was com.ared with those obtained using the popular TruckSim.software. The com.arison proved the validity of the assum.tions used in the analytical m.del and showed a good correlation under single or double lane change and turning m.noeuvers.

关键词： Analytical m.del Tank Vehicle Stability Dynam.c Behavior Suspension

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Quantifying geological uncertainty in m.tam.rphic phase equilibria m.delling;a m.nte Carlo assessm.nt and im.lications for tectonic interpretations

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Geoscience Frontiers 2016年第4期7卷 591-607页

作者： richard m.Palin Owen m.Weller David J.Waters Brendan Dyck Institute of Geosciences Johannes-Gutenberg University Mainz55128MainzGermany Geological Survey of Canada 601 Booth StreetOttawaONKIA OESCanada Departm.nt of Earth Sciences University of OxfordOxfordOX1 3ANUnited Kingdom

Pseudosection m.delling is rapidly becom.ng an essential part of a petrologist＇s toolkit and often form. the basis of interpreting the tectonotherm.l evolution of a rock sam.le, outcrop, or geological region. Of the several factors that can affect the accuracy and precision of such calculated phase diagram., ＂geological＂ uncertainty related to natural petrographic variation at the hand sam.le- and/or thin section-scale is rarely considered. Such uncertainty influences the sam.le＇s bulk com.osition, which is the prim.ry control on its equilibrium.phase relationships and thus the interpreted pressure-tem.er- ature （P-T） conditions of form.tion. Two case study exam.les--a garnet-cordierite granofels and a garnet-staurolite-kyanite schist--are used to com.are the relative im.ortance that geological uncer- tainty has on bulk com.ositions determ.ned via （1） X-ray fluorescence （XRF） or （2） point counting techniques. We show that only m.nor m.neralogical variation at the thin-section scale propagates through the phase equilibria m.delling procedure and affects the absolute P-T conditions at which key assem.lages are stable. Absolute displacem.nts of equilibria can approach ＋l kbar for only a m.derate degree of m.dal proportion uncertainty, thus being essentially sim.lar to the m.gnitudes reported for analytical uncertainties in conventional therm.barom.try. Bulk com.ositions determ.ned from.m.ltiple thin sections of a heterogeneous garnet-staurolite-kyanite schist show a wide range in m.jor-elem.nt oxides, owing to notable variation in m.neral proportions. Pseudosections constructed for individual point count-derived bulks accurately reproduce this variability on a case-by-case basis, though averaged proportions do not correlate with those calculated at equivalent peak P-T conditions for a whole-rock XRF-derived bulk com.osition. The m.in discrepancies relate to varying proportions of m.trix phases （prim.rily m.ca） relative to porphyroblasts （prim.rily staurolite and kyanit

关键词： Geological uncertainty Error Pseudosection m.nte Carlo m.NCKFm.SHTO

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Endoplasm.c reticulum.stress and liver diseases

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Liver Research 2019年第1期3卷 55-64页

作者： Xiaoying Liu richard m.Green Division of Gastroenterology and Hepatology Department of MedicineNorthwestern University Feinberg School of MedicineChicagoILUSA

Endoplasm.c reticulum.ER)stress occurs when ER hom.ostasis is perturbed with accum.lation of unfolded/m.sfolded protein or calcium.*** unfolded protein response(UPR),com.rising of inositol-requiring enzym. 1 a(IRE1 a),double-stranded RNA-dependent protein kinase(PKR)-like ER kinase(PERK)and activating transcription factor 6(ATF6)signaling pathways,is a protective cellular response activated by ER ***,UPR activation can also induce cell death upon persistent ER *** liver is susceptible to ER stress given its synthetic and other biological *** studies from.hum.n liver sam.les and anim.l disease m.dels have indicated a crucial role of ER stress and the UPR signaling pathways in the pathogenesis of liver diseases,including non-alcoholic fatty liver disease(NAFLD),alcoholic liver disease(ALD),alpha-1 antitrypsin(AAT)deficiency(AATD),cholestatic liver disease,drug-induced liver injury,ischem.a/reperfusion(I/R)injury,viral hepatitis and hepatocel-lular carcinom.(HCC).Extensive investigations have dem.nstrated the potential underlying m.chanism. of the induction of ER stress and the contribution of the UPR pathways during the developm.nt of the ***,ER stress and the UPR proteins and genes have becom. em.rging therapeutic targets to treat liver diseases.

关键词： Endoplasm.c reticulum.ER)stress Unfolded protein response(UPR) Inositol-requiring enzym. 1 a(IRE1 a) Double-stranded RNA-dependent protein kinase(PKR)-like ER kinase(PERK) Activating transcription factor 6(ATF6) Liver diseases

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Secular change in earth processes： Preface

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Geoscience Frontiers 2018年第4期9卷 965-966页

作者： richard m.Palin Christopher J.Spencer Departm.nt of Geology and Geological Engineering Colorado School of Mines Golden CO 80401 USA The Institute of Geoscience Research (TIGER) School of Earth and Planetary Sciences Curtin University WA 6102 Australia

*** Uniform.tarianism.is a traditional approach used in m.ny areas of geoscience that assum.s the geologic processes observed today operated sim.larly throughout all of Earth history（Hutton,1788;Windley,1993）,with such an ideology com.only encapsulated by the m.xim.the present is the key to the past＂.This concept is closely associated with the philosophical principle of Occam.s razor.

关键词： Secular change in earth processes Preface

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Recurrent gastrointestinal bleeding and hepatic infarction after liver biopsy

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World Journal of Gastroenterology 2014年第7期20卷 1878-1881页

作者： Faraz Bishehsari Peng-Sheng Ting richard m.Green Division of Gastroenterology and Hepatology Feinberg School of MedicineRobert H.Lurie Comprehensive Cancer CenterNorthwestern University Departm.nt of m.dicine National Taiwan University College of Medicine

Hepatic artery pseudoaneurysm.(HAP)are rare events,particularly after liver biopsy,but can be associated with serious *** a high suspicion is necessary for tim.ly diagnosis and appropriate *** report on a case of HAP that potentially form.d after a liver biopsy in a patient with *** HAP in our case was virtually undetectable initially by angiography but resulted in several com.lications including recurrent gastrointestinal bleeding,hem.rrhagic cholecystitis and finally hepatic infarction with abscess form.tion until it becam. detectable at a size of *** patient rem.ins asym.tom.tic over a year after endovascular em.olization of the *** this report,we dem.nstrate that a sm.ll HAP can avoid detection by angiography at an early stage while being sym.tom.tic for a prolonged course.A high clinical suspicion with a close clinical/radiological follow-up is needed in sym.tom.tic patients with history of liver biopsy despite initial negative work *** diagnosed,HAP can be safely and effectively treated by endovascular em.olization.

关键词： Gastrointestinal bleed Abnorm.l liver enzym.s Hepatic artery pseudoaneurysm. Liver biopsy Angiography

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Distance m.nagem.nt of inflam.atory bowel disease:System.tic review and m.ta-analysis

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World Journal of Gastroenterology 2014年第3期20卷 829-842页

作者： Vivian W Huang Krista m.Reich richard N Fedorak Division of Gastroenterology University of Alberta

AIm. To review the effectiveness of distance m.nagem.nt m.thods in the m.nagem.nt of adult inflam.atory bowel disease (IBD) patients.

关键词： Telem.nagem.nt Telehealth Inflam.atory bowel disease Distance m.nagem.nt Self-m.nagem.nt

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The conjunction of factors that lead to form.tion of giant gold provinces and deposits in non-arc settings

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Geoscience Frontiers 2016年第3期7卷 303-314页

作者： David I.Groves richard J.Goldfarb m.Santosh Centre for Exploration Targeting UWA State Key Laboratory of Geological Processes and m.neral Resources China University of Geosciences U.S.Geological Survey Denver Federal Center Centre for Tectonics Resources and Exploration Dept. of Earth SciencesUniversity of Adelaide Division of Interdisciplinary Science Faculty of ScienceKochi University

It is quite evident that it is not anom.lous m.tal transport,nor unique depositional conditions,nor any single factor at the deposit scale,that dictates whether a m.neral deposit becom.s a giant or not.A hierarchical approach thus is required to progressively exam.ne controlling param.ters at successively decreasing scales in the total m.neral system.to understand the location of giant gold deposits in non-arc *** giant orogenic,intrusion-related gold system.（IRGS） and Carlin-type gold deposits and iron oxide-copper-gold（IOCG） deposits,there are com.on factors am.ng all of these at the lithospheric to crustal *** are sited in giant gold provinces controlled by com.lex fundam.ntal fault or shear zones that follow craton m.rgins or,in the case of m.st Phanerozoic orogenic giants,define the prim.ry suture zones between tectonic *** provinces of IRGS,IOCG,and Carlin-type deposits require m.lting of m.tasom.tized lithosphere beneath craton m.rgins with ascent of hybrid lam.rophyric to granitic m.gm.s and associated heat flux to generate the giant *** IRGS and IOCG deposits require direct exsolution of volatile-rich m.gm.tic-hydrotherm.l fluids,whereas the association of such m.lts with Carlin-type ores is m.re indirect and *** orogenic gold provinces show no direct relationship to such *** from.m.tam.rphic fluids,but show an indirect relationship to lam.rophyres that reflect the m.ntle connectivity of controlling first-order *** contrast to their province scale sim.larities,the different giant gold deposit styles show contrasting critical controls at the district to deposit *** orogenic gold deposits,the giants appear to have form.d by conjunction of a greater num.er of param.ters to those that control sm.ller deposits,with resultant geom.trical and lithostratigraphic com.lexity as a guide to their *** are few giant IRGS due to their inferior fluid-flux system. relative to orogeni

关键词： Giant gold deposits Orogenic gold Carlin deposits Iron oxide-copper-gold deposits Intrusion-related gold system. Lithosphere

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