Endoplasmic reticulum stress and liver diseases

作     者：Xiaoying Liu Richard M.Green Xiaoying Liu;Richard M.Green

作者机构：Division of Gastroenterology and HepatologyDepartment of MedicineNorthwestern University Feinberg School of MedicineChicagoILUSA 

出 版 物：《Liver Research》 (肝脏研究（英文）)

年 卷 期：2019年第3卷第1期

页      面：55-64页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by USA National Institute of Diabetes and Digestive and Kidney Diseases(NIDDK)R01 DK093807 

主　　题：Endoplasmic reticulum(ER)stress Unfolded protein response(UPR) Inositol-requiring enzyme 1 a(IRE1 a) Double-stranded RNA-dependent protein kinase(PKR)-like ER kinase(PERK) Activating transcription factor 6(ATF6) Liver diseases 

摘      要：Endoplasmic reticulum(ER)stress occurs when ER homeostasis is perturbed with accumulation of unfolded/misfolded protein or calcium *** unfolded protein response(UPR),comprising of inositol-requiring enzyme 1 a(IRE1 a),double-stranded RNA-dependent protein kinase(PKR)-like ER kinase(PERK)and activating transcription factor 6(ATF6)signaling pathways,is a protective cellular response activated by ER ***,UPR activation can also induce cell death upon persistent ER *** liver is susceptible to ER stress given its synthetic and other biological *** studies from human liver samples and animal disease models have indicated a crucial role of ER stress and the UPR signaling pathways in the pathogenesis of liver diseases,including non-alcoholic fatty liver disease(NAFLD),alcoholic liver disease(ALD),alpha-1 antitrypsin(AAT)deficiency(AATD),cholestatic liver disease,drug-induced liver injury,ischemia/reperfusion(I/R)injury,viral hepatitis and hepatocel-lular carcinoma(HCC).Extensive investigations have demonstrated the potential underlying mechanisms of the induction of ER stress and the contribution of the UPR pathways during the development of the ***,ER stress and the UPR proteins and genes have become emerging therapeutic targets to treat liver diseases.