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RecBERT:Semantic recommendation engine with large language model enhanced query segmentation for k-nearest neighbors ranking retrieval

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Intelligent and Converged Networks 2024年第1期5卷 42-52页

作者： richard Wu the Dublin Unified School District and the SF Artificial Intelligence Club DublinCA 94568USA

The increasing amount of user traffic on Internet discussion forums has led to a huge amount of unstructured natural language data in the form of user *** modern recommendation systems rely on manual tagging,relying on administrators to label the features of a class,or story,which a user comment corresponds *** common approach is to use pre-trained word embeddings to compare class descriptions for textual similarity,then use a distance metric such as cosine similarity or Euclidean distance to find top k ***,neither approach is able to fully utilize this user-generated unstructured natural language data,reducing the scope of these recommendation *** paper studies the application of domain adaptation on a transformer for the set of user comments to be indexed,and the use of simple contrastive learning for the sentence transformer fine-tuning process to generate meaningful semantic embeddings for the various user comments that apply to each *** order to match a query containing content from multiple user comments belonging to the same class,the construction of a subquery channel for computing class-level similarity is *** channel uses query segmentation of the aggregate query into subqueries,performing k-nearest neighbors(KNN)search on each individual *** achieves state-of-the-art performance,outperforming other state-of-the-art models in accuracy,precision,recall,and F1 score for classifying comments between four and eight classes,*** outperforms the most precise state-of-the-art model(distilRoBERTa)in precision by 6.97%for matching comments between eight classes.

关键词： sentence transformer simple contrastive learning large language models query segmentation k-nearest neighbors

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Production Process and Properties of a Highly Porous Al Alloy Made Using NaCl Droplets as a Space Holder

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Acta Metallurgica Sinica(English Letters) 2015年第8期28卷 1034-1040页

作者： Manuela Covaciu Andrew richard Kennedy Faculty of Engineering University of Nottingham Faculty of Material Science and Engineering Universitatea Tehnica din Cluj-Napoca School of Engineering Pontificia Universidad Católica de Chile

Porous Al structures have been made using a porogen leaching method but with additional novel steps. In this way, Al-0.25Cu-0.6Si-1.0Mg alloys with interconnected, open cells have been made, with high levels of porosity（up to 89%）. The use of 4 to 5 mm diameter sodium chloride droplets combined with interspersion of the metal powder and droplets in the die and dissolution of the salt before sintering was found to enable easier interspersion of the two components, resulting in good connectivity of the beads via the formation of ‘‘windows＇＇ between the pores, and rapid elimination of salt from the structure. Porous Al with densities in the range of 0.28–0.86 g/cm3 exhibited compressive yield strengths in the range of 0.14 to 7.5 MPa, with no difference being observed between the samples made by this route and by more conventional dissolution of the salt after sintering. These novel steps widen the possibility for porous metal manufacture to other materials, not limited by the need to have a sintering temperature below that for the melting point of salt.

关键词： Aluminium alloy Sodium chloride Porous metal

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Performance of slotted pores in particle manufacture using rotating membrane emulsification

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Particuology 2009年第2期7卷 114-120页

作者： Nita Aryanti richard A. Williams Institute of Particle Science and Engineering School of ProcessEnvironmental & Materials EngineeringUniversity of LeedsLeeds LS2 9JTUK

This paper addresses the use of different slotted pores in rotating membrane emulsification technology. Pores of square and rectangular shapes were studied to understand the effect of aspect ratio （1-3.5） and their orientation on oil droplet formation. Increasing the membrane rotation speed decreased the droplet size, and the oil droplets produced were more uniform using slotted pores as compared to circular geometry. At a given rotation speed, the droplet size was mainly determined by the pore size and the fluid velocity of oil through the pore （pore fluid velocity）. The ratio of droplet diameter to the equivalent diameter of the slotted pore increased with the pore fluid velocity. At a given pore fluid velocity and rotation speed, pore orientation significantly influences the droplet formation rate： horizontally disposed pores （with their longer side perpendicular to the membrane axis） generate droplets at double the rate of vertically disposed pores. This work indicates practical benefits in the use of slotted membranes over conventional methods.

关键词： Membrane emulsification Slotted pore Tubular membrane Rotating emulsification Size control High throughput

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A framework for quantifying properties of 3-dimensional movement-based signals

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Current Zoology 2010年第3期56卷 327-336页

作者： Shaun TD NEW richard A PETERS ARC Centre of Excellence in Vision Science Division of EvolutionEcology & GeneticsResearch School of BiologyThe Australian National University

Understanding how signal properties are optimized for the reliable transmission of information requires accurate de- scription of the signal in time and space. For movement-based signals where movement is restricted to a single plane, measure- ments from a single viewpoint can be used to consider a range of viewing positions based on simple geometric calculations. However, considerations of signal properties from a range of viewing positions for movements extending into three-dimensions （3D） are more problematic. We present here a new framework that overcomes this limitation, and enables us to quantify the extent to which movement-based signals are view-specific. To illustrate its application, a Jacky lizard tail flick signal was filmed with synchronized cameras and the position of the tail tip digitized for both recordings. Camera aligmnent enabled tl^e construction of a 3D display action pattern profile. We analyzed the profile directly and used it to create a detailed 3D animation. In the virtual environment, we were able to film the same signal from multiple viewing positions and using a computational motion analysis algorithm （gradient detector model） to measure local image velocity in order to predict view dependent differences in signal properties. This approach will enable consideration of a range of questions concerning movement-based signal design and evolu- tion that were previously out of reach [Current Zoology 56 （3）： 327-336, 2010].

关键词： Signal evolution Sensory Ecology Movement-based signal 3D Display Action Pattern

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MicroRNAs:new players in the DNA damage response

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Journal of Molecular Cell Biology 2011年第3期3卷 151-158页

作者： Hailiang Hu richard A.Gatti Department of Pathology and Laboratory Medicine David Geffen School of Medicine at UCLALos AngelesCA 90095-1732USA Department of Human Genetics David Geffen School of Medicine at UCLALos AngelesCA 90095-1732USA

The DNA damage response(DDR)is a signal transduction pathway that decides the cell’s fate either to repair DNA damage or to undergo apoptosis if there is too much ***-translational modifications modulate the assembly and activity of protein complexes during the DDR ***(miRNAs)are emerging as a class of endogenous gene modulators that control protein levels,thereby adding a new layer of regulation to the *** this review,we describe a new role for miRNAs in regulating the cellular response to DNA damage with a focus on DNA double-strand break *** also discuss the implications of miRNA’s role in the DDR to stem cells,including embryonic stem cells and cancer stem cells,stressing the potential applications for miRNAs to be used as sensitizers for cancer radiotherapy and chemotherapy.

关键词： microRNA DNA damage response radiosensitivity stem cells

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The role of interleukin-18 in glioblastoma pathology implies therapeutic potential of two old drugs-disulfiram and ritonavir

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Chinese Journal of Cancer 2015年第4期34卷 161-165页

作者： richard E Kast International Initiative for Accelerated Improvement of Glioblastoma Care Study Center

Based on reporting in the last several years,an impressive but dismal list of cytotoxic chemotherapies that fail to prolong the median overall survival of patients with glioblastoma has prompted the development of treatment protocols designed to interfere with growth-facilitating signaling systems by using non-cytotoxic,non-oncology *** recognition of the pro-mobility stimulus,interleukin-18,as a driver of centrifugal glioblastoma cell migration allows potential treatment adjuncts with disulfiram and *** and ritonavir are well-tolerated,non-cytotoxic,non-oncology chemotherapeutic drugs that are marketed for the treatment of alcoholism and human immunodeficiency virus(HIV) infection,*** drugs exhibit an interleukin-18—inhibiting *** the favorable tolerability profile of disulfiram and ritonavir,the unlikely drug-drug interaction with temozolomide,and the poor prognosis of glioblastoma,trials of addition of disulfiram and ritonavir to current standard initial treatment of glioblastoma would be warranted.

关键词：白细胞介素-18 胶质细胞治疗方案人类免疫缺陷病毒硫病理细胞毒性治疗药物

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State of the Art in Alcohol Sensing with 2D Materials

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Nano-Micro Letters 2020年第3期12卷 22-54页

作者： Ramin Boroujerdi Amr Abdelkader richard Paul Faculty of Science and Technology Bournemouth UniversityTalbot CampusFern BarrowPoole BH125BBUK Department of Engineering University of CambridgeCambridge CB30FSUK

Since the discovery of graphene,the star among new materials,there has been a surge of attention focused on the monatomic and monomolecular sheets which can be obtained by exfoliation of layered *** materials are known as two-dimensional(2D)materials and offer enormous versatility and *** ultimate single atom,or molecule,thickness of the 2D materials sheets provides the highest surface to weight ratio of all the nanomaterials,which opens the door to the design of more sensitive and reliable chemical *** variety of properties and the possibility of tuning the chemical and surface properties of the 2D materials increase their potential as selective sensors,targeting chemical species that were previously difficult to *** planar structure and the mechanical flexibility of the sheets allow new sensor designs and put 2D materials at the forefront of all the candidates for wearable *** developing sensors for alcohol,the response time is an essential factor for many industrial and forensic applications,particularly when it comes to hand-held ***,we review recent developments in the applications of 2D materials in sensing alcohols along with a study on parameters that affect the sensing *** review also discusses the strategies used to develop the sensor along with their mechanisms of sensing and provides a critique of the current limitations of 2D materials-based alcohol sensors and an outlook for the future research required to overcome the challenges.

关键词： Sensors and biosensors Alcohol probes Electrochemical detectors Ethanol metabolites 2D materials

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Hereditary pancreatitis

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World Journal of Gastroenterology 2003年第1期9卷 1-4页

作者： richard M Charnley Consultant Surgeon Freeman HospitalNewcastle upon TyneNE7 7DNUK

Hereditary pancreatitis is an autosomal dominant condition,which results in recurrent attacks of acute pancreatitis,progressing to chronic pancreatitis often at a young *** majority of patients with hereditary pancreatitis expressone of two mutations (R122H or N29I) in the cationictrypsinogen gene (PRSS1 gene). It has been hypothesisedthat one of these mutations, the R122H mutation causespancreatitis by altering a trypsin recognition site sopreventing deactivation of trypsin within the pancreas andprolonging its action, resulting in autodigestion. Families withthese two mutations have been identified in many countriesand there are also other rarer mutations, which have alsobeen linked to hereditary *** with hereditary pancreatitis present in the sameway as those with sporadic pancreatitis but at an earlierage. It is common for patients to remain undiagnosed formany years, particularly ifthey present with non-specificsymptoms. Hereditary pancreatitis should always beconsidered in patients who present with recurrent pancreatitiswith a family history of pancreatic disease. If patients withthe 2 common mutations are compared, those with theR122H mutation are more likely to present at a younger ageand are more likely to require surgical intervention than thosewith N29I. Hereditary pancreatitis carries a 40 % lifetimerisk of pancreatic cancer with those patients aged between50 to 70 being most at risk in whom screening tests maybecome important.

关键词： Trypsin Genetic Counseling Genetic Screening Humans Pancreatitis Point Mutation Risk Factors Trypsinogen

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Metallic biliary stents for malignant obstructive jaundice:a review

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World Journal of Gastroenterology 2000年第5期6卷 643-646页

作者： richard A.Kozarek Section of Gastroenterology Virginia Mason Medical CenterSeattleWAUSA MD

Affecting 8-10 patients per 100000population,pancreatic cancer is the primary causeof malignant obstructive jaundice and is thepresenting feature in over three quarters of ***,using modern imagingtechniques,such as endoscopic ultrasound orpancreatic protocol computed tomography withvascular reconstruction,80%-90% proveunrescctable for ***,this jaundicewas treated surgically with biliary ***

关键词： pancreatic neoplasms bile duct neoplasms cholangiopancreatography endoscopic retrograde cholestasis stents

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Cell transplantation to replace retinal ganglion cells faces challenges-the Switchboard Dilemma

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Neural Regeneration Research 2021年第6期16卷 1138-1143页

作者： Yuan Liu richard K.Lee Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiamiFLUSA

The mammalian retina displays incomplete intrinsic regenerative capacities;therefore,retina degeneration is a major cause of irreversible blindness such as glaucoma,agerelated macular degeneration and diabetic *** diseases lead to the loss of retinal cells and serious vision loss in the late *** cell transplantation is a great promising novel treatment for these incurable retinal degenerative diseases and represents an exciting area of regenerative *** suitable stem cell sources for transplantation including human embryonic stem cells,induced pluripotent stem cells and adult stem cells have been identified as promising target ***,the retina is an elegant neuronal complex composed of various types of cells with different *** replacement of these different types of cells by transplantation should be addressed *** far,retinal pigment epithelium transplantation has achieved the most advanced stage of clinical trials,while transplantation of retinal neurons such as retinal ganglion cells and photoreceptors has been mostly studied in pre-clinical animal *** this review,we opine on the key problems that need to be addressed before stem cells transplantation,especially for replacing injured retinal ganglion cells,may be used practically for treatment.A key problem we have called the Switchboard Dilemma is a major block to have functional retinal ganglion cell *** use the public switchboard telephone network as an example to illustrate different difficulties for replacing damaged components in the retina that allow for visual *** ganglion cell transplantation is confronted by significant hurdles,because retinal ganglion cells receive signals from different interneurons,integrate and send signals to the correct targets of the visual system,which functions similar to the switchboard in a telephone network-therefore the Switchboard Dilemma.

关键词： cell transplantation optic nerve regeneration photoreceptors retina degeneration retinal ganglion cells stem cells

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